Research Topics
Species | Charles StephensenSummaryAffiliation: Agricultural Research Service Country: USA Publications
Research Grants
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Publications
Vitamins C and E in adolescents and young adults with HIV infectionCharles B Stephensen
US Department of Agriculture Agricultural Research Service, Western Human Nutrition Research Center at the University of California Davis, Davis, CA 95616, USA
Am J Clin Nutr 83:870-9. 2006..Oxidative stress during HIV infection may impair immune function, cause more rapid disease progression, and increase requirements for dietary antioxidants such as vitamins C and E...- Glutathione, glutathione peroxidase, and selenium status in HIV-positive and HIV-negative adolescents and young adultsCharles B Stephensen
US Department of Agriculture Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA
Am J Clin Nutr 85:173-81. 2007..Antioxidant nutrient deficiencies may hasten the progression of HIV disease by impairing antioxidant defenses... 
Disruption of Rxra gene in thymocytes and T lymphocytes modestly alters lymphocyte frequencies, proliferation, survival and T helper type 1/type 2 balanceCharles B Stephensen
USDA Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, CA 95616, USA
Immunology 121:484-98. 2007..These differences were modest in magnitude and their impact on disease resistance is yet to be examined...- Fish oil and inflammatory disease: is asthma the next target for n-3 fatty acid supplements?Charles B Stephensen
US Department of Agriculture Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, California, USA
Nutr Rev 62:486-9. 2004..Such supplements also provide symptomatic relief for rheumatoid arthritis patients. Recent research suggests that asthma, another highly prevalent, chronic inflammatory disease, may also respond to fish oil supplements... - Vitamin D status in adolescents and young adults with HIV infectionCharles B Stephensen
US Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center at the University of California, Davis, CA 95616, USA
Am J Clin Nutr 83:1135-41. 2006..Vitamin D status affects immune function and thus may affect the progress of HIV infection... - Immune activation and oxidative damage in HIV-positive and HIV-negative adolescentsCharles B Stephensen
United States Department of Agriculture Western Human Nutrition Research Center and Department of Nutrition, University of California at Davis, Davis, CA 95616, USA
J Acquir Immune Defic Syndr 38:180-90. 2005..Plasma ceruloplasmin was associated with decreased oxidative damage in HIV-positive subjects, although this association was not seen in those taking ART... - Plasma cytokines and oxidative damage in HIV-positive and HIV-negative adolescents and young adults: a protective role for IL-10?Charles B Stephensen
USDA ARS Western Human Nutrition Research Center at the University of California, Davis and Department of Nutrition, University of California, Davis, CA 95616, USA
Free Radic Res 39:859-64. 2005..This finding is consistent with a protective role for IL-10 in diminishing oxidative damage during immune activation... - Vitamin A deficiency increases the in vivo development of IL-10-positive Th2 cells and decreases development of Th1 cells in miceCharles B Stephensen
U S Department of Agriculture, Western Human Nutrition Research Center at the University of California, Davis, and Nutrition Department, University of California, Davis, CA 95616, USA
J Nutr 134:2660-6. 2004..4 +/- 0.67 and 47.0 +/- 2.8%, respectively). Thus vitamin A deficiency, at the time of initial antigen exposure, enhances the development of IL-10-producing Th2 or T regulatory cells and diminishes the development of Th1 memory cells... - Diets rich in polyphenols and vitamin A inhibit the development of type I autoimmune diabetes in nonobese diabetic miceSusan J Zunino
USDA, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA
J Nutr 137:1216-21. 2007..These data suggest that diets rich in polyphenols or vitamin A have protective effects against autoimmune inflammatory attack of the islet beta cells and have the potential to reduce the onset and pathogenesis of autoimmune diabetes... 
