Randy E Sacco

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. doi request reprint Respiratory syncytial virus infection in cattle
    R E Sacco
    National Animal Disease Center, Ruminant Diseases and Immunology Research Unit, Ames, IA 50010, USA Email
    Vet Pathol 51:427-36. 2014
  2. pmc Neonatal calf infection with respiratory syncytial virus: drawing parallels to the disease in human infants
    Randy E Sacco
    Ruminant Diseases and Immunology Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, Iowa 50010, USA
    Viruses 4:3731-53. 2012
  3. pmc Differential expression of cytokines in response to respiratory syncytial virus infection of calves with high or low circulating 25-hydroxyvitamin D3
    Randy E Sacco
    Ruminant Diseases and Immunology Research Unit, National Animal Disease Center, United States Department of Agriculture, Agricultural Research Service, Ames, Iowa, United States of America
    PLoS ONE 7:e33074. 2012
  4. doi request reprint Porcine TLR3 characterization and expression in response to influenza virus and Bordetella bronchiseptica
    Randy E Sacco
    National Animal Disease Center, USDA ARS, Ames, IA 50010, USA
    Vet Immunol Immunopathol 142:57-63. 2011
  5. pmc Differential expression of cytokine transcripts in neonatal and adult ovine alveolar macrophages in response to respiratory syncytial virus or toll-like receptor ligation
    Sasha J Fach
    Immunobiology Graduate Program, Iowa State University, Ames, IA, USA
    Vet Immunol Immunopathol 136:55-64. 2010
  6. doi request reprint Influenza virus coinfection with Bordetella bronchiseptica enhances bacterial colonization and host responses exacerbating pulmonary lesions
    Crystal L Loving
    Respiratory Diseases of Livestock Research Unit, USDA, Agricultural Research Service, National Animal Disease Center, Ames, IA 50010, USA
    Microb Pathog 49:237-45. 2010
  7. pmc Neonatal ovine pulmonary dendritic cells support bovine respiratory syncytial virus replication with enhanced interleukin (IL)-4 And IL-10 gene transcripts
    Sasha J Fach
    Immunobiology Graduate Program, Iowa State University, Ames, Iowa, USA
    Viral Immunol 20:119-30. 2007
  8. doi request reprint Differences in clinical disease and immune response of pigs challenged with a high-dose versus low-dose inoculum of porcine reproductive and respiratory syndrome virus
    Crystal L Loving
    Respiratory Diseases of Livestock Research Unit, U S Department of Agriculture, Agricultural Research Service, National Animal Disease Center, Ames, Iowa 50010, USA
    Viral Immunol 21:315-25. 2008
  9. pmc Differential chemokine and cytokine production by neonatal bovine γδ T-cell subsets in response to viral toll-like receptor agonists and in vivo respiratory syncytial virus infection
    Jodi L McGill
    Ruminant Diseases and Immunology Research Unit, National Animal Disease Center, Agricultural Research Service, Ames, IA 50010, USA
    Immunology 139:227-44. 2013
  10. ncbi request reprint Pulmonary dendritic cells isolated from neonatal and adult ovine lung tissue
    Sasha J Fach
    Immunobiology Graduate Program, Iowa State University, Ames, IA, USA
    Vet Immunol Immunopathol 112:171-82. 2006

Detail Information

Publications22

  1. doi request reprint Respiratory syncytial virus infection in cattle
    R E Sacco
    National Animal Disease Center, Ruminant Diseases and Immunology Research Unit, Ames, IA 50010, USA Email
    Vet Pathol 51:427-36. 2014
    ....
  2. pmc Neonatal calf infection with respiratory syncytial virus: drawing parallels to the disease in human infants
    Randy E Sacco
    Ruminant Diseases and Immunology Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, Iowa 50010, USA
    Viruses 4:3731-53. 2012
    ..This review will summarize available data that provide parallels between bovine RSV infection in neonatal calves and human RSV in infants...
  3. pmc Differential expression of cytokines in response to respiratory syncytial virus infection of calves with high or low circulating 25-hydroxyvitamin D3
    Randy E Sacco
    Ruminant Diseases and Immunology Research Unit, National Animal Disease Center, United States Department of Agriculture, Agricultural Research Service, Ames, Iowa, United States of America
    PLoS ONE 7:e33074. 2012
    ..Further examination of the potential effects of vitamin D status on RSV disease resolution will require longer-term studies with immunologically sufficient and deficient vitamin D levels...
