Barbara Shukitt-Hale

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. doi request reprint Berry fruit supplementation and the aging brain
    Barbara Shukitt-Hale
    USDA ARS Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Agric Food Chem 56:636-41. 2008
  2. doi request reprint Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus
    Barbara Shukitt-Hale
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Nutr Neurosci 11:172-82. 2008
  3. doi request reprint Effects of blackberries on motor and cognitive function in aged rats
    Barbara Shukitt-Hale
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Nutr Neurosci 12:135-40. 2009
  4. ncbi request reprint Changes in gene expression in the rat hippocampus following exposure to 56Fe particles and protection by berry diets
    Barbara Shukitt-Hale
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Cent Nerv Syst Agents Med Chem 13:36-42. 2013
  5. doi request reprint The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells
    Amanda N Carey
    United States Department of Agriculture, Agricultural Research Services, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Nutr Neurosci 16:13-20. 2013
  6. ncbi request reprint Effects of Concord grape juice on cognitive and motor deficits in aging
    Barbara Shukitt-Hale
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Nutrition 22:295-302. 2006
  7. pmc Differential protection among fractionated blueberry polyphenolic families against DA-, Abeta(42)- and LPS-induced decrements in Ca(2+) buffering in primary hippocampal cells
    James A Joseph
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Agric Food Chem 58:8196-204. 2010
  8. doi request reprint Recent advances in berry supplementation and age-related cognitive decline
    LAUREN M WILLIS
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Clin Nutr Metab Care 12:91-4. 2009
  9. ncbi request reprint Fruit polyphenols and their effects on neuronal signaling and behavior in senescence
    James A Joseph
    Tufts University, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Rm 919, Boston, MA 02111, USA
    Ann N Y Acad Sci 1100:470-85. 2007
  10. ncbi request reprint Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats
    Gemma Casadesus
    USDA, HNRC on Aging at Tufts University, Boston, MA, USA
    Nutr Neurosci 7:309-16. 2004

Collaborators

Detail Information

Publications46

  1. doi request reprint Berry fruit supplementation and the aging brain
    Barbara Shukitt-Hale
    USDA ARS Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Agric Food Chem 56:636-41. 2008
    ..The purpose of this paper is to discuss the benefits of these interventions in rodent models and to describe the putative molecular mechanisms involved in their benefits...
  2. doi request reprint Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus
    Barbara Shukitt-Hale
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Nutr Neurosci 11:172-82. 2008
    ..These results indicate that blueberry polyphenols attenuate learning impairments following neurotoxic insult and exert anti-inflammatory actions, perhaps via alteration of gene expression...
  3. doi request reprint Effects of blackberries on motor and cognitive function in aged rats
    Barbara Shukitt-Hale
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Nutr Neurosci 12:135-40. 2009
    ..These data support our previous investigations in which we have seen improved motor and cognitive performance in aged rats after supplementation with other berry fruits...
  4. ncbi request reprint Changes in gene expression in the rat hippocampus following exposure to 56Fe particles and protection by berry diets
    Barbara Shukitt-Hale
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Cent Nerv Syst Agents Med Chem 13:36-42. 2013
    ..Therefore, these data suggest that (56)Fe particle irradiation causes changes in gene expression in rats that are ameliorated by berry fruit diets...
  5. doi request reprint The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells
    Amanda N Carey
    United States Department of Agriculture, Agricultural Research Services, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Nutr Neurosci 16:13-20. 2013
    ....
  6. ncbi request reprint Effects of Concord grape juice on cognitive and motor deficits in aging
    Barbara Shukitt-Hale
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Nutrition 22:295-302. 2006
    ....
  7. pmc Differential protection among fractionated blueberry polyphenolic families against DA-, Abeta(42)- and LPS-induced decrements in Ca(2+) buffering in primary hippocampal cells
    James A Joseph
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Agric Food Chem 58:8196-204. 2010
    ..Thus, these results suggest that, except for a few instances, the lesser the polyphenolic fractionation, the greater the effects, especially with respect to prevention of ROS and stress signal generation and viability...
  8. doi request reprint Recent advances in berry supplementation and age-related cognitive decline
    LAUREN M WILLIS
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Clin Nutr Metab Care 12:91-4. 2009
    ..To summarize recent findings and current concepts in the beneficial effects of berry consumption on brain function during aging...
