Joan K Lunney
Affiliation: Agricultural Research Service
- Veterinary immunology: opportunities and challengesJoan K Lunney
Immunology and Disease Resistance Laboratory, Building 1040, Room 105, Beltsville, MD 20705, USA
Trends Immunol 23:4-6. 2002..The 6th International Veterinary Immunology Symposium (6IVIS) was held in Uppsala, Sweden from 15-20 July 2001...
- Deciphering the involvement of innate immune factors in the development of the host response to PRRSV vaccinationAtabak R Royaee
Animal Parasitic Disease Laboratory, Animal and Natural Resources Institute, Beltsville Human Nutrition Research Center, ARS, BARC, USDA, Beltsville, MD 20705, USA
Vet Immunol Immunopathol 102:199-216. 2004..Thus, while exogenous addition of IFNA during PRRSV vaccination has an impact on the development of a Th1 immune response, other alterations will be required for substantial boosting of virus-specific protection...
- Interleukin-8, interleukin-1beta, and interferon-gamma levels are linked to PRRS virus clearanceJoan K Lunney
Animal Parasitic Diseases Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, U S Department of Agriculture, Beltsville, Maryland 20705, USA
Viral Immunol 23:127-34. 2010..These results indicate that while each cytokine individually has minor effects on the length of virus replication, the combination of cytokine activities should be considered when understanding the role of immunity in persistence...
- Advances in swine biomedical model genomicsJoan K Lunney
APDL, BARC, ARS, United States Department of Agriculture, Beltsville, MD 20705, USA
Int J Biol Sci 3:179-84. 2007....
- Structural and functional annotation of the porcine immunomeHarry D Dawson
USDA ARS, Beltsville Human Nutrition Research Center, Diet, Genomics, Immunology Laboratory, Beltsville, MD 20705, USA
BMC Genomics 14:332. 2013..The completion of the pig genome provides the opportunity to annotate the pig immunome, and compare and contrast pig and human immune systems...
- Genetic control of host resistance to porcine reproductive and respiratory syndrome virus (PRRSV) infectionJoan K Lunney
Animal Parasitic Diseases Laboratory, ANRI, ARS, USDA, BARC East, Beltsville, MD 20705, USA
Virus Res 154:161-9. 2010..Additionally these studies may reveal alternate PRRS control mechanisms that can be exploited for novel drugs, biotherapeutics and vaccine designs...
- Report from the second international symposium on animal genomics for animal health: critical needs, challenges and potential solutionsSteve C Bishop
Office of National Programs, ARS, REE, USDA, 5601 Sunnyside Ave, Beltsville, MD 20705, USA
BMC Proc 5:S1. 2011..This report captures key points made by symposium participants during the roundtable discussion and serves as a roadmap to steer future research priorities in animal genomics research...
- Comparison of detection methods for Toxoplasma gondii in naturally and experimentally infected swineDolores E Hill
United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Animal Parasitic Diseases Laboratory, BARC East Beltsville, MD 20705, USA
Vet Parasitol 141:9-17. 2006..gondii infection in tissues from naturally and experimentally infected pigs. The results indicate that a serum-based ELISA is the most sensitive method, of those tested, for detection of T. gondii infected swine...
- Identification of key immune mediators regulating T helper 1 responses in swineHarry D Dawson
Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, USDA, Bldg 307C, Room 213, BARC East, Beltsville, MD 20705, USA
Vet Immunol Immunopathol 100:105-11. 2004..Based on their demonstrated utility in establishing an immune response pathway, these PCR assays should be valuable additions to our swine immune toolkit...
- Localized multigene expression patterns support an evolving Th1/Th2-like paradigm in response to infections with Toxoplasma gondii and Ascaris suumHarry D Dawson
Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Dept of Agriculture, Bldg 307C, Room 214, BARC East, Beltsville, MD 20705, USA
Infect Immun 73:1116-28. 2005....
- Expressed gene sequence and bioactivity of the IFNgamma-response chemokine CXCL11 of swine and cattlePatricia Boyd
Animal Parasitic Diseases Laboratory, ANRI, ARS, USDA, Building 1040, Room 103, BARC East, Beltsville, MD 20705, USA
Vet Immunol Immunopathol 136:170-5. 2010..This work provides valuable new reagents for investigating basic immunity as well as vaccine and disease responses in swine and cattle, goals of the U.S. Veterinary Immune Reagent Network which supported this effort...
