LINDSAY HOUGH

Summary

Affiliation: Albany Medical College
Country: USA

Publications

  1. pmc Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic
    Lindsay B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY, USA
    Pain 152:878-87. 2011
  2. pmc Non-opioid antinociception produced by brain stem injections of improgan: significance of local, but not cross-regional, cannabinoid mechanisms
    Lindsay B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Brain Res 1247:62-70. 2009
  3. pmc H3 receptors and pain modulation: peripheral, spinal, and brain interactions
    Lindsay B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    J Pharmacol Exp Ther 336:30-7. 2011
  4. pmc CC12, a high-affinity ligand for [3H]cimetidine binding, is an improgan antagonist
    Lindsay B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Neuropharmacology 52:1244-55. 2007
  5. ncbi request reprint Inhibition of improgan antinociception by the cannabinoid (CB)(1) antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A): lack of obligatory role for endocannabinoids acting at CB(1) receptor
    L B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    J Pharmacol Exp Ther 303:314-22. 2002
  6. ncbi request reprint Pain-relieving drugs and the brain histaminergic system: multiple analgesic mechanisms from histamine, improgan and cimetidine
    L B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, USA
    Inflamm Res 53:S43-4. 2004
  7. ncbi request reprint Significance of GABAergic systems in the action of improgan, a non-opioid analgesic
    L B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Life Sci 68:2751-7. 2001
  8. ncbi request reprint Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice
    L B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, Albany, NY 12208, USA
    Brain Res 880:102-8. 2000
  9. ncbi request reprint A third life for burimamide. Discovery and characterization of a novel class of non-opioid analgesics derived from histamine antagonists
    L B Hough
    Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Ann N Y Acad Sci 909:25-40. 2000
  10. ncbi request reprint Pharmacokinetic characterization of the indole alkaloid ibogaine in rats
    L B Hough
    Department of Pharmacology and Neuroscience, Albany Medical College, NY, USA
    Methods Find Exp Clin Pharmacol 22:77-81. 2000

Research Grants

  1. P450 Epoxygenase Mechanisms of Opioid Analgesia
    LINDSAY HOUGH; Fiscal Year: 2010
  2. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2003
  3. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2006
  4. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2007
  5. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2009
  6. HISTAMINERGIC MECHANISMS OF ANALGESIA
    LINDSAY HOUGH; Fiscal Year: 1992
  7. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 1999

