EDMUND GOSSELIN

Summary

Affiliation: Albany Medical College
Country: USA

Publications

  1. pmc Multiple mechanisms mediate enhanced immunity generated by mAb-inactivated F. tularensis immunogen
    Bibiana V Iglesias
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Immunol Cell Biol 91:139-48. 2013
  2. pmc Mucosal immunization with an unadjuvanted vaccine that targets Streptococcus pneumoniae PspA to human Fcγ receptor type I protects against pneumococcal infection through complement- and lactoferrin-mediated bactericidal activity
    Constantine Bitsaktsis
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA
    Infect Immun 80:1166-80. 2012
  3. ncbi request reprint Natural killer and CD8 T cells dominate the response by human peripheral blood mononuclear cells to inactivated Francisella tularensis live vaccine strain
    Edmund J Gosselin
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Hum Immunol 66:1039-49. 2005
  4. ncbi request reprint Fc receptor-targeted mucosal vaccination as a novel strategy for the generation of enhanced immunity against mucosal and non-mucosal pathogens
    Edmund J Gosselin
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Arch Immunol Ther Exp (Warsz) 57:311-23. 2009
  5. pmc Utilization of Fc receptors as a mucosal vaccine strategy against an intracellular bacterium, Francisella tularensis
    Deepak B Rawool
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 180:5548-57. 2008
  6. pmc Differential requirements for protection against mucosal challenge with Francisella tularensis in the presence versus absence of cholera toxin B and inactivated F. tularensis
    Constantine Bitsaktsis
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 182:4899-909. 2009
  7. pmc Production of genetically engineered biotinylated interleukin-2 and its application in a rapid nonradioactive assay for T-cell activation
    Robert A Jordan
    Transplantation Immunology Laboratory Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208 3479, USA
    Clin Diagn Lab Immunol 10:339-44. 2003
  8. ncbi request reprint Enhanced antigen-specific antibody and cytokine responses when targeting antigen to human FcGAMMA receptor type I using an anti-human FcGAMMA receptor type I-streptavidin fusion protein in an adjuvant-free system
    Elisaveta Adamova
    Center for Immunology and Microbial Disease, MC 151, Albany Medical College, Albany, NY 12208, USA
    Immunol Invest 34:417-29. 2005

Collaborators

  • James R Drake
  • Karsten R O Hazlett
  • D W Metzger
  • Constantine Bitsaktsis
  • Bibiana V Iglesias
  • Ying Li
  • Diane R Gosselin
  • Deepak B Rawool
  • Giang Pham
  • Nitin V Kurkure
  • Elisaveta Adamova
  • Mark T Preissler
  • Robert A Jordan
  • Kristen Porter
  • Susan K Hollingshead
  • Jesus Colino
  • Clifford M Snapper
  • Bibiana Iglesias
  • Yili Lin
  • Mary C Walsh
  • Robert F Graziano
  • Karen Hale
  • Jeffrey A Banas

Detail Information

Publications8

  1. pmc Multiple mechanisms mediate enhanced immunity generated by mAb-inactivated F. tularensis immunogen
    Bibiana V Iglesias
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Immunol Cell Biol 91:139-48. 2013
    ..These results demonstrate that multiple cellular/immune mechanisms contribute to FcR-enhanced immunity...
  2. pmc Mucosal immunization with an unadjuvanted vaccine that targets Streptococcus pneumoniae PspA to human Fcγ receptor type I protects against pneumococcal infection through complement- and lactoferrin-mediated bactericidal activity
    Constantine Bitsaktsis
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA
    Infect Immun 80:1166-80. 2012
    ..Immune serum also showed an enhanced bactericidal activity directed against S. pneumoniae that appears to be lactoferrin mediated...
  3. ncbi request reprint Natural killer and CD8 T cells dominate the response by human peripheral blood mononuclear cells to inactivated Francisella tularensis live vaccine strain
    Edmund J Gosselin
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Hum Immunol 66:1039-49. 2005
    ..tularensis vaccines that use inactivated organisms. In addition, important new knowledge is added to our understanding of the human immune response to F. tularensis LVS...
  4. ncbi request reprint Fc receptor-targeted mucosal vaccination as a novel strategy for the generation of enhanced immunity against mucosal and non-mucosal pathogens
    Edmund J Gosselin
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Arch Immunol Ther Exp (Warsz) 57:311-23. 2009
    ....
  5. pmc Utilization of Fc receptors as a mucosal vaccine strategy against an intracellular bacterium, Francisella tularensis
    Deepak B Rawool
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 180:5548-57. 2008
    ..tularensis, a category A biothreat agent. In summary, these studies show for the first time the use of FcRs as a highly effective vaccination strategy against a highly virulent mucosal intracellular pathogen...
  6. pmc Differential requirements for protection against mucosal challenge with Francisella tularensis in the presence versus absence of cholera toxin B and inactivated F. tularensis
    Constantine Bitsaktsis
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 182:4899-909. 2009
    ..Thus, these data indicate that enhanced Th1 responses can supersede the requirement for anti-F. tularensis-specific IgA. This observation also has important ramifications for vaccine development against this organism...
  7. pmc Production of genetically engineered biotinylated interleukin-2 and its application in a rapid nonradioactive assay for T-cell activation
    Robert A Jordan
    Transplantation Immunology Laboratory Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208 3479, USA
    Clin Diagn Lab Immunol 10:339-44. 2003
    ..In addition, the availability of a recombinant biotinylated human IL-2 will permit the production of a uniform product suitable for diagnostic and clinical application...
  8. ncbi request reprint Enhanced antigen-specific antibody and cytokine responses when targeting antigen to human FcGAMMA receptor type I using an anti-human FcGAMMA receptor type I-streptavidin fusion protein in an adjuvant-free system
    Elisaveta Adamova
    Center for Immunology and Microbial Disease, MC 151, Albany Medical College, Albany, NY 12208, USA
    Immunol Invest 34:417-29. 2005
    ..Furthermore, antibody isotype and cytokine responses following immunization with hFcgammaRI-targeted antigen, suggest enhancement of both Th1 and Th2 responses...

Research Grants4

  1. Protective Activity of a Multi-Functional Immunogen
    EDMUND GOSSELIN; Fiscal Year: 2007
    ..Thus, these studies and this vaccine strategy will be applicable to vaccines against a wide variety of pathogens in adult, pediatric, and immunocompromised populations. ..
  2. Mechanisms Involved in, and Development of, FcR-Enhanced Mucosal Vaccination
    Edmund J Gosselin; Fiscal Year: 2010
    ....
  3. Mechanisms Involved in, and Development of, FcR-Enhanced Mucosal Vaccination
    EDMUND GOSSELIN; Fiscal Year: 2009
    ....