Research Topics
Species | James A JosephSummaryAffiliation: Agricultural Research Service Country: USA Publications
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Publications
Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of agingJames A Joseph
US Department of Agriculture, Agricultural Research Service, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
J Agric Food Chem 56:10544-51. 2008..Results indicated that pterostilbene was effective in reversing cognitive behavioral deficits, as well as dopamine release, and working memory was correlated with pterostilbene levels in the hippocampus...- Grape juice, berries, and walnuts affect brain aging and behaviorJames A Joseph
USDA Agricultural Research Service, Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 139:1813S-7S. 2009..Taken together, these results suggest that a greater intake of high-antioxidant foods such as berries, Concord grapes, and walnuts may increase "health span" and enhance cognitive and motor function in aging... - Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampusBarbara Shukitt-Hale
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Nutr Neurosci 11:172-82. 2008..These results indicate that blueberry polyphenols attenuate learning impairments following neurotoxic insult and exert anti-inflammatory actions, perhaps via alteration of gene expression... - Effects of blackberries on motor and cognitive function in aged ratsBarbara Shukitt-Hale
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Nutr Neurosci 12:135-40. 2009..These data support our previous investigations in which we have seen improved motor and cognitive performance in aged rats after supplementation with other berry fruits... 
Effects of Concord grape juice on cognitive and motor deficits in agingBarbara Shukitt-Hale
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
Nutrition 22:295-302. 2006....- Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated agingBarbara Shukitt-Hale
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States
Neurobiol Aging 28:1187-94. 2007..These data suggest that (56)Fe particle irradiation causes deficits in behavior and signaling in rats which were ameliorated by an antioxidant diet and that the polyphenols in these fruits might be acting in different brain regions... 
Differential protection among fractionated blueberry polyphenolic families against DA-, Abeta(42)- and LPS-induced decrements in Ca(2+) buffering in primary hippocampal cellsJames A Joseph
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Agric Food Chem 58:8196-204. 2010..Thus, these results suggest that, except for a few instances, the lesser the polyphenolic fractionation, the greater the effects, especially with respect to prevention of ROS and stress signal generation and viability...- Recent advances in berry supplementation and age-related cognitive declineLAUREN M WILLIS
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Curr Opin Clin Nutr Metab Care 12:91-4. 2009..To summarize recent findings and current concepts in the beneficial effects of berry consumption on brain function during aging... - Blueberry antagonism of C-2 ceramide disruption of Ca2+ responses and recovery in MAChR-transfected COS-7 cellJames A Joseph
USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
J Alzheimers Dis 15:429-41. 2008..Results are discussed in terms of the effects on lipid induced changes in plasma membranes... - Walnut extract inhibits LPS-induced activation of BV-2 microglia via internalization of TLR4: possible involvement of phospholipase D2LAUREN M WILLIS
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Inflammation 33:325-33. 2010..These studies represent the first to describe the anti-inflammatory effects of walnuts in microglia, which could lead to nutritional interventions in the prevention and treatment of neurodegeneration... - Plum juice, but not dried plum powder, is effective in mitigating cognitive deficits in aged ratsBarbara Shukitt-Hale
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
Nutrition 25:567-73. 2009..The objective of this study was to investigate supplementation with Prunus domestica L. in mitigating age-related deficits in cognitive function... - Fruit polyphenols and their effects on neuronal signaling and behavior in senescenceJames A Joseph
Tufts University, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Rm 919, Boston, MA 02111, USA
Ann N Y Acad Sci 1100:470-85. 2007..The purpose of this article is to discuss the benefits of these interventions in rodent models and to describe the putative molecular mechanisms involved in their benefits... - Dose-dependent effects of walnuts on motor and cognitive function in aged ratsLAUREN M WILLIS
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Br J Nutr 101:1140-4. 2009..These findings show for the first time that moderate dietary walnut supplementation can improve cognitive and motor performance in aged rats... - Modulation of cognition and behavior in aged animals: role for antioxidant- and essential fatty acid-rich plant foodsLAUREN M WILLIS
US Department of Agriculture, Agricultural Research Service, Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
Am J Clin Nutr 89:1602S-1606S. 2009.... - Nutritional intervention in brain aging: reducing the effects of inflammation and oxidative stressFrancis C Lau
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
Subcell Biochem 42:299-318. 2007..Thus, nutritional intervention may exert therapeutic protection against age-related deficits and neurodegenerative diseases... - Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microgliaFrancis C Lau
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
