John A Manthey

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. pmc Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes
    LaNita A Nichols
    Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    Lipids Health Dis 10:36. 2011
  2. doi request reprint Anti-inflammatory activity of an orange peel polymethoxylated flavone, 3',4',3,5,6,7,8-heptamethoxyflavone, in the rat carrageenan/paw edema and mouse lipopolysaccharide-challenge assays
    John A Manthey
    U S Citrus and Subtropical Products Laboratory, Agricultural Research Service, U S Department of Agriculture, 600 Avenue S, Northwest, Winter Haven, Florida 33881, USA
    J Agric Food Chem 56:9399-403. 2008
  3. doi request reprint Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry
    John A Manthey
    Citrus and Subtropical Products Research Laboratory, Agricultural Research Service, US Department of Agriculture, Winter Haven, Florida 33881, USA
    J Agric Food Chem 59:145-51. 2011
  4. doi request reprint Influences of harvest date and location on the levels of beta-carotene, ascorbic acid, total phenols, the in vitro antioxidant capacity, and phenolic profiles of five commercial varieties of mango (Mangifera indica L.)
    John A Manthey
    Citrus and Subtropical Products Laboratory, Agricultural Research Service, U S Department of Agriculture, Winter Haven, Florida 33881, USA
    J Agric Food Chem 57:10825-30. 2009
  5. doi request reprint Biotransformations of 6',7'-dihydroxybergamottin and 6',7'-epoxybergamottin by the citrus-pathogenic fungi diminish cytochrome P450 3A4 inhibitory activity
    Kyung Myung
    US Horticultural Research Laboratory, Agricultural Research Service, US Department of Agriculture, Fort Pierce, FL 34945, USA
    Bioorg Med Chem Lett 22:2279-82. 2012
  6. doi request reprint Binding of furanocoumarins in grapefruit juice to Aspergillus niger hyphae
    Kyung Myung
    Citrus and Subtropical Products Laboratory, Agricultural Research Service, U S Department of Agriculture, 600 Ave S, N W, Winter Haven, FL 33881, USA
    Appl Microbiol Biotechnol 78:401-7. 2008
  7. ncbi request reprint Organic vs conventionally grown Rio Red whole grapefruit and juice: comparison of production inputs, market quality, consumer acceptance, and human health-bioactive compounds
    Gene E Lester
    Kika de la Garza Subtropical Agricultural Research Center, Agricultural Research Service, U S Department of Agriculture, Weslaco, Texas 78596, USA
    J Agric Food Chem 55:4474-80. 2007
  8. doi request reprint Removal of furanocoumarins in grapefruit juice by edible fungi
    Kyung Myung
    United States Citrus and Subtropical Products Laboratory, Agricultural Research Service, United States Department of Agriculture, 600 Avenue S, Northwest, Winter Haven, Florida 33881, USA
    J Agric Food Chem 56:12064-8. 2008
  9. ncbi request reprint Total antioxidant activity and fiber content of select Florida-grown tropical fruits
    Kanjana Mahattanatawee
    Citrus and Subtropical Products Laboratory, South Atlantic Area, Agricultural Research Service, United States Department of Agriculture, 600 Avenue S, Northwest, Winter Haven, Florida 33881, USA
    J Agric Food Chem 54:7355-63. 2006
  10. ncbi request reprint Distribution of furanocoumarins in grapefruit juice fractions
    John A Manthey
    Citrus and Subtropical Products Laboratory, Agricultural Research Service, US Department of Agriculture, Winter Haven, Florida 33881, USA
    J Agric Food Chem 53:5158-63. 2005

