STANLEY GLICK

Summary

Affiliation: Albany Medical College
Country: USA

Publications

  1. ncbi request reprint Enantioselective behavioral effects of sibutramine metabolites
    S D Glick
    Department of Pharmacology and Neuroscience MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 397:93-102. 2000
  2. pmc Brain regions mediating alpha3beta4 nicotinic antagonist effects of 18-MC on methamphetamine and sucrose self-administration
    Stanley D Glick
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 599:91-5. 2008
  3. ncbi request reprint 18-Methoxycoronaridine acts in the medial habenula and/or interpeduncular nucleus to decrease morphine self-administration in rats
    Stanley D Glick
    Center for Neuropharmacology and Neuroscience Albany Medical College, MC 136, 47 New Scotland Avenue, NY 12208, USA
    Eur J Pharmacol 537:94-8. 2006
  4. pmc Brain regions mediating α3β4 nicotinic antagonist effects of 18-MC on nicotine self-administration
    Stanley D Glick
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 669:71-5. 2011
  5. ncbi request reprint Modulation of nicotine self-administration in rats by combination therapy with agents blocking alpha 3 beta 4 nicotinic receptors
    Stanley D Glick
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 448:185-91. 2002
  6. ncbi request reprint 18-Methoxycoronaridine (18-MC) and ibogaine: comparison of antiaddictive efficacy, toxicity, and mechanisms of action
    S D Glick
    Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Ann N Y Acad Sci 914:369-86. 2000
  7. ncbi request reprint Antagonism of alpha 3 beta 4 nicotinic receptors as a strategy to reduce opioid and stimulant self-administration
    Stanley D Glick
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 438:99-105. 2002
  8. ncbi request reprint Comparative effects of dextromethorphan and dextrorphan on morphine, methamphetamine, and nicotine self-administration in rats
    S D Glick
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 422:87-90. 2001
  9. ncbi request reprint Development of novel medications for drug addiction. The legacy of an African shrub
    S D Glick
    Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Ann N Y Acad Sci 909:88-103. 2000
  10. pmc Effects of nicotine, methamphetamine and cocaine on extracellular levels of acetylcholine in the interpeduncular nucleus of rats
    Rifat J Hussain
    Center for Neuropharmacology and Neuroscience, MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, United States of America
    Neurosci Lett 440:270-4. 2008

Research Grants

  1. NEURO-BEHAVIORAL MECHANISMS OF DRUG ADDICTION
    STANLEY GLICK; Fiscal Year: 1992
  2. NEUROBEHAVIORAL MECHANISMS OF DRUG ADDICTION
    STANLEY GLICK; Fiscal Year: 2001
  3. DIENCEPHALIC MECHANISMS OF DRUG ABUSE
    STANLEY GLICK; Fiscal Year: 2007
  4. PHARMACOLOGY & NEUROSCIENCE TRAINING IN DRUG ABUSE
    STANLEY GLICK; Fiscal Year: 2007

