Matthew J Picklo

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. ncbi request reprint Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A)
    Tonya C Murphy
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58203, USA
    J Neurochem 86:298-305. 2003
  2. doi request reprint Glutathionyl systems and metabolic dysfunction in obesity
    Matthew J Picklo
    M J Picklo and E E Vomhof DeKrey are with the Grand Forks Human Nutrition Research Center, USDA ARS, Grand Forks, North Dakota, USA M J Picklo is with the Department of Chemistry, University of North Dakota, Grand Forks, North Dakota, USA E K Long is with the Department of Surgery, University of Minnesota, Minneapolis, Minnesota USA
    Nutr Rev 73:858-68. 2015
  3. doi request reprint Antioxidant supplementation and obesity have independent effects on hepatic oxylipin profiles in insulin-resistant, obesity-prone rats
    Matthew J Picklo
    USDA ARS Grand Forks Human Nutrition Research Center 2420 2 nd Avenue North Grand Forks, ND 58203 9034, USA Department of Chemistry, University of North Dakota, Grand Forks, ND 58201, USA Electronic address
    Free Radic Biol Med 89:182-91. 2015
  4. pmc S-Glutathionylation of hepatic and visceral adipose proteins decreases in obese rats
    Matthew J Picklo
    USDA ARS Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota, USA
    Obesity (Silver Spring) 21:297-305. 2013
  5. doi request reprint Trans-4-oxo-2-nonenal potently alters mitochondrial function
    Matthew J Picklo
    Agricultural Research Center, Grand Forks Human Nutrition Research Center, U S Department of Agriculture, Grand Forks, ND 58203 9034, USA
    Free Radic Biol Med 50:400-7. 2011
  6. ncbi request reprint Quantification of trans-4-hydroxy-2-nonenal enantiomers and metabolites by LC-ESI-MS/MS
    Ales Honzatko
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, ND 58203, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 857:115-22. 2007
  7. ncbi request reprint Enantioselective oxidation of trans-4-hydroxy-2-nonenal is aldehyde dehydrogenase isozyme and Mg2+ dependent
    Jiri Brichac
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, North Dakota 58202 9024, USA
    Chem Res Toxicol 20:887-95. 2007
  8. pmc Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially
    Susan K Raatz
    US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58203, USA
    J Acad Nutr Diet 113:282-7. 2013
  9. doi request reprint Trans-4-hydroxy-2-hexenal is a neurotoxic product of docosahexaenoic (22:6; n-3) acid oxidation
    Eric K Long
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, North Dakota 58203, USA
    J Neurochem 105:714-24. 2008
  10. ncbi request reprint Inhibition of aldehyde detoxification in CNS mitochondria by fungicides
    Laura J Leiphon
    Department of Pharmacology, Physiology, and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA
    Neurotoxicology 28:143-9. 2007

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A)
    Tonya C Murphy
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58203, USA
    J Neurochem 86:298-305. 2003
    ..The data suggest that a relationship between the detoxification of SSA and the neurotoxic aldehyde HNE exists in the CNS. Furthermore, these studies show that multiple hepatic aldehyde dehydrogenases are able to oxidize HNE...
  2. doi request reprint Glutathionyl systems and metabolic dysfunction in obesity
    Matthew J Picklo
    M J Picklo and E E Vomhof DeKrey are with the Grand Forks Human Nutrition Research Center, USDA ARS, Grand Forks, North Dakota, USA M J Picklo is with the Department of Chemistry, University of North Dakota, Grand Forks, North Dakota, USA E K Long is with the Department of Surgery, University of Minnesota, Minneapolis, Minnesota USA
    Nutr Rev 73:858-68. 2015
    ..g., energy metabolism, inflammation, and insulin resistance). ..
