Janet A Novotny

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. pmc Single nucleotide polymorphisms in CETP, SLC46A1, SLC19A1, CD36, BCMO1, APOA5, and ABCA1 are significant predictors of plasma HDL in healthy adults
    Andrew J Clifford
    Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616, USA
    Lipids Health Dis 12:66. 2013
  2. doi request reprint Anthocyanin kinetics are dependent on anthocyanin structure
    Janet A Novotny
    U S Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA
    Br J Nutr 107:504-9. 2012
  3. pmc Discrepancy between the Atwater factor predicted and empirically measured energy values of almonds in human diets
    Janet A Novotny
    USDA, Agricultural Research Service, Beltsville Human Nutrition Research Center, MD, USA
    Am J Clin Nutr 96:296-301. 2012
  4. doi request reprint Vitamin K absorption and kinetics in human subjects after consumption of 13C-labelled phylloquinone from kale
    Janet A Novotny
    US Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Building 307B, Room 219, BARC East, Beltsville, MD 20705, USA
    Br J Nutr 104:858-62. 2010
  5. pmc Beta-carotene conversion to vitamin A decreases as the dietary dose increases in humans
    Janet A Novotny
    USDA Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA
    J Nutr 140:915-8. 2010
  6. ncbi request reprint Molybdenum intake influences molybdenum kinetics in men
    Janet A Novotny
    USDA Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA
    J Nutr 137:37-42. 2007
  7. doi request reprint Bioavailability of anthocyanins from purple carrot juice: effects of acylation and plant matrix
    Craig S Charron
    Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, Beltsville, Maryland 20705, USA
    J Agric Food Chem 57:1226-30. 2009
  8. ncbi request reprint Isotopic labeling and LC-APCI-MS quantification for investigating absorption of carotenoids and phylloquinone from kale (Brassica oleracea)
    Anne C Kurilich
    U S Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, Maryland 20705, USA
    J Agric Food Chem 51:4877-83. 2003
  9. ncbi request reprint Plasma appearance of labeled beta-carotene, lutein, and retinol in humans after consumption of isotopically labeled kale
    Janet A Novotny
    United States Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA
    J Lipid Res 46:1896-903. 2005
  10. ncbi request reprint Plasma and urine responses are lower for acylated vs nonacylated anthocyanins from raw and cooked purple carrots
    Anne C Kurilich
    Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, Beltsville, Maryland 20705, USA
    J Agric Food Chem 53:6537-42. 2005

