S D Glick

Summary

Affiliation: Albany Medical College
Country: USA

Publications

  1. ncbi Mechanisms of antiaddictive actions of ibogaine
    S D Glick
    Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Ann N Y Acad Sci 844:214-26. 1998
  2. ncbi 18-Methoxycoronardine attenuates nicotine-induced dopamine release and nicotine preferences in rats
    S D Glick
    Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Psychopharmacology (Berl) 139:274-80. 1998
  3. ncbi Evidence for roles of kappa-opioid and NMDA receptors in the mechanism of action of ibogaine
    S D Glick
    Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Brain Res 749:340-3. 1997
  4. ncbi Effects of cyclazocine on cocaine self-administration in rats
    S D Glick
    Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Eur J Pharmacol 357:9-14. 1998
  5. ncbi The potential anti-addictive agent, 18-methoxycoronaridine, blocks the sensitized locomotor and dopamine responses produced by repeated morphine treatment
    K K Szumlinski
    Department of Pharmacology and Neuroscience MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY, USA
    Brain Res 864:13-23. 2000
  6. ncbi Interactions between 18-methoxycoronaridine (18-MC) and cocaine: dissociation of behavioural and neurochemical sensitization
    K K Szumlinski
    Center for Neuropharmacology and Neuroscience MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Brain Res 871:245-58. 2000
  7. ncbi Attenuation of the reinforcing efficacy of morphine by 18-methoxycoronaridine
    I M Maisonneuve
    Department of Pharmacology and Neuroscience, MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 383:15-21. 1999
  8. ncbi A two-population model of rat rotational behavior: effects of unilateral nigrostriatal 6-hydroxydopamine on striatal neurochemistry and amphetamine-induced rotation
    R M Shapiro
    Department of Pharmacology and Toxicology, Albany Medical College, Union University, NY 12208
    Brain Res 426:323-31. 1987
  9. ncbi (+/-)Cyclazocine blocks the dopamine response to nicotine
    I M Maisonneuve
    Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Neuroreport 10:693-6. 1999
  10. ncbi Differential effects of ibogaine on behavioural and dopamine sensitization to cocaine
    K K Szumlinski
    Center for Neuropharmacology and Neuroscience, MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 398:259-62. 2000

