James R Drake

Summary

Affiliation: Albany Medical College
Country: USA

Publications

  1. pmc Cis and trans regulatory mechanisms control AP2-mediated B cell receptor endocytosis via select tyrosine-based motifs
    Kathleen Busman-Sahay
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, United States of America
    PLoS ONE 8:e54938. 2013
  2. pmc BCR ubiquitination controls BCR-mediated antigen processing and presentation
    Lisa Drake
    Albany Medical College, Center for Immunology and Microbial Disease, 47 New Scotland Ave, MC 151, Albany, NY 12208, USA
    Blood 108:4086-93. 2006
  3. pmc The Syk-binding ubiquitin ligase c-Cbl mediates signaling-dependent B cell receptor ubiquitination and B cell receptor-mediated antigen processing and presentation
    Bhuvana Katkere
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 287:16636-44. 2012
  4. pmc Physiological-range temperature changes modulate cognate antigen processing and presentation mediated by lipid raft-restricted ubiquitinated B cell receptor molecules
    Bhuvana Katkere
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 185:5032-9. 2010
  5. doi request reprint The Ia.2 epitope defines a subset of lipid raft-resident MHC class II molecules crucial to effective antigen presentation
    Kathleen Busman-Sahay
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 186:6710-7. 2011
  6. pmc Francisella tularensis elicits IL-10 via a PGE₂-inducible factor, to drive macrophage MARCH1 expression and class II down-regulation
    Danielle Hunt
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, United States of America
    PLoS ONE 7:e37330. 2012
  7. pmc Francisella tularensis induces ubiquitin-dependent major histocompatibility complex class II degradation in activated macrophages
    Justin E Wilson
    Albany Medical College, Center for Immunology and Microbial Disease, 47 New Scotland Ave, MC 151, Albany, NY 12208, USA
    Infect Immun 77:4953-65. 2009
  8. ncbi request reprint Dynamics of MHC class II-activating signals in murine resting B cells
    Toufic O Nashar
    Albany Medical College, Center for Immunology and Microbial Disease, Albany, NY 12208, USA
    J Immunol 176:827-38. 2006
  9. ncbi request reprint The effect of B cell receptor signaling on antigen endocytosis and processing
    Erica M McGovern
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
    Immunol Invest 33:143-56. 2004
  10. ncbi request reprint Functional and structural requirements for the internalization of distinct BCR-ligand complexes
    Adriana Caballero
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Eur J Immunol 36:3131-45. 2006

Collaborators

  • THOMAS KAWULA
  • Elizabeth A Repasky
  • Xiao Yun Wen
  • Tamara L McNealy
  • Michael Marks
  • Karsten R O Hazlett
  • Satoshi Ishido
  • Daniel J Loegering
  • Bhuvana Katkere
  • Kathleen Busman-Sahay
  • Adriana Caballero
  • Toufic O Nashar
  • Justin E Wilson
  • Lisa Drake
  • Danielle Hunt
  • Bibiana V Iglesias
  • Anthony M Franchini
  • Jonathan A Harton
  • Sarah Rosa
  • Edmund J Gosselin
  • Matthew D Woolard
  • Mark T Preissler
  • Erica M McGovern
  • Amy E Moquin
  • Michelle A Putnam
  • J Andres Melendez
  • Giang Pham
  • Anand Sitaram
  • Kristen Porter
  • Constantine Bitsaktsis
  • Karis A Weih
  • Paul A Roche
  • Elizabeth Sargent
  • Leigh A Jania
  • Jeffrey A Frelinger
  • Lucinda L Hensley
  • Erica M McGovern-Brindisi
  • Laura Kaiser
  • Christopher Outcalt
  • Megan Merrihew
  • Timothy A Gondre-Lewis
  • Emily Sorge