  3. doi request reprint Antioxidant supplementation and obesity have independent effects on hepatic oxylipin profiles in insulin-resistant, obesity-prone rats
    Matthew J Picklo
    USDA ARS Grand Forks Human Nutrition Research Center 2420 2 nd Avenue North Grand Forks, ND 58203 9034, USA Department of Chemistry, University of North Dakota, Grand Forks, ND 58201, USA Electronic address
    Free Radic Biol Med 89:182-91. 2015
    ..Our data demonstrate that antioxidant supplementation and obesity impact hepatic LOX- and CYP450-dependent oxylipin metabolism. ..
  4. pmc S-Glutathionylation of hepatic and visceral adipose proteins decreases in obese rats
    Matthew J Picklo
    USDA ARS Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota, USA
    Obesity (Silver Spring) 21:297-305. 2013
    ..Although oxidation of protein-bound thiols (PSH) is increased in multiple diseases, it is not known whether there are changes in PSH oxidation species in obesity...
  5. doi request reprint Trans-4-oxo-2-nonenal potently alters mitochondrial function
    Matthew J Picklo
    Agricultural Research Center, Grand Forks Human Nutrition Research Center, U S Department of Agriculture, Grand Forks, ND 58203 9034, USA
    Free Radic Biol Med 50:400-7. 2011
    ..Quantum mechanical calculations provided insights into the basis for the elevated reactivity of 4-ONE>HNE. Our data demonstrate that 4-ONE is a potent effector of lipid peroxidation in the mitochondrial environment...
  6. ncbi request reprint Quantification of trans-4-hydroxy-2-nonenal enantiomers and metabolites by LC-ESI-MS/MS
    Ales Honzatko
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, ND 58203, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 857:115-22. 2007
    ..Metabolic profiles of HNE biotransformation, including the enantiomeric disposition of HNE, will provide useful biomarker data regarding lipid peroxidation in disease states...
  7. ncbi request reprint Enantioselective oxidation of trans-4-hydroxy-2-nonenal is aldehyde dehydrogenase isozyme and Mg2+ dependent
    Jiri Brichac
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, North Dakota 58202 9024, USA
    Chem Res Toxicol 20:887-95. 2007
    ..These results demonstrate that enantioselective utilization of substrates, including HNE, by ALDHs is dependent upon the ALDH isozyme and the presence of Mg 2+ ions...
  8. pmc Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially
    Susan K Raatz
    US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58203, USA
    J Acad Nutr Diet 113:282-7. 2013
    ..0001). The addition of farmed Atlantic salmon to the diet twice per week for 4 weeks at portions of 180 g and 270 g modifies phospholipid fatty acid proportions of n-3 and n-6 in a level associated with decreased risk for CVD...
  9. doi request reprint Trans-4-hydroxy-2-hexenal is a neurotoxic product of docosahexaenoic (22:6; n-3) acid oxidation
    Eric K Long
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, North Dakota 58203, USA
    J Neurochem 105:714-24. 2008
    ..5-fold less efficiently than HNE. Our data demonstrate that HHE and HNE have similarities but also differences in their neurotoxic mechanisms and metabolism...
  10. ncbi request reprint Inhibition of aldehyde detoxification in CNS mitochondria by fungicides
    Laura J Leiphon
    Department of Pharmacology, Physiology, and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA
    Neurotoxicology 28:143-9. 2007
    ....
  11. pmc Direct and indirect high-performance liquid chromatography enantioseparation of trans-4-hydroxy-2-nonenoic acid
    Jiri Brichac
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, ND 58203 9024, USA
    J Chromatogr A 1149:305-11. 2007
    ..The indirect separation method was successfully applied for the determination of enantiomeric ratio of HNEA in rat brain mitochondrial lysate, and showed that HNEA was formed (R)-enantioselectively from HNE...
