Thomas D Friedrich

Summary

Affiliation: Albany Medical College
Country: USA

Publications

  1. ncbi Distinct patterns of MCM protein binding in nuclei of S phase and rereplicating SV40-infected monkey kidney cells
    Thomas D Friedrich
    Albany Medical College, Center for Immunology and Microbial Diseases, Albany, New York 12208, USA
    Cytometry A 68:10-8. 2005
  2. ncbi Biaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part I
    Michael P Trova
    AMRI, Medicinal Chemistry Department, 26 Corporate Circle, Albany, NY 12212 5098, USA
    Bioorg Med Chem Lett 19:6608-12. 2009
  3. ncbi Negative regulation of mitotic promoting factor by the checkpoint kinase chk1 in simian virus 40 lytic infection
    Eiji Okubo
    Center for Immunology and Microbial Disease, Albany Medical College, New York 12208, USA
    J Virol 77:1257-67. 2003
  4. ncbi Reduced expression of p27kip1 and increased hepatocyte proliferation in p53-deficient mice
    Chuanwei Yang
    Center for Immunology and Microbial Disease, Albany Medical College, New York, USA
    Mol Carcinog 36:15-22. 2003
  5. ncbi Heterobiaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part II
    Michael P Trova
    AMRI, Medicinal Chemistry Department, 26 Corporate Circle, Albany, NY 12212 5098, USA
    Bioorg Med Chem Lett 19:6613-7. 2009
  6. ncbi 5-Functionalized indazoles as glucocorticoid receptor agonists
    Mei Bai
    AMRI, Albany, NY 12212 5098, USA
    Bioorg Med Chem Lett 20:3017-20. 2010
  7. ncbi Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives
    Kassoum Nacro
    Discovery Research and Development, Albany Molecular Research Inc, Albany, NY 12213 5098, USA
    Bioorg Med Chem 15:4237-46. 2007

Collaborators

  • Stewart Sell
  • Z Darzynkiewicz
  • Michael P Trova
  • Denise Peace
  • John M Lehman
  • Mei Bai
  • Patricia Snider
  • Travis Benanti
  • Mark Bielaska
  • Keith D Barnes
  • Steven Tregay
  • Susan Salamone
  • Xiaozhang Zheng
  • Peter R Guzzo
  • R Jason Herr
  • Kassoum Nacro
  • Eiji Okubo
  • Chuanwei Yang
  • Mark A Wolf
  • Grant Carr
  • Russell J DeOrazio
  • Douglas B Kitchen
  • Alexander Usyatinsky
  • Kevin Fitzpatrick
  • Svetlana Dobritsa
  • Mohammed Sajad
  • Michael A Lynch
  • Alison Wilson
  • Yu Hui
  • Lori Burry
  • Christine Murphy
  • Curt Barford
  • Thuy Nguyen Duong
  • Simon Haydar
  • Jennifer Smith
  • Harold O'Grady
  • Matthew Rainka
  • Luis Alicea
  • Matthew Johnson
  • Joseph Bilotta
  • Michael Wyle
  • Joseph Toporowski
  • Brian Bliss
  • Conxiang Charles Zha
  • Zoran Ilic
  • Mingzeng Sun

Detail Information

Publications7

  1. ncbi Distinct patterns of MCM protein binding in nuclei of S phase and rereplicating SV40-infected monkey kidney cells
    Thomas D Friedrich
    Albany Medical College, Center for Immunology and Microbial Diseases, Albany, New York 12208, USA
    Cytometry A 68:10-8. 2005
    ..0 was associated with rebinding of the minichromosome maintenance (MCM) hexamer, the putative replicative helicase, to chromatin...
  2. ncbi Biaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part I
    Michael P Trova
    AMRI, Medicinal Chemistry Department, 26 Corporate Circle, Albany, NY 12212 5098, USA
    Bioorg Med Chem Lett 19:6608-12. 2009
    ..In particular, derivative 21h demonstrated a >750-fold improvement in the growth inhibition of HeLa cells compared to roscovitine (2)...
  3. ncbi Negative regulation of mitotic promoting factor by the checkpoint kinase chk1 in simian virus 40 lytic infection
    Eiji Okubo
    Center for Immunology and Microbial Disease, Albany Medical College, New York 12208, USA
    J Virol 77:1257-67. 2003
    ..In addition, chemical inhibition of Chk1 activity suggests that Chk1 contributes to the absence of mitosis during SV40 lytic infection...
  4. ncbi Reduced expression of p27kip1 and increased hepatocyte proliferation in p53-deficient mice
    Chuanwei Yang
    Center for Immunology and Microbial Disease, Albany Medical College, New York, USA
    Mol Carcinog 36:15-22. 2003
    ..We postulate that this increased proliferation leads to increased susceptibility to aflatoxin-induced hepatocarcinogenesis...
  5. ncbi Heterobiaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part II
    Michael P Trova
    AMRI, Medicinal Chemistry Department, 26 Corporate Circle, Albany, NY 12212 5098, USA
    Bioorg Med Chem Lett 19:6613-7. 2009
    ..In particular, derivatives 18 g and 9 c demonstrated 1000-fold and 1250-fold improvements, respectively, in the growth inhibition of HeLa cells compared to roscovitine (1)...
  6. ncbi 5-Functionalized indazoles as glucocorticoid receptor agonists
    Mei Bai
    AMRI, Albany, NY 12212 5098, USA
    Bioorg Med Chem Lett 20:3017-20. 2010
    ....
  7. ncbi Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives
    Kassoum Nacro
    Discovery Research and Development, Albany Molecular Research Inc, Albany, NY 12213 5098, USA
    Bioorg Med Chem 15:4237-46. 2007
    ..When compared to luotonin A, several compounds exhibited an improved topoisomerase I-dependent growth inhibition of a human leukemia cell line...