Susan J Zunino

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. ncbi request reprint Resveratrol-induced apoptosis is enhanced in acute lymphoblastic leukemia cells by modulation of the mitochondrial permeability transition pore
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, One Shields Ave, 3202A Meyer Hall, University of California, Davis, CA 95616, USA
    Cancer Lett 240:123-34. 2006
  2. ncbi request reprint Diets rich in polyphenols and vitamin A inhibit the development of type I autoimmune diabetes in nonobese diabetic mice
    Susan J Zunino
    USDA, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA
    J Nutr 137:1216-21. 2007
  3. ncbi request reprint Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA
    Cancer Lett 254:119-27. 2007
  4. doi request reprint Dietary strawberries increase the proliferative response of CD3/CD28-activated CD8⁺ T cells and the production of TNF-α in lipopolysaccharide-stimulated monocytes from obese human subjects
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, USA
    Br J Nutr 110:2011-9. 2013
  5. pmc Dietary resveratrol does not delay engraftment, sensitize to vincristine or inhibit growth of high-risk acute lymphoblastic leukemia cells in NOD/SCID mice
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA 95616, USA
    Int J Oncol 41:2207-12. 2012
  6. pmc Oral or parenteral administration of curcumin does not prevent the growth of high-risk t(4;11) acute lymphoblastic leukemia cells engrafted into a NOD/SCID mouse model
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA 95616, USA
    Int J Oncol 42:741-8. 2013
  7. doi request reprint Dietary strawberry powder reduces blood glucose concentrations in obese and lean C57BL/6 mice, and selectively lowers plasma C-reactive protein in lean mice
    Mardi A Parelman
    Department of Nutrition, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Br J Nutr 108:1789-99. 2012
  8. pmc Novel in vivo model of inducible multi-drug resistance in acute lymphoblastic leukemia with chromosomal translocation t(4;11)
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, United States
    Cancer Lett 296:49-54. 2010
  9. ncbi request reprint Parthenolide treatment activates stress signaling proteins in high-risk acute lymphoblastic leukemia cells with chromosomal translocation t(4;11)
    Susan J Zunino
    United States Department of Agriculture, Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA
    Int J Oncol 37:1307-13. 2010
  10. ncbi request reprint Dietary grape powder increases IL-1β and IL-6 production by lipopolysaccharide-activated monocytes and reduces plasma concentrations of large LDL and large LDL-cholesterol particles in obese humans
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA95616, USA
    Br J Nutr 112:369-80. 2014