  9. ncbi request reprint Fruit polyphenols and their effects on neuronal signaling and behavior in senescence
    James A Joseph
    Tufts University, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Rm 919, Boston, MA 02111, USA
    Ann N Y Acad Sci 1100:470-85. 2007
    ..The purpose of this article is to discuss the benefits of these interventions in rodent models and to describe the putative molecular mechanisms involved in their benefits...
  10. ncbi request reprint Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats
    Gemma Casadesus
    USDA, HNRC on Aging at Tufts University, Boston, MA, USA
    Nutr Neurosci 7:309-16. 2004
    ..Therefore, cognitive improvements afforded by polyphenolic-rich fruits such as blueberries appear, in part, to be mediated by their effects on hippocampal plasticity...
  11. doi request reprint Anthocyanin-rich açai (Euterpe oleracea Mart.) fruit pulp fractions attenuate inflammatory stress signaling in mouse brain BV-2 microglial cells
    Shibu M Poulose
    Human Nutrition Research Center on Aging at Tufts University, Agricultural Research Service, US Department of Agriculture, Boston, Massachusetts 02111, United States
    J Agric Food Chem 60:1084-93. 2012
    ..The current study offers valuable insights into the protective effects of açai pulp fractions on brain cells, which could have implications for improved cognitive and motor functions...
  12. ncbi request reprint Fruit polyphenolics and brain aging: nutritional interventions targeting age-related neuronal and behavioral deficits
    Rachel L Galli
    USDA ARS, HNRCA at Tufts University, Boston, Massachusetts 02111, USA
    Ann N Y Acad Sci 959:128-32. 2002
    ....
  13. ncbi request reprint The cognitive impact of nutritional homocysteinemia in apolipoprotein-E deficient mice
    Aron M Troen
    Jean Mayer USDA Human Nutrition Research Centre on Aging, Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    J Alzheimers Dis 9:381-92. 2006
    ..Instead, they indicate that different "types" of homocysteinemia, or in other words different impairments of nutritional metabolism affecting homocysteine levels, may lead to different end organ dysfunctions and/or diseases...
  14. ncbi request reprint Stilbenes and anthocyanins reduce stress signaling in BV-2 mouse microglia
    Amanda N Carey
    Human Nutrition Research Center on Aging at Tufts University, Agricultural Research Service, U S Department of Agriculture, Boston, Massachusetts 02111, United States
    J Agric Food Chem 61:5979-86. 2013
    ..These results lend further support that blueberry and its active components are able to combat some of the inflammatory mediators of aging at the cellular level. ..
  15. ncbi request reprint Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds
    James A Joseph
    US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, and the Institute of Pathology, Case Western Reserve University, Cleveland, USA
    Am J Clin Nutr 81:313S-316S. 2005
    ....
  16. doi request reprint Modulation of cognition and behavior in aged animals: role for antioxidant- and essential fatty acid-rich plant foods
    LAUREN M WILLIS
    US Department of Agriculture, Agricultural Research Service, Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Am J Clin Nutr 89:1602S-1606S. 2009
    ....
  17. doi request reprint Plum juice, but not dried plum powder, is effective in mitigating cognitive deficits in aged rats
    Barbara Shukitt-Hale
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Nutrition 25:567-73. 2009
    ..The objective of this study was to investigate supplementation with Prunus domestica L. in mitigating age-related deficits in cognitive function...
  18. doi request reprint Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging
    James A Joseph
    US Department of Agriculture, Agricultural Research Service, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Agric Food Chem 56:10544-51. 2008
    ..Results indicated that pterostilbene was effective in reversing cognitive behavioral deficits, as well as dopamine release, and working memory was correlated with pterostilbene levels in the hippocampus...
  19. ncbi request reprint Effect of age on the radial arm water maze-a test of spatial learning and memory
    Barbara Shukitt-Hale
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Neurobiol Aging 25:223-9. 2004
    ..The RAWM is a reliable, sensitive, and powerful additional test to assess age-related spatial learning and memory deficits, combining the advantages of the Morris water maze and the radial arm maze while minimizing the disadvantages...
  20. ncbi request reprint Nutritional intervention in brain aging: reducing the effects of inflammation and oxidative stress
    Francis C Lau
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Subcell Biochem 42:299-318. 2007
    ..Thus, nutritional intervention may exert therapeutic protection against age-related deficits and neurodegenerative diseases...
