Katharine Herrick-Davis

Summary

Affiliation: Albany Medical College
Country: USA

Publications

  1. pmc Functional significance of serotonin receptor dimerization
    Katharine Herrick-Davis
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Neil Hellman Medical Research Building, Mail code, 136, 47 New Scotland Ave, Albany, NY, 12208, USA
    Exp Brain Res 230:375-86. 2013
  2. pmc Oligomer size of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor revealed by fluorescence correlation spectroscopy with photon counting histogram analysis: evidence for homodimers without monomers or tetramers
    Katharine Herrick-Davis
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 287:23604-14. 2012
  3. ncbi request reprint Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors
    K Herrick-Davis
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA
    J Pharmacol Exp Ther 295:226-32. 2000
  4. pmc Serotonin 5-HT(2C) receptor homodimerization is not regulated by agonist or inverse agonist treatment
    Katharine Herrick-Davis
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, United States
    Eur J Pharmacol 568:45-53. 2007
  5. ncbi request reprint Serotonin 5-HT2C receptor homodimer biogenesis in the endoplasmic reticulum: real-time visualization with confocal fluorescence resonance energy transfer
    Katharine Herrick-Davis
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 281:27109-16. 2006
  6. ncbi request reprint Inhibition of serotonin 5-hydroxytryptamine2c receptor function through heterodimerization: receptor dimers bind two molecules of ligand and one G-protein
    Katharine Herrick-Davis
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 280:40144-51. 2005
  7. ncbi request reprint Biochemical and biophysical characterization of serotonin 5-HT2C receptor homodimers on the plasma membrane of living cells
    Katharine Herrick-Davis
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    Biochemistry 43:13963-71. 2004
  8. ncbi request reprint Stable expression of constitutively activated mutant h5HT6 and h5HT7 serotonin receptors: inverse agonist activity of antipsychotic drugs
    Anil Purohit
    Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Psychopharmacology (Berl) 179:461-9. 2005
  9. ncbi request reprint Constitutive activity of G-protein coupled receptors: emphasis on serotonin receptors
    Milt Teitler
    Center for Neuroscience and Neuropharmacology, Albany Medical College, 47 New Scotland Avenue, Albany, N Y 12208, USA
    Curr Top Med Chem 2:529-38. 2002
  10. ncbi request reprint Risperidone irreversibly binds to and inactivates the h5-HT7 serotonin receptor
    Carol Smith
    A 136, Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA
    Mol Pharmacol 70:1264-70. 2006

Research Grants

  1. MOLECULAR BIOLOGY OF MUTANT 5-HT2C SEROTONIN RECEPTORS
    Katharine Herrick Davis; Fiscal Year: 1999
  2. MOLECULAR BIOLOGY OF MUTANT 5-HT2C SEROTONIN RECEPTORS
    Katharine Herrick Davis; Fiscal Year: 2000
  3. MOLECULAR BIOLOGY OF MUTANT 5-HT2C SEROTONIN RECEPTORS
    Katharine Herrick Davis; Fiscal Year: 2001
  4. MOLECULAR BIOLOGY OF MUTANT 5-HT2C SEROTONIN RECEPTORS
    Katharine Herrick Davis; Fiscal Year: 2003
  5. MOLECULAR BIOLOGY OF MUTANT 5-HT2C SEROTONIN RECEPTORS
    Katharine Herrick Davis; Fiscal Year: 2004
  6. MOLECULAR BIOLOGY OF MUTANT 5-HT2C SEROTONIN RECEPTORS
    Katharine Herrick Davis; Fiscal Year: 2005
  7. MOLECULAR BIOLOGY OF MUTANT 5-HT2C SEROTONIN RECEPTORS
    Katharine Herrick Davis; Fiscal Year: 2006

Collaborators

  • Milt Teitler
  • Dana R Crawford
  • TARA LINDSLEY
  • R A Glennon
  • Katharine Herrick Davis
  • Carol Smith
  • Anil Purohit
  • Małgorzata Dukat
  • William G Barnes
  • Ashraf A Rahman
  • Brian Grella
  • Jean Chang-Fong
  • Joseph Mazurkiewicz
  • Nicole Toohey
  • Tariq Rahman
  • Lindsay B Hough
  • Ellinor Grinde
  • Maha Khalifa Daoud
  • Alberto Malvezzi
  • Antonia Taveres do Amaral
  • Nicholas A Mitchell
  • James Addo

Detail Information

Publications19

  1. pmc Functional significance of serotonin receptor dimerization
    Katharine Herrick-Davis
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Neil Hellman Medical Research Building, Mail code, 136, 47 New Scotland Ave, Albany, NY, 12208, USA
    Exp Brain Res 230:375-86. 2013
    ..The functional significance will be discussed in terms of G-protein activation following ligand binding to one or two protomers in a dimeric structure, the formation of heterodimers, and the development of bivalent ligands. ..
  2. pmc Oligomer size of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor revealed by fluorescence correlation spectroscopy with photon counting histogram analysis: evidence for homodimers without monomers or tetramers
    Katharine Herrick-Davis
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 287:23604-14. 2012
    ..PCH analysis of the FCS data were best described by a one-component dimer model without monomers or tetramers. Therefore, it is concluded that 5-HT(2C) receptors freely diffusing within the plasma membrane are dimeric...
  3. ncbi request reprint Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors
    K Herrick-Davis
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA
    J Pharmacol Exp Ther 295:226-32. 2000
    ..These data also imply that dysfunction of brain 5-HT(2C) receptor systems may be one of the factors involved in the etiology of psychosis...
  4. pmc Serotonin 5-HT(2C) receptor homodimerization is not regulated by agonist or inverse agonist treatment
    Katharine Herrick-Davis
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, United States
    Eur J Pharmacol 568:45-53. 2007
    ..The results indicate that serotonin 5-HT(2C) receptors form homodimers regardless of whether they are in an inactive or active conformation and are not regulated by drug treatment...
  5. ncbi request reprint Serotonin 5-HT2C receptor homodimer biogenesis in the endoplasmic reticulum: real-time visualization with confocal fluorescence resonance energy transfer
    Katharine Herrick-Davis
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 281:27109-16. 2006
    ....
  6. ncbi request reprint Inhibition of serotonin 5-hydroxytryptamine2c receptor function through heterodimerization: receptor dimers bind two molecules of ligand and one G-protein
    Katharine Herrick-Davis
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 280:40144-51. 2005
    ..These results are consistent with a model in which one GPCR dimer binds two molecules of ligand and one G-protein and indicate that dimerization is essential for 5-HT receptor function...
  7. ncbi request reprint Biochemical and biophysical characterization of serotonin 5-HT2C receptor homodimers on the plasma membrane of living cells
    Katharine Herrick-Davis
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    Biochemistry 43:13963-71. 2004
    ..In addition, a confocal-based FRET method for monitoring receptor dimerization directly on the plasma membrane of living cells is described...
  8. ncbi request reprint Stable expression of constitutively activated mutant h5HT6 and h5HT7 serotonin receptors: inverse agonist activity of antipsychotic drugs
    Anil Purohit
    Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Psychopharmacology (Berl) 179:461-9. 2005
    ..Typical and atypical antipsychotic drugs were assayed for their potencies as inverse agonists at these mutated receptors...
  9. ncbi request reprint Constitutive activity of G-protein coupled receptors: emphasis on serotonin receptors
    Milt Teitler
    Center for Neuroscience and Neuropharmacology, Albany Medical College, 47 New Scotland Avenue, Albany, N Y 12208, USA
    Curr Top Med Chem 2:529-38. 2002
    ..Studies are presented demonstrating the procedures for producing and characterizing constitutive activated forms of serotonin receptors, including the demonstration of inverse agonist activity of drugs on these receptors...
  10. ncbi request reprint Risperidone irreversibly binds to and inactivates the h5-HT7 serotonin receptor
    Carol Smith
    A 136, Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA
    Mol Pharmacol 70:1264-70. 2006
    ..At the very least, the possibility that highly prescribed drugs, such as risperidone, are irreversibly antagonizing GPCR function in vivo is noteworthy...
  11. ncbi request reprint Fluorescence correlation spectroscopy and photon-counting histogram analysis of receptor-receptor interactions
    Katharine Herrick-Davis
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA
    Methods Cell Biol 117:181-96. 2013
    ..Since molecular brightness is directly proportional to the number of fluorescent molecules, it can be used to monitor receptor-receptor interactions and to decode the number of receptor monomers present in an oligomeric complex. ..
  12. ncbi request reprint Creation, expression, and characterization of a constitutively active mutant of the human serotonin 5-HT6 receptor
    Anil Purohit
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    Synapse 47:218-24. 2003
    ..The inverse agonist action of clozapine indicates that drugs displaying competitive antagonist activity at native 5-HT(6) receptors may display inverse agonist activity at the constitutively activated form of the receptor...
  13. pmc Fluorescence correlation spectroscopy analysis of serotonin, adrenergic, muscarinic, and dopamine receptor dimerization: the oligomer number puzzle
    Katharine Herrick-Davis
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York K H D, E G, J E M and Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, Connecticut A C
    Mol Pharmacol 84:630-42. 2013
    ..The results of this study demonstrate that biogenic amine receptors freely diffusing within the plasma membrane are predominantly homodimers. ..
  14. ncbi request reprint Characterization of a new mRNA species from the human histamine N-methyltransferase gene
    William G Barnes
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, Albany, NY 12208, USA
    Genomics 83:168-71. 2004
    ..These studies show that HNMT-S is a new mRNA species and putative protein product from HNMT. The physiological role of HNMT-S remains to be investigated...
  15. ncbi request reprint Arylguanidine and arylbiguanide binding at 5-HT3 serotonin receptors: a QSAR study
    Richard A Glennon
    Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA
    Bioorg Med Chem 11:4449-54. 2003
    ..A broader examination of 35 arylguanidines and arylbiguanides revealed that affinity could be described by molecular polarizability, a Chi index term (8chiP), and the sum of all (-Cl) E-State values (SsCl) in the molecule...
  16. ncbi request reprint Conformationally-restricted analogues and partition coefficients of the 5-HT3 serotonin receptor ligands meta-chlorophenylbiguanide (mCPBG) and meta-chlorophenylguanidine (mCPG)
    Ashraf A Rahman
    Department of Medicinal Chemistry, School of Pharmacy, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0540, USA
    Bioorg Med Chem Lett 13:1119-23. 2003
    ..38). The quinazoline structure may represent a pharmacologically-active conformation of these agents, and the arylbiguanides were found more lipid soluble than their arylguanidine counterparts at physiological pH...
  17. ncbi request reprint Binding of beta-carbolines at 5-HT(2) serotonin receptors
    Brian Grella
    Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298 0540, USA
    Bioorg Med Chem Lett 13:4421-5. 2003
    ..A binding profile was obtained for selected beta-carbolines...
  18. ncbi request reprint Binding of tryptamine analogs at h5-HT1E receptors: a structure-affinity investigation
    Małgorzata Dukat
    Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA
    Bioorg Med Chem 12:2545-52. 2004
    ..This finding was supported using quantitative structure-activity analysis (QSAR) techniques such as comparative molecular field analysis (CoMFA) and the program QsarIS...
  19. ncbi request reprint Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors
    Jean Chang-Fong
    Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA
    Bioorg Med Chem Lett 12:155-8. 2002
    ..Detailed re-examination of a compound previously reported to display 100-fold 5-HT(2C) selectivity [i.e., S(+)-5,6-difluoro-alpha-methylisotryptamine] revealed that its selectivity versus 5-HT(2A) receptors was, at best, only 10-fold...

