J A Banas
Affiliation: Albany Medical College
- Virulence properties of Streptococcus mutansJeffrey A Banas
Center for Immunology and Microbial Disease, Albany Medical College, MC 151, 47 New Scotland Avenue, Albany, NY 12208, USA
Front Biosci 9:1267-77. 2004..Further understanding of how these components work together in the development of dental caries will be aided by the recent completion of the sequence of the S. mutans genome and experimental designs that model the dental plaque biofilm...
- Glucan-binding proteins of the oral streptococciJ A Banas
Center for Immunology and Microbial Disease, Albany Medical College, NY 12208, USA
Crit Rev Oral Biol Med 14:89-99. 2003..Future studies will greatly advance the understanding of the distribution, function, and regulation of the GBPs and place into perspective the facets of their contributions to the biology of the oral streptococci...
- Inactivation of the gbpA gene of Streptococcus mutans increases virulence and promotes in vivo accumulation of recombinations between the glucosyltransferase B and C genesK R Hazlett
Department of Microbiology, Immunology, and Molecular Genetics, Albany Medical College, New York 12208, USA
Infect Immun 66:2180-5. 1998..mutans, leading to the accumulation of gtfBC recombinants whose reduced glucosyltransferase activity restores a less cariogenic plaque structure...
- The regulation of Streptococcus mutans glucan-binding protein A expressionJ A Banas
Department of Microbiology, Immunology, and Molecular Genetics, Albany Medical College, NY 12208, USA
FEMS Microbiol Lett 154:289-92. 1997..mutans. Expression of GBP-A was optimal under anaerobiosis and neutral pH conditions, and correlated with optimal growth. The addition of sucrose to the growth medium did not elevate the expression of GBP-A...
- An in vitro model for studying the contributions of the Streptococcus mutans glucan-binding protein A to biofilm structureJ A Banas
Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
Methods Enzymol 337:425-33. 2001..These methods may also be useful in the screening of mutants that would be of greatest for testing in multispecies biofilms, animal models, or more complex biofilm models...
- Circular dichroism analysis of the glucan binding domain of Streptococcus mutans glucan binding protein-AW Haas
Albany Medical College A68, NY 12208, USA
Biochim Biophys Acta 1384:112-20. 1998..The fluorescence emission maximum at 339 nm suggested that the majority of the tryptophans were located in the interior of the protein. This maximum shifted to higher energy upon binding to the ligand dextran...
- Francisella tularensis LVS grown in macrophages has reduced ability to stimulate the secretion of inflammatory cytokines by macrophages in vitroDaniel J Loegering
Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
Microb Pathog 41:218-25. 2006..tularensis that is associated with decreased stimulation of cytokine secretion, inhibition of LPS-stimulated secretion of inflammatory cytokines by macrophages and increased lethality in mice...
- Evidence that accumulation of mutants in a biofilm reflects natural selection rather than stress-induced adaptive mutationJeffrey A Banas
University of Iowa College of Dentistry, Dows Institute Research, Dental Science N 436, Iowa City, IA 52242, USA
Appl Environ Microbiol 73:357-61. 2007..We report here that natural selection was the primary force behind the accumulation of the deletion mutants...
- Streptococcus mutans glucan-binding protein-A affects Streptococcus gordonii biofilm architectureJeffrey A Banas
Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA
FEMS Microbiol Lett 267:80-8. 2007..The magnitude of the GbpA effect appears to be dependent on the quantity and linkage of available glucan...
- Glucan-binding proteins are essential for shaping Streptococcus mutans biofilm architectureDavid J Lynch
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY, USA
FEMS Microbiol Lett 268:158-65. 2007..The loss of an extracellular Gbp, either GbpA or GbpD, also profoundly changed the biofilm architecture, each in a unique manner...
- Genome-wide identification of Francisella tularensis virulence determinantsJingliang Su
Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
Infect Immun 75:3089-101. 2007..Deletional mutation analysis confirmed that this locus is essential for F. tularensis virulence...
- Generation of a human IgG3-streptavidin fusion protein. Implications for the inhibition and elimination of auto-reactive B cellsMark T Preissler
Albany Medical College, Center for Immunology and Microbial Disease, Albany, NY 12208, USA
Hum Antibodies 12:77-92. 2003..In summary, these studies describe an approach, which has the potential to be used as a treatment to inhibit or remove antigen-specific (auto-reactive) B cells...