  12. doi request reprint Ethanol withdrawal increases glutathione adducts of 4-hydroxy-2-hexenal but not 4-hydroxyl-2-nonenal in the rat cerebral cortex
    Eric K Long
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, ND 58203 9037, USA
    Free Radic Biol Med 48:384-90. 2010
    ..These results indicate that selective oxidative damage to n-3 PUFAs occurs in the cerebral cortex as a result of ethanol withdrawal and that 4-hydroxy-2-hexenal is metabolized to the GSH adduct more efficiently than HNE...
  13. ncbi request reprint Mitochondrial effects of lipid-derived neurotoxins
    Matthew J Picklo
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203, USA
    J Alzheimers Dis 12:185-93. 2007
    ..Lastly, we examine the role of mitochondrial aldehyde detoxification pathways and their potential role in the development of AD...
  14. ncbi request reprint Metabolism of 4-hydroxy-trans-2-nonenal by central nervous system mitochondria is dependent on age and NAD+ availability
    Melissa J Meyer
    Department of Pharmacology, University of North Dakota School of Medicine and Health Science, Grand Forks, North Dakota 58203, USA
    Chem Res Toxicol 17:1272-9. 2004
    ..These results demonstrate that in situ mitochondrial aldehyde detoxification is affected by decrements in NAD(+) availability and complex I activity...
  15. doi request reprint The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism
    Emilie E Vomhof-DeKrey
    Grand Forks Human Nutrition Research Center, USDA ARS, Grand Forks, ND 58203, USA
    J Nutr Biochem 23:1201-6. 2012
    ..Understanding the relationship of Nrf2 and energy metabolism in cells, tissues and physiologic systems will provide novel insights for nutritional interventions for obesity and its comorbidities such as diabetes...
  16. doi request reprint Structural characterization of alpha,beta-unsaturated aldehydes by GC/MS is dependent upon ionization method
    Eric K Long
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, ND 58202 9024, USA
    Lipids 43:765-74. 2008
    ..These data indicate that EI-MS and PICI-MS are more amenable for structural analysis of alpha,beta-unsaturated aldehydes than ECNI-MS...
  17. doi request reprint Trans-4-hydroxy-2-hexenal, a product of n-3 fatty acid peroxidation: make some room HNE
    Eric K Long
    Department of Pharmacology, Physiology, and Therapeutics, Grand Forks, ND 58203 9037, USA
    Free Radic Biol Med 49:1-8. 2010
    ..From this review, it is clear that further study is needed to determine the biochemical and physiological roles of HHE and its related aldehyde, trans-4-oxo-2-hexenal...
  18. ncbi request reprint Analysis of HNE metabolism in CNS models
    Alena Kubatova
    Department of Chemistry, University of North Dakota, Grand Forks, North Dakota 58203, USA
    Redox Rep 12:16-9. 2007
    ..Further metabolic analysis of HNE disposition is needed to clarify which pathways are truly important in normal and pathological states in the CNS...
  19. ncbi request reprint Mitochondrial oxidation of 4-hydroxy-2-nonenal in rat cerebral cortex
    Tonya C Murphy
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58203, USA
    J Neurochem 84:1313-21. 2003
    ..These data indicate that oxidation of HNE to its corresponding acid is a major detoxification pathway of HNE in the CNS and that mitochondria play a role in this process...
  20. ncbi request reprint Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal
    Paul A Grimsrud
    Department of Biochemistry, Molecular Biology and Biophysics, The University of Minnesota, Minneapolis, Minnesota 55455, USA
    Mol Cell Proteomics 6:624-37. 2007
    ....
  21. pmc Intake of seafood in the US varies by age, income, and education level but not by race-ethnicity
    Lisa Jahns
    United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, 2420 2nd Avenue N, Grand Forks, ND, 58203, USA
    Nutrients 6:6060-75. 2014
    ..Approximately 80%-90% of seafood consumers did not meet seafood recommendations when needs were estimated by energy requirements. A great deal of work remains to move Americans toward seafood consumption at current recommended levels. ..
