Research Topics
| Barbara Shukitt-HaleSummaryAffiliation: Agricultural Research Service Country: USA Publications
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Detail Information
Publications
Berry fruit supplementation and the aging brainBarbara Shukitt-Hale
USDA ARS Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
J Agric Food Chem 56:636-41. 2008..The purpose of this paper is to discuss the benefits of these interventions in rodent models and to describe the putative molecular mechanisms involved in their benefits...- Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampusBarbara Shukitt-Hale
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Nutr Neurosci 11:172-82. 2008..These results indicate that blueberry polyphenols attenuate learning impairments following neurotoxic insult and exert anti-inflammatory actions, perhaps via alteration of gene expression... - Effects of blackberries on motor and cognitive function in aged ratsBarbara Shukitt-Hale
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Nutr Neurosci 12:135-40. 2009..These data support our previous investigations in which we have seen improved motor and cognitive performance in aged rats after supplementation with other berry fruits... 
Differential protection among fractionated blueberry polyphenolic families against DA-, Abeta(42)- and LPS-induced decrements in Ca(2+) buffering in primary hippocampal cellsJames A Joseph
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Agric Food Chem 58:8196-204. 2010..Thus, these results suggest that, except for a few instances, the lesser the polyphenolic fractionation, the greater the effects, especially with respect to prevention of ROS and stress signal generation and viability...
Effects of Concord grape juice on cognitive and motor deficits in agingBarbara Shukitt-Hale
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
Nutrition 22:295-302. 2006....- Fruit polyphenols and their effects on neuronal signaling and behavior in senescenceJames A Joseph
Tufts University, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Rm 919, Boston, MA 02111, USA
Ann N Y Acad Sci 1100:470-85. 2007..The purpose of this article is to discuss the benefits of these interventions in rodent models and to describe the putative molecular mechanisms involved in their benefits... - Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged ratsGemma Casadesus
USDA, HNRC on Aging at Tufts University, Boston, MA, USA
Nutr Neurosci 7:309-16. 2004..Therefore, cognitive improvements afforded by polyphenolic-rich fruits such as blueberries appear, in part, to be mediated by their effects on hippocampal plasticity... - Recent advances in berry supplementation and age-related cognitive declineLAUREN M WILLIS
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Curr Opin Clin Nutr Metab Care 12:91-4. 2009..To summarize recent findings and current concepts in the beneficial effects of berry consumption on brain function during aging... - Anthocyanin-rich açai (Euterpe oleracea Mart.) fruit pulp fractions attenuate inflammatory stress signaling in mouse brain BV-2 microglial cellsShibu M Poulose
Human Nutrition Research Center on Aging at Tufts University, Agricultural Research Service, US Department of Agriculture, Boston, Massachusetts 02111, United States
J Agric Food Chem 60:1084-93. 2012..The current study offers valuable insights into the protective effects of açai pulp fractions on brain cells, which could have implications for improved cognitive and motor functions... - The cognitive impact of nutritional homocysteinemia in apolipoprotein-E deficient miceAron M Troen
Jean Mayer USDA Human Nutrition Research Centre on Aging, Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
J Alzheimers Dis 9:381-92. 2006..Instead, they indicate that different "types" of homocysteinemia, or in other words different impairments of nutritional metabolism affecting homocysteine levels, may lead to different end organ dysfunctions and/or diseases... - Fruit polyphenolics and brain aging: nutritional interventions targeting age-related neuronal and behavioral deficitsRachel L Galli
USDA ARS, HNRCA at Tufts University, Boston, Massachusetts 02111, USA
Ann N Y Acad Sci 959:128-32. 2002.... - Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compoundsJames A Joseph
US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, and the Institute of Pathology, Case Western Reserve University, Cleveland, USA
Am J Clin Nutr 81:313S-316S. 2005.... - Modulation of cognition and behavior in aged animals: role for antioxidant- and essential fatty acid-rich plant foodsLAUREN M WILLIS
US Department of Agriculture, Agricultural Research Service, Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
Am J Clin Nutr 89:1602S-1606S. 2009.... - Plum juice, but not dried plum powder, is effective in mitigating cognitive deficits in aged ratsBarbara Shukitt-Hale
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
Nutrition 25:567-73. 2009..The objective of this study was to investigate supplementation with Prunus domestica L. in mitigating age-related deficits in cognitive function... - Effect of age on the radial arm water maze-a test of spatial learning and memoryBarbara Shukitt-Hale
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Neurobiol Aging 25:223-9. 2004..The RAWM is a reliable, sensitive, and powerful additional test to assess age-related spatial learning and memory deficits, combining the advantages of the Morris water maze and the radial arm maze while minimizing the disadvantages... - Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of agingJames A Joseph
US Department of Agriculture, Agricultural Research Service, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
J Agric Food Chem 56:10544-51. 2008..Results indicated that pterostilbene was effective in reversing cognitive behavioral deficits, as well as dopamine release, and working memory was correlated with pterostilbene levels in the hippocampus... - Nutritional intervention in brain aging: reducing the effects of inflammation and oxidative stressFrancis C Lau
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
Subcell Biochem 42:299-318. 2007..Thus, nutritional intervention may exert therapeutic protection against age-related deficits and neurodegenerative diseases... - Grape juice, berries, and walnuts affect brain aging and behaviorJames A Joseph
USDA Agricultural Research Service, Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 139:1813S-7S. 2009..Taken together, these results suggest that a greater intake of high-antioxidant foods such as berries, Concord grapes, and walnuts may increase "health span" and enhance cognitive and motor function in aging... - Dose-dependent effects of walnuts on motor and cognitive function in aged ratsLAUREN M WILLIS
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Br J Nutr 101:1140-4. 2009..These findings show for the first time that moderate dietary walnut supplementation can improve cognitive and motor performance in aged rats... - B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in miceAron M Troen
Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
Proc Natl Acad Sci U S A 105:12474-9. 2008..Similar microvascular changes may mediate the association of hyperhomocysteinemia with human age-related cognitive decline... - Short-term nutritional folate deficiency in rats has a greater effect on choline and acetylcholine metabolism in the peripheral nervous system than in the brain, and this effect escalates with ageNatalia A Crivello
Nutrition and Neurocognition Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging JM USDA HNRCA at Tufts University, Boston, MA 02111, USA
Nutr Res 30:722-30. 2010.... - The beneficial effects of fruit polyphenols on brain agingFrancis C Lau
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Neurobiol Aging 26:128-32. 2005..Furthermore, we have shown that short-term blueberry (BB) supplementation increases hippocampal plasticity. These findings are briefly reviewed in this paper... - Exposure to 16O-particle radiation causes aging-like decrements in rats through increased oxidative stress, inflammation and loss of autophagyShibu M Poulose
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Radiat Res 176:761-9. 2011..This is the first report to show the molecular effects of (16)O-particle radiation on oxidative stress, inflammation and loss of autophagy in the brain of young rats... - Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteineAron M Troen
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 138:2502-9. 2008.... - Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotectionRachel L Galli
Neuroscience Laboratory, USDA-ARS Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
Neurobiol Aging 27:344-50. 2006..Results are discussed in terms of the multiplicity of the effects of the BB supplementation which appear to range from antioxidant/anti-inflammatory activity to signaling... - Hippocampal neurogenesis and PSA-NCAM expression following exposure to 56Fe particles mimics that seen during aging in ratsGemma Casadesus
VSDA, HNRC on Aging, Tufts University, Boston, MA, USA
Exp Gerontol 40:249-54. 2005..Additionally, irradiated subjects show decreased levels of PSA-NCAM expression. These changes are consistent with those found in aged subjects indicating that heavy-particle irradiation is an adequate model for the study of aging... - Dopamine neurotoxicity: age-dependent behavioral and histological effectsIppolita Cantuti-Castelvetri
USDA Human Nutrition Research Center on Aging at Tufts University, Room 919, 711 Washington Street, Boston, MA 02111, USA
Neurobiol Aging 24:697-706. 2003..These results suggest that a neurochemical deficit and not cell loss per se within the nigrostriatal system underlies the motor behavioral deficits observed in the middle-aged rats... - Qualitative versus quantitative caloric intake: are they equivalent paths to successful aging?Gemma Casadesus
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Rm 919, Boston, MA 02111, USA
Neurobiol Aging 23:747-69. 2002..The two interventions will be compared and contrasted in terms of their effectiveness, safety, and generalization capacity for human treatment... - Dietary polyunsaturated fatty acids improve cholinergic transmission in the aged brainLauren Meredith Willis
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA
Genes Nutr 4:309-14. 2009..The data reviewed herein indicate that, at least in animal studies, inclusion of PUFAs in the diet can improve cholinergic transmission in the brain, possibly leading to improvements in cognitive functioning... - Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegansMark A Wilson
Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
Aging Cell 5:59-68. 2006..In conclusion, polyphenolic compounds in blueberries had robust and reproducible benefits during aging that were separable from antioxidant effects... - Diet as a factor in behavioral radiation protection following exposure to heavy particlesBernard M Rabin
University of Maryland Baltimore County, Baltimore, MD 21250, USA
Gravit Space Biol Bull 18:71-7. 2005.... - Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated agingBarbara Shukitt-Hale
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States
Neurobiol Aging 28:1187-94. 2007..These data suggest that (56)Fe particle irradiation causes deficits in behavior and signaling in rats which were ameliorated by an antioxidant diet and that the polyphenols in these fruits might be acting in different brain regions... - Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memoryCristina Andres-Lacueva
Nutrition and Food Science Department-CeRTA, Pharmacy Faculty, University of Barcelona, Barcelona, Spain
Nutr Neurosci 8:111-20. 2005..These findings suggest that these compounds may deliver their antioxidant and signaling modifying capabilities centrally... - Effects of heavy particle irradiation and diet on amphetamine- and lithium chloride-induced taste avoidance learning in ratsBernard M Rabin
Department of Psychology, UMBC, 1000 Hilltop Circle, Baltimore, MD 21250, USA
Brain Res 953:31-6. 2002..The failure of either irradiation or diet to influence LiCl-induced responding suggests that oxidative stress may not be involved in CTA learning following injection of LiCl... - Roles of vitamins E and C on neurodegenerative diseases and cognitive performanceAntonio Martin
Neuroscience Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Nutr Rev 60:308-26. 2002..Several studies reveal a link between diets rich in fruits and vegetables containing generous amounts of vitamins E and C and lower incidence of certain chronic diseases... - Blueberry supplemented diet: effects on object recognition memory and nuclear factor-kappa B levels in aged ratsPilar Goyarzu
National Autonomous University of Mexico, Mexico City, Mexico
Nutr Neurosci 7:75-83. 2004..Normalized NF-kappaB levels (averaged across regions and in several individual regions) correlated negatively and significantly with the object memory scores... - Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous systemKuresh A Youdim
Antioxidant Research Group, Wolfson Centre for Age-Related Diseases, Guy's King's and St. Thomas's School of Biomedical Sciences, King's College, London SE1 9RT, UK
Free Radic Biol Med 37:1683-93. 2004..Therefore cognitive aging, according to this hypothesis, should be slowed, and possibly even reversed, by appropriately increasing levels of antioxidants or decreasing overproduction of free radicals in the body... - Effects of age and diet on the heavy particle-induced disruption of operant responding produced by a ground-based model for exposure to cosmic raysBernard M Rabin
Department of Psychology, UMBC, 1000 Hilltop Circle, Baltimore, MD 21250, USA
Brain Res 1036:122-9. 2005..The results indicate that diets containing strawberry extract may provide a significant level of radiation protection on exploratory class missions...