Collaborators

Detail Information

Publications26

  1. pmc Single nucleotide polymorphisms in CETP, SLC46A1, SLC19A1, CD36, BCMO1, APOA5, and ABCA1 are significant predictors of plasma HDL in healthy adults
    Andrew J Clifford
    Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616, USA
    Lipids Health Dis 12:66. 2013
    ..We used a linear regression model. Selected genes corresponded to folate metabolism, vitamins B-12, A, and E, and cholesterol pathways or lipid metabolism...
  2. doi request reprint Anthocyanin kinetics are dependent on anthocyanin structure
    Janet A Novotny
    U S Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA
    Br J Nutr 107:504-9. 2012
    ..Fractional elimination of non-acylated compounds was slower than that for acylated anthocyanins. These results provide the first information about the kinetics of individual anthocyanins in human beings...
  3. pmc Discrepancy between the Atwater factor predicted and empirically measured energy values of almonds in human diets
    Janet A Novotny
    USDA, Agricultural Research Service, Beltsville Human Nutrition Research Center, MD, USA
    Am J Clin Nutr 96:296-301. 2012
    ..The energy content of foods is primarily determined by the Atwater factors, which may not be accurate for certain food groups. Nuts are a food group for which substantial evidence suggests that the Atwater factors may be poorly predictive...
  4. doi request reprint Vitamin K absorption and kinetics in human subjects after consumption of 13C-labelled phylloquinone from kale
    Janet A Novotny
    US Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Building 307B, Room 219, BARC East, Beltsville, MD 20705, USA
    Br J Nutr 104:858-62. 2010
    ..Modelling results demonstrated a mean (n 6) bioavailability of phylloquinone from kale to be 4.7%. Plasma and tissue half-times for phylloquinone were found to be 8.8 and 215 h, respectively...
  5. pmc Beta-carotene conversion to vitamin A decreases as the dietary dose increases in humans
    Janet A Novotny
    USDA Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA
    J Nutr 140:915-8. 2010
    ..The plasma AUC for ROH-d4 increased 36% from the 20-mg dose to the 40-mg dose. These results establish that, in humans, beta-carotene conversion to vitamin A decreases as the dietary dose increases...
  6. ncbi request reprint Molybdenum intake influences molybdenum kinetics in men
    Janet A Novotny
    USDA Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA
    J Nutr 137:37-42. 2007
    ..The physiological adaptations to changing intake that the model demonstrated may help prevent molybdenum deficiency and toxicity...
  7. doi request reprint Bioavailability of anthocyanins from purple carrot juice: effects of acylation and plant matrix
    Craig S Charron
    Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, Beltsville, Maryland 20705, USA
    J Agric Food Chem 57:1226-30. 2009
    ..Because the treatments were consumed as juice, it could be discerned that the difference in bioavailability of acylated versus nonacylated anthocyanins was not primarily caused by interactions with the plant matrix...
  8. ncbi request reprint Isotopic labeling and LC-APCI-MS quantification for investigating absorption of carotenoids and phylloquinone from kale (Brassica oleracea)
    Anne C Kurilich
    U S Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, Maryland 20705, USA
    J Agric Food Chem 51:4877-83. 2003
    ..10 microM), and phylloquinone peaked at 7 h (3.0 nM). This method of labeling kale with (13)C was successful for producing clearly defined kinetic curves for (13)C-lutein,(13)C-beta-carotene, (13)C-retinol, and (13)C-phylloquinone...
  9. ncbi request reprint Plasma appearance of labeled beta-carotene, lutein, and retinol in humans after consumption of isotopically labeled kale
    Janet A Novotny
    United States Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA
    J Lipid Res 46:1896-903. 2005
    ..It is possible that this relationship was mediated either through some aspect of beta-carotene absorption or via the common pathways of metabolism for postdose and endogenous retinoid...
  10. ncbi request reprint Plasma and urine responses are lower for acylated vs nonacylated anthocyanins from raw and cooked purple carrots
    Anne C Kurilich
    Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, Beltsville, Maryland 20705, USA
    J Agric Food Chem 53:6537-42. 2005
    ..Cooking increased the recovery of nonacylated anthocyanins but not acylated anthocyanins. Large dose size significantly reduced recovery of both acylated and nonacylated anthocyanins, suggesting saturation of absorption mechanisms...
  11. doi request reprint Measured energy value of pistachios in the human diet
    David J Baer
    US Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA
    Br J Nutr 107:120-5. 2012
    ..In conclusion, pistachio nuts contain less metabolisable energy than that calculated from the Atwater general factors. Accurate information about metabolisable energy content of foods is important for reliable food labelling...
  12. ncbi request reprint Effects of the interaction of sex and food intake on the relation between energy expenditure and body composition
    David R Paul
    Diet and Human Performance Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705, USA
    Am J Clin Nutr 79:385-9. 2004
    ..It is possible that variables such as sex, food intake, or both may in part explain this poor coupling...
  13. ncbi request reprint effect of dose size on bioavailability of acylated and nonacylated anthocyanins from red cabbage (Brassica oleracea L. Var. capitata)
    Craig S Charron
