Chandra Shekhar Bakshi

Summary

Affiliation: Albany Medical College
Country: USA

Publications

  1. pmc An improved vaccine for prevention of respiratory tularemia caused by Francisella tularensis SchuS4 strain
    Chandra Shekhar Bakshi
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Vaccine 26:5276-88. 2008
  2. ncbi request reprint Prophylactic and therapeutic use of antibodies for protection against respiratory infection with Francisella tularensis
    Girish S Kirimanjeswara
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue Albany, NY 12208, USA
    J Immunol 179:532-9. 2007
  3. pmc Identification of a live attenuated vaccine candidate for tularemia prophylaxis
    Manish Mahawar
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, United States of America
    PLoS ONE 8:e61539. 2013
  4. pmc Identification of Francisella tularensis live vaccine strain CuZn superoxide dismutase as critical for resistance to extracellularly generated reactive oxygen species
    Amanda A Melillo
    Center for Immunology and Microbial Disease, MC 151, Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA
    J Bacteriol 191:6447-56. 2009
  5. ncbi request reprint Matrix metalloproteinase 9 activity enhances host susceptibility to pulmonary infection with type A and B strains of Francisella tularensis
    Meenakshi Malik
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Immunol 178:1013-20. 2007
  6. pmc Superoxide dismutase B gene (sodB)-deficient mutants of Francisella tularensis demonstrate hypersensitivity to oxidative stress and attenuated virulence
    Chandra Shekhar Bakshi
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208 3479, USA
    J Bacteriol 188:6443-8. 2006
  7. pmc Repression of inflammasome by Francisella tularensis during early stages of infection
    Rachel J Dotson
    Albany College of Pharmacy and Health Sciences, Albany, New York 12208, USA
    J Biol Chem 288:23844-57. 2013
  8. pmc Contribution of citrulline ureidase to Francisella tularensis strain Schu S4 pathogenesis
    Manish Mahawar
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208 3479, USA
    J Bacteriol 191:4798-806. 2009
  9. pmc Francisella tularensis antioxidants harness reactive oxygen species to restrict macrophage signaling and cytokine production
    Amanda A Melillo
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 285:27553-60. 2010
  10. pmc Identification of a novel Francisella tularensis factor required for intramacrophage survival and subversion of innate immune response
    Manish Mahawar
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 287:25216-29. 2012

Collaborators

  • D W Metzger
  • David G Thanassi
  • Amit Gaggar
  • Karsten R O Hazlett
  • Meenakshi Malik
  • Manish Mahawar
  • Seham M Rabadi
  • Amanda A Melillo
  • Sukalyani Banik
  • Rachel J Dotson
  • Sally V Catlett
  • J Andres Melendez
  • Girish S Kirimanjeswara
  • Timothy J Sellati
  • Zhuo Ma
  • Jonathan A Harton
  • Aaloki Shah
  • Vanessa T Mora
  • Christopher R Doyle
  • Harshita Rane
  • Elizabeth L Westcott
  • Stephen Bradley
  • Maninjay K Atianand
  • Vanessa Mora
  • Jason F Huntley
  • Rajendra Singh
  • Jacqueline M Golden
  • Kathleen McCabe
  • Patricia L Jackson
  • J Edwin Blalock
  • Steven A Lotz
  • Bikash Sahay