Detail Information

Publications17

  1. pmc Cis and trans regulatory mechanisms control AP2-mediated B cell receptor endocytosis via select tyrosine-based motifs
    Kathleen Busman-Sahay
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, United States of America
    PLoS ONE 8:e54938. 2013
    ....
  2. pmc BCR ubiquitination controls BCR-mediated antigen processing and presentation
    Lisa Drake
    Albany Medical College, Center for Immunology and Microbial Disease, 47 New Scotland Ave, MC 151, Albany, NY 12208, USA
    Blood 108:4086-93. 2006
    ....
  3. pmc The Syk-binding ubiquitin ligase c-Cbl mediates signaling-dependent B cell receptor ubiquitination and B cell receptor-mediated antigen processing and presentation
    Bhuvana Katkere
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 287:16636-44. 2012
    ....
  4. pmc Physiological-range temperature changes modulate cognate antigen processing and presentation mediated by lipid raft-restricted ubiquitinated B cell receptor molecules
    Bhuvana Katkere
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 185:5032-9. 2010
    ....
  5. doi request reprint The Ia.2 epitope defines a subset of lipid raft-resident MHC class II molecules crucial to effective antigen presentation
    Kathleen Busman-Sahay
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 186:6710-7. 2011
    ..These results establish the Ia.2 epitope as defining a lipid raft-resident MHC class II conformer vital to the initiation of MHC class II-restricted B cell-T cell interactions...
  6. pmc Francisella tularensis elicits IL-10 via a PGE₂-inducible factor, to drive macrophage MARCH1 expression and class II down-regulation
    Danielle Hunt
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, United States of America
    PLoS ONE 7:e37330. 2012
    ....
  7. pmc Francisella tularensis induces ubiquitin-dependent major histocompatibility complex class II degradation in activated macrophages
    Justin E Wilson
    Albany Medical College, Center for Immunology and Microbial Disease, 47 New Scotland Ave, MC 151, Albany, NY 12208, USA
    Infect Immun 77:4953-65. 2009
    ..tularensis infection...
  8. ncbi request reprint Dynamics of MHC class II-activating signals in murine resting B cells
    Toufic O Nashar
    Albany Medical College, Center for Immunology and Microbial Disease, Albany, NY 12208, USA
    J Immunol 176:827-38. 2006
    ..Based on these results, a new model that highlights the role of MHC II-activating signals in regulation of Ag presentation by B cells is proposed...
  9. ncbi request reprint The effect of B cell receptor signaling on antigen endocytosis and processing
    Erica M McGovern
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
    Immunol Invest 33:143-56. 2004
    ....
  10. ncbi request reprint Functional and structural requirements for the internalization of distinct BCR-ligand complexes
    Adriana Caballero
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Eur J Immunol 36:3131-45. 2006
    ..Thus, these results demonstrate that the nature of the ligand ultimately determines the functional requirements and relative contribution of lipid rafts and other membrane structures to the internalization of BCR-ligand complexes...
  11. pmc Multiple mechanisms mediate enhanced immunity generated by mAb-inactivated F. tularensis immunogen
    Bibiana V Iglesias
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Immunol Cell Biol 91:139-48. 2013
    ..These results demonstrate that multiple cellular/immune mechanisms contribute to FcR-enhanced immunity...
  12. ncbi request reprint The pathway of antigen uptake and processing dictates MHC class II-mediated B cell survival and activation
    Toufic O Nashar
    Albany Medical College, Center for Immunology and Microbial Disease, Albany, NY 12208, USA
    J Immunol 174:1306-16. 2005
    ..We propose that the context in which CII-peptide complexes are present in the membrane following BCR uptake and processing leads to B cell survival. Thus, appropriate targeting of Ag ensures generation of relevant immune responses...
  13. pmc FcγR-driven release of IL-6 by macrophages requires NOX2-dependent production of reactive oxygen species
    Anthony M Franchini
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 288:25098-108. 2013
    ..In conclusion, our findings demonstrate that ROS participate in elicitation of an effective innate immune in response to antigen-containing immune complexes through FcγR. ..
  14. ncbi request reprint Lipid raft-independent B cell receptor-mediated antigen internalization and intracellular trafficking
    Michelle A Putnam
    Center for Immunology and Microbial Disease, Albany Medical College, NY 12208, USA
    J Immunol 170:905-12. 2003
    ..e., clathrin-coated pits and plasma membrane lipid rafts) that deliver internalized ligands to distinct intracellular compartments. Furthermore, Ag-BCR complexes differentially access these two distinct internalization pathways...
  15. pmc Francisella tularensis LVS grown in macrophages has reduced ability to stimulate the secretion of inflammatory cytokines by macrophages in vitro
    Daniel J Loegering
    Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Microb Pathog 41:218-25. 2006
    ..tularensis that is associated with decreased stimulation of cytokine secretion, inhibition of LPS-stimulated secretion of inflammatory cytokines by macrophages and increased lethality in mice...
  16. ncbi request reprint Low-level signaling generated by FcgammaRIIB-B cell receptor co-ligation establishes a state of global B cell receptor nonresponsiveness
    Mark T Preissler
    Albany Medical College, Center for Immunology and Microbial Disease, Albany, New York 12208, USA
    Immunol Invest 34:53-70. 2005
    ..These results suggest that in vivo treatments with low levels of BCR-FcgammaRIIB cross-linking reagent can induce BCR-FcgammaRIIB co-ligation and establish a condition of B cell nonresponsiveness...
  17. ncbi request reprint Francisella tularensis-infected macrophages release prostaglandin E2 that blocks T cell proliferation and promotes a Th2-like response
    Matthew D Woolard
    Department of Microbiology and Immunology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 178:2065-74. 2007
    ..From these data, we conclude that F. tularensis can alter host T cell responses by causing macrophages to produce PGE(2). This study defines a previously unknown mechanism used by F. tularensis to modulate adaptive immunity...