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Enantioselective behavioral effects of sibutramine metabolites
    S D Glick
    Department of Pharmacology and Neuroscience MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 397:93-102. 2000
    ..The results suggest that these enantioselective metabolites of sibutramine could be safe and effective treatments for obesity as well as possibly for depression...
  2. pmc Brain regions mediating alpha3beta4 nicotinic antagonist effects of 18-MC on methamphetamine and sucrose self-administration
    Stanley D Glick
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 599:91-5. 2008
    ..The data also suggest that the basolateral amygdala along with a different pathway involving alpha3beta4 receptors in the dorsolateral tegmentum mediate the effect of 18-MC on sucrose self-administration...
  3. ncbi request reprint 18-Methoxycoronaridine acts in the medial habenula and/or interpeduncular nucleus to decrease morphine self-administration in rats
    Stanley D Glick
    Center for Neuropharmacology and Neuroscience Albany Medical College, MC 136, 47 New Scotland Avenue, NY 12208, USA
    Eur J Pharmacol 537:94-8. 2006
    ..These and other data are consistent with the hypothesis that 18-MC decreases morphine self-administration by blocking alpha3beta4 nicotinic receptors in the habenulo-interpeduncular pathway...
  4. pmc Brain regions mediating α3β4 nicotinic antagonist effects of 18-MC on nicotine self-administration
    Stanley D Glick
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 669:71-5. 2011
    ..The data also suggest that an action of 18-MC in the interpeduncular nucleus may attenuate aversive and/or depressive effects of nicotine...
  5. ncbi request reprint Modulation of nicotine self-administration in rats by combination therapy with agents blocking alpha 3 beta 4 nicotinic receptors
    Stanley D Glick
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 448:185-91. 2002
    ..Antagonists of alpha3beta4 nicotinic receptors may represent a totally novel approach to treating polydrug abuse...
  6. ncbi request reprint 18-Methoxycoronaridine (18-MC) and ibogaine: comparison of antiaddictive efficacy, toxicity, and mechanisms of action
    S D Glick
    Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Ann N Y Acad Sci 914:369-86. 2000
    ..The data suggest that 18-MC has a narrower spectrum of actions and will have a substantially greater therapeutic index than ibogaine...
  7. ncbi request reprint Antagonism of alpha 3 beta 4 nicotinic receptors as a strategy to reduce opioid and stimulant self-administration
    Stanley D Glick
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 438:99-105. 2002
    ..18-Methoxycoronaridine apparently has greater selectivity for this site than other agents and may be the first of a new class of synthetic agents acting via this novel mechanism to produce a broad spectrum of anti-addictive activity...
  8. ncbi request reprint Comparative effects of dextromethorphan and dextrorphan on morphine, methamphetamine, and nicotine self-administration in rats
    S D Glick
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 422:87-90. 2001
    ..The results also suggest that dextromethorphan should be tested extensively as a potential treatment for diverse populations of drug-abusing patients...
  9. ncbi request reprint Development of novel medications for drug addiction. The legacy of an African shrub
    S D Glick
    Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Ann N Y Acad Sci 909:88-103. 2000
    ..18-MC also has (+) and (-) enantiomers, both of which are active. Considered together, all of the data indicate that 18-MC should be safer than ibogaine and at least as efficacious as an anti-addictive medication...
  10. pmc Effects of nicotine, methamphetamine and cocaine on extracellular levels of acetylcholine in the interpeduncular nucleus of rats
    Rifat J Hussain
    Center for Neuropharmacology and Neuroscience, MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, United States of America
    Neurosci Lett 440:270-4. 2008
    ..These results suggest that the habenulo-intepeduncular pathway may be a common target for drugs of abuse and, by modulating the mesolimbic pathway, may mediate unique aspects of the rewarding effects of different drugs...
  11. ncbi request reprint Novel iboga alkaloid congeners block nicotinic receptors and reduce drug self-administration
    Christopher J Pace
    Center for Neuropharmacology and Neuroscience, The Albany Medical College, MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 492:159-67. 2004
    ..These compounds may constitute a new class of synthetic agents that act via the nicotinic alpha3beta4 mechanism to combat addiction...
  12. ncbi request reprint Selective disruption of nucleus accumbens gating mechanisms in rats behaviorally sensitized to methamphetamine
    Anne Marie Brady
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Neurosci 25:6687-95. 2005
    ....
  13. ncbi request reprint Attenuation of morphine withdrawal signs by intracerebral administration of 18-methoxycoronaridine
    Vishal Panchal
    Center for Neuropharmacology and Neuroscience MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 525:98-104. 2005
    ..The present findings suggest that 18-MC may act in all three nuclei to suppress various signs of opioid withdrawal...
  14. pmc 18-Methoxycoronaridine blocks acquisition but enhances reinstatement of a cocaine place preference
    Sarah E McCallum
    Albany Medical College, Albany, NY, USA
    Neurosci Lett 458:57-9. 2009
    ..Our results are consistent with those obtained using ibogaine, but reinforce the notion that acquisition, expression and reinstatement of a CPP likely involve separate mechanisms...
  15. pmc Neural encoding of psychomotor activation in the nucleus accumbens core, but not the shell, requires cannabinoid receptor signaling
    Joshua T Morra
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Neurosci 30:5102-7. 2010
    ..We therefore propose that endocannabinoid modulation of psychomotor activation is preferentially driven by CB1 receptor-dependent interneuron activity in the nucleus accumbens core...
  16. doi request reprint 18-Methoxycoronaridine, a potential anti-obesity agent, does not produce a conditioned taste aversion in rats
    Olga D Taraschenko
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY, USA