Collaborators

Detail Information

Publications15

  1. pmc Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes
    LaNita A Nichols
    Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    Lipids Health Dis 10:36. 2011
    ....
  2. doi request reprint Anti-inflammatory activity of an orange peel polymethoxylated flavone, 3',4',3,5,6,7,8-heptamethoxyflavone, in the rat carrageenan/paw edema and mouse lipopolysaccharide-challenge assays
    John A Manthey
    U S Citrus and Subtropical Products Laboratory, Agricultural Research Service, U S Department of Agriculture, 600 Avenue S, Northwest, Winter Haven, Florida 33881, USA
    J Agric Food Chem 56:9399-403. 2008
    ....
  3. doi request reprint Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry
    John A Manthey
    Citrus and Subtropical Products Research Laboratory, Agricultural Research Service, US Department of Agriculture, Winter Haven, Florida 33881, USA
    J Agric Food Chem 59:145-51. 2011
    ..In most cases the glucuronides occurred at substantially higher concentrations than the aglycone metabolites. Low levels of NOB and TAN and their metabolites were detectable in rat blood serum even at 24 h after treatment...
  4. doi request reprint Influences of harvest date and location on the levels of beta-carotene, ascorbic acid, total phenols, the in vitro antioxidant capacity, and phenolic profiles of five commercial varieties of mango (Mangifera indica L.)
    John A Manthey
    Citrus and Subtropical Products Laboratory, Agricultural Research Service, U S Department of Agriculture, Winter Haven, Florida 33881, USA
    J Agric Food Chem 57:10825-30. 2009
    ..Large fruit-to-fruit variations in the concentrations of these compounds occurred within sets of mangoes of the same cultivar with the same harvest location and date...
  5. doi request reprint Biotransformations of 6',7'-dihydroxybergamottin and 6',7'-epoxybergamottin by the citrus-pathogenic fungi diminish cytochrome P450 3A4 inhibitory activity
    Kyung Myung
    US Horticultural Research Laboratory, Agricultural Research Service, US Department of Agriculture, Fort Pierce, FL 34945, USA
    Bioorg Med Chem Lett 22:2279-82. 2012
    ..The inhibitory activity of 4 towards human intestinal cytochrome P450 3A4 (CYP3A4) was greatly decreased (IC(50) >172.0 μM) compared to 2 (IC(50)=0.81 μM)...
  6. doi request reprint Binding of furanocoumarins in grapefruit juice to Aspergillus niger hyphae
    Kyung Myung
    Citrus and Subtropical Products Laboratory, Agricultural Research Service, U S Department of Agriculture, 600 Ave S, N W, Winter Haven, FL 33881, USA
    Appl Microbiol Biotechnol 78:401-7. 2008
    ..This removal of the FCs from GFJ led to a reduced inhibition of CYP 3A4 activity in in vitro assays by both GFJ and GFJ extracts...
  7. ncbi request reprint Organic vs conventionally grown Rio Red whole grapefruit and juice: comparison of production inputs, market quality, consumer acceptance, and human health-bioactive compounds
    Gene E Lester
    Kika de la Garza Subtropical Agricultural Research Center, Agricultural Research Service, U S Department of Agriculture, Weslaco, Texas 78596, USA
    J Agric Food Chem 55:4474-80. 2007
    ..Organic fruit had a commercially preferred thinner peel, and the juice was higher in ascorbic acid and sugars and lower in nitrate and the drug interactive furanocoumarins...
  8. doi request reprint Removal of furanocoumarins in grapefruit juice by edible fungi
    Kyung Myung
    United States Citrus and Subtropical Products Laboratory, Agricultural Research Service, United States Department of Agriculture, 600 Avenue S, Northwest, Winter Haven, Florida 33881, USA
    J Agric Food Chem 56:12064-8. 2008
    ..The removal of FCs was independent of pH in GFJ. Dried fungal material of M. esculenta was also effective in removing FCs from GFJ and occurred with GFJ samples prepared from both fresh grapefruit and GFJ concentrate...
  9. ncbi request reprint Total antioxidant activity and fiber content of select Florida-grown tropical fruits
    Kanjana Mahattanatawee
    Citrus and Subtropical Products Laboratory, South Atlantic Area, Agricultural Research Service, United States Department of Agriculture, 600 Avenue S, Northwest, Winter Haven, Florida 33881, USA
    J Agric Food Chem 54:7355-63. 2006
    ..Preliminary descriptions are given of the phenols in red/white pitaya (dragonfruit), lychee, and mamey sapote, these fruit being thus far uncharacterized in the literature...
  10. ncbi request reprint Distribution of furanocoumarins in grapefruit juice fractions
    John A Manthey
    Citrus and Subtropical Products Laboratory, Agricultural Research Service, US Department of Agriculture, Winter Haven, Florida 33881, USA
    J Agric Food Chem 53:5158-63. 2005
    ..MS analysis of this furanocoumarin-enriched fraction provided evidence of additional furanocoumarins in grapefruit juice that remain to be fully characterized and evaluated for their roles in the grapefruit-drug interactions...
  11. ncbi request reprint Fractionation of orange peel phenols in ultrafiltered molasses and mass balance studies of their antioxidant levels
    John A Manthey
    Citrus and Subtropical Products Laboratory, Southern Atlantic Area, Agricultural Research Service, U S Department of Agriculture, 600 Avenue S N W, Winter Haven, FL 33881, USA
    J Agric Food Chem 52:7586-92. 2004
    ..The miscellaneous phenolic-containing fractions, in which a large portion of the total phenolic content in molasses occurred, also constituted a major portion of the total antioxidants in ultrafiltered molasses...
  12. doi request reprint Aspergillus niger metabolism of citrus furanocoumarin inhibitors of human cytochrome P450 3A4
    Kyung Myung
    Citrus and Subtropical Products Laboratory, Agricultural Research Service, US Department of Agriculture, 600 Ave S, N W, Winter Haven, FL, 33881, USA
    Appl Microbiol Biotechnol 78:343-9. 2008
    ..A possible enzyme-catalyzed pathway for the grapefruit FC metabolism involving the cleavage of the geranyl group and the addition of a sulfate group is proposed...
  13. ncbi request reprint Fourier transform infrared spectroscopic analysis of the polymethoxylated flavone content of orange oil residues
    John A Manthey
    Citrus and Subtropical Products Laboratory, Agricultural Research Service, U S Department of Agriculture, Winter Haven, Florida 33881, USA
    J Agric Food Chem 54:3215-8. 2006
    ..The detection limit by this method is approximately 0.1% PMF...
  14. ncbi request reprint Flavonoids in cell function
    John A Manthey
    US Department of Agriculture, Citrus and Subtropical Products Laboratory, Winter Haven, FL 33881, USA
    Adv Exp Med Biol 505:1-7. 2002
  15. ncbi request reprint Antiproliferative activities of citrus flavonoids against six human cancer cell lines
    John A Manthey
    U S Citrus and Subtropical Products Laboratory, South Atlantic Area, Agricultural Research Service, U S Department of Agriculture, 600 Avenue S, N W, Winter Haven, Florida 33881, USA
    J Agric Food Chem 50:5837-43. 2002
    ..Glycosylation of these compounds removed their activity. The strong antiproliferative activities of the polymethoxylated flavones suggest that they may have use as anticancer agents in humans...