Darshan S Kelley

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. ncbi Sweet bing cherries lower circulating concentrations of markers for chronic inflammatory diseases in healthy humans
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, USDA, USA
    J Nutr 143:340-4. 2013
  2. ncbi Docosahexaenoic acid supplementation improved lipocentric but not glucocentric markers of insulin sensitivity in hypertriglyceridemic men
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, and Department of Nutrition, University of California, Davis, California 95616, USA
    Metab Syndr Relat Disord 10:32-8. 2012
  3. ncbi Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects
    Darshan S Kelley
    Western Human Nutrition Research Center, ARS, USDA, Department of Nutrition, University of California Davis, CA 95616, USA
    Proc Nutr Soc 71:322-31. 2012
  4. ncbi DHA supplementation decreases serum C-reactive protein and other markers of inflammation in hypertriglyceridemic men
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, USDA, and Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 139:495-501. 2009
  5. ncbi Flaxseed oil prevents trans-10, cis-12-conjugated linoleic acid-induced insulin resistance in mice
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, and Department of Nutrition, University of California Davis, 430 West Health Sciences Drive, Davis, CA 95616, USA
    Br J Nutr 101:701-8. 2009
  6. ncbi Docosahexaenoic acid supplementation decreases remnant-like particle-cholesterol and increases the (n-3) index in hypertriglyceridemic men
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, USDA and Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 138:30-5. 2008
  7. ncbi Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, University of California Davis, CA 95616 8683, USA
    Am J Clin Nutr 86:324-33. 2007
  8. ncbi Consumption of Bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and women
    Darshan S Kelley
    U S Department of Agriculture ARS, Western Regional Research Center, Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 136:981-6. 2006
  9. ncbi Docosahexaenoic acid prevents trans-10, cis-12-conjugated linoleic acid-induced nonalcoholic fatty liver disease in mice by altering expression of hepatic genes regulating fatty acid synthesis and oxidation
    Dawn M Fedor
    Western Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture and Department of Nutrition, University of California Davis, Davis, CA 95616, USA
    Metab Syndr Relat Disord 10:175-80. 2012
  10. ncbi Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids
    Yuriko Adkins
    Western Human Nutrition Research Center, ARS, USDA, University of California Davis, CA 95616, USA
    J Nutr Biochem 21:781-92. 2010