Collaborators

Detail Information

Publications33

  1. pmc Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic
    Lindsay B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY, USA
    Pain 152:878-87. 2011
    ..A model is proposed in which (1) improgan activates an unknown receptor to trigger downstream P450 activity, and (2) brainstem epoxygenase activity is a point of convergence for opioid and nonopioid analgesic signaling...
  2. pmc Non-opioid antinociception produced by brain stem injections of improgan: significance of local, but not cross-regional, cannabinoid mechanisms
    Lindsay B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Brain Res 1247:62-70. 2009
    ..These studies show that improgan activates pain-relieving mechanisms in the PAG and the RM, both of which may utilize local cannabinoid mechanisms...
  3. pmc H3 receptors and pain modulation: peripheral, spinal, and brain interactions
    Lindsay B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    J Pharmacol Exp Ther 336:30-7. 2011
    ..Newer H(3) inverse agonists with potent, selective, and brain-penetrating properties show efficacy in several neuropathic and arthritis pain models, but the sites and mechanisms for these actions remain poorly understood...
  4. pmc CC12, a high-affinity ligand for [3H]cimetidine binding, is an improgan antagonist
    Lindsay B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Neuropharmacology 52:1244-55. 2007
    ..Elucidation of this mechanism will enhance understanding of the biochemistry of pain relief...
  5. ncbi request reprint Inhibition of improgan antinociception by the cannabinoid (CB)(1) antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A): lack of obligatory role for endocannabinoids acting at CB(1) receptor
    L B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    J Pharmacol Exp Ther 303:314-22. 2002
    ..SR141716A will facilitate the study of improgan-like analgesics...
  6. ncbi request reprint Pain-relieving drugs and the brain histaminergic system: multiple analgesic mechanisms from histamine, improgan and cimetidine
    L B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, USA
    Inflamm Res 53:S43-4. 2004
  7. ncbi request reprint Significance of GABAergic systems in the action of improgan, a non-opioid analgesic
    L B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Life Sci 68:2751-7. 2001
    ..Since muscimol is the first compound discovered which inhibits improgan analgesia, muscimol will be a useful tool for the further characterization of this new class of pain-relieving substances...
  8. ncbi request reprint Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice
    L B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, Albany, NY 12208, USA
    Brain Res 880:102-8. 2000
    ..These studies demonstrate that improgan analgesia does not require intact MOR-1, DOR-1, or KOR-1 genes, and support the hypothesis that improgan-like analgesics act in the CNS by non-opioid mechanisms...
  9. ncbi request reprint A third life for burimamide. Discovery and characterization of a novel class of non-opioid analgesics derived from histamine antagonists
    L B Hough
    Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Ann N Y Acad Sci 909:25-40. 2000
    ..Studies in progress are characterizing the sites and mechanisms of action of improgan, and developing brain-penetrating derivatives that could be useful for clinical pain...
  10. ncbi request reprint Pharmacokinetic characterization of the indole alkaloid ibogaine in rats
    L B Hough
    Department of Pharmacology and Neuroscience, Albany Medical College, NY, USA
    Methods Find Exp Clin Pharmacol 22:77-81. 2000
    ..The sequestration of ibogaine by adipose tissue probably contributes to a protracted persistence of drug in the body. This persistence may be underestimated by the beta half-life reported in the present study...
  11. ncbi request reprint Antinociceptive activity of derivatives of improgran and burimamide
    L B Hough
    Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Pharmacol Biochem Behav 65:61-6. 2000
    ..Although the mechanism of improgan antinociception remains unknown, the present results show promise for the further development of safe, effective, and potent pain-relieving compounds...
  12. ncbi request reprint Antinociceptive activity of chemical congeners of improgan: optimization of side chain length leads to the discovery of a new, potent, non-opioid analgesic
    Lindsay B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, Albany, NY 12208, USA
    Neuropharmacology 51:447-56. 2006
    ..The present results show that VUF5420 is a high potency, improgan-like, non-opioid analgesic which may indirectly activate cannabinoid pain-relieving mechanisms...
  13. pmc Antinociceptive activity of furan-containing congeners of improgan and ranitidine
    L B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, Albany, NY 12208, USA
    Bioorg Med Chem Lett 17:5715-9. 2007
    ..These non-imidazole, improgan-like pain relievers further define the structural requirements for analgesics of this class and are important tools for ongoing mechanism-based studies...
  14. ncbi request reprint Absence of antinociceptive tolerance to improgan, a cimetidine analog, in rats
    M D Bannoura
    Department of Pharmacology and Neuroscience, Albany Medical College, Albany, NY
    Brain Res 814:218-21. 1998
    ..Thus, improgan produced highly effective analgesia without the development of tolerance...
  15. ncbi request reprint A role for spinal, but not supraspinal, alpha(2) adrenergic receptors in the actions of improgan, a powerful, non-opioid analgesic
    K Svokos
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC-136, Albany, NY 12208, USA
    Brain Res 923:12-9. 2001
    ..Like several other classes of analgesics, improgan-like drugs seem to activate non-opioid, descending pain-relieving circuits...
  16. ncbi request reprint Antinociceptive activity of impentamine, a histamine congener, after CNS administration
    L B Hough
    Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Life Sci 64:PL79-86. 1999
    ....
  17. ncbi request reprint Activation of brain stem nuclei by improgan, a non-opioid analgesic
    J W Nalwalk
    Center of Neuropharmacology and Neuroscience MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Brain Res 1021:248-55. 2004
    ..Unlike these other analgesics, improgan does not act in the spinal cord or in CNS areas outside of the brain stem...
  18. ncbi request reprint Absence of 5-HT3 and cholinergic mechanisms in improgan antinociception
    J W Nalwalk
    Center of Neuropharmacology and Neuroscience, MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, United States
    Pharmacol Biochem Behav 80:505-10. 2005
    ..These results show no role for supraspinal cholinergic and 5-HT(3) receptors in improgan antinociception. The findings help to narrow the search for the relevant mediators of the action of this novel analgesic agent...
  19. pmc Effects of acetylenic epoxygenase inhibitors on recombinant cytochrome p450s
    Melissa A VanAlstine
    Chemistry Department, Adelphi University, Garden City, New York, USA
    Drug Metab Dispos 39:1221-6. 2011
    ..These results will facilitate the judicious use of PPOH and MS-PPOH for epoxygenase research...
  20. ncbi request reprint Inhibition of chemical and low-intensity mechanical nociception by activation of histamine H3 receptors
    Keri E Cannon
    Center for Neuropharmacology and Neuroscience, Albany Medical School, NY 12206, USA
    J Pain 6:193-200. 2005
    ..The present study shows that drugs that stimulate H 3 receptors can reduce behavioral responses produced by some, but not all, painful stimuli. Thus, H 3 agonists could be a new type of therapy for certain kinds of pain disorders...
  21. ncbi request reprint Depletion of brain histamine produces regionally selective protection against thiamine deficiency-induced lesions in the rat
    Philip J Langlais
    Behavioral Neurobiology Section, Department of Psychology, San Diego State University, California 92182, USA
    Metab Brain Dis 17:199-210. 2002
    ..Furthermore, these data suggest either a dissociation between seizures and thalamic lesions or a significant role of histamine in seizure-related damage to the thalamus...
  22. ncbi request reprint Improgan antinociception does not require neuronal histamine or histamine receptors
    Jalal Izadi Mobarakeh
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Brain Res 974:146-52. 2003
    ..The present findings strongly support the hypothesis that neuronal histamine and its receptors fail to play a role in improgan-induced antinociception...
  23. pmc High-affinity binding of [3H]cimetidine to a heme-containing protein in rat brain
    Rebecca Stadel
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Ave, Albany, NY 12208, USA
    Drug Metab Dispos 36:614-21. 2008
    ..Finally, CC12 is a new, potent inhibitor of CYP2B6 and CYP2C19 that may be a valuable tool for P450 research...
  24. pmc Activation of peripheral and spinal histamine H3 receptors inhibits formalin-induced inflammation and nociception, respectively
    Keri E Cannon
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, Albany, NY 12206, USA
    Pharmacol Biochem Behav 88:122-9. 2007
    ..Pharmacological stimulation of H3 receptors could be an important therapeutic approach for many disorders related to deep dermal or inflammatory pain...
  25. pmc Significance of cannabinoid CB1 receptors in improgan antinociception
    Neal C Gehani
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Pain 8:850-60. 2007
    ..Improgan may use a marijuana-like (cannabinoid) pain-relieving mechanism, but it is shown presently that the principal cannabinoid receptor in the brain (CB(1)) is not solely responsible for improgan analgesia...
  26. pmc Improgan-induced hypothermia: a role for cannabinoid receptors in improgan-induced changes in nociceptive threshold and body temperature
    Catherine L Salussolia
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, Albany, NY 12206, USA
    Brain Res 1152:42-8. 2007
    ..Pretreatment with CC12 (183 microg, ivt) produced complete inhibition of both the antinociception and the hypothermia produced by improgan, suggesting the possible role of an unknown improgan receptor in both of these effects...
  27. ncbi request reprint Cannabinoid-improgan cross-tolerance: Improgan is a cannabinomimetic analgesic lacking affinity at the cannabinoid CB1 receptor
    Julia W Nalwalk
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, Albany, NY 12208, USA
    Eur J Pharmacol 549:79-83. 2006
    ..Either possibility offers the potential for developing new types of analgesics...
  28. ncbi request reprint Antinociceptive, brain-penetrating derivatives related to improgan, a non-opioid analgesic
    Lindsay B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, NY 12208, USA
    Eur J Pharmacol 522:38-46. 2005
    ....
  29. ncbi request reprint Effects of cimetidine-like drugs on recombinant GABAA receptors
    Keri E Cannon
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Ave, Albany, NY 12206, USA
    Life Sci 75:2551-8. 2004
    ....
  30. ncbi request reprint Characterization of a new mRNA species from the human histamine N-methyltransferase gene
    William G Barnes
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, Albany, NY 12208, USA
    Genomics 83:168-71. 2004
    ..These studies show that HNMT-S is a new mRNA species and putative protein product from HNMT. The physiological role of HNMT-S remains to be investigated...
  31. ncbi request reprint Activation of spinal histamine H3 receptors inhibits mechanical nociception
    Keri E Cannon
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Ave, Albany, NY 12206, USA
    Eur J Pharmacol 470:139-47. 2003
    ..e. mechanical vs. thermal) inhibition of nociception by these receptors, and to assess the efficacy of spinally delivered histamine H(3) receptor agonists for the treatment for pain...
  32. pmc Immunohistochemical localization of histamine H3 receptors in rodent skin, dorsal root ganglia, superior cervical ganglia, and spinal cord: potential antinociceptive targets
    Keri E Cannon
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, Albany, NY 12208, USA
    Pain 129:76-92. 2007
    ..Taken with recently published behavioral results, the present findings suggest that periarterial, peptidergic, H3R-containing A delta fibers may be sources of high threshold mechanical nociception...
  33. ncbi request reprint Membrane-bound histamine N-methyltransferase in mouse brain: possible role in the synaptic inactivation of neuronal histamine
    William G Barnes
    Center for Neuropharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    J Neurochem 82:1262-71. 2002
    ..Although molecular studies have not yet identified the nature of this activity, the present work suggests that levels of biologically active histamine may be controlled by an extracellular process...

Research Grants23

  1. P450 Epoxygenase Mechanisms of Opioid Analgesia
    LINDSAY HOUGH; Fiscal Year: 2010
    ..This proposal will uncover new biochemical mechanisms for pain relief, and test a new group of chemicals for pain-relieving properties. This research could lead to the development of new, non-addicting pain relievers. ..
  2. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2003
    ....
  3. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2006
    ..These experiments will help to discover the mechanism of action of this novel class of agents, and lead to the development of new pharmacotherapies for pain. ..
  4. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2007
    ..These collaborative experiments between pharmacologists, neurophysiologists and chemists will discover the mechanism of action of this novel class of agents and lead to the development of new, non-opioid pharmacotherapies for pain. ..
  5. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2009
    ..abstract_text> ..
  6. HISTAMINERGIC MECHANISMS OF ANALGESIA
    LINDSAY HOUGH; Fiscal Year: 1992
    ..These studies will enhance our knowledge of antinociceptive mechanisms, and may lead to the development of novel, clinically useful agents for the relief of pain...
  7. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 1999
    ..These studies will clarify the mechanisms by which MOR relieves pain, enhance the understanding of histaminergic antinociceptive mechanisms, and may lead to the discovery of non-addicting, novel medications for the treatment of pain. ..