Detail Information

Publications14

  1. pmc An improved vaccine for prevention of respiratory tularemia caused by Francisella tularensis SchuS4 strain
    Chandra Shekhar Bakshi
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    Vaccine 26:5276-88. 2008
    ..Collectively, this study describes an improved live vaccine candidate against respiratory tularemia that has an attenuated virulence and enhanced protective efficacy than the LVS...
  2. ncbi request reprint Prophylactic and therapeutic use of antibodies for protection against respiratory infection with Francisella tularensis
    Girish S Kirimanjeswara
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue Albany, NY 12208, USA
    J Immunol 179:532-9. 2007
    ..Thus, this study provides the first evidence for the therapeutic use of Abs in Francisella-infected individuals...
  3. pmc Identification of a live attenuated vaccine candidate for tularemia prophylaxis
    Manish Mahawar
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, United States of America
    PLoS ONE 8:e61539. 2013
    ..This study describes a live attenuated vaccine which may prove to be an ideal vaccine candidate for prevention of respiratory tularemia...
  4. pmc Identification of Francisella tularensis live vaccine strain CuZn superoxide dismutase as critical for resistance to extracellularly generated reactive oxygen species
    Amanda A Melillo
    Center for Immunology and Microbial Disease, MC 151, Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA
    J Bacteriol 191:6447-56. 2009
    ..To conclude, this study demonstrates that SodB and SodC act to confer protection against host-derived oxidants and contribute to intramacrophage survival and virulence of F. tularensis in mice...
  5. ncbi request reprint Matrix metalloproteinase 9 activity enhances host susceptibility to pulmonary infection with type A and B strains of Francisella tularensis
    Meenakshi Malik
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Immunol 178:1013-20. 2007
    ....
  6. pmc Superoxide dismutase B gene (sodB)-deficient mutants of Francisella tularensis demonstrate hypersensitivity to oxidative stress and attenuated virulence
    Chandra Shekhar Bakshi
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208 3479, USA
    J Bacteriol 188:6443-8. 2006
    ..The sodB(Ft) mutant also was significantly attenuated for virulence in mice. Thus, this study has identified sodB as an important F. tularensis virulence factor...
  7. pmc Repression of inflammasome by Francisella tularensis during early stages of infection
    Rachel J Dotson
    Albany College of Pharmacy and Health Sciences, Albany, New York 12208, USA
    J Biol Chem 288:23844-57. 2013
    ..tularensis. Collectively, this study provides evidence that F. tularensis LVS represses inflammasome activation and that F. tularensis-encoded FTL_0325 mediates this effect. ..
  8. pmc Contribution of citrulline ureidase to Francisella tularensis strain Schu S4 pathogenesis
    Manish Mahawar
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208 3479, USA
    J Bacteriol 191:4798-806. 2009
    ..To conclude, this study demonstrates that ctu contributes to intracellular survival, in vivo growth, and pathogenesis. However, ctu is not an absolute requirement for the virulence of F. tularensis Schu S4 in mice...
  9. pmc Francisella tularensis antioxidants harness reactive oxygen species to restrict macrophage signaling and cytokine production
    Amanda A Melillo
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 285:27553-60. 2010
    ..Together, these findings suggest a novel role for bacterial antioxidants in restricting macrophage activation through their ability to preserve phosphatases that temper kinase signaling and proinflammatory cytokine production...
  10. pmc Identification of a novel Francisella tularensis factor required for intramacrophage survival and subversion of innate immune response
    Manish Mahawar
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 287:25216-29. 2012
    ..Collectively, this study reports a novel F. tularensis factor that is required for innate immune subversion caused by this deadly bacterium...
  11. ncbi request reprint Mucosal immunopathogenesis of Francisella tularensis
    Dennis W Metzger
    Center for Immunology and Microbial Disease, MC 151, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Ann N Y Acad Sci 1105:266-83. 2007
    ....
  12. ncbi request reprint T-bet deficiency facilitates airway colonization by Mycoplasma pulmonis in a murine model of asthma
    Chandra Shekhar Bakshi
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 177:1786-95. 2006
    ..For its part, airways exhibiting an asthmatic phenotype provide a fertile environment that promotes colonization by Mycoplasma spp. and one which is ill-equipped to kill and clear respiratory pathogens...
  13. ncbi request reprint EmrA1 membrane fusion protein of Francisella tularensis LVS is required for resistance to oxidative stress, intramacrophage survival and virulence in mice
    Zhuo Ma
    Department of Basic and Social Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York, USA
    Mol Microbiol 91:976-95. 2014
    ..This study exposes unique links between transporter activity and the antioxidant defence mechanisms of F.‚ÄČtularensis...
  14. pmc Toll-like receptor 2 is required for control of pulmonary infection with Francisella tularensis
    Meenakshi Malik
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, MC151, ME205B, Albany, NY 12208 3479, USA
    Infect Immun 74:3657-62. 2006
    ..This pattern of cytokine production may contribute to the exaggerated pathogenesis seen in TLR2-/- mice. Collectively, these findings suggest that TLR2 plays an important role in tempering the host response to pneumonic tularemia...