J Neurosci Res 85:1010-7. 2007..The results suggest that blueberry polyphenols attenuate inflammatory responses of brain microglia and could be potentially useful in modulation of inflammatory conditions in the CNS... - Blueberry treatment antagonizes C-2 ceramide-induced stress signaling in muscarinic receptor-transfected COS-7 cellsJames A Joseph
USDA HNRCA at Tufts University, Boston, Massachusetts 02111, USA
J Agric Food Chem 58:3380-92. 2010..We are exploring these interactions further, but it is clear that increases in ceramide, to the same levels as are seen in aging, can have profound effects on calcium clearance and signaling during oxidative stress... - Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compoundsJames A Joseph
US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, and the Institute of Pathology, Case Western Reserve University, Cleveland, USA
Am J Clin Nutr 81:313S-316S. 2005.... - The M3 muscarinic receptor i3 domain confers oxidative stress protection on calcium regulation in transfected COS-7 cellsJames A Joseph
USDA HNRC, Tufts University, Boston, MA 02111, USA
Aging Cell 3:263-71. 2004..Results suggest that the longer i3 loop of the M3 may decrease OSS, possibly playing a role in targeting antioxidants to specific receptor sites that impart OSS... - Berry fruit supplementation and the aging brainBarbara Shukitt-Hale
USDA ARS Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
J Agric Food Chem 56:636-41. 2008..The purpose of this paper is to discuss the benefits of these interventions in rodent models and to describe the putative molecular mechanisms involved in their benefits... - Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotectionRachel L Galli
Neuroscience Laboratory, USDA-ARS Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
Neurobiol Aging 27:344-50. 2006..Results are discussed in terms of the multiplicity of the effects of the BB supplementation which appear to range from antioxidant/anti-inflammatory activity to signaling... - Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged ratsGemma Casadesus
USDA, HNRC on Aging at Tufts University, Boston, MA, USA
Nutr Neurosci 7:309-16. 2004..Therefore, cognitive improvements afforded by polyphenolic-rich fruits such as blueberries appear, in part, to be mediated by their effects on hippocampal plasticity... - Fruit extracts antagonize Abeta- or DA-induced deficits in Ca2+ flux in M1-transfected COS-7 cellsJames A Joseph
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Alzheimers Dis 6:403-11; discussion 443-9. 2004..Interestingly, assessments of DA-induced decrements in viability revealed that all of the extracts had some protective effects. These findings suggest that the putative toxic effects of Abeta or DA might be reduced by HA fruit extracts... - Age-related changes in neutral sphingomyelin-specific phospholipase C activity in striatum, hippocampus, and frontal cortex: implication for sensitivity to stress and inflammationNatalia A Crivello
Nutrition and Neurocognition Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Neurochem Int 47:573-9. 2005..1.4.12; N-Sase), a key enzyme of sphingolipid metabolism and sphingolipid-induced signaling... - Hippocampal neurogenesis and PSA-NCAM expression following exposure to 56Fe particles mimics that seen during aging in ratsGemma Casadesus
VSDA, HNRC on Aging, Tufts University, Boston, MA, USA
Exp Gerontol 40:249-54. 2005..Additionally, irradiated subjects show decreased levels of PSA-NCAM expression. These changes are consistent with those found in aged subjects indicating that heavy-particle irradiation is an adequate model for the study of aging... - The beneficial effects of fruit polyphenols on brain agingFrancis C Lau
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Neurobiol Aging 26:128-32. 2005..Furthermore, we have shown that short-term blueberry (BB) supplementation increases hippocampal plasticity. These findings are briefly reviewed in this paper... - Fruit polyphenolics and brain aging: nutritional interventions targeting age-related neuronal and behavioral deficitsRachel L Galli
USDA ARS, HNRCA at Tufts University, Boston, Massachusetts 02111, USA
Ann N Y Acad Sci 959:128-32. 2002.... - Aging modifies brain region-specific vulnerability to experimental oxidative stress induced by low dose hydrogen peroxideNatalia A Crivello
Nutrition and Neurocognition Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA
Age (Dordr) 29:191-203. 2007.... - Short-term nutritional folate deficiency in rats has a greater effect on choline and acetylcholine metabolism in the peripheral nervous system than in the brain, and this effect escalates with ageNatalia A Crivello
Nutrition and Neurocognition Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging JM USDA HNRCA at Tufts University, Boston, MA 02111, USA
Nutr Res 30:722-30. 2010.... - Effect of age on the radial arm water maze-a test of spatial learning and memoryBarbara Shukitt-Hale
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Neurobiol Aging 25:223-9. 2004..The RAWM is a reliable, sensitive, and powerful additional test to assess age-related spatial learning and memory deficits, combining the advantages of the Morris water maze and the radial arm maze while minimizing the disadvantages... - Dopamine neurotoxicity: age-dependent behavioral and histological effectsIppolita Cantuti-Castelvetri
USDA Human Nutrition Research Center on Aging at Tufts University, Room 919, 711 Washington Street, Boston, MA 02111, USA
Neurobiol Aging 24:697-706. 2003..These results suggest that a neurochemical deficit and not cell loss per se within the nigrostriatