Darshan S Kelley

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. ncbi request reprint Modulation of body composition and immune cell functions by conjugated linoleic acid in humans and animal models: benefits vs. risks
    D S Kelley
    Western Human Nutrition Research Center, ARS, USDA, Department of Nutrition, University of California Davis, Davis, California 95616, USA
    Lipids 38:377-86. 2003
  2. ncbi request reprint Contrasting effects of t10,c12- and c9,t11-conjugated linoleic acid isomers on the fatty acid profiles of mouse liver lipids
    D S Kelley
    Western Human Nutrition Research Center, ARS, USDA, Department of Nutrition, University of California, Davis, California 95616, USA
    Lipids 39:135-41. 2004
  3. ncbi request reprint Consumption of Bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and women
    Darshan S Kelley
    U S Department of Agriculture ARS, Western Regional Research Center, Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 136:981-6. 2006
  4. ncbi request reprint Similar effects of c9,t11-CLA and t10,c12-CLA on immune cell functions in mice
    D S Kelley
    Western Human Nutrition Research Center, ARS, USDA, and Department of Nutrition, University of California, Davis 95616, USA
    Lipids 37:725-8. 2002
  5. ncbi request reprint Fatty acid composition of liver, adipose tissue, spleen, and heart of mice fed diets containing t10, c12-, and c9, t11-conjugated linoleic acid
    Darshan S Kelley
    Western Human Nutrition Research Center, ARS, USDA, and Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616, USA
    Prostaglandins Leukot Essent Fatty Acids 74:331-8. 2006
  6. ncbi request reprint Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, University of California Davis, CA 95616 8683, USA
    Am J Clin Nutr 86:324-33. 2007
  7. ncbi request reprint Dietary supplementation with conjugated linoleic acid increased its concentration in human peripheral blood mononuclear cells, but did not alter their function
    D S Kelley
    U S Department of Agriculture, Western Human Nutrition Research Center, University of California, Department of Nutrition, Davis 95616, USA
    Lipids 36:669-74. 2001
  8. ncbi request reprint Modulation of human immune and inflammatory responses by dietary fatty acids
    D S Kelley
    Western Human Nutrition Research Center, ARS USDA, and the Department of Nutrition, University of California at Davis, Davis, California, USA
    Nutrition 17:669-73. 2001
  9. ncbi request reprint Dietary conjugated linoleic acid did not alter immune status in young healthy women
    D S Kelley
    U S Department of Agriculture, University of California, Department of Nutrition, Davis 95616, USA
    Lipids 35:1065-71. 2000
  10. ncbi request reprint Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men
    D S Kelley
    USDA, ARS, Western Human Nutrition Research Center, Presidio of San Francisco, California 94129, USA
    Lipids 34:317-24. 1999

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Modulation of body composition and immune cell functions by conjugated linoleic acid in humans and animal models: benefits vs. risks
    D S Kelley
    Western Human Nutrition Research Center, ARS, USDA, Department of Nutrition, University of California Davis, Davis, California 95616, USA
    Lipids 38:377-86. 2003
    ..On the basis of the published data, CLA supplementation of adult human diets to improve body composition or enhance immune functions cannot be recommended at this time...
  2. ncbi request reprint Contrasting effects of t10,c12- and c9,t11-conjugated linoleic acid isomers on the fatty acid profiles of mouse liver lipids
    D S Kelley
    Western Human Nutrition Research Center, ARS, USDA, Department of Nutrition, University of California, Davis, California 95616, USA
    Lipids 39:135-41. 2004
    ..Thus, the two isomers differed not only in their effects on the weights of total liver lipids and lipid fractions but also on the FA profile of the lipid fractions...
  3. ncbi request reprint Consumption of Bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and women
    Darshan S Kelley
    U S Department of Agriculture ARS, Western Regional Research Center, Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 136:981-6. 2006
    ..Results of the present study suggest a selective modulatory effect of sweet cherries on CRP, NO, and RANTES. Such anti-inflammatory effects may be beneficial for the management and prevention of inflammatory diseases...
  4. ncbi request reprint Similar effects of c9,t11-CLA and t10,c12-CLA on immune cell functions in mice
    D S Kelley
    Western Human Nutrition Research Center, ARS, USDA, and Department of Nutrition, University of California, Davis 95616, USA
    Lipids 37:725-8. 2002
    ..Thus, the two CLA isomers had similar effects on all response variables tested. The discrepancies among the results from previous studies did not seem to be caused by the differences in the isomer composition of CLA used...
  5. ncbi request reprint Fatty acid composition of liver, adipose tissue, spleen, and heart of mice fed diets containing t10, c12-, and c9, t11-conjugated linoleic acid
    Darshan S Kelley
    Western Human Nutrition Research Center, ARS, USDA, and Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616, USA
    Prostaglandins Leukot Essent Fatty Acids 74:331-8. 2006
    ..The functional consequences of such changes in tissue fatty acid composition need to be investigated...
  6. ncbi request reprint Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, University of California Davis, CA 95616 8683, USA
    Am J Clin Nutr 86:324-33. 2007
    ..The effects of docosahexaenoic acid (DHA) on the mean size and concentrations of VLDL, LDL, and HDL subclasses have not been previously studied...
  7. ncbi request reprint Dietary supplementation with conjugated linoleic acid increased its concentration in human peripheral blood mononuclear cells, but did not alter their function
    D S Kelley
    U S Department of Agriculture, Western Human Nutrition Research Center, University of California, Department of Nutrition, Davis 95616, USA
    Lipids 36:669-74. 2001
    ..None of the variables tested changed in the control group. Our results show that CLA supplementation increased its concentration in PBMC lipids, but did not alter their functions...
  8. ncbi request reprint Modulation of human immune and inflammatory responses by dietary fatty acids
    D S Kelley
    Western Human Nutrition Research Center, ARS USDA, and the Department of Nutrition, University of California at Davis, Davis, California, USA
    Nutrition 17:669-73. 2001
    ..The potential for the use of fish oils in the management of these diseases is tremendous, even though further studies are needed to establish safe and adequate intake levels of omega-3 fatty acids...
  9. ncbi request reprint Dietary conjugated linoleic acid did not alter immune status in young healthy women
    D S Kelley
    U S Department of Agriculture, University of California, Department of Nutrition, Davis 95616, USA
    Lipids 35:1065-71. 2000
    ..These data suggest that short-term CLA supplementation in healthy volunteers is safe, but it does not have any added benefit to their immune status...
  10. ncbi request reprint Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men
    D S Kelley
    USDA, ARS, Western Human Nutrition Research Center, Presidio of San Francisco, California 94129, USA
    Lipids 34:317-24. 1999
    ..Our results show that inhibitory effects of DHA on immune cell functions varied with the cell type, and that the inhibitory effects are not mediated through increased production of PGE2 and LTB4...
  11. ncbi request reprint Dietary docosahexaenoic acid and immunocompetence in young healthy men
    D S Kelley
    USDA, ARS, Western Human Nutrition Research Center, Presidio of San Francisco, California 94129, USA
    Lipids 33:559-66. 1998
    ..Our results show that when total fat intake is low and held constant, DHA consumption does not inhibit many of the lymphocyte functions which have been reported to be inhibited by fish oil consumption...
  12. ncbi request reprint Arachidonic acid supplementation enhances synthesis of eicosanoids without suppressing immune functions in young healthy men
    D S Kelley
    United States Department of Agriculture, Agricultural Research Service, Presidio of San Francisco, California 94129, USA
    Lipids 33:125-30. 1998
    ..The opposing effects of PGE2 and LTB4 may have led to the lack of change in immune functions tested...
  13. pmc DHA supplementation decreases serum C-reactive protein and other markers of inflammation in hypertriglyceridemic men
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, USDA, and Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 139:495-501. 2009
    ..The mean size of VLDL particles was positively associated with plasma concentrations of neutrophils and CRP. In conclusion, DHA may lessen the inflammatory response by altering blood lipids and their fatty acid composition...
  14. doi request reprint Docosahexaenoic acid supplementation improved lipocentric but not glucocentric markers of insulin sensitivity in hypertriglyceridemic men
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, and Department of Nutrition, University of California, Davis, California 95616, USA
    Metab Syndr Relat Disord 10:32-8. 2012
    ..Results from some human and animal studies suggest that docosahexaenoic acid (22:6n-3; DHA) may be more effective than eicosapentaenoic acid (20:5n-3; EPA) in the prevention of IR...