  21. pmc Short-term nutritional folate deficiency in rats has a greater effect on choline and acetylcholine metabolism in the peripheral nervous system than in the brain, and this effect escalates with age
    Natalia A Crivello
    Nutrition and Neurocognition Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging JM USDA HNRCA at Tufts University, Boston, MA 02111, USA
    Nutr Res 30:722-30. 2010
    ....
  22. ncbi request reprint The beneficial effects of fruit polyphenols on brain aging
    Francis C Lau
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Neurobiol Aging 26:128-32. 2005
    ..Furthermore, we have shown that short-term blueberry (BB) supplementation increases hippocampal plasticity. These findings are briefly reviewed in this paper...
  23. doi request reprint Grape juice, berries, and walnuts affect brain aging and behavior
    James A Joseph
    USDA Agricultural Research Service, Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:1813S-7S. 2009
    ..Taken together, these results suggest that a greater intake of high-antioxidant foods such as berries, Concord grapes, and walnuts may increase "health span" and enhance cognitive and motor function in aging...
  24. pmc B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice
    Aron M Troen
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    Proc Natl Acad Sci U S A 105:12474-9. 2008
    ..Similar microvascular changes may mediate the association of hyperhomocysteinemia with human age-related cognitive decline...
  25. doi request reprint Dose-dependent effects of walnuts on motor and cognitive function in aged rats
    LAUREN M WILLIS
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Br J Nutr 101:1140-4. 2009
    ..These findings show for the first time that moderate dietary walnut supplementation can improve cognitive and motor performance in aged rats...
  26. ncbi request reprint Restoration of stressor-induced calcium dysregulation and autophagy inhibition by polyphenol-rich açaí (Euterpe spp.) fruit pulp extracts in rodent brain cells in vitro
    Shibu M Poulose
    U S Department of Agriculture, Agricultural Research Service, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Nutrition 30:853-62. 2014
    ....
  27. pmc Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging
    Barbara Shukitt-Hale
    United States Department of Agriculture ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA
    Age (Dordr) 35:2183-92. 2013
    ..Therefore, coffee, in achievable amounts, may reduce both motor and cognitive deficits in aging...
  28. doi request reprint Blueberries and neuronal aging
    Barbara Shukitt-Hale
    Agricultural Research Service, United States Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Gerontology 58:518-23. 2012
    ..Appropriately, the US Department of Agriculture has figured prominently in these discoveries, through the efforts of two USDA researchers who worked for the department 100 years apart...
  29. ncbi request reprint Exposure to 16O-particle radiation causes aging-like decrements in rats through increased oxidative stress, inflammation and loss of autophagy
    Shibu M Poulose
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Radiat Res 176:761-9. 2011
    ..This is the first report to show the molecular effects of (16)O-particle radiation on oxidative stress, inflammation and loss of autophagy in the brain of young rats...
  30. ncbi request reprint Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection
    Rachel L Galli
    Neuroscience Laboratory, USDA ARS Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Neurobiol Aging 27:344-50. 2006
    ..Results are discussed in terms of the multiplicity of the effects of the BB supplementation which appear to range from antioxidant/anti-inflammatory activity to signaling...
  31. pmc Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteine
    Aron M Troen
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 138:2502-9. 2008
    ....
  32. ncbi request reprint Hippocampal neurogenesis and PSA-NCAM expression following exposure to 56Fe particles mimics that seen during aging in rats
    Gemma Casadesus
    VSDA, HNRC on Aging, Tufts University, Boston, MA, USA
    Exp Gerontol 40:249-54. 2005
    ..Additionally, irradiated subjects show decreased levels of PSA-NCAM expression. These changes are consistent with those found in aged subjects indicating that heavy-particle irradiation is an adequate model for the study of aging...
  33. doi request reprint Neuronal stress following exposure to 56Fe particles and the effects of antioxidant-rich diets
    Shibu M Poulose
    Human Nutrition Research Center on Aging, USDA ARS, Boston, MA 02111, USA
    J Radiat Res 55:i73-i74. 2014
    ..This paper was presented at the NASA Session at Heavy Ion in Therapy and Space Radiation Symposium 2013. ..
  34. ncbi request reprint Qualitative versus quantitative caloric intake: are they equivalent paths to successful aging?
    Gemma Casadesus
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Rm 919, Boston, MA 02111, USA
    Neurobiol Aging 23:747-69. 2002
    ..The two interventions will be compared and contrasted in terms of their effectiveness, safety, and generalization capacity for human treatment...