Research Grants9

  1. Establishing the Molecular Mechanisms of BCR Endocytosis
    James Drake; Fiscal Year: 2007
    ..Moreover, application of these findings will allow for the development of improved vaccines and approaches to control autoimmunity. ..
  2. BCR Modulation of MHC Class II Structure and Function
    James Drake; Fiscal Year: 2001
    ..Type II peptide-class II complexes. The goal of the third specific aim of this grant application is to determine the immunological consequences of the differences between Type I and Type II peptide-class II complexes. ..
  3. BCR Modulation of MHC Class II Structure and Function
    James Drake; Fiscal Year: 2002
    ..Type II peptide-class II complexes. The goal of the third specific aim of this grant application is to determine the immunological consequences of the differences between Type I and Type II peptide-class II complexes. ..
  4. BCR Modulation of MHC Class II Structure and Function
    James Drake; Fiscal Year: 2001
    ..Type II peptide-class II complexes. The goal of the third specific aim of this grant application is to determine the immunological consequences of the differences between Type I and Type II peptide-class II complexes. ..
  5. BCR Modulation of MHC Class II Structure and Function
    James Drake; Fiscal Year: 2003
    ..Type II peptide-class II complexes. The goal of the third specific aim of this grant application is to determine the immunological consequences of the differences between Type I and Type II peptide-class II complexes. ..
  6. BCR Modulation of MHC Class II Structure and Function
    James Drake; Fiscal Year: 2004
    ..Type II peptide-class II complexes. The goal of the third specific aim of this grant application is to determine the immunological consequences of the differences between Type I and Type II peptide-class II complexes. ..
  7. Establishing the Molecular Mechanisms of BCR Endocytosis
    James Drake; Fiscal Year: 2009
    ..Moreover, application of these findings will allow for the development of improved vaccines and approaches to control autoimmunity. ..
  8. Establishing the Molecular Mechanisms of BCR Endocytosis
    James R Drake; Fiscal Year: 2010
    ..Moreover, application of these findings will allow for the development of improved vaccines and approaches to control autoimmunity. ..