Research Topics
Species | Robert W LiSummaryAffiliation: Agricultural Research Service Country: USA Publications
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Detail Information
Publications
Exploring the host transcriptome for mechanisms underlying protective immunity and resistance to nematode infections in ruminantsRobert W Li
USDA ARS, Bovine Functional Genomics Laboratory, Beltsville, MD, USA
Vet Parasitol 190:1-11. 2012..This review summarizes recent progress and limitations of understanding regulatory genetic networks and biological pathways that affect host resistance and susceptibility to nematode infection in ruminants...
Alterations in the porcine colon microbiota induced by the gastrointestinal nematode Trichuris suisRobert W Li
USDA ARS ANRI, Bovine Functional Genomics Laboratory, Beltsville, Maryland, USA
Infect Immun 80:2150-7. 2012..Our findings should facilitate development of strategies for parasitic control in pigs and humans...- Cytoskeleton remodeling and alterations in smooth muscle contractility in the bovine jejunum during nematode infectionRobert W Li
Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, USDA ARS, Beltsville, MD 20705, USA
Funct Integr Genomics 12:35-44. 2012..Together, these data suggest that smooth muscle hypercontractility may be initiated as a result of a primary C. oncophora infection, which may represent a mechanism for host responses in the jejunum during nematode infection... - Perturbation dynamics of the rumen microbiota in response to exogenous butyrateRobert W Li
United States Department of Agriculture Agricultural Research Service, Bovine Functional Genomics Laboratory, Beltsville, Maryland, United States of America
PLoS ONE 7:e29392. 2012..Our findings provide insight into perturbation dynamics of the rumen microbial ecosystem and should guide efforts in formulating optimal uses of probiotic bacteria treating human diseases... - Characterization of the rumen microbiota of pre-ruminant calves using metagenomic toolsRobert W Li
Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, United States Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705, USA
Environ Microbiol 14:129-39. 2012..Our results provide insight into rumen microbiota dynamics and will facilitate efforts in formulating optimal early-weaning strategies... - Infection with the gastrointestinal nematode Ostertagia ostertagi in cattle affects mucus biosynthesis in the abomasumManuela Rinaldi
Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
Vet Res 42:61. 2011.... - Genome wide analysis of the bovine mucin genes and their gastrointestinal transcription profilePrisca R Hoorens
Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
BMC Genomics 12:140. 2011..The aim of the current study was to identify all members of the bovine mucin family by genome mining and subsequently investigate the transcription pattern of these mucins in the GI tract... - The vitamin D receptor and inducible nitric oxide synthase associated pathways in acquired resistance to Cooperia oncophora infection in cattleRobert W Li
Animal and Natural Resources Institute, United States Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705, USA
Vet Res 42:48. 2011..Our findings facilitate the understanding of molecular mechanisms underlying the development of acquired resistance, which could have an important implication in vaccine design... - Metagenome plasticity of the bovine abomasal microbiota in immune animals in response to Ostertagia ostertagi infectionRobert W Li
Animal and Natural Resources Institute, United States Department of Agriculture, Agricultural Research Service, Beltsville, Maryland, United States of America
PLoS ONE 6:e24417. 2011..A minimal disruption in the bovine abomasal microbiota by reinfection may contribute equally to the restoration of gastric function in immune animals... - Characterization of the abomasal transcriptome for mechanisms of resistance to gastrointestinal nematodes in cattleRobert W Li
Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, USDA ARS, Beltsville, MD 20705, USA
Vet Res 42:114. 2011..Our results provide insights into the development of host immunity to gastrointestinal nematode infection and will facilitate understanding of mechanism underlying host resistance... - Localized complement activation in the development of protective immunity against Ostertagia ostertagi infections in cattleRobert W Li
Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, United States Department of Agriculture, Beltsville, MD 20705, USA
Vet Parasitol 174:247-56. 2010..These results are the first evidence that local complement activation may be involved in the development of long-term protective immunity and provide a novel mechanistic insight into resistance against O. ostertagi in cattle... - Mucin biosynthesis in the bovine goblet cell induced by Cooperia oncophora infectionRobert W Li
Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, USDA ARS, Beltsville, MD 20705, USA
Vet Parasitol 165:281-9. 2009.... 
