Thomas T Y Wang

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. doi request reprint Indole-3-carbinol and 3',3'-diindolylmethane modulate androgen's effect on C-C chemokine ligand 2 and monocyte attraction to prostate cancer cells
    Eun Kyung Kim
    Nutritional Sciences Research Group, Division of Cancer Prevention, National Cancer Institute, NIH, Bethesda, USA
    Cancer Prev Res (Phila) 6:519-29. 2013
  2. doi request reprint Differential effects of resveratrol and its naturally occurring methylether analogs on cell cycle and apoptosis in human androgen-responsive LNCaP cancer cells
    Thomas T Y Wang
    Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705, USA
    Mol Nutr Food Res 54:335-44. 2010
  3. pmc Differential effects of resveratrol on androgen-responsive LNCaP human prostate cancer cells in vitro and in vivo
    Thomas T Y Wang
    Diet, Genomics and Immunology Laboratory, Beltsville Human Nutrition Research Center, United States Department of Agriculture, 10300 Baltimore Avenue, Beltsville, MD 20705, USA
    Carcinogenesis 29:2001-10. 2008
  4. ncbi request reprint Molecular signatures of soy-derived phytochemicals in androgen-responsive prostate cancer cells: a comparison study using DNA microarray
    Yoko Takahashi
    Phytonutrients Laboratory, Beltsville Human Nutrition Research Center, ARS, USDA, Beltsville, Maryland 20705, USA
    Mol Carcinog 45:943-56. 2006
  5. ncbi request reprint Genistein affects androgen-responsive genes through both androgen- and estrogen-induced signaling pathways
    Yoko Takahashi
    Phytonutrients Laboratory, Beltsville Human Nutrition Research Center, U S Department of Agriculture, Beltsville, Maryland 20705, USA
    Mol Carcinog 45:18-25. 2006
  6. doi request reprint Broccoli-derived phytochemicals indole-3-carbinol and 3,3'-diindolylmethane exerts concentration-dependent pleiotropic effects on prostate cancer cells: comparison with other cancer preventive phytochemicals
    Thomas T Y Wang
    Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, Maryland 20705, USA
    Mol Carcinog 51:244-56. 2012
  7. ncbi request reprint 17beta-Estradiol differentially regulates androgen-responsive genes through estrogen receptor-beta- and extracellular-signal regulated kinase-dependent pathways in LNCaP human prostate cancer cells
    Yoko Takahashi
    Phytonutrients Laboratory, Beltsville Human Nutrition Research Center, U S Department of Agriculture, Beltsville, Maryland 20705, USA
    Mol Carcinog 46:117-29. 2007
  8. ncbi request reprint Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in the androgen-responsive human prostate cancer cell line LNCaP
    Steven E Trasino
    Phytonutrients Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705, USA
    Exp Biol Med (Maywood) 232:762-71. 2007
  9. doi request reprint Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells
    Steven E Trasino
    Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705, USA
    Mol Cancer Ther 8:1934-45. 2009
  10. ncbi request reprint Using DNA microarray analyses to elucidate the effects of genistein in androgen-responsive prostate cancer cells: identification of novel targets
    Yoko Takahashi
    Phytonutrients Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service USDA, Beltsville, MD 20705, USA
    Mol Carcinog 41:108-119. 2004