  15. doi request reprint The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle
    Dawn M Fedor
    Western Human Nutrition Research Center, ARS, USDA and Department of Nutrition, University of California Davis, Davis, California, USA
    Metab Syndr Relat Disord 11:63-70. 2013
    ..The effect of CLA on fatty acid compositions of adipose tissue and muscle and whether DHA can prevent those CLA-induced changes in fatty acid composition is not known...
  16. doi request reprint Sweet bing cherries lower circulating concentrations of markers for chronic inflammatory diseases in healthy humans
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, USDA, USA
    J Nutr 143:340-4. 2013
    ..However, results from the present study demonstrate that cherry consumption selectively reduced several biomarkers associated with inflammatory diseases...
  17. doi request reprint Docosahexaenoic acid prevents trans-10, cis-12-conjugated linoleic acid-induced nonalcoholic fatty liver disease in mice by altering expression of hepatic genes regulating fatty acid synthesis and oxidation
    Dawn M Fedor
    Western Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture and Department of Nutrition, University of California Davis, Davis, CA 95616, USA
    Metab Syndr Relat Disord 10:175-80. 2012
    ..The effective dose of DHA and mechanisms involved are poorly understood...
  18. ncbi request reprint Docosahexaenoic acid supplementation decreases remnant-like particle-cholesterol and increases the (n-3) index in hypertriglyceridemic men
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, USDA and Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 138:30-5. 2008
    ..30), and HDL-C:Apo A (r = -0.25). Supplementation with placebo oil did not alter any of the response variables tested. Decreased atherogenic RLP-C and increased cardio-protective (n-3) index may improve cardio-vascular health...
  19. doi request reprint Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids
    Yuriko Adkins
    Western Human Nutrition Research Center, ARS, USDA, University of California Davis, CA 95616, USA
    J Nutr Biochem 21:781-92. 2010
    ..This review examines the various mechanisms by which n-3 PUFA exert beneficial effects against CVD...
  20. doi request reprint Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, USA
    Br J Nutr 108:900-9. 2012
    ..Dietary strawberry powder reduced risk factors for CVD, stroke and diabetes in obese volunteers, suggesting a potential role for strawberries as a dietary means to decrease obesity-related disease...
  21. doi request reprint Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men
    Kevin Dawson
    Center of Excellence in Nutritional Genomics, University of California Davis, Davis, CA 95616, USA
    J Nutr Biochem 23:616-21. 2012
    ..These results provide supporting evidence for the anti-inflammatory effects of DHA supplementation, and reveal previously unrecognized genes that are regulated by DHA and are associated with risk factors of cardiovascular diseases...
  22. doi request reprint Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects
    Darshan S Kelley
    Western Human Nutrition Research Center, ARS, USDA, Department of Nutrition, University of California Davis, CA 95616, USA
    Proc Nutr Soc 71:322-31. 2012
    ..In conclusion, n-3 PUFA decreased several risk factors for atherosclerosis without any serious adverse effects...
  23. doi request reprint Flaxseed oil prevents trans-10, cis-12-conjugated linoleic acid-induced insulin resistance in mice
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, and Department of Nutrition, University of California Davis, 430 West Health Sciences Drive, Davis, CA 95616, USA
    Br J Nutr 101:701-8. 2009
    ..The present results suggest that some adverse effects of CLA may be due to n-3 PUFA deficiency and that these can be corrected by a concomitant increase in the intake of alpha-linolenic acid, 18 : 3n-3...
  24. pmc Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans
    Patrice Armstrong
    USDA Western Human Nutrition Research Center, Davis, CA, USA
    J Nutr 142:1417-28. 2012
    ..No changes were seen in LDL particle or cholesterol concentrations, heart rate, or blood pressure. These findings indicate that the efficacy of FO supplements vary by ALOX5 genotype...
  25. ncbi request reprint The effect of conjugated linoleic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans
    P Benito
    Western Human Nutrition Research Center, USDA, One Shields Ave, University of California, Davis, CA 95616, USA
    Lipids 36:221-7. 2001
    ..Short-term consumption of CLA does not seem to exhibit antithrombotic properties in humans...
  26. doi request reprint Prevention of insulin resistance by n-3 polyunsaturated fatty acids
    Dawn Fedor
    Western Human Nutrition Research Center, ARS, USDA Department of Nutrition, University of California, Davis, California 95616, USA
    Curr Opin Clin Nutr Metab Care 12:138-46. 2009
    ..Review results from recent human and animal studies regarding the effects of n-3 polyunsaturated fatty acid (PUFA) in the prevention of insulin resistance...
  27. ncbi request reprint Dietary trans 10, cis 12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver
    Reuven Rasooly
    Western Human Nutrition Research Center, ARS, USDA, Davis, CA, USA
    Br J Nutr 97:58-66. 2007
    ..Since FMO and cyt P450 are also involved in drug detoxification, suppression of the transcription of these genes by CLA may have other health consequences besides development of fatty liver...
  28. ncbi request reprint Trans-10,cis-12 CLA increases liver and decreases adipose tissue lipids in mice: possible roles of specific lipid metabolism genes
    J M Warren
    Western Human Nutrition Research Center, ARS, USDA, and Department of Nutrition, University of California, Davis, California 95616, USA
    Lipids 38:497-504. 2003
    ..These initial results suggest that changes associated with energy homeostasis and insulin action may mediate the effects of t10,c12-CLA on lipid metabolism...
  29. ncbi request reprint Consumption of cherries lowers plasma urate in healthy women
    Robert A Jacob
    U S Department of Agriculture ARS Western Human Nutrition Research Center, University of California at Davis, Davis, CA 95616, USA
    J Nutr 133:1826-9. 2003
    ..The trend toward decreased inflammatory indices (CRP and NO) adds to the in vitro evidence that compounds in cherries may inhibit inflammatory pathways...
  30. ncbi request reprint The effects of dietary selenium on the immune system in healthy men
    W C Hawkes
    U.S. Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, University of California at Davis, 95616, USA
    Biol Trace Elem Res 81:189-213. 2001
    ..This study indicates that the immune-enhancing properties of selenium in humans are the result, at least in part, of improved activation and proliferation of B-lymphocytes and perhaps enhanced T-cell function...
  31. ncbi request reprint Immune functions are maintained in healthy men with low zinc intake
    Kathryn Pinna
    Department of Nutritional Sciences, University of California, Berkeley 94720, USA
    J Nutr 132:2033-6. 2002
    ..The results suggest that changes in lymphocyte proliferation and IL-2R expression may be early markers of mild zinc deficiency...
  32. ncbi request reprint The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans
    G J Nelson
    Western Human Nutrition Research Center, ARS, USDA, San Francisco, California 94129, USA
    Lipids 32:1129-36. 1997
    ....
  33. ncbi request reprint The effect of conjugated linoleic acid on plasma lipoproteins and tissue fatty acid composition in humans
    P Benito
    Western Human Nutrition Research Center, USDA, One Shields Ave, University of California, Davis, CA 95616, USA
    Lipids 36:229-36. 2001
    ..The supplementation did increase CLA in the plasma but only 4.23% of the ingested CLA was present in the plasma at any given time. No adverse effect of CLA supplementation was detected in this study...
  34. ncbi request reprint Docosahexaenoic Acid (DHA) But Not Eicosapentaenoic Acid (EPA) Prevents Trans-10, Cis-12 Conjugated Linoleic Acid (CLA)-Induced Insulin Resistance in Mice
    Madhuri Vemuri
    Western Human Nutrition Research Center, ARS, USDA, and Department of Nutrition, University of California, Davis, California
    Metab Syndr Relat Disord 5:315-22. 2007
    ..These findings may have clinical implications in the dietary management of patients at risk of insulin resistance and diabetes...
  35. ncbi request reprint Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men
    Judith R Turnlund
    US Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis 95616, USA
    Am J Clin Nutr 79:1037-44. 2004
    ..Short-term high copper intake does not appear to affect indexes of copper status or functions related to copper status, but the effects of long-term high copper intake are unknown...
  36. ncbi request reprint Regulation of cellular differentiation and apoptosis by fatty acids and their metabolites
    I L Rudolph
    Western Human Nutrition Research Center, ARS, USDA, Department of Nutrition, University of California, Davis, CA 95616, USA
    Nutr Res 21:381-93. 2001
    ..Studies using the physiological concentrations of the fatty acids and standardized experimental conditions need to be conducted to establish effects of fatty acids and their metabolites on these cellular processes...
  37. ncbi request reprint The innate immune system: friend and foe
    Charles B Stephensen
    Am J Clin Nutr 83:187-8. 2006