Research Topics
| STANLEY GLICKSummaryAffiliation: Albany Medical College Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Enantioselective behavioral effects of sibutramine metabolitesS D Glick
Department of Pharmacology and Neuroscience MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
Eur J Pharmacol 397:93-102. 2000..The results suggest that these enantioselective metabolites of sibutramine could be safe and effective treatments for obesity as well as possibly for depression...
Brain regions mediating alpha3beta4 nicotinic antagonist effects of 18-MC on methamphetamine and sucrose self-administrationStanley D Glick
Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
Eur J Pharmacol 599:91-5. 2008..The data also suggest that the basolateral amygdala along with a different pathway involving alpha3beta4 receptors in the dorsolateral tegmentum mediate the effect of 18-MC on sucrose self-administration...- 18-Methoxycoronaridine acts in the medial habenula and/or interpeduncular nucleus to decrease morphine self-administration in ratsStanley D Glick
Center for Neuropharmacology and Neuroscience Albany Medical College, MC 136, 47 New Scotland Avenue, NY 12208, USA
Eur J Pharmacol 537:94-8. 2006..These and other data are consistent with the hypothesis that 18-MC decreases morphine self-administration by blocking alpha3beta4 nicotinic receptors in the habenulo-interpeduncular pathway... - Brain regions mediating α3β4 nicotinic antagonist effects of 18-MC on nicotine self-administrationStanley D Glick
Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
Eur J Pharmacol 669:71-5. 2011..The data also suggest that an action of 18-MC in the interpeduncular nucleus may attenuate aversive and/or depressive effects of nicotine... - Modulation of nicotine self-administration in rats by combination therapy with agents blocking alpha 3 beta 4 nicotinic receptorsStanley D Glick
Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
Eur J Pharmacol 448:185-91. 2002..Antagonists of alpha3beta4 nicotinic receptors may represent a totally novel approach to treating polydrug abuse... - 18-Methoxycoronaridine (18-MC) and ibogaine: comparison of antiaddictive efficacy, toxicity, and mechanisms of actionS D Glick
Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA
Ann N Y Acad Sci 914:369-86. 2000..The data suggest that 18-MC has a narrower spectrum of actions and will have a substantially greater therapeutic index than ibogaine... - Antagonism of alpha 3 beta 4 nicotinic receptors as a strategy to reduce opioid and stimulant self-administrationStanley D Glick
Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
Eur J Pharmacol 438:99-105. 2002..18-Methoxycoronaridine apparently has greater selectivity for this site than other agents and may be the first of a new class of synthetic agents acting via this novel mechanism to produce a broad spectrum of anti-addictive activity... - Comparative effects of dextromethorphan and dextrorphan on morphine, methamphetamine, and nicotine self-administration in ratsS D Glick
Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
Eur J Pharmacol 422:87-90. 2001..The results also suggest that dextromethorphan should be tested extensively as a potential treatment for diverse populations of drug-abusing patients... - Development of novel medications for drug addiction. The legacy of an African shrubS D Glick
Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA
Ann N Y Acad Sci 909:88-103. 2000..18-MC also has (+) and (-) enantiomers, both of which are active. Considered together, all of the data indicate that 18-MC should be safer than ibogaine and at least as efficacious as an anti-addictive medication... 
Effects of nicotine, methamphetamine and cocaine on extracellular levels of acetylcholine in the interpeduncular nucleus of ratsRifat J Hussain
Center for Neuropharmacology and Neuroscience, MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, United States of America
Neurosci Lett 440:270-4. 2008..These results suggest that the habenulo-intepeduncular pathway may be a common target for drugs of abuse and, by modulating the mesolimbic pathway, may mediate unique aspects of the rewarding effects of different drugs...- Novel iboga alkaloid congeners block nicotinic receptors and reduce drug self-administrationChristopher J Pace
Center for Neuropharmacology and Neuroscience, The Albany Medical College, MC-136, 47 New Scotland Avenue, Albany, NY 12208, USA
Eur J Pharmacol 492:159-67. 2004..These compounds may constitute a new class of synthetic agents that act via the nicotinic alpha3beta4 mechanism to combat addiction... - Selective disruption of nucleus accumbens gating mechanisms in rats behaviorally sensitized to methamphetamineAnne Marie Brady
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
J Neurosci 25:6687-95. 2005.... - Attenuation of morphine withdrawal signs by intracerebral administration of 18-methoxycoronaridineVishal Panchal
Center for Neuropharmacology and Neuroscience MC-136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
Eur J Pharmacol 525:98-104. 2005..The present findings suggest that 18-MC may act in all three nuclei to suppress various signs of opioid withdrawal... - 18-Methoxycoronaridine blocks acquisition but enhances reinstatement of a cocaine place preferenceSarah E McCallum
Albany Medical College, Albany, NY, USA
Neurosci Lett 458:57-9. 2009..Our results are consistent with those obtained using ibogaine, but reinforce the notion that acquisition, expression and reinstatement of a CPP likely involve separate mechanisms... - Neural encoding of psychomotor activation in the nucleus accumbens core, but not the shell, requires cannabinoid receptor signalingJoshua T Morra
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
J Neurosci 30:5102-7. 2010..We therefore propose that endocannabinoid modulation of psychomotor activation is preferentially driven by CB1 receptor-dependent interneuron activity in the nucleus accumbens core... - 18-Methoxycoronaridine, a potential anti-obesity agent, does not produce a conditioned taste aversion in ratsOlga D Taraschenko