Canonical pathways and networks regulated by estrogen in the bovine mammary glandRobert W Li
Animal and Natural Resources Institute, United States Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705, USA
Funct Integr Genomics 8:55-68. 2008....- A temporal shift in regulatory networks and pathways in the bovine small intestine during Cooperia oncophora infectionRobert W Li
Bovine Functional Genomics Laboratory, U S Department of Agriculture Agricultural Research Service, BARC East, Beltsville, MD 20705, USA
Int J Parasitol 39:813-24. 2009..oncophora. These results provide a potential molecular roadmap for future studies aimed at defining host immune responses and understanding protective immunity against gastrointestinal nematodes... - A sentinel function for teat tissues in dairy cows: dominant innate immune response elements define early response to E. coli mastitisManuela Rinaldi
USDA ARS, Beltsville, MD 20705, USA
Funct Integr Genomics 10:21-38. 2010..Data support an important sentinel function for the teat, as these tissues responded rapidly and intensely, with production of cytokines and antimicrobial peptides... - Enhanced mitochondrial complex gene function and reduced liver size may mediate improved feed efficiency of beef cattle during compensatory growthErin E Connor
Beltsville Agricultural Research Center, ARS, USDA, MD 20705, USA
Funct Integr Genomics 10:39-51. 2010.... - Genome-wide ChIP-seq mapping and analysis reveal butyrate-induced acetylation of H3K9 and H3K27 correlated with transcription activity in bovine cellsJoo Heon Shin
Lieber Institute for Brain Development, Johns Hopkins University, 855 North Wolfe Street, Suite 102, Baltimore, MD 21205, USA
Funct Integr Genomics 12:119-30. 2012..Our results reveal that butyrate-induced acetylation in H3K9 and H3K27 changes the sequence-based binding preference of histone H3 and underlies the potential mechanisms of gene expression regulation induced by butyrate... - Local inflammation as a possible mechanism of resistance to gastrointestinal nematodes in Angus heifersRobert W Li
Bovine Functional Genomics Laboratory, USDA ARS, Beltsville, MD 20705, USA
Vet Parasitol 145:100-7. 2007..These data indicate that resistant animals can better maintain inflammatory responses at the site of infection, suggesting a possible novel mechanism of resistance... - Butyrate induces profound changes in gene expression related to multiple signal pathways in bovine kidney epithelial cellsRobert W Li
Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, United States Department of Agriculture Agricultural Research Service, Beltsville, MD 20705, USA
BMC Genomics 7:234. 2006..These oligonucleotides represent approximately 45,383 unique cattle sequences... - Identification of estrogen-responsive genes in the parenchyma and fat pad of the bovine mammary gland by microarray analysisRobert W Li
Bovine Functional Genomics Laboratory, United States Department of Agriculture-Agricultural Research Service, Beltsville, Maryland 20705, USA
Physiol Genomics 27:42-53. 2006..The distinctive expression patterns regulated by estrogen in parenchyma and fat pad shed light on the need for both tissues to obtain normal mammary development... - Production and utilization of a high-density oligonucleotide microarray in channel catfish, Ictalurus punctatusRobert W Li
USDA, Agricultural Research Service, Catfish Genetics Research Unit, Stoneville, MS 38776, USA
BMC Genomics 7:134. 2006..This platform was used to profile gene expression in catfish spleens 2 h, 4 h, 8 h and 24 h after injection of lipopolysaccharide (LPS)... - Lipopolysaccharide-induced early response genes in bovine peripheral blood mononuclear cells implicate GLG1/E-selectin as a key ligand-receptor interactionCong jun Li
Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, U S Department of Agriculture, BARC East, 10300 Baltimore Avenue, Beltsville, MD 20705, USA
Funct Integr Genomics 9:335-49. 2009..In particular, gene expression data identified Golgi complex-localized glycoprotein 1/endothelial-selectin as a key ligand-receptor interaction in the early response of cells... - Quantification of Transcriptome Responses of the Rumen Epithelium to Butyrate Infusion using RNA-seq TechnologyRansom L Baldwin
USDA ARS, Bovine Functional Genomics Laboratory, Beltsville, MD, USA
Gene Regul Syst Bio 6:67-80. 2012.... - Analysis of copy number variations among diverse cattle breedsGeorge E Liu
USDA ARS, ANRI, Bovine Functional Genomics Laboratory, Beltsville, Maryland 20705, USA
Genome Res 20:693-703. 2010..Our results provide a valuable resource beyond microsatellites and single nucleotide polymorphisms to explore the full dimension of genetic variability for future cattle genomic research... - Characteristics of peri-implantation porcine concepti population and maternal milieu influence the transcriptome profileLe Ann Blomberg
Animal Biosciences and Biotechnology Laboratory, USDA Agricultural Research Service, Animal and Natural Resources Institute, Beltsville, MD 20705, USA
Mol Reprod Dev 77:978-89. 2010..Also highlighted were ways by which the conceptus' microenvironment might be affected and developmental factors that may be of interest to interrogate further to determine if, and how, they affect embryo competency/elongation... - Identification of conserved regulatory elements in mammalian promoter regions: a case study using the PCK1 promoterGeorge E Liu
Bovine Functional Genomics Laboratory, Beltsville Agricultural Research Center, Beltsville, MD 20705, USA
Genomics Proteomics Bioinformatics 6:129-43. 2008..Our full set of TFBS predictions is freely available at http://bfgl.anri.barc.usda.gov/tfbsConsSites... - Pathway analysis identifies perturbation of genetic networks induced by butyrate in a bovine kidney epithelial cell lineCong jun Li
Growth Biology Laboratory, Animal and Natural Resources Institute ARS, U S Derpartment of Agriculture, 10300 Baltimore Avenue, BARC East, Beltsville, MD 20705, USA
Funct Integr Genomics 7:193-205. 2007..The present findings provide a basis for understanding the full range of the biological roles and the molecular mechanisms that butyrate may play in animal cell growth, proliferation, and energy metabolisms... - Characterization of the longissimus lumborum transcriptome response to adding propionate to the diet of growing Angus beef steersRansom L Baldwin
Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, United States Department of Agriculture Agricultural Research Service, Beltsville, Maryland 20705, USA
Physiol Genomics 44:543-50. 2012..lipolytic activities)... - Gene expression in bovine rumen epithelium during weaning identifies molecular regulators of rumen development and growthErin E Connor
Bovine Functional Genomics Laboratory, Agricultural Research Service, USDA, 10300 Baltimore Avenue, Bldg 306, BARC East, Beltsville, MD 20705, USA
Funct Integr Genomics 13:133-42. 2013.... - Comparative proteomic and regulatory network analyses of the elongating pig conceptusSéverine A Degrelle
USDA Agricultural Research Service, Animal and Natural Resources Institute, Animal Biosciences and Biotechnology Laboratory, Beltsville, MD, USA
Proteomics 9:2678-94. 2009..This proteomic study helps to elucidate the biological mechanisms underlying the early embryonic development of the pig... - Alpha-Tocopherol Alters Transcription Activities that Modulates Tumor Necrosis Factor Alpha (TNF-α) Induced Inflammatory Response in Bovine CellsCong jun Li
Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, ARS, USDA, 10300 Baltimore Ave, Beltsville, MD 20705
Gene Regul Syst Bio 6:1-14. 2012..We concluded that α-tocopherol pre-treatment has a significant antagonistic effect that modulates the cell's response to the TNF-α challenge by altering the gene expression activities of some important signaling molecules... - Comparison of the transcriptomes of long-term label retaining-cells and control cells microdissected from mammary epithelium: an initial study to characterize potential stem/progenitor cellsRatan K Choudhary
Department of Animal and Avian Sciences, University of Maryland College Park, MD, USA
Front Oncol 3:21. 2013..Insights into the biology of stem cells will be gained by confirmation and characterization of candidate MaSC markers identified in this study... - Genomic organisation and expression of the natural killer cell enhancing factor (NKEF) gene in channel catfish, Ictalurus punctatus (Rafinesque)Robert W Li
USDA, Agricultural Research Service, Catfish Genetics Research Unit, Stoneville, MS 38776, USA
Fish Shellfish Immunol 20:72-82. 2006..1 cM from locus IpCG0177 (r=0.05; LOD=45.8), 6.0 cM from a novel immune type receptor, syntenic (40 cM) with T-cell receptor alpha, and not linked with MHC loci... - Neospora caninum: comparative gene expression profiling of Neospora caninum wild type and a temperature sensitive cloneRobert W Li
Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, Beltsville Agricultural Research Center, USDA ARS, Beltsville, MD 20705, United States
Exp Parasitol 129:346-54. 2011.... - Alpha-Tocopherol Modulates Transcriptional Activities that Affect Essential Biological Processes in Bovine CellsCong jun Li
Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, ARS, USDA, 10300 Baltimore Ave, Beltsville, MD, 20705, USA
Gene Regul Syst Bio 4:109-24. 2010..The data also provided direct evidence that α-tocopherol is involved in maintaining immuno-homeostasis through targeting the C3 (Complement Component 3) gene... - Transcriptomic alterations in human prostate cancer cell LNCaP tumor xenograft modulated by dietary phenethyl isothiocyanateRobert W Li
U S Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Bovine Functional Genomics Laboratory, Beltsville, Maryland
Mol Carcinog 52:426-37. 2013..2012 Wiley Periodicals, Inc...