Collaborators

Detail Information

Publications22

  1. ncbi Sweet bing cherries lower circulating concentrations of markers for chronic inflammatory diseases in healthy humans
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, USDA, USA
    J Nutr 143:340-4. 2013
    ..However, results from the present study demonstrate that cherry consumption selectively reduced several biomarkers associated with inflammatory diseases...
  2. ncbi Docosahexaenoic acid supplementation improved lipocentric but not glucocentric markers of insulin sensitivity in hypertriglyceridemic men
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, and Department of Nutrition, University of California, Davis, California 95616, USA
    Metab Syndr Relat Disord 10:32-8. 2012
    ..Results from some human and animal studies suggest that docosahexaenoic acid (22:6n-3; DHA) may be more effective than eicosapentaenoic acid (20:5n-3; EPA) in the prevention of IR...
  3. ncbi Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects
    Darshan S Kelley
    Western Human Nutrition Research Center, ARS, USDA, Department of Nutrition, University of California Davis, CA 95616, USA
    Proc Nutr Soc 71:322-31. 2012
    ..In conclusion, n-3 PUFA decreased several risk factors for atherosclerosis without any serious adverse effects...
  4. ncbi DHA supplementation decreases serum C-reactive protein and other markers of inflammation in hypertriglyceridemic men
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, USDA, and Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 139:495-501. 2009
    ..The mean size of VLDL particles was positively associated with plasma concentrations of neutrophils and CRP. In conclusion, DHA may lessen the inflammatory response by altering blood lipids and their fatty acid composition...
  5. ncbi Flaxseed oil prevents trans-10, cis-12-conjugated linoleic acid-induced insulin resistance in mice
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, and Department of Nutrition, University of California Davis, 430 West Health Sciences Drive, Davis, CA 95616, USA
    Br J Nutr 101:701-8. 2009
    ..The present results suggest that some adverse effects of CLA may be due to n-3 PUFA deficiency and that these can be corrected by a concomitant increase in the intake of alpha-linolenic acid, 18 : 3n-3...
  6. ncbi Docosahexaenoic acid supplementation decreases remnant-like particle-cholesterol and increases the (n-3) index in hypertriglyceridemic men
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, USDA and Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 138:30-5. 2008
    ..30), and HDL-C:Apo A (r = -0.25). Supplementation with placebo oil did not alter any of the response variables tested. Decreased atherogenic RLP-C and increased cardio-protective (n-3) index may improve cardio-vascular health...
  7. ncbi Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men
    Darshan S Kelley
    Western Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, University of California Davis, CA 95616 8683, USA
    Am J Clin Nutr 86:324-33. 2007
    ..The effects of docosahexaenoic acid (DHA) on the mean size and concentrations of VLDL, LDL, and HDL subclasses have not been previously studied...
  8. ncbi Consumption of Bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and women
    Darshan S Kelley
    U S Department of Agriculture ARS, Western Regional Research Center, Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 136:981-6. 2006
    ..Results of the present study suggest a selective modulatory effect of sweet cherries on CRP, NO, and RANTES. Such anti-inflammatory effects may be beneficial for the management and prevention of inflammatory diseases...
  9. ncbi Docosahexaenoic acid prevents trans-10, cis-12-conjugated linoleic acid-induced nonalcoholic fatty liver disease in mice by altering expression of hepatic genes regulating fatty acid synthesis and oxidation
    Dawn M Fedor
    Western Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture and Department of Nutrition, University of California Davis, Davis, CA 95616, USA
    Metab Syndr Relat Disord 10:175-80. 2012
    ..The effective dose of DHA and mechanisms involved are poorly understood...
  10. ncbi Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids
    Yuriko Adkins
    Western Human Nutrition Research Center, ARS, USDA, University of California Davis, CA 95616, USA
    J Nutr Biochem 21:781-92. 2010
    ..This review examines the various mechanisms by which n-3 PUFA exert beneficial effects against CVD...
  11. ncbi Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, USA
    Br J Nutr 108:900-9. 2012
    ..Dietary strawberry powder reduced risk factors for CVD, stroke and diabetes in obese volunteers, suggesting a potential role for strawberries as a dietary means to decrease obesity-related disease...
  12. ncbi Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans
    Patrice Armstrong
    USDA Western Human Nutrition Research Center, Davis, CA, USA
    J Nutr 142:1417-28. 2012
    ..No changes were seen in LDL particle or cholesterol concentrations, heart rate, or blood pressure. These findings indicate that the efficacy of FO supplements vary by ALOX5 genotype...
  13. ncbi Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men
    Kevin Dawson
    Center of Excellence in Nutritional Genomics, University of California Davis, Davis, CA 95616, USA
    J Nutr Biochem 23:616-21. 2012
    ..These results provide supporting evidence for the anti-inflammatory effects of DHA supplementation, and reveal previously unrecognized genes that are regulated by DHA and are associated with risk factors of cardiovascular diseases...
  14. ncbi Fatty acid composition of liver, adipose tissue, spleen, and heart of mice fed diets containing t10, c12-, and c9, t11-conjugated linoleic acid
    Darshan S Kelley
    Western Human Nutrition Research Center, ARS, USDA, and Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616, USA
    Prostaglandins Leukot Essent Fatty Acids 74:331-8. 2006
    ..The functional consequences of such changes in tissue fatty acid composition need to be investigated...
  15. ncbi Dietary trans 10, cis 12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver
    Reuven Rasooly
    Western Human Nutrition Research Center, ARS, USDA, Davis, CA, USA
    Br J Nutr 97:58-66. 2007
    ..Since FMO and cyt P450 are also involved in drug detoxification, suppression of the transcription of these genes by CLA may have other health consequences besides development of fatty liver...
  16. ncbi Prevention of insulin resistance by n-3 polyunsaturated fatty acids
    Dawn Fedor
    Western Human Nutrition Research Center, ARS, USDA Department of Nutrition, University of California, Davis, California 95616, USA
    Curr Opin Clin Nutr Metab Care 12:138-46. 2009
    ..Review results from recent human and animal studies regarding the effects of n-3 polyunsaturated fatty acid (PUFA) in the prevention of insulin resistance...
  17. ncbi The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle
    Dawn M Fedor
    Western Human Nutrition Research Center, ARS, USDA and Department of Nutrition, University of California Davis, Davis, California, USA
    Metab Syndr Relat Disord 11:63-70. 2013
    ..The effect of CLA on fatty acid compositions of adipose tissue and muscle and whether DHA can prevent those CLA-induced changes in fatty acid composition is not known...
  18. ncbi Docosahexaenoic Acid (DHA) But Not Eicosapentaenoic Acid (EPA) Prevents Trans-10, Cis-12 Conjugated Linoleic Acid (CLA)-Induced Insulin Resistance in Mice
    Madhuri Vemuri
    Western Human Nutrition Research Center, ARS, USDA, and Department of Nutrition, University of California, Davis, California
    Metab Syndr Relat Disord 5:315-22. 2007
    ..These findings may have clinical implications in the dietary management of patients at risk of insulin resistance and diabetes...
  19. ncbi Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men
    Judith R Turnlund
    US Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis 95616, USA
    Am J Clin Nutr 79:1037-44. 2004
    ..Short-term high copper intake does not appear to affect indexes of copper status or functions related to copper status, but the effects of long-term high copper intake are unknown...
  20. ncbi Consumption of cherries lowers plasma urate in healthy women
    Robert A Jacob
    U S Department of Agriculture ARS Western Human Nutrition Research Center, University of California at Davis, Davis, CA 95616, USA
    J Nutr 133:1826-9. 2003
    ..The trend toward decreased inflammatory indices (CRP and NO) adds to the in vitro evidence that compounds in cherries may inhibit inflammatory pathways...
  21. ncbi Immune functions are maintained in healthy men with low zinc intake
    Kathryn Pinna
    Department of Nutritional Sciences, University of California, Berkeley 94720, USA
    J Nutr 132:2033-6. 2002
    ..The results suggest that changes in lymphocyte proliferation and IL-2R expression may be early markers of mild zinc deficiency...
  22. ncbi The innate immune system: friend and foe
    Charles B Stephensen
    Am J Clin Nutr 83:187-8. 2006