- Perspectives for artificial insemination and genomics to improve global swine populationsRoger J Gerrits
Biotechnology and Germplasm Laboratory, ANRI, BARC, ARS, USDA, Beltsville, MD, USA
Theriogenology 63:283-99. 2005..AI, in vitro embryo production and embryo transfer will be the preferred means of implementing these new technologies to enhance efficiency of pig production in the future...
- Molecular genetics of the swine major histocompatibility complex, the SLA complexJoan K Lunney
USDA, ARS, BARC, APDL, Beltsville, MD 20705, USA
Dev Comp Immunol 33:362-74. 2009..It concludes by discussing the role of SLA genes in swine models of transplantation, xenotransplantation, cancer and allergy and in swine production traits and responses to infectious disease and vaccines...
- Probing genetic control of swine responses to PRRSV infection: current progress of the PRRS host genetics consortiumJoan K Lunney
Animal Parasitic Diseases Laboratory, BARC, ARS, USDA, Beltsville, MD 20705, USA
BMC Proc 5:S30. 2011..Understanding the role of host genetics in resistance to porcine reproductive and respiratory syndrome virus (PRRSV) infection, and the effects of PRRS on pig health and related growth, are goals of the PRRS Host Genetics Consortium (PHGC)...
- Porcine differential gene expression in response to Salmonella enterica serovars Choleraesuis and TyphimuriumJolita J Uthe
US Department of Agriculture, Animal Research Service, National Animal Disease Center, 2300 Dayton Avenue, Ames, IA 50010, USA
Mol Immunol 44:2900-14. 2007..Collectively, these data reveal specific porcine genes with differences in gene expression kinetics that may be responsible for the variation in disease progression observed in swine infected with Typhimurium compared to Choleraesuis...
- Cytokines and synthetic double-stranded RNA augment the T helper 1 immune response of swine to porcine reproductive and respiratory syndrome virusWilliam A Meier
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA
Vet Immunol Immunopathol 102:299-314. 2004..Conceivably, such intervention could be applied to improve the formulation of anti-PRRSV vaccines...
- Global transcriptional response of porcine mesenteric lymph nodes to Salmonella enterica serovar TyphimuriumYanfang Wang
Department of Animal Science and Center for Integrated Animal Genomics Iowa State University, Ames, IA 50010, USA
Genomics 90:72-84. 2007..We propose that such NFkappaB suppression in antigen-presenting cells may be the mechanism by which S. Typhimurium eludes a strong inflammatory response to establish a carrier status in pigs...
- Rapid assignment of swine leukocyte antigen haplotypes in pedigreed herds using a polymerase chain reaction-based assayGregory W Martens
Pathology Department, Baylor University Medical Center, 3500 Junius St, Dallas, TX 75246, USA
Immunogenetics 55:395-401. 2003..This combination of allele-specific and positive control primers produced specific and robust PCR-site-specific primer assays for assigning SLA haplotypes in the two populations...
- Gene expression profiling in Salmonella Choleraesuis-infected porcine lung using a long oligonucleotide microarrayShu Hong Zhao
Department of Animal Science, Iowa State University, 2255 Kildee Hall, Ames, 50011, USA
Mamm Genome 17:777-89. 2006..These data represent the first thorough investigation of gene regulation pathways that control an important porcine respiratory and foodborne bacterial infection...
- Validation of a first-generation long-oligonucleotide microarray for transcriptional profiling in the pigShu Hong Zhao
Department of Animal Science, 2255 Kildee Hall, Iowa State University, Ames, IA 50011, USA
Genomics 86:618-25. 2005..This is essential validation for investigators using the Qiagen-NRSP8 array for porcine functional genomics and for using the pig in modeling important physiological problems...
- Summary of the animal homologue section of HLDA8Armin Saalmuller
Clinical Immunology, Veterinary University of Vienna, Vienna, Austria
Cell Immunol 236:51-8. 2005..Our results suggest the suitability of crossreactive mAb for the animal model studies. Moreover, these findings contribute to our understanding of the evolution of the immune system...
- A full-length cDNA infectious clone of North American type 1 porcine reproductive and respiratory syndrome virus: expression of green fluorescent protein in the Nsp2 regionYing Fang
Center for Infectious Disease Research and Vaccinology, Department of Veterinary Science, Box 2175, South Dakota State University, Brookings, SD 57007 1396, USA
J Virol 80:11447-55. 2006..The availability of this North American type 1 infectious clone provides an important research tool for further study of the basic viral biology and pathogenic mechanisms of this group of type 1 PRRSV in the United States...