  22. ncbi request reprint Enantioselective metabolism of trans-4-hydroxy-2-nonenal by brain mitochondria
    Ales Honzatko
    Department of Pharmacology, Physiology, and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202 9024, USA
    Free Radic Biol Med 39:913-24. 2005
    ..These studies demonstrate that the chirality of HNE affects its mitochondrial metabolism and potentially other processes in the central nervous system...
  23. ncbi request reprint Nitrate-based vasodilators inhibit multiple vascular aldehyde dehydrogenases
    Tonya C Murphy
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Cardiovasc Toxicol 5:321-32. 2005
    ..The inhibition of ALDH3A, but not ALDH2, could be prevented by the addition of dithiothreitol. These studies demonstrate that GTN and ISDN possess selectivity for ALDH inactivation with different mechanisms of inactivation...
  24. ncbi request reprint Astrocytic biotransformation of trans-4-hydroxy-2-nonenal is dose-dependent
    Alena Kubatova
    Department of Chemistry, University of North Dakota, Grand Forks, 58202, USA
    Chem Res Toxicol 19:844-51. 2006
    ..Occurrence of 1,4-dihydroxynonene was observed as well. These data suggest that the biotransformation of HNE yields products with differing or enhanced toxicity, as well as nontoxic products...
  25. ncbi request reprint Inhibition of cardiac myocyte contraction by 4-hydroxy-trans-2-nonenal
    Nicholas S Aberle
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA
    Cardiovasc Toxicol 4:21-8. 2004
    ..These findings reveal a possible role of HNE in the lipid peroxidation-associated cardiac contractile dysfunction that is likely mediated through HNE metabolism and mitogen-activated protein kinase activation...
  26. doi request reprint N-acetylcysteine supplementation decreases osteoclast differentiation and increases bone mass in mice fed a high-fat diet
    Jay J Cao
    USDA, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND
    J Nutr 144:289-96. 2014
    ..These results show that NAC supplementation increases the bone mass of obese mice induced by an HF diet through elevating glutathione status and decreasing bone resorption. ..
  27. doi request reprint Obesity reduces methionine sulphoxide reductase activity in visceral adipose tissue
    Eric O Uthus
    USDA Grand Forks Human Nutrition Research Center, Grand Forks, ND 58203 9034, USA
    Free Radic Res 45:1052-60. 2011
    ..MsrB activity was similarly reduced only in visceral fat. The data indicate that Msr activity is reduced by obesity and may alter oxidative stress signalling of obesity...
  28. pmc Issues of fish consumption for cardiovascular disease risk reduction
    Susan K Raatz
    Grand Forks Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Grand Forks, ND 58201, USA
    Nutrients 5:1081-97. 2013
    ..This review highlights some of the work that needs to be carried out to meet the demand for fish and to positively affect intake levels to meet fish intake recommendations for CVD risk reduction...
  29. pmc Baking reduces prostaglandin, resolvin, and hydroxy-fatty acid content of farm-raised Atlantic salmon (Salmo salar)
    Susan K Raatz
    Grand Forks Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, Grand Forks, North Dakota 58203 9034, United States
    J Agric Food Chem 59:11278-86. 2011
    ..The extent to which the levels of MHFA, prostanoids, and resolvins in the raw or baked fish have physiologic consequence for humans needs to be determined...
  30. ncbi request reprint 4-Hydroxy-trans-2-nonenoic acid is a gamma-hydroxybutyrate receptor ligand in the cerebral cortex and hippocampus
    Tonya C Murphy
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, USA
    J Neurochem 89:1462-70. 2004
    ..7-fold with age in the cerebral cortex of rats. Our data demonstrate that an HNE metabolite, formed in rat and human brain, is a signaling molecule analogous to other bioactive lipid peroxidation products...
  31. ncbi request reprint Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation
    Ethan Nguyen
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Biochim Biophys Acta 1637:107-12. 2003
    ..Trans-2-hexenal (HEX) and crotonaldehyde (100 microM each) did not inhibit activity. These data suggest that acrolein and HNE disrupt SSA metabolism and may have subsequent effects on CNS neurochemistry...