Research Grants8

  1. MOLECULAR BIOLOGY OF MUTANT 5-HT2C SEROTONIN RECEPTORS
    Katharine Herrick Davis; Fiscal Year: 1999
    ....
  2. MOLECULAR BIOLOGY OF MUTANT 5-HT2C SEROTONIN RECEPTORS
    Katharine Herrick Davis; Fiscal Year: 2000
    ....
  3. MOLECULAR BIOLOGY OF MUTANT 5-HT2C SEROTONIN RECEPTORS
    Katharine Herrick Davis; Fiscal Year: 2001
    ....
  4. MOLECULAR BIOLOGY OF MUTANT 5-HT2C SEROTONIN RECEPTORS
    Katharine Herrick Davis; Fiscal Year: 2003
    ....
  5. MOLECULAR BIOLOGY OF MUTANT 5-HT2C SEROTONIN RECEPTORS
    Katharine Herrick Davis; Fiscal Year: 2004
    ....
  6. MOLECULAR BIOLOGY OF MUTANT 5-HT2C SEROTONIN RECEPTORS
    Katharine Herrick Davis; Fiscal Year: 2005
    ....
  7. MOLECULAR BIOLOGY OF MUTANT 5-HT2C SEROTONIN RECEPTORS
    Katharine Herrick Davis; Fiscal Year: 2006
    ....