Vitamin A status is associated with T-cell responses in Bangladeshi menShaikh M Ahmad
Department of Nutrition, Program in International and Community Nutrition, University of California, Davis, CA, USA
Br J Nutr 102:797-802. 2009..These data show that increasing vitamin A stores above the level that maintains normal vision enhances some measures of T-cell-mediated immunity, suggesting a difference in requirements for maintaining vision and immune function...- Moderate antioxidant supplementation has no effect on biomarkers of oxidant damage in healthy men with low fruit and vegetable intakesRobert A Jacob
U S Department of Agriculture ARS Western Human Nutrition Research Center, University of California at Davis, 95616 8683, USA
J Nutr 133:740-3. 2003..In healthy young men, the endogenous antioxidant defense system and a modest intake of dietary antioxidants are adequate to minimize levels of in vivo oxidant damage such that they cannot be differentiated by current methods... - Vitamin A deficiency decreases and high dietary vitamin A increases disease severity in the mouse model of asthmaGertrud U Schuster
Nutrition Department, U S Department of Agriculture Western Human Nutrition Research Center, University of California Davis, 430 West Health Science Drive, Davis, CA 95616, USA
J Immunol 180:1834-42. 2008..These data suggest that excessive intake of vitamin A may increase the risk or severity of asthma in industrialized countries whereas vitamin A deficiency continues to increase mortality from infectious diseases in developing countries... - Markers of innate immune function are associated with vitamin a stores in menShaikh M Ahmad
Department of Nutrition, University of California, Davis, CA 95616, USA
J Nutr 139:377-85. 2009..The negative association of stores with serum IL-6 and IL-17 suggests that not all protective responses are similarly enhanced by vitamin A... - Vitamin A enhances in vitro Th2 development via retinoid X receptor pathwayCharles B Stephensen
U S Department of Agriculture Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, CA 95616, USA
J Immunol 168:4495-503. 2002..These data show that stimulation of the RXR pathway enhances Th2 development, perhaps by affecting the relative expression of pertinent transcription factors, cytokines, and cytokine receptors... - Vitamin A, beta-carotene, and mother-to-child transmission of HIVCharles B Stephensen
USDA Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, CA 95616, USA
Nutr Rev 61:280-4. 2003..Overall, there is no reduction in either mortality or HIV transmission in two recent studies. Contrary to expectations, one study reported an increased risk of transmission using vitamin A plus beta-carotene supplements... - Vitamin D intake needed to maintain target serum 25-hydroxyvitamin D concentrations in participants with low sun exposure and dark skin pigmentation is substantially higher than current recommendationsLaura M Hall
Nutrition Department, University of California, Davis, CA, 95616, USA
J Nutr 140:542-50. 2010..To achieve 25(OH)D > or =75 nmol/L, we estimate that EA individuals with high sun exposure need 1300 iu/d vitamin D intake in the winter and AA individuals with low sun exposure need 2100-3100 iu/d year-round... - Lysine deficiency and feed restriction independently alter cationic amino acid transporter expression in chickens (Gallus gallus domesticus)Brooke D Humphrey
Department of Animal Science, University of California, Davis, CA 95616, USA
Comp Biochem Physiol A Mol Integr Physiol 143:218-27. 2006..By expressing high affinity CAT isoforms, developing lymphocytes may have a greater ability to obtain lysine than their surrounding tissue during a lysine deficiency... - Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytesReuven Rasooly
U S Department of Agriculture USDA Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, CA, 95616, USA
J Immunol 175:7916-29. 2005..Thus, this effect on Bcl2a1 expression may account for the decreased apoptosis seen in naive T lymphocytes treated with RXR agonists... - Men with low vitamin A stores respond adequately to primary yellow fever and secondary tetanus toxoid vaccinationShaikh M Ahmad
Program in International and Community Nutrition, Department of Nutrition, University of California Davis, CA 95616, USA
J Nutr 138:2276-83. 2008..084 micromol/g. Such increases may enhance vaccine protection but raise the question of whether immune-mediated chronic diseases may by exacerbated by high-level dietary vitamin A... - Metabolic profiling of major vitamin D metabolites using Diels-Alder derivatization and ultra-performance liquid chromatography-tandem mass spectrometryPavel A Aronov
Department of Entomology, University of California, Davis, CA, 95616, USA
Anal Bioanal Chem 391:1917-30. 2008..5 mL human serum at a lower limit of quantification of 25 pg/mL. Precision ranged from 1.6-4.8 % and 5-16 % for 25-hydroxyvitamin D(3) and 1alpha,25-dihydroxyvitamin D(3), respectively, using solid-phase extraction... - Commentary: A hypothesis concerning vitamin A supplementation, vaccines, and childhood mortalityCharles B Stephensen
USDA Western Human Nutrition Research Center, and Nutrition Department, University of California, Davis, CA 95616-8669, USA
Int J Epidemiol 32:828-9. 2003 - Glucose and cationic amino acid transporter expression in growing chickens (Gallus gallus domesticus)Brooke D Humphrey
Department of Animal Science, University of California, 1 Shields Avenue, Davis, CA 95616, USA
Comp Biochem Physiol A Mol Integr Physiol 138:515-25. 2004..05). The thymus had the lowest high affinity GLUT and total CAT mRNA expression on day 14 posthatch. Therefore, T lymphocytes within the thymus may be most susceptible to glucose and cationic amino acid supply...
Research Grants
- Vitamin A Regulates Th1/Th2 Development via RXR PathwayCharles Stephensen; Fiscal Year: 2007..In addition, receptor-selective retinoids are currently used in cancer therapy and are being evaluated for diabetes. This work will help evaluate possible side effects of these therapies. ..
- Variation in the ALOX5 gene and response to omega-3 fatty acid supplementsCharles Stephensen; Fiscal Year: 2007..Indicators of cardiovascular risk will also be assessed before and after intervention, including blood lipid profile, blood pressure, heart rate, and plasma CRP, glucose and insulin concentrations. ..