Collaborators

Detail Information

Publications33

  1. ncbi Mechanisms of antiaddictive actions of ibogaine
    S D Glick
    Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Ann N Y Acad Sci 844:214-26. 1998
    ..Different receptors, or combinations of receptors, may mediate interactions of ibogaine with different drugs of abuse...
  2. ncbi 18-Methoxycoronardine attenuates nicotine-induced dopamine release and nicotine preferences in rats
    S D Glick
    Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Psychopharmacology (Berl) 139:274-80. 1998
    ..The results suggest that 18-MC might be the prototype of a new treatment for smoking...
  3. ncbi Evidence for roles of kappa-opioid and NMDA receptors in the mechanism of action of ibogaine
    S D Glick
    Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Brain Res 749:340-3. 1997
    ..The data suggest that both kappa-opioid agonist and NMDA antagonist actions of ibogaine contribute to its putative anti-addictive effects...
  4. ncbi Effects of cyclazocine on cocaine self-administration in rats
    S D Glick
    Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Eur J Pharmacol 357:9-14. 1998
    ..Although the mechanistic basis for the results are not entirely understood, the data suggest that (+/-)-cyclazocine should be considered as a potential treatment for cocaine dependence...
  5. ncbi The potential anti-addictive agent, 18-methoxycoronaridine, blocks the sensitized locomotor and dopamine responses produced by repeated morphine treatment
    K K Szumlinski
    Department of Pharmacology and Neuroscience MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY, USA
    Brain Res 864:13-23. 2000
    ..It is suggested that the potential anti-addictive efficacy of 18-MC might be related to an ability to restore normal functioning to a hypersensitive mesolimbic dopamine system produced by previous repeated morphine administration...
  6. ncbi Interactions between 18-methoxycoronaridine (18-MC) and cocaine: dissociation of behavioural and neurochemical sensitization
    K K Szumlinski
    Center for Neuropharmacology and Neuroscience MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Brain Res 871:245-58. 2000
    ....
  7. ncbi Attenuation of the reinforcing efficacy of morphine by 18-methoxycoronaridine
    I M Maisonneuve
    Department of Pharmacology and Neuroscience, MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 383:15-21. 1999
    ..Together, the microdialysis and self-administration data suggest that 18-methoxycoronaridine profoundly alters mechanisms crucial to the development and maintenance of opioid addiction...
  8. ncbi A two-population model of rat rotational behavior: effects of unilateral nigrostriatal 6-hydroxydopamine on striatal neurochemistry and amphetamine-induced rotation
    R M Shapiro
    Department of Pharmacology and Toxicology, Albany Medical College, Union University, NY 12208
    Brain Res 426:323-31. 1987
    ....
  9. ncbi (+/-)Cyclazocine blocks the dopamine response to nicotine
    I M Maisonneuve
    Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Neuroreport 10:693-6. 1999
    ..The results suggest that the effects of both enantiomers contribute to the effects of the racemate; (+/-)cyclazocine may decrease the rewarding effect of nicotine and may be the prototype of a potentially novel treatment for smoking...
  10. ncbi Differential effects of ibogaine on behavioural and dopamine sensitization to cocaine
    K K Szumlinski
    Center for Neuropharmacology and Neuroscience, MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 398:259-62. 2000
    ..This result demonstrates that ibogaine pretreatment can reverse one of the neuroadaptations produced by chronic cocaine administration, an effect that may contribute to its putative anti-addictive property...
  11. ncbi Comparative effects of dextromethorphan and dextrorphan on morphine, methamphetamine, and nicotine self-administration in rats
    S D Glick
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 422:87-90. 2001
    ..The results also suggest that dextromethorphan should be tested extensively as a potential treatment for diverse populations of drug-abusing patients...
  12. ncbi Time-dependent interactions between iboga agents and cocaine
    I M Maisonneuve
    Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Eur J Pharmacol 336:123-6. 1997
    ..These time-dependent effects, which could not be attributed to the motor activity induced by the iboga agents alone, account for divergent results reported in the literature...
  13. ncbi Enantioselective behavioral effects of sibutramine metabolites
    S D Glick
    Department of Pharmacology and Neuroscience MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 397:93-102. 2000
    ..The results suggest that these enantioselective metabolites of sibutramine could be safe and effective treatments for obesity as well as possibly for depression...
  14. ncbi 18-Methoxycoronaridine (18-MC) and ibogaine: comparison of antiaddictive efficacy, toxicity, and mechanisms of action
    S D Glick
    Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Ann N Y Acad Sci 914:369-86. 2000
    ..The data suggest that 18-MC has a narrower spectrum of actions and will have a substantially greater therapeutic index than ibogaine...
  15. ncbi Interactions between iboga agents and methamphetamine sensitization: studies of locomotion and stereotypy in rats
    K K Szumlinski
    Center for Neuropharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Psychopharmacology (Berl) 151:234-41. 2000
    ....
  16. ncbi Enhanced cocaine self-administration in adult rats prenatally exposed to cocaine
    R W Keller
    Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Neurosci Lett 205:153-6. 1996
    ..These results suggest that prenatal cocaine exposure can alter cocaine reinforcement in adult animals...
  17. ncbi Development of novel medications for drug addiction. The legacy of an African shrub
    S D Glick
    Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Ann N Y Acad Sci 909:88-103. 2000
    ..18-MC also has (+) and (-) enantiomers, both of which are active. Considered together, all of the data indicate that 18-MC should be safer than ibogaine and at least as efficacious as an anti-addictive medication...
