E O Uthus

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. ncbi request reprint Simultaneous detection of S-adenosylmethionine and S-adenosylhomocysteine in mouse and rat tissues by capillary electrophoresis
    Eric O Uthus
    USDA ARS Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA
    Electrophoresis 24:1221-6. 2003
  2. ncbi request reprint Differential effects of dietary selenium (se) and folate on methyl metabolism in liver and colon of rats
    Eric O Uthus
    USDA ARS Grand Forks Human Nutrition Research Center, P O Box 9034, Grand Forks, ND 58202 9034, USA
    Biol Trace Elem Res 109:201-14. 2006
  3. ncbi request reprint Dietary selenium affects homocysteine metabolism differently in Fisher-344 rats and CD-1 mice
    Eric O Uthus
    USDA, ARS, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA
    J Nutr 137:1132-6. 2007
  4. ncbi request reprint Altered methionine metabolism in long living Ames dwarf mice
    Eric O Uthus
    US Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, P O Box 9034, Grand Forks, ND 58202, USA
    Exp Gerontol 38:491-8. 2003
  5. ncbi request reprint Selenium deficiency in Fisher-344 rats decreases plasma and tissue homocysteine concentrations and alters plasma homocysteine and cysteine redox status
    E O Uthus
    U S Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA
    J Nutr 132:1122-8. 2002
  6. ncbi request reprint Copper deficiency decreases plasma homocysteine in rats
    Eric O Uthus
    US Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA
    J Nutr 137:1370-4. 2007
  7. ncbi request reprint Dietary folate and selenium affect dimethylhydrazine-induced aberrant crypt formation, global DNA methylation and one-carbon metabolism in rats
    Cindy D Davis
    US Department of Agriculture, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202 9034, USA
    J Nutr 133:2907-14. 2003
  8. ncbi request reprint Dietary arsenic affects dimethylhydrazine-induced aberrant crypt formation and hepatic global DNA methylation and DNA methyltransferase activity in rats
    Eric O Uthus
    United States Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA
    Biol Trace Elem Res 103:133-45. 2005
  9. ncbi request reprint Dietary selenium and arsenic affect DNA methylation in vitro in Caco-2 cells and in vivo in rat liver and colon
    C D Davis
    U S Department of Agriculture, Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota 58202 9034, USA
    J Nutr 130:2903-9. 2000
  10. ncbi request reprint Dietary nickel and folic acid interact to affect folate and methionine metabolism in the rat
    E O Uthus
    United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, ND 58202 9034, USA
    Biol Trace Elem Res 58:25-33. 1997

Detail Information

Publications25

  1. ncbi request reprint Simultaneous detection of S-adenosylmethionine and S-adenosylhomocysteine in mouse and rat tissues by capillary electrophoresis
    Eric O Uthus
    USDA ARS Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA
    Electrophoresis 24:1221-6. 2003
    ..The method is linear over ranges of 1-100 microM SAM and 1-250 microM SAH. This method can be used to determine tissue concentrations of SAM and SAH, two metabolites that can provide insight into many biological processes...
  2. ncbi request reprint Differential effects of dietary selenium (se) and folate on methyl metabolism in liver and colon of rats
    Eric O Uthus
    USDA ARS Grand Forks Human Nutrition Research Center, P O Box 9034, Grand Forks, ND 58202 9034, USA
    Biol Trace Elem Res 109:201-14. 2006
    ..This suggests that selenium deficiency appears to be a more important modifier of methyl metabolism than either adequate or supplemental selenium...
  3. ncbi request reprint Dietary selenium affects homocysteine metabolism differently in Fisher-344 rats and CD-1 mice
    Eric O Uthus
    USDA, ARS, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA
    J Nutr 137:1132-6. 2007
    ....
  4. ncbi request reprint Altered methionine metabolism in long living Ames dwarf mice
    Eric O Uthus
    US Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, P O Box 9034, Grand Forks, ND 58202, USA
    Exp Gerontol 38:491-8. 2003
    ..Taken together, the data suggest that methionine metabolism may play a role in oxidative defense in the dwarf mouse and should be studied as a potential mechanism of extended lifespan...