    Pharmacol Biochem Behav 96:247-50. 2010
    ..Consistent with previous data, 18-MC appears to have proactive effect for 24h and it does not induce a conditioned taste aversion...
  17. doi request reprint Resistance of male Sprague-Dawley rats to sucrose-induced obesity: effects of 18-methoxycoronaridine
    Olga D Taraschenko
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY, United States
    Physiol Behav 102:126-31. 2011
    ..Such gender disparities could be secondary to sex-specific alterations in cholinergic mechanisms of feeding and body weight regulation...
  18. pmc Morphine-induced changes in acetylcholine release in the interpeduncular nucleus and relationship to changes in motor behavior in rats
    Olga D Taraschenko
    Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Neuropharmacology 53:18-26. 2007
    ..The latter results suggest that tolerance to morphine's effect on the cholinergic habenulo-interpeduncular pathway is related to its sensitizing effects on the mesostriatal dopaminergic pathways...
  19. pmc 18-methoxycoronaridine: a potential new treatment for obesity in rats?
    Olga D Taraschenko
    Center for Neuropharmacology and Neuroscience MC 136, Albany Medical College, Albany, NY 12208, USA
    Psychopharmacology (Berl) 201:339-50. 2008
    ....
  20. ncbi request reprint 18-MC acts in the medial habenula and interpeduncular nucleus to attenuate dopamine sensitization to morphine in the nucleus accumbens
    Olga D Taraschenko
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    Synapse 61:547-60. 2007
    ..The results suggest that 18-MC acts in the habenulo-interpeduncular pathway to modulate the effects of repeated morphine in the dopaminergic mesolimbic system...
  21. ncbi request reprint Differential interactions of desipramine with amphetamine and methamphetamine: evidence that amphetamine releases dopamine from noradrenergic neurons in the medial prefrontal cortex
    James R Shoblock
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA
    Neurochem Res 29:1437-42. 2004
    ..It is proposed that amphetamine releases dopamine in the prefrontal cortex primarily through norepinephrine transporters, whereas methamphetamine interacts minimally with norepinephrine transporters...
  22. ncbi request reprint Is antagonism of alpha3beta4 nicotinic receptors a strategy to reduce morphine dependence?
    Olga D Taraschenko
    Center for Neuropharmacology and Neuroscience MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 513:207-18. 2005
    ..The results of the present study provide evidence that alpha3beta4 nicotinic receptors are involved in the expression of at least two signs of opioid withdrawal...
  23. ncbi request reprint Changes in electrophysiological properties of nucleus accumbens neurons depend on the extent of behavioral sensitization to chronic methamphetamine
    Anne Marie Brady
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    Ann N Y Acad Sci 1003:358-63. 2003
  24. ncbi request reprint Anti-addictive actions of an iboga alkaloid congener: a novel mechanism for a novel treatment
    Isabelle M Maisonneuve
    Center for Neuropharmacology and Neuroscience, Albany Medical College, MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Pharmacol Biochem Behav 75:607-18. 2003
    ....
  25. ncbi request reprint Differences between d-methamphetamine and d-amphetamine in rats: working memory, tolerance, and extinction
    James R Shoblock
    Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Avenue MC 136, Albany, NY 12208, USA
    Psychopharmacology (Berl) 170:150-6. 2003
    ..Since working memory depends on PFC DA, it was postulated that AMPH would also be more potent than METH at affecting working memory...
  26. ncbi request reprint Effects of dextromethorphan on dopamine release in the nucleus accumbens: Interactions with morphine
    Caren L Steinmiller
    Center for Neuropharmacology and Neuroscience MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Pharmacol Biochem Behav 74:803-10. 2003
    ..These results with dextromethorphan suggest that the mechanism mediating the effects of dextromethorphan on drug self-administration involves modulation of the dopaminergic mesolimbic pathway...
  27. ncbi request reprint Neurochemical and behavioral differences between d-methamphetamine and d-amphetamine in rats
    James R Shoblock
    Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Avenue MC 136, Albany, NY 12208, USA
    Psychopharmacology (Berl) 165:359-69. 2003
    ..Although METH is generally accepted to be more addictive and potent than its analogue AMPH, there are no known neurobiological differences in action between the two drugs that may account for such differences...
  28. ncbi request reprint Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents
    Martin E Kuehne
    Department of Chemistry, University of Vermont, Burlington, Vermont 05405, USA
    J Med Chem 46:2716-30. 2003
    ..The opioid activities were relatively low, and the alpha3beta4 nicotinic acetylcholine receptor activities were found to correlate with in vivo antiaddictive activities...
  29. ncbi request reprint Metabolism of 18-methoxycoronaridine, an ibogaine analog, to 18-hydroxycoronaridine by genetically variable CYP2C19
    Wenjiang Zhang
    Center for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Drug Metab Dispos 30:663-9. 2002
    ..The apparent selectivity of this pathway for CYP2C19 suggests 18-MC as a potentially useful probe of CYP2C19 activity in vitro and in vivo...

Research Grants22

  1. NEURO-BEHAVIORAL MECHANISMS OF DRUG ADDICTION
    STANLEY GLICK; Fiscal Year: 1992
    ..These studies should provide basic information on mechanisms of drug actions as well as an animal model for understanding interindividual differences in drug preferences and patterns of abuse among humans...
  2. NEUROBEHAVIORAL MECHANISMS OF DRUG ADDICTION
    STANLEY GLICK; Fiscal Year: 2001
    ..This research may result in novel treatments for addictive disorders in humans. ..
  3. DIENCEPHALIC MECHANISMS OF DRUG ABUSE
    STANLEY GLICK; Fiscal Year: 2007
    ..The work proposed here may ultimately result in new kinds of treatments for drug abuse. ..
  4. PHARMACOLOGY & NEUROSCIENCE TRAINING IN DRUG ABUSE
    STANLEY GLICK; Fiscal Year: 2007
    ..All aspects of the program are administered by the director and an executive committee of administrative and training faculty. ..