Detail Information

Publications15

  1. doi request reprint Indole-3-carbinol and 3',3'-diindolylmethane modulate androgen's effect on C-C chemokine ligand 2 and monocyte attraction to prostate cancer cells
    Eun Kyung Kim
    Nutritional Sciences Research Group, Division of Cancer Prevention, National Cancer Institute, NIH, Bethesda, USA
    Cancer Prev Res (Phila) 6:519-29. 2013
    ..These results show that androgen may regulate CCL2 and promote inflammatory microenvironment in prostate tumors and that this process can be blocked by broccoli-derived compounds...
  2. doi request reprint Differential effects of resveratrol and its naturally occurring methylether analogs on cell cycle and apoptosis in human androgen-responsive LNCaP cancer cells
    Thomas T Y Wang
    Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705, USA
    Mol Nutr Food Res 54:335-44. 2010
    ..These results provide mechanistic information on how resveratrol and its methylether analogs may act to contribute to potential antiprostate cancer activity...
  3. pmc Differential effects of resveratrol on androgen-responsive LNCaP human prostate cancer cells in vitro and in vivo
    Thomas T Y Wang
    Diet, Genomics and Immunology Laboratory, Beltsville Human Nutrition Research Center, United States Department of Agriculture, 10300 Baltimore Avenue, Beltsville, MD 20705, USA
    Carcinogenesis 29:2001-10. 2008
    ..In summary, resveratrol may act through modulation of steroid hormone-dependent pathways to inhibit prostate cancer cell growth in both culture and xenografts, but exposure in vivo may be of concern...
  4. ncbi request reprint Molecular signatures of soy-derived phytochemicals in androgen-responsive prostate cancer cells: a comparison study using DNA microarray
    Yoko Takahashi
    Phytonutrients Laboratory, Beltsville Human Nutrition Research Center, ARS, USDA, Beltsville, Maryland 20705, USA
    Mol Carcinog 45:943-56. 2006
    ..Moreover, these results also allow for the identification of candidate mechanism(s) by which soy phytochemicals and soy may act in prostate cancer cells...
  5. ncbi request reprint Genistein affects androgen-responsive genes through both androgen- and estrogen-induced signaling pathways
    Yoko Takahashi
    Phytonutrients Laboratory, Beltsville Human Nutrition Research Center, U S Department of Agriculture, Beltsville, Maryland 20705, USA
    Mol Carcinog 45:18-25. 2006
    ..These results indicate that genistein selectively alters expression of ARG mRNAs in LNCaP cells through modulation of both androgen- and estrogen-induced signaling pathways...
  6. doi request reprint Broccoli-derived phytochemicals indole-3-carbinol and 3,3'-diindolylmethane exerts concentration-dependent pleiotropic effects on prostate cancer cells: comparison with other cancer preventive phytochemicals
    Thomas T Y Wang
    Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, Maryland 20705, USA
    Mol Carcinog 51:244-56. 2012
    ..Based on our results, a model for cancer protective effects of DIM and I3C was proposed...
  7. ncbi request reprint 17beta-Estradiol differentially regulates androgen-responsive genes through estrogen receptor-beta- and extracellular-signal regulated kinase-dependent pathways in LNCaP human prostate cancer cells
    Yoko Takahashi
    Phytonutrients Laboratory, Beltsville Human Nutrition Research Center, U S Department of Agriculture, Beltsville, Maryland 20705, USA
    Mol Carcinog 46:117-29. 2007
    ..These results provide mechanistic evidence supporting a direct effect of estrogen, mediated through ER-beta- and ERK-dependent pathways, on specific molecular targets in human prostate cancer cells...
  8. ncbi request reprint Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in the androgen-responsive human prostate cancer cell line LNCaP
    Steven E Trasino
    Phytonutrients Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705, USA
    Exp Biol Med (Maywood) 232:762-71. 2007
    ..Taken together, these data suggest that (i) the RA biosynthesis enzyme ALDH1A3 is androgen responsive and (ii) DHT up-regulation of ALDH1A3 can increase the oxidation of retinal to RA and indirectly affect RA bioactivity and metabolism...
  9. doi request reprint Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells
    Steven E Trasino
    Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705, USA
    Mol Cancer Ther 8:1934-45. 2009
    ..Our study also reveals that ABCA1 gene expression is differentially regulated by synthetic and natural LXR ligands, possibly involving kinase mediated signal transduction...
  10. ncbi request reprint Using DNA microarray analyses to elucidate the effects of genistein in androgen-responsive prostate cancer cells: identification of novel targets
    Yoko Takahashi
    Phytonutrients Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service USDA, Beltsville, MD 20705, USA
    Mol Carcinog 41:108-119. 2004
    ..Based on these results, we propose that the regulation of AR-mediated pathways is potentially the most relevant chemopreventive mechanism for genistein administered at physiologic levels...
  11. ncbi request reprint Estrogen receptor alpha as a target for indole-3-carbinol
    Thomas T Y Wang
    Phytonutrients Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, Beltsville, MD 20705, USA
    J Nutr Biochem 17:659-64. 2006
    ....
  12. doi request reprint Selenoprotein W modulates control of cell cycle entry
    Wayne Chris Hawkes
    USDA Agricultural Research Service, Western Human Nutrition Research Center, University of California at Davis, Davis, CA, USA
    Biol Trace Elem Res 131:229-44. 2009
    ..These results suggest that SEPW1 and the G1/S transition are physiological targets of Se in breast and prostate epithelial cells...
  13. ncbi request reprint beta-naphthoflavone, an inducer of xenobiotic metabolizing enzymes, inhibits firefly luciferase activity
    Thomas T Y Wang
    Phytonutrients Laboratory, ARS, BHNRC, U S Department of Agriculture, Beltsville, Maryland 20705, USA
    Anal Biochem 304:122-6. 2002
  14. doi request reprint Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration-dependent modulation of multiple nuclear receptor-mediated pathways in androgen-responsive prostate cancer cell LNCaP
    Thomas T Y Wang
    Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, Beltsville, Maryland
    Mol Carcinog 52:676-85. 2013
    ..Based on these results we reasoned that sirtinol exerts pleiotropic effects in cells and that biological effects of sirtinol may not be due solely to inhibition of sirtuin. © 2012 Wiley Periodicals, Inc. ..
  15. doi request reprint Transcriptomic alterations in human prostate cancer cell LNCaP tumor xenograft modulated by dietary phenethyl isothiocyanate
    Robert W Li
    U S Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Bovine Functional Genomics Laboratory, Beltsville, MD, USA
    Mol Carcinog 52:426-37. 2013
    ..This study represents the first use of RNAseq to analyze tumors from animals consuming dietary phenethyl isothiocyanate and to identify potential molecular signatures that may explain the cancer protective effect of this compound...