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Resveratrol-induced apoptosis is enhanced in acute lymphoblastic leukemia cells by modulation of the mitochondrial permeability transition pore
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, One Shields Ave, 3202A Meyer Hall, University of California, Davis, CA 95616, USA
    Cancer Lett 240:123-34. 2006
    ..These data suggest targeting the MPTP sensitizes B- and T-cell ALL to the anti-cancer activity of resveratrol, and may be particularly useful for the treatment of high-risk t(4;11) ALL...
  2. ncbi request reprint Diets rich in polyphenols and vitamin A inhibit the development of type I autoimmune diabetes in nonobese diabetic mice
    Susan J Zunino
    USDA, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA
    J Nutr 137:1216-21. 2007
    ..These data suggest that diets rich in polyphenols or vitamin A have protective effects against autoimmune inflammatory attack of the islet beta cells and have the potential to reduce the onset and pathogenesis of autoimmune diabetes...
  3. ncbi request reprint Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA
    Cancer Lett 254:119-27. 2007
    ..Parthenolide-induced elevation of hypochlorite anion was observed only in the two t(4;11) lines. These data suggest parthenolide may have potential as a potent and novel therapeutic agent against pre-B ALLs...
  4. doi request reprint Dietary strawberries increase the proliferative response of CD3/CD28-activated CD8⁺ T cells and the production of TNF-α in lipopolysaccharide-stimulated monocytes from obese human subjects
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, USA
    Br J Nutr 110:2011-9. 2013
    ..These data suggest that dietary strawberries may increase the immunological response of T-lymphocytes and monocytes in obese people who are at greater risk for developing infections...
  5. pmc Dietary resveratrol does not delay engraftment, sensitize to vincristine or inhibit growth of high-risk acute lymphoblastic leukemia cells in NOD/SCID mice
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA 95616, USA
    Int J Oncol 41:2207-12. 2012
    ..These data do not support the concept that dietary resveratrol has potential as a preventative agent against the growth of high-risk t(4;11) ALL...
  6. pmc Oral or parenteral administration of curcumin does not prevent the growth of high-risk t(4;11) acute lymphoblastic leukemia cells engrafted into a NOD/SCID mouse model
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA 95616, USA
    Int J Oncol 42:741-8. 2013
    ..In contrast to the findings in previous in vitro models, the current data indicate that orally or parenterally administered curcumin is not a potent preventive agent against high‑risk t(4;11) acute lymphoblastic leukemia...
  7. doi request reprint Dietary strawberry powder reduces blood glucose concentrations in obese and lean C57BL/6 mice, and selectively lowers plasma C-reactive protein in lean mice
    Mardi A Parelman
    Department of Nutrition, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Br J Nutr 108:1789-99. 2012
    ..These results, although modest, support a promising role for dietary strawberries in reducing the risks associated with obesity and diabetes, and regulating the levels of inflammatory markers in non-obese individuals...
  8. pmc Novel in vivo model of inducible multi-drug resistance in acute lymphoblastic leukemia with chromosomal translocation t(4;11)
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, United States
    Cancer Lett 296:49-54. 2010
    ..These data describe a novel inducible model for investigating multi-drug resistance mechanisms in high-risk t(4;11) ALL...
  9. ncbi request reprint Parthenolide treatment activates stress signaling proteins in high-risk acute lymphoblastic leukemia cells with chromosomal translocation t(4;11)
    Susan J Zunino
    United States Department of Agriculture, Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA
    Int J Oncol 37:1307-13. 2010
    ....
  10. ncbi request reprint Dietary grape powder increases IL-1β and IL-6 production by lipopolysaccharide-activated monocytes and reduces plasma concentrations of large LDL and large LDL-cholesterol particles in obese humans
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA95616, USA
    Br J Nutr 112:369-80. 2014
    ..These data suggest that dietary grapes may decrease atherogenic lipid fractions in obese individuals and increase the sensitivity of monocytes in a population at a greater risk of developing infections. ..
  11. ncbi request reprint Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, USA
    Br J Nutr 108:900-9. 2012
    ..Dietary strawberry powder reduced risk factors for CVD, stroke and diabetes in obese volunteers, suggesting a potential role for strawberries as a dietary means to decrease obesity-related disease...
  12. pmc Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, USA
    Int J Oncol 40:1277-84. 2012
    ..These data indicate that in contrast to findings in in vitro models, parenterally administered resveratrol does not have potential as a preventive agent against high risk t(4;11) ALL...
  13. doi request reprint Resveratrol alters proliferative responses and apoptosis in human activated B lymphocytes in vitro
    Susan J Zunino
    USDA, Agricultural Research Service, Western Human Nutrition Research Center, Davis, CA 95616, USA
    J Nutr 139:1603-8. 2009
    ..These data show that human B lymphocyte proliferation and apoptosis are modified by physiological concentrations of resveratrol and suggest that exposure of human B cells to resveratrol may increase survival by upregulating Bcl-2...
  14. doi request reprint Carnosol delays chemotherapy-induced DNA fragmentation and morphological changes associated with apoptosis in leukemic cells
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis 95616, USA
    Nutr Cancer 61:94-102. 2009
    ....
  15. ncbi request reprint Nitric oxide is synthesized in acute leukemia cells after exposure to phenolic antioxidants and initially protects against mitochondrial membrane depolarization
    Christian Kellner
    Friedrich Alexander University of Erlangen Nurnberg, D91058 Erlangen, Germany
    Cancer Lett 215:43-52. 2004
    ....
  16. ncbi request reprint Efficient eukaryotic expression of fluorescent scFv fusion proteins directed against CD antigens for FACS applications
    Matthias Peipp
    Chair of Genetics, University of Erlangen, Nuremberg, Staudtstrasse 5, D 91058 Erlangen, Germany
    J Immunol Methods 285:265-80. 2004
    ..Thus, for a number of analytical applications, fluorescent scFv fusion proteins offer advantages over the use of complete primary antibodies and chemically labeled fluorescent secondary antibodies...
  17. ncbi request reprint Interferon-gamma increases the expression of glycosylated CD95 in B-leukemic cells: an inducible model to study the role of glycosylation in CD95-signalling and trafficking
    Jan Dörrie
    Chair of Genetics, Friedrich Alexander University of Erlangen Nurnberg, Staudtstr 5, Erlangen, D91058, Germany
    Cytokine 18:98-107. 2002
    ..In conclusion, IFN-gamma treatment of the B-lineage leukaemia lines provides a novel, inducible system for the further characterization of post-translational modifications involved in modulating sensitivity to CD95-signalling...
  18. ncbi request reprint A recombinant CD7-specific single-chain immunotoxin is a potent inducer of apoptosis in acute leukemic T cells
    Matthias Peipp
    Chair of Genetics, University of Erlangen Nuremberg, Staudtstrasse 5, D 91058 Erlangen, Germany
    Cancer Res 62:2848-55. 2002
    ..These findings justify further evaluation of the agent in view of potential therapeutic applications...

Research Grants2

  1. Evaluation of resveratrol and curcumin as therapeutics against high-risk leukemia
    SUSAN ZUNINO; Fiscal Year: 2007
    ..These studies will provide information about whether the plant antioxidants resveratrol and curcumin may be novel and efficient alternatives for the treatment of high-risk leukemia. ..