Thomas D Friedrich

Summary

Affiliation: Albany Medical College
Country: USA

Publications

  1. ncbi request reprint Distinct patterns of MCM protein binding in nuclei of S phase and rereplicating SV40-infected monkey kidney cells
    Thomas D Friedrich
    Albany Medical College, Center for Immunology and Microbial Diseases, Albany, New York 12208, USA
    Cytometry A 68:10-8. 2005
  2. doi request reprint Biaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part I
    Michael P Trova
    AMRI, Medicinal Chemistry Department, 26 Corporate Circle, Albany, NY 12212 5098, USA
    Bioorg Med Chem Lett 19:6608-12. 2009
  3. pmc Negative regulation of mitotic promoting factor by the checkpoint kinase chk1 in simian virus 40 lytic infection
    Eiji Okubo
    Center for Immunology and Microbial Disease, Albany Medical College, New York 12208, USA
    J Virol 77:1257-67. 2003
  4. ncbi request reprint Reduced expression of p27kip1 and increased hepatocyte proliferation in p53-deficient mice
    Chuanwei Yang
    Center for Immunology and Microbial Disease, Albany Medical College, New York, USA
    Mol Carcinog 36:15-22. 2003
  5. doi request reprint Heterobiaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part II
    Michael P Trova
    AMRI, Medicinal Chemistry Department, 26 Corporate Circle, Albany, NY 12212 5098, USA
    Bioorg Med Chem Lett 19:6613-7. 2009
  6. doi request reprint 5-Functionalized indazoles as glucocorticoid receptor agonists
    Mei Bai
    AMRI, Albany, NY 12212 5098, USA
    Bioorg Med Chem Lett 20:3017-20. 2010
  7. ncbi request reprint Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives
    Kassoum Nacro
    Discovery Research and Development, Albany Molecular Research Inc, Albany, NY 12213 5098, USA
    Bioorg Med Chem 15:4237-46. 2007

Collaborators

  • Stewart Sell
  • Z Darzynkiewicz
  • Michael P Trova
  • Denise Peace
  • John M Lehman
  • Mei Bai
  • Steven Tregay
  • Susan Salamone
  • Mark Bielaska
  • Keith D Barnes
  • Patricia Snider
  • Xiaozhang Zheng
  • Travis Benanti
  • Peter R Guzzo
  • R Jason Herr
  • Kassoum Nacro
  • Eiji Okubo
  • Chuanwei Yang
  • Douglas B Kitchen
  • Mark A Wolf
  • Kevin Fitzpatrick
  • Alexander Usyatinsky
  • Svetlana Dobritsa
  • Mohammed Sajad
  • Michael A Lynch
  • Grant Carr
  • Russell J DeOrazio
  • Jennifer Smith
  • Joseph Bilotta
  • Harold O'Grady
  • Matthew Rainka
  • Alison Wilson
  • Michael Wyle
  • Yu Hui
  • Luis Alicea
  • Curt Barford
  • Joseph Toporowski
  • Thuy Nguyen Duong
  • Simon Haydar
  • Matthew Johnson
  • Brian Bliss
  • Lori Burry
  • Christine Murphy
  • Conxiang Charles Zha
  • Zoran Ilic
  • Mingzeng Sun

Detail Information

Publications7

  1. ncbi request reprint Distinct patterns of MCM protein binding in nuclei of S phase and rereplicating SV40-infected monkey kidney cells
    Thomas D Friedrich
    Albany Medical College, Center for Immunology and Microbial Diseases, Albany, New York 12208, USA
    Cytometry A 68:10-8. 2005
    ..0 was associated with rebinding of the minichromosome maintenance (MCM) hexamer, the putative replicative helicase, to chromatin...
  2. doi request reprint Biaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part I
    Michael P Trova
    AMRI, Medicinal Chemistry Department, 26 Corporate Circle, Albany, NY 12212 5098, USA
    Bioorg Med Chem Lett 19:6608-12. 2009
    ..In particular, derivative 21h demonstrated a >750-fold improvement in the growth inhibition of HeLa cells compared to roscovitine (2)...
  3. pmc Negative regulation of mitotic promoting factor by the checkpoint kinase chk1 in simian virus 40 lytic infection
    Eiji Okubo
    Center for Immunology and Microbial Disease, Albany Medical College, New York 12208, USA
    J Virol 77:1257-67. 2003
    ..In addition, chemical inhibition of Chk1 activity suggests that Chk1 contributes to the absence of mitosis during SV40 lytic infection...
  4. ncbi request reprint Reduced expression of p27kip1 and increased hepatocyte proliferation in p53-deficient mice
    Chuanwei Yang
    Center for Immunology and Microbial Disease, Albany Medical College, New York, USA
    Mol Carcinog 36:15-22. 2003
    ..We postulate that this increased proliferation leads to increased susceptibility to aflatoxin-induced hepatocarcinogenesis...
  5. doi request reprint Heterobiaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part II
    Michael P Trova
    AMRI, Medicinal Chemistry Department, 26 Corporate Circle, Albany, NY 12212 5098, USA
    Bioorg Med Chem Lett 19:6613-7. 2009
    ..In particular, derivatives 18 g and 9 c demonstrated 1000-fold and 1250-fold improvements, respectively, in the growth inhibition of HeLa cells compared to roscovitine (1)...
  6. doi request reprint 5-Functionalized indazoles as glucocorticoid receptor agonists
    Mei Bai
    AMRI, Albany, NY 12212 5098, USA
    Bioorg Med Chem Lett 20:3017-20. 2010
    ....
  7. ncbi request reprint Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives
    Kassoum Nacro
    Discovery Research and Development, Albany Molecular Research Inc, Albany, NY 12213 5098, USA
    Bioorg Med Chem 15:4237-46. 2007
    ..When compared to luotonin A, several compounds exhibited an improved topoisomerase I-dependent growth inhibition of a human leukemia cell line...