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY, USA
Pharmacol Biochem Behav 96:247-50. 2010..Consistent with previous data, 18-MC appears to have proactive effect for 24h and it does not induce a conditioned taste aversion... - Resistance of male Sprague-Dawley rats to sucrose-induced obesity: effects of 18-methoxycoronaridineOlga D Taraschenko
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY, United States
Physiol Behav 102:126-31. 2011..Such gender disparities could be secondary to sex-specific alterations in cholinergic mechanisms of feeding and body weight regulation... - Morphine-induced changes in acetylcholine release in the interpeduncular nucleus and relationship to changes in motor behavior in ratsOlga D Taraschenko
Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
Neuropharmacology 53:18-26. 2007..The latter results suggest that tolerance to morphine's effect on the cholinergic habenulo-interpeduncular pathway is related to its sensitizing effects on the mesostriatal dopaminergic pathways... - 18-methoxycoronaridine: a potential new treatment for obesity in rats?Olga D Taraschenko
Center for Neuropharmacology and Neuroscience MC 136, Albany Medical College, Albany, NY 12208, USA
Psychopharmacology (Berl) 201:339-50. 2008.... - 18-MC acts in the medial habenula and interpeduncular nucleus to attenuate dopamine sensitization to morphine in the nucleus accumbensOlga D Taraschenko
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
Synapse 61:547-60. 2007..The results suggest that 18-MC acts in the habenulo-interpeduncular pathway to modulate the effects of repeated morphine in the dopaminergic mesolimbic system... - Differential interactions of desipramine with amphetamine and methamphetamine: evidence that amphetamine releases dopamine from noradrenergic neurons in the medial prefrontal cortexJames R Shoblock
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA
Neurochem Res 29:1437-42. 2004..It is proposed that amphetamine releases dopamine in the prefrontal cortex primarily through norepinephrine transporters, whereas methamphetamine interacts minimally with norepinephrine transporters... - Is antagonism of alpha3beta4 nicotinic receptors a strategy to reduce morphine dependence?Olga D Taraschenko
Center for Neuropharmacology and Neuroscience MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
Eur J Pharmacol 513:207-18. 2005..The results of the present study provide evidence that alpha3beta4 nicotinic receptors are involved in the expression of at least two signs of opioid withdrawal... - Changes in electrophysiological properties of nucleus accumbens neurons depend on the extent of behavioral sensitization to chronic methamphetamineAnne Marie Brady
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
Ann N Y Acad Sci 1003:358-63. 2003 - Anti-addictive actions of an iboga alkaloid congener: a novel mechanism for a novel treatmentIsabelle M Maisonneuve
Center for Neuropharmacology and Neuroscience, Albany Medical College, MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
Pharmacol Biochem Behav 75:607-18. 2003.... - Differences between d-methamphetamine and d-amphetamine in rats: working memory, tolerance, and extinctionJames R Shoblock
Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Avenue MC 136, Albany, NY 12208, USA
Psychopharmacology (Berl) 170:150-6. 2003..Since working memory depends on PFC DA, it was postulated that AMPH would also be more potent than METH at affecting working memory... - Effects of dextromethorphan on dopamine release in the nucleus accumbens: Interactions with morphineCaren L Steinmiller
Center for Neuropharmacology and Neuroscience MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
Pharmacol Biochem Behav 74:803-10. 2003..These results with dextromethorphan suggest that the mechanism mediating the effects of dextromethorphan on drug self-administration involves modulation of the dopaminergic mesolimbic pathway... - Neurochemical and behavioral differences between d-methamphetamine and d-amphetamine in ratsJames R Shoblock
Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Avenue MC 136, Albany, NY 12208, USA
Psychopharmacology (Berl) 165:359-69. 2003..Although METH is generally accepted to be more addictive and potent than its analogue AMPH, there are no known neurobiological differences in action between the two drugs that may account for such differences... - Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agentsMartin E Kuehne
Department of Chemistry, University of Vermont, Burlington, Vermont 05405, USA
J Med Chem 46:2716-30. 2003..The opioid activities were relatively low, and the alpha3beta4 nicotinic acetylcholine receptor activities were found to correlate with in vivo antiaddictive activities... - Metabolism of 18-methoxycoronaridine, an ibogaine analog, to 18-hydroxycoronaridine by genetically variable CYP2C19Wenjiang Zhang
Center for Addiction and Mental Health, University of Toronto, Toronto, Canada
Drug Metab Dispos 30:663-9. 2002..The apparent selectivity of this pathway for CYP2C19 suggests 18-MC as a potentially useful probe of CYP2C19 activity in vitro and in vivo...
Research Grants
- NEURO-BEHAVIORAL MECHANISMS OF DRUG ADDICTIONSTANLEY GLICK; Fiscal Year: 1992..These studies should provide basic information on mechanisms of drug actions as well as an animal model for understanding interindividual differences in drug preferences and patterns of abuse among humans...
- NEUROBEHAVIORAL MECHANISMS OF DRUG ADDICTIONSTANLEY GLICK; Fiscal Year: 2001..This research may result in novel treatments for addictive disorders in humans. ..
- DIENCEPHALIC MECHANISMS OF DRUG ABUSESTANLEY GLICK; Fiscal Year: 2007..The work proposed here may ultimately result in new kinds of treatments for drug abuse. ..
- PHARMACOLOGY & NEUROSCIENCE TRAINING IN DRUG ABUSESTANLEY GLICK; Fiscal Year: 2007..All aspects of the program are administered by the director and an executive committee of administrative and training faculty. ..