  5. ncbi request reprint Selenium deficiency in Fisher-344 rats decreases plasma and tissue homocysteine concentrations and alters plasma homocysteine and cysteine redox status
    E O Uthus
    U S Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA
    J Nutr 132:1122-8. 2002
    ..02 microg selenium/g diet and those fed 0.05 or 0.1 microg selenium/g diet. The metabolic consequences of a marked decrease in plasma homocysteine and smaller but significant decreases in tissue homocysteine are not known...
  6. ncbi request reprint Copper deficiency decreases plasma homocysteine in rats
    Eric O Uthus
    US Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA
    J Nutr 137:1370-4. 2007
    ..The net effect of increased Gclc and decreased Bhmt would be a decrease in homocysteine as a result of Cu deficiency...
  7. ncbi request reprint Dietary folate and selenium affect dimethylhydrazine-induced aberrant crypt formation, global DNA methylation and one-carbon metabolism in rats
    Cindy D Davis
    US Department of Agriculture, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202 9034, USA
    J Nutr 133:2907-14. 2003
    ..These results suggest that selenium deprivation ameliorates some of the effects of folate deficiency, probably by shunting the buildup of homocysteine (as a result of folate deficiency) to glutathione...
  8. ncbi request reprint Dietary arsenic affects dimethylhydrazine-induced aberrant crypt formation and hepatic global DNA methylation and DNA methyltransferase activity in rats
    Eric O Uthus
    United States Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA
    Biol Trace Elem Res 103:133-45. 2005
    ..5 microg As/g. The data suggest that there is a threshold for As toxicity and that possibly too little dietary As could also be detrimental...
  9. ncbi request reprint Dietary selenium and arsenic affect DNA methylation in vitro in Caco-2 cells and in vivo in rat liver and colon
    C D Davis
    U S Department of Agriculture, Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota 58202 9034, USA
    J Nutr 130:2903-9. 2000
    ..1 or 2.0 microg selenium/g diets as either selenite or selenomethionine. Thus, alterations in DNA methylation may be a potential mechanism, whereby deficient dietary selenium increases liver and colon tumorigenesis...
  10. ncbi request reprint Dietary nickel and folic acid interact to affect folate and methionine metabolism in the rat
    E O Uthus
    United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, ND 58202 9034, USA
    Biol Trace Elem Res 58:25-33. 1997
    ..Possibly the physiological function of nickel could be related to the tissue concentration of 5-methyltetrahydrofolate (MTHF) or tetrahydrofolate (THF)...
  11. doi request reprint High dietary intake of sodium selenite does not affect gene mutation frequency in rat colon and liver
    Huawei Zeng
    United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202 9034, USA
    Biol Trace Elem Res 131:71-80. 2009
    ....
  12. ncbi request reprint Specific activity of methionine sulfoxide reductase in CD-1 mice is significantly affected by dietary selenium but not zinc
    Eric O Uthus
    US Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA
    Biol Trace Elem Res 115:265-76. 2007
    ..Finally, the results show that the oxidative effects of limited BSO treatment did not upregulate Msr activity...
  13. doi request reprint Dietary selenium (Se) and copper (Cu) interact to affect homocysteine metabolism in rats
    Eric O Uthus
    Grand Forks Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, Grand Forks, ND 58202 9034, USA
    Biol Trace Elem Res 129:213-20. 2009
    ..However, the up-regulation of liver Gclc alone cannot explain why rats fed with the doubly deficient diet have the lowest pHcys and the highest pGSH...
  14. pmc Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse
    Eric O Uthus
    US Department of Agriculture, ARS, Grand Forks Human Nutrition Research Center, ND 58202 9034, USA
    Mech Ageing Dev 127:444-50. 2006
    ....
  15. ncbi request reprint Mechanistic aspects of the interaction between selenium and arsenic
    Huawei Zeng
    Agricultural Research Service, Grand Forks Human Nutrition Research Center, United States Department of Agriculture, 2420, 2nd Avenue, Grand Forks, ND 58202 9034, USA
    J Inorg Biochem 99:1269-74. 2005
    ..This article focuses on these proposed mechanisms and how anti-carcinogenic effects of selenium may be affected by arsenic...