  18. ncbi Two kinds of nigrostriatal asymmetry: relationship to dopaminergic drug sensitivity and 6-hydroxydopamine lesion effects in Long-Evans rats
    S D Glick
    Department of Pharmacology and Toxicology, Albany Medical College, NY 12208
    Brain Res 450:334-41. 1988
    ..The results suggest that the two populations differ with respect to the balance between pre- and postsynaptic elements within the striatum...
  19. ncbi Specificity of behavioral and neurochemical dysfunction in the chakragati mouse: a novel genetic model of a movement disorder
    L W Fitzgerald
    Department of Pharmacology and Toxicology, Albany Medical College, NY 12208
    Brain Res 608:247-58. 1993
    ..The implications of these and past findings are discussed in relation to current thinking about hyperkinetic motor syndromes in humans involving reduced basal ganglia outflow...
  20. ncbi Iboga interactions with psychomotor stimulants: panacea in the paradox?
    K K Szumlinski
    Center for Neuropharmacology and Neuroscience, MC 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Toxicon 39:75-86. 2001
    ..These data indicate that iboga agents might attenuate stimulant self-administration by reversing the neuroadaptations theoretically implicated in drug craving and compulsive drug-seeking behavior...
  21. ncbi Pretreatment with the putative anti-addictive drug, ibogaine, increases the potency of cocaine to elicit locomotor responding: a study with acute and chronic cocaine-treated rats
    K K Szumlinski
    Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Psychopharmacology (Berl) 145:227-33. 1999
    ..Results of single-dose studies suggest that the effects of pretreatment with the putative anti-addictive compound, ibogaine, on drug-induced locomotor behavior depends on the previous drug history of the animal...
  22. ncbi Effects of prenatal cocaine exposure on the mesocorticolimbic dopamine system: an in vivo microdialysis study in the rat
    R W Keller
    Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Brain Res 742:71-9. 1996
    ..accumbens of pups which returns to normal with aging. While this initial difference normalizes, prenatal cocaine exposure induces other persistent changes in adulthood...
  23. ncbi Prolonged antagonism of morphine-induced locomotor stimulation by kappa opioid agonists: enhancement by prior morphine exposure
    S M Pearl
    Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA
    Neurosci Lett 213:5-8. 1996
    ..p. administered once a day for 2 days). The present data suggest that kappa-micro opioid interactions may occur over time periods that exceed the acute durations of drug actions...
  24. ncbi Paw preference, rotation, and dopamine function in Collins HI and LO mouse strains
    D M Nielsen
    Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA
    Physiol Behav 61:525-35. 1997
    ..Even though the directions of paw preference and rotation were not correlated, HI and LO mice of differing paw and rotational directional preferences showed differences in DA neurochemistry in the NAS and striatum...
  25. ncbi Sedative and anxiolytic effects of zopiclone's enantiomers and metabolite
    J N Carlson
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Eur J Pharmacol 415:181-9. 2001
    ....
  26. ncbi Music-induced context preference following cocaine conditioning in rats
    J E Polston
    Center for Neuropharmacology and Neuroscience, Albany Medical College, 43 New Scotland Avenue, Albany, NY 12208, USA
    Behav Neurosci 125:674-80. 2011
    ....
  27. ncbi Music and methamphetamine: conditioned cue-induced increases in locomotor activity and dopamine release in rats
    J E Polston
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Pharmacol Biochem Behav 98:54-61. 2011
    ..These findings support other evidence showing the importance of these brain regions in conditioned learning paradigms, and demonstrate that music is an effective conditioned stimulus warranting further investigation...
  28. ncbi Biphasic dose-related effects of morphine on dopamine release
    I M Maisonneuve
    Center for Neuropharmacology and Neuroscience, MC 136, Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA
    Drug Alcohol Depend 65:55-63. 2001
    ..The results of this study are discussed in terms of their implications for interpreting drug interactions with morphine and with relationship to morphine's mode of action at mu and kappa opioid receptors...
  29. ncbi 18-Methoxycoronaridine blocks context-induced reinstatement following cocaine self-administration in rats
    J E Polston
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Pharmacol Biochem Behav 103:83-94. 2012
    ..The fact that 18-MC blocked cue-induced reinstatement suggests that α3β4 nicotinic receptors may be involved in the mechanism of craving, and that 18-MC may help prevent relapse to drug addiction in humans...
  30. ncbi Iboga compounds reverse the behavioural disinhibiting and corticosterone effects of acute methamphetamine: Implications for their antiaddictive properties
    K K Szumlinski
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Pharmacol Biochem Behav 69:485-91. 2001
    ..Furthermore, these data indicate that this reversal is related to effects of iboga compounds on the stimulation of neuroendocrine systems by stimulant drugs...
  31. ncbi Effect of striatal implantation of bovine adrenal chromaffin cells on turning behavior in a rat model of Parkinson's disease
    L R Fitzgerald
    Department of Pharmacology and Toxicology, Albany Medical College, NY 12208
    Brain Res 481:373-7. 1989
    ....
  32. ncbi Pharmacokinetic characterization of the indole alkaloid ibogaine in rats
    L B Hough
    Department of Pharmacology and Neuroscience, Albany Medical College, NY, USA
    Methods Find Exp Clin Pharmacol 22:77-81. 2000
    ..The sequestration of ibogaine by adipose tissue probably contributes to a protracted persistence of drug in the body. This persistence may be underestimated by the beta half-life reported in the present study...
  33. ncbi Inhibition of the mammalian target of rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitization
    J Wu
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY, USA
    Neuroscience 172:104-9. 2011
    ..These data elucidate a novel mechanism by which the mTOR pathway mediates cocaine-induced behavioral changes and could suggest a new interventional strategy for drug abuse...