    Diet and Human Performance Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, 10300 Baltimore Avenue, Beltsville, Maryland 20705, USA
    J Agric Food Chem 55:5354-62. 2007
    ..The results show that red cabbage anthocyanins were excreted in both intact and metabolized forms and that recovery of nonacylated anthocyanins in urine was >4-fold that of acylated anthocyanins...
  14. ncbi request reprint Molybdenum kinetics in men differ during molybdenum depletion and repletion
    Janet A Novotny
    U S Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, Beltsville, MD 20705, USA
    J Nutr 136:953-7. 2006
    ..This is a minimum estimate because subjects in this study were in a molybdenum-sparing state. These findings provide an understanding of the adaptations in molybdenum metabolism that take place during depletion and repletion...
  15. ncbi request reprint Personality characteristics as predictors of underreporting of energy intake on 24-hour dietary recall interviews
    Janet A Novotny
    US Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet and Human Performance Laboratory, Beltsville, MD 20705, USA
    J Am Diet Assoc 103:1146-51. 2003
    ..To identify characteristics associated with misreporting of energy intake during 24-hour dietary recalls (24 HR)...
  16. ncbi request reprint Methods for determining the metabolism of alpha-linolenic acid in human subjects from intrinsically-labeled food
    Robert J Pawlosky
    Food Composition Laboratory, Beltsville, MD 20705, USA
    Forum Nutr 56:75-7. 2003
  17. ncbi request reprint Anthocyanin excretion by humans increases linearly with increasing strawberry dose
    Colleen Carkeet
    Food Components and Health Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, USDA, Beltsville, MD 20705, USA
    J Nutr 138:897-902. 2008
    ..These results suggest that pelargonidin 3-glucoside absorption and metabolism are not saturated at masses < or = 60 micromol, thus showing that more strawberry anthocyanin can be absorbed with increasing dose...
  18. ncbi request reprint Intrinsic labeling of plants for bioavailability studies
    Janet A Novotny
    USDA, BHNRC, DHPL, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA
    Adv Exp Med Biol 537:131-9. 2003
  19. pmc Assessment of DNA damage and repair in adults consuming allyl isothiocyanate or Brassica vegetables
    Craig S Charron
    US Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA
    J Nutr Biochem 24:894-902. 2013
    ..In summary, DNA damage appeared to be induced in the short term by AITC and AITC-rich products, but that damage disappeared quickly, and neither AITC nor AITC-rich products affected DNA base excision repair...
  20. pmc This kinetic, bioavailability, and metabolism study of RRR-α-tocopherol in healthy adults suggests lower intake requirements than previous estimates
    Janet A Novotny
    Food Components and Health Laboratory, USDA, Beltsville, MD, USA
    J Nutr 142:2105-11. 2012
    ..These findings suggest that the dietary requirement for vitamin E may be less than that currently recommended and these results will be important for future updates of intake recommendations...
  21. ncbi request reprint What can pharmacokinetic models tell us about the disposition of lycopene and the potential role of lycopene in cancer prevention?
    Janet A Novotny
    U S Department of Agriculture, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA
    J Nutr 135:2048S-9S. 2005
  22. ncbi request reprint The effect of daily alcohol intake on breath alcohol concentrations of postmenopausal women after a bolus dose
    Janet A Novotny
    Beltsville Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Beltsville, Maryland 20705, USA
    J Stud Alcohol 64:380-3. 2003
    ..This study was designed to test whether daily alcohol intake can influence parameters related to rate of alcohol clearance and systemic alcohol exposure...
  23. ncbi request reprint A physiological pharmacokinetic model describing the disposition of lycopene in healthy men
    Veda Diwadkar-Navsariwala
    Department of Human Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Lipid Res 44:1927-39. 2003
    ..This may have important implications for planning clinical trials with pharmacological doses of lycopene in cancer control and prevention if absorption saturation occurs at levels that are already being consumed in the population...
  24. ncbi request reprint Structural characterization and detection of kale flavonoids by electrospray ionization mass spectrometry
    Junmei Zhang
    Department of Chemistry and Biochemistry, University of Texas, Austin, Texas 78712, USA
    Anal Chem 75:6401-7. 2003
    ..Compared to UV detection, ESI-MS in the deprotonation mode provided lower detection limits, and both higher sensitivity and selectivity, in addition to structural characterization of the kale flavonols by CAD...
  25. doi request reprint Effects of anthocyanin and carotenoid combinations on foliage and immature fruit color of Capsicum annuum L
    Gordon J Lightbourn
    Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Hered 99:105-11. 2008
    ..Utilizing Capsicum pigment variants, we determine the biochemical factors responsible for violet versus black-pigmented pepper tissue in the context of described pepper color genes...
  26. ncbi request reprint A feasibility study quantifying in vivo human alpha-tocopherol metabolism
    Andrew J Clifford
    Department of Nutrition, University of California, Davis, Davis, CA 5616 8669, USA
    Am J Clin Nutr 84:1430-41. 2006
    ..Quantitation of human vitamin E metabolism is incomplete, so we quantified RRR- and all-rac-alpha-tocopherol metabolism in an adult...