  32. doi request reprint Consumption of Honey, Sucrose, and High-Fructose Corn Syrup Produces Similar Metabolic Effects in Glucose-Tolerant and -Intolerant Individuals
    Susan K Raatz
    USDA Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND and Department of Food Science and Nutrition, University of Minnesota, St Paul, MN
    J Nutr 145:2265-72. 2015
    ..Public health recommendations call for a reduction in added sugars; however, controversy exists over whether all nutritive sweeteners produce similar metabolic effects...
  33. doi request reprint Skin and plasma carotenoid response to a provided intervention diet high in vegetables and fruit: uptake and depletion kinetics
    Lisa Jahns
    From the USDA Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND LJ, LDW, and MJP the University of North Dakota, Grand Forks, ND LKJ the Yale School of Public Health and Yale Cancer Center, New Haven, CT STM and BC and the Department of Physics and Astronomy, University of Utah, Salt Lake City, UT IVE and WG
    Am J Clin Nutr 100:930-7. 2014
    ..Resonance Raman spectroscopy (RRS) is an innovative method for assessing carotenoids in skin noninvasively...
  34. ncbi request reprint Midpolarity and nonpolar wood smoke particulate matter fractions deplete glutathione in RAW 264.7 macrophages
    Alena Kubatova
    Energy and Environmental Research Center, P O Box 9018, University of North Dakota, Grand Forks, North Dakota 58202 9018, USA
    Chem Res Toxicol 19:255-61. 2006
    ..However, other unidentified PM constituents contribute to GSH depletion as well. The results indicate the toxicological importance of oxygenated organics found in midpolarity PM fractions...
  35. doi request reprint Total dietary fat and fatty acid content modifies plasma phospholipid fatty acids, desaturase activity indices, and urinary prostaglandin E in women
    Susan K Raatz
    ARS, USDA, Human Nutrition Research Center, Grand Forks, ND 58203, USA
    Nutr Res 32:1-7. 2012
    ....
  36. doi request reprint NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes
    Emilie E Vomhof-DeKrey
    Grand Forks Human Nutrition Research Center, USDA ARS, Grand Forks, ND 58203, USA
    Free Radic Biol Med 53:690-700. 2012
    ..These data demonstrate a biphasic response of Nrf2 and NQO1 during adipocyte differentiation that is regulated by Keap1- and GSK-3β-dependent mechanisms, and that hypertrophy is negatively regulated by NQO1 activity...
  37. doi request reprint Involuntary wheel running improves but does not fully reverse the deterioration of bone structure of obese rats despite decreasing adiposity
    Jay J Cao
    Grand Forks Human Nutrition Research Center, USDA, Agricultural Research Service, 2420 2nd Ave N, Grand Forks, ND, 58202 9034, USA
    Calcif Tissue Int 97:145-55. 2015
    ..Furthermore, vitamin C and E supplementation has no additional benefits on bone structural properties during exercise...
  38. doi request reprint Ethanol intoxication increases hepatic N-lysyl protein acetylation
    Matthew J Picklo
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, 501 N Columbia Road, Grand Forks, ND 58203 9037, USA
    Biochem Biophys Res Commun 376:615-9. 2008
    ..Mitochondrial content of the deacetylase Sirt3 was unchanged by 6 weeks of ethanol exposure. These data indicate ethanol intoxication changes the acetylation status of, and likely the activity of, multiple mitochondrial proteins...
  39. ncbi request reprint Oxidation of 4-hydroxynonenal in rat brain slices
    Tonya Murphy
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Chem Biol Interact 143:101-5. 2003
    ..HNEAcid was found exclusively in the incubation media, suggesting that HNEAcid is exported from the cells of the slice. These data demonstrate that HNE detoxification through the oxidation pathway occur in the cerebral cortex...