Research Topics
Genomes and GenesSpecies | James R DrakeSummaryAffiliation: Albany Medical College Country: USA Publications
Research Grants
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Detail Information
Publications
BCR ubiquitination controls BCR-mediated antigen processing and presentationLisa Drake
Albany Medical College, Center for Immunology and Microbial Disease, 47 New Scotland Ave, MC 151, Albany, NY 12208, USA
Blood 108:4086-93. 2006....
Physiological-range temperature changes modulate cognate antigen processing and presentation mediated by lipid raft-restricted ubiquitinated B cell receptor moleculesBhuvana Katkere
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
J Immunol 185:5032-9. 2010....- Francisella tularensis elicits IL-10 via a PGE₂-inducible factor, to drive macrophage MARCH1 expression and class II down-regulationDanielle Hunt
Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, United States of America
PLoS ONE 7:e37330. 2012.... - The Syk-binding ubiquitin ligase c-Cbl mediates signaling-dependent B cell receptor ubiquitination and B cell receptor-mediated antigen processing and presentationBhuvana Katkere
Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
J Biol Chem 287:16636-44. 2012.... - Francisella tularensis induces ubiquitin-dependent major histocompatibility complex class II degradation in activated macrophagesJustin E Wilson
Albany Medical College, Center for Immunology and Microbial Disease, 47 New Scotland Ave, MC 151, Albany, NY 12208, USA
Infect Immun 77:4953-65. 2009..tularensis infection... 
Functional and structural requirements for the internalization of distinct BCR-ligand complexesAdriana Caballero
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
Eur J Immunol 36:3131-45. 2006..Thus, these results demonstrate that the nature of the ligand ultimately determines the functional requirements and relative contribution of lipid rafts and other membrane structures to the internalization of BCR-ligand complexes...- Dynamics of MHC class II-activating signals in murine resting B cellsToufic O Nashar
Albany Medical College, Center for Immunology and Microbial Disease, Albany, NY 12208, USA
J Immunol 176:827-38. 2006..Based on these results, a new model that highlights the role of MHC II-activating signals in regulation of Ag presentation by B cells is proposed... - The effect of B cell receptor signaling on antigen endocytosis and processingErica M McGovern
Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
Immunol Invest 33:143-56. 2004.... - The Ia.2 epitope defines a subset of lipid raft-resident MHC class II molecules crucial to effective antigen presentationKathleen Busman-Sahay
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
J Immunol 186:6710-7. 2011..These results establish the Ia.2 epitope as defining a lipid raft-resident MHC class II conformer vital to the initiation of MHC class II-restricted B cell-T cell interactions... - The pathway of antigen uptake and processing dictates MHC class II-mediated B cell survival and activationToufic O Nashar
Albany Medical College, Center for Immunology and Microbial Disease, Albany, NY 12208, USA
J Immunol 174:1306-16. 2005..We propose that the context in which CII-peptide complexes are present in the membrane following BCR uptake and processing leads to B cell survival. Thus, appropriate targeting of Ag ensures generation of relevant immune responses... - Lipid raft-independent B cell receptor-mediated antigen internalization and intracellular traffickingMichelle A Putnam
Center for Immunology and Microbial Disease, Albany Medical College, NY 12208, USA
J Immunol 170:905-12. 2003..e., clathrin-coated pits and plasma membrane lipid rafts) that deliver internalized ligands to distinct intracellular compartments. Furthermore, Ag-BCR complexes differentially access these two distinct internalization pathways... - Francisella tularensis LVS grown in macrophages has reduced ability to stimulate the secretion of inflammatory cytokines by macrophages in vitroDaniel J Loegering
Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
Microb Pathog 41:218-25. 2006..tularensis that is associated with decreased stimulation of cytokine secretion, inhibition of LPS-stimulated secretion of inflammatory cytokines by macrophages and increased lethality in mice... - Low-level signaling generated by FcgammaRIIB-B cell receptor co-ligation establishes a state of global B cell receptor nonresponsivenessMark T Preissler
Albany Medical College, Center for Immunology and Microbial Disease, Albany, New York 12208, USA
Immunol Invest 34:53-70. 2005..These results suggest that in vivo treatments with low levels of BCR-FcgammaRIIB cross-linking reagent can induce BCR-FcgammaRIIB co-ligation and establish a condition of B cell nonresponsiveness... - Francisella tularensis-infected macrophages release prostaglandin E2 that blocks T cell proliferation and promotes a Th2-like responseMatthew D Woolard
Department of Microbiology and Immunology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
J Immunol 178:2065-74. 2007..From these data, we conclude that F. tularensis can alter host T cell responses by causing macrophages to produce PGE(2). This study defines a previously unknown mechanism used by F. tularensis to modulate adaptive immunity...
Research Grants
- Establishing the Molecular Mechanisms of BCR EndocytosisJames Drake; Fiscal Year: 2007..Moreover, application of these findings will allow for the development of improved vaccines and approaches to control autoimmunity. ..
- BCR Modulation of MHC Class II Structure and FunctionJames Drake; Fiscal Year: 2004..Type II peptide-class II complexes. The goal of the third specific aim of this grant application is to determine the immunological consequences of the differences between Type I and Type II peptide-class II complexes. ..
- Establishing the Molecular Mechanisms of BCR EndocytosisJames R Drake; Fiscal Year: 2010..Moreover, application of these findings will allow for the development of improved vaccines and approaches to control autoimmunity. ..