  4. doi request reprint Porcine TLR3 characterization and expression in response to influenza virus and Bordetella bronchiseptica
    Randy E Sacco
    National Animal Disease Center, USDA ARS, Ames, IA 50010, USA
    Vet Immunol Immunopathol 142:57-63. 2011
    ..Based on our work and that of others, TLR3 likely plays a key role in the immune response of lung cells to influenza virus infection in several mammalian species...
  5. pmc Differential expression of cytokine transcripts in neonatal and adult ovine alveolar macrophages in response to respiratory syncytial virus or toll-like receptor ligation
    Sasha J Fach
    Immunobiology Graduate Program, Iowa State University, Ames, IA, USA
    Vet Immunol Immunopathol 136:55-64. 2010
    ..Differential regulation of cytokines in neonatal AMvarphis compared to adult AMvarphis in response to RSV could be a contributory factor to more severe clinical episodes seen in neonates...
  6. doi request reprint Influenza virus coinfection with Bordetella bronchiseptica enhances bacterial colonization and host responses exacerbating pulmonary lesions
    Crystal L Loving
    Respiratory Diseases of Livestock Research Unit, USDA, Agricultural Research Service, National Animal Disease Center, Ames, IA 50010, USA
    Microb Pathog 49:237-45. 2010
    ..Overall, Flu infection increased Bb colonization and enhanced production of proinflammatory mediators that likely contribute to exacerbated pulmonary lesions...
  7. pmc Neonatal ovine pulmonary dendritic cells support bovine respiratory syncytial virus replication with enhanced interleukin (IL)-4 And IL-10 gene transcripts
    Sasha J Fach
    Immunobiology Graduate Program, Iowa State University, Ames, Iowa, USA
    Viral Immunol 20:119-30. 2007
    ..Overall, these findings are the first to demonstrate that neonatal lung DCs support in vivo BRSV replication and produce type II cytokines after viral infection...
  8. doi request reprint Differences in clinical disease and immune response of pigs challenged with a high-dose versus low-dose inoculum of porcine reproductive and respiratory syndrome virus
    Crystal L Loving
    Respiratory Diseases of Livestock Research Unit, U S Department of Agriculture, Agricultural Research Service, National Animal Disease Center, Ames, Iowa 50010, USA
    Viral Immunol 21:315-25. 2008
    ..IFN-gamma may play a role in PRRSV pathogenesis, as serum levels increased significantly in pigs challenged with the high dose of PRRSV...
  9. pmc Differential chemokine and cytokine production by neonatal bovine γδ T-cell subsets in response to viral toll-like receptor agonists and in vivo respiratory syncytial virus infection
    Jodi L McGill
    Ruminant Diseases and Immunology Research Unit, National Animal Disease Center, Agricultural Research Service, Ames, IA 50010, USA
    Immunology 139:227-44. 2013
    ..Based on our results, we propose that circulating γδ T cells are poised to rapidly respond to viral infection and suggest an important role for γδ T cells in the innate immune response of the bovine neonate...
  10. ncbi request reprint Pulmonary dendritic cells isolated from neonatal and adult ovine lung tissue
    Sasha J Fach
    Immunobiology Graduate Program, Iowa State University, Ames, IA, USA
    Vet Immunol Immunopathol 112:171-82. 2006
    ..These data support growing evidence that neonatal immune responses may differ from adults due to different microenvironmental influences rather than differences in dendritic cell maturation states...
  11. doi request reprint Bovine milk proteome: quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis
    Timothy A Reinhardt
    Ruminant Diseases and Immunology Unit, National Animal Disease Center, USDA ARS, Ames IA 50010, USA
    J Proteomics 82:141-54. 2013
    ..Protein composition changes found in milk exosomes, MFGM and whey during an infection provides new and comprehensive information on milk protein composition in general as well as changes occurring during an infection...
  12. pmc Signal regulatory protein alpha (SIRPalpha) cells in the adaptive response to ESAT-6/CFP-10 protein of tuberculous mycobacteria
    W Ray Waters
    National Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Ames, Iowa, United States of America
    PLoS ONE 4:e6414. 2009
    ..In tissue culture models, signal regulatory protein (SIRP)alpha (also referred to as macrophage fusion receptor or CD172a) is essential for multi-nucleate giant cell formation...