  35. ncbi request reprint Dopamine neurotoxicity: age-dependent behavioral and histological effects
    Ippolita Cantuti-Castelvetri
    USDA Human Nutrition Research Center on Aging at Tufts University, Room 919, 711 Washington Street, Boston, MA 02111, USA
    Neurobiol Aging 24:697-706. 2003
    ..These results suggest that a neurochemical deficit and not cell loss per se within the nigrostriatal system underlies the motor behavioral deficits observed in the middle-aged rats...
  36. doi request reprint Berry fruit enhances beneficial signaling in the brain
    Marshall G Miller
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, United States
    J Agric Food Chem 60:5709-15. 2012
    ..Recent clinical trials have extended these antioxidant, anti-inflammatory, and cognition-sparing effects to humans. This paper reviews recent evidence for the beneficial signaling effects of berry fruits on the brain and behavior. ..
  37. pmc Dietary polyunsaturated fatty acids improve cholinergic transmission in the aged brain
    Lauren Meredith Willis
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA
    Genes Nutr 4:309-14. 2009
    ..The data reviewed herein indicate that, at least in animal studies, inclusion of PUFAs in the diet can improve cholinergic transmission in the brain, possibly leading to improvements in cognitive functioning...
  38. pmc Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans
    Mark A Wilson
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
    Aging Cell 5:59-68. 2006
    ..In conclusion, polyphenolic compounds in blueberries had robust and reproducible benefits during aging that were separable from antioxidant effects...
  39. ncbi request reprint Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory
    Cristina Andres-Lacueva
    Nutrition and Food Science Department CeRTA, Pharmacy Faculty, University of Barcelona, Barcelona, Spain
    Nutr Neurosci 8:111-20. 2005
    ..These findings suggest that these compounds may deliver their antioxidant and signaling modifying capabilities centrally...
  40. ncbi request reprint Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging
    Barbara Shukitt-Hale
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States
    Neurobiol Aging 28:1187-94. 2007
    ..These data suggest that (56)Fe particle irradiation causes deficits in behavior and signaling in rats which were ameliorated by an antioxidant diet and that the polyphenols in these fruits might be acting in different brain regions...
  41. ncbi request reprint Diet as a factor in behavioral radiation protection following exposure to heavy particles
    Bernard M Rabin
    University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Gravit Space Biol Bull 18:71-7. 2005
    ....
  42. ncbi request reprint Effects of heavy particle irradiation and diet on amphetamine- and lithium chloride-induced taste avoidance learning in rats
    Bernard M Rabin
    Department of Psychology, UMBC, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Brain Res 953:31-6. 2002
    ..The failure of either irradiation or diet to influence LiCl-induced responding suggests that oxidative stress may not be involved in CTA learning following injection of LiCl...
  43. ncbi request reprint Roles of vitamins E and C on neurodegenerative diseases and cognitive performance
    Antonio Martin
    Neuroscience Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Nutr Rev 60:308-26. 2002
    ..Several studies reveal a link between diets rich in fruits and vegetables containing generous amounts of vitamins E and C and lower incidence of certain chronic diseases...
  44. ncbi request reprint Effects of age and diet on the heavy particle-induced disruption of operant responding produced by a ground-based model for exposure to cosmic rays
    Bernard M Rabin
    Department of Psychology, UMBC, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Brain Res 1036:122-9. 2005
    ..The results indicate that diets containing strawberry extract may provide a significant level of radiation protection on exploratory class missions...
  45. ncbi request reprint Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system
    Kuresh A Youdim
    Antioxidant Research Group, Wolfson Centre for Age Related Diseases, Guy s King s and St Thomas s School of Biomedical Sciences, King s College, London SE1 9RT, UK
    Free Radic Biol Med 37:1683-93. 2004
    ..Therefore cognitive aging, according to this hypothesis, should be slowed, and possibly even reversed, by appropriately increasing levels of antioxidants or decreasing overproduction of free radicals in the body...
  46. ncbi request reprint Blueberry supplemented diet: effects on object recognition memory and nuclear factor-kappa B levels in aged rats
    Pilar Goyarzu
    National Autonomous University of Mexico, Mexico City, Mexico
    Nutr Neurosci 7:75-83. 2004
    ..Normalized NF-kappaB levels (averaged across regions and in several individual regions) correlated negatively and significantly with the object memory scores...