  16. ncbi request reprint Growth hormone alters methionine and glutathione metabolism in Ames dwarf mice
    Holly M Brown-Borg
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Mech Ageing Dev 126:389-98. 2005
    ..Taken together, the current results along with data from previous studies support a role for growth hormone in the regulation of antioxidative defense and ultimately, life span in organisms with altered GH or IGF-1 signaling...
  17. doi request reprint Determination of the specific activities of methionine sulfoxide reductase A and B by capillary electrophoresis
    Eric O Uthus
    Grand Forks Human Nutrition Research Center, U S Department of Agriculture Agricultural Research Service USDA ARS, Grand Forks, ND 58202, USA
    Anal Biochem 401:68-73. 2010
    ..The CE method is compared with high-performance liquid chromatography (HPLC) as determined by comparing results from measurements of hepatic enzyme activities in mice fed either deficient or adequate selenium...
  18. ncbi request reprint Dietary selenite and azadeoxycytidine treatments affect dimethylhydrazine-induced aberrant crypt formation in rat colon and DNA methylation in HT-29 cells
    Cindy D Davis
    U S Department of Agriculture, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202 9034, USA
    J Nutr 132:292-7. 2002
    ..These results suggest that aza-dC treatment may protect selenium-deficient rats against carcinogen-induced aberrant crypt formation...
  19. ncbi request reprint Use of bioimpedance spectroscopy to estimate body water distribution in rats fed high dietary sulfur amino acids
    K Yokoi
    U S Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota 58202 9034, USA
    J Nutr 131:1302-8. 2001
    ..These results suggest that dietary homocystine changes the distribution of body water and that sulfur amino acids can affect membrane porosity and/or membrane thickness...
  20. ncbi request reprint Growth hormone alters components of the glutathione metabolic pathway in Ames dwarf mice
    Holly M Brown-Borg
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Ann N Y Acad Sci 1019:317-20. 2004
    ..05). Taken together, the current results along with data from previous studies support a role for growth hormone in the regulation of antioxidative defense and, ultimately, life span in organisms with altered GH or IGF-1 signaling...
  21. ncbi request reprint Interaction between zinc and iron in rats: experimental results and mathematical analysis of blood parameters
    E O Uthus
    USDA, ARS, Grand Forks Human Nutrition Research Center, ND 58202-9034, USA
    Biol Trace Elem Res 82:167-83. 2001
    ..The complete dataset can be found at http://www.gfhnrc.ars.usda.gov/fezn...
  22. ncbi request reprint Nickel deficiency diminishes sperm quantity and movement in rats
    Katsuhiko Yokoi
    United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202 9034, USA
    Biol Trace Elem Res 93:141-54. 2003
    ..The findings support the hypothesis that nickel has an essential function that possibly could affect reproductive performance in higher animals, perhaps through affecting a CNG channel function...
  23. ncbi request reprint Does dietary selenium affect plasma homocysteine concentrations in humans?
    Cindy D Davis
    J Nutr 133:2392; author reply 2393. 2003
  24. ncbi request reprint DNA methylation, cancer susceptibility, and nutrient interactions
    Cindy D Davis
    Nutritional Sciences Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Boulevard, Suite 3159, Rockville, MD 20892 7328, USA
    Exp Biol Med (Maywood) 229:988-95. 2004
    ..Other dietary components such as vitamin B(12), alcohol, and selenium may modify the response to inadequate dietary folate...
  25. ncbi request reprint Response of liver and heart trace elements in rats to the interaction between dietary zinc and iron
    Boris Zaslavsky
    FDA CBER HFM 217, Rockville, MD 20852 1448, USA
    Biol Trace Elem Res 88:165-83. 2002
    ..This article presents the hypothesis that grouped parameters may be useful as status indicators. The complete dataset can be found at http://www.gfhnrc.ars. usda.gov/fezn...