  13. ncbi request reprint Innate cytokine responses in porcine macrophage populations: evidence for differential recognition of double-stranded RNA
    Crystal L Loving
    Immunobiology Graduate Program, Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    J Immunol 177:8432-9. 2006
    ..In summary, differential dsRNA-induced cytokine expression patterns between AMphi and PMphi provide evidence that dsRNA recognition and subsequent signaling is likely mediated via TLR3 in AMphi and PKR in PMphi...
  14. doi request reprint Bovine milk exosome proteome
    Timothy A Reinhardt
    Ruminant Diseases and Immunology Unit, National Animal Disease Center, USDA ARS, Ames, IA 50010, USA
    J Proteomics 75:1486-92. 2012
    ..The protein composition of milk exosomes provides new information on milk protein composition and the potential physiological significance of exosomes to mammary physiology...
  15. ncbi request reprint Immune response in mice and swine to DNA vaccines derived from the Pasteurella multocida toxin gene
    Karen B Register
    Respiratory Diseases of Livestock Research Unit, USDA Agricultural Research, Service National Animal Disease Center, P O Box 70, Ames, IA 50010, United States
    Vaccine 25:6118-28. 2007
    ..This report documents, for the first time, the ability of a DNA vaccine to elicit immune responses to the P. multocida toxin in both mice and swine...
  16. doi request reprint Specific Recognition of Mycobacterial Protein and Peptide Antigens by γδ T Cell Subsets following Infection with Virulent Mycobacterium bovis
    Jodi L McGill
    Ruminant Diseases and Immunology Research Unit, National Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Ames, IA 50010
    J Immunol 192:2756-69. 2014
    ..bovis infection of cattle represents an excellent model of tuberculosis in humans, contribute to our overall understanding of the role of γδ T cells in the mycobacterial-specific immune response. ..
  17. pmc Human respiratory syncytial virus Memphis 37 grown in HEp-2 cells causes more severe disease in lambs than virus grown in Vero cells
    Rachel J Derscheid
    Department of Veterinary Pathology Iowa State University College of Veterinary Medicine, 1600 S 16th St, Ames, IA 50011 1250, USA
    Viruses 5:2881-97. 2013
    ..Thus, our results provide convincing in vivo evidence for differences in viral infectivity that corroborate previous in vitro mechanistic studies demonstrating differences in the G glycoprotein expression by RSV grown in Vero cells. ..
  18. pmc Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus
    Crystal L Loving
    Immunobiology Graduate Program, Iowa State University, Ames, Iowa, USA
    Immunology 120:217-29. 2007
    ..DC response to PRRSV was limited to IFN-beta transcription, which may be inadequate in triggering the adaptive immune response...
  19. doi request reprint The Ca(2+)/H(+) antiporter TMEM165 expression, localization in the developing, lactating and involuting mammary gland parallels the secretory pathway Ca(2+) ATPase (SPCA1)
    Timothy A Reinhardt
    Ruminant Diseases and Immunology Research Unit, USDA ARS, National Animal Disease Center, Ames, IA 50010, USA Electronic address
    Biochem Biophys Res Commun 445:417-21. 2014
    ....
  20. pmc Reduced clearance of respiratory syncytial virus infection in a preterm lamb model
    David K Meyerholz
    Department of Veterinary Pathology, Iowa State University, 2740 Veterinary Medicine, Ames, IA 50011 1250, USA
    Microbes Infect 6:1312-9. 2004
    ..This work suggests that perinatal RSV clearance is age-dependent, which may explain the severity of RSV infection in preterm infants. The preterm lamb model is useful for assessing age-dependent mechanisms of severe RSV infection...
  21. pmc Evaluation of enzyme-linked immunosorbent assays for detection of Mycoplasma bovis-specific antibody in bison sera
    Karen B Register
    Ruminant Diseases and Immunology Research Unit, USDA, Agricultural Research Service, National Animal Disease Center, Ames, Iowa, USA
    Clin Vaccine Immunol 20:1405-9. 2013
    ..Optimal performance was obtained when the capture antigen was derived from bison isolates rather than cattle isolates and when a protein G conjugate rather than an anti-bovine IgG conjugate was used for the detection of bison IgG. ..
  22. pmc Comparison of ribotyping and restriction enzyme analysis for inter- and intraspecies discrimination of Bordetella avium and Bordetella hinzii
    Karen B Register
    Respiratory Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Ames, Iowa 50010, USA
    J Clin Microbiol 41:1512-9. 2003
    ..At least some of the newly recognized B. hinzii isolates have been previously reported to cause disease in poults, suggesting that the pathogenicity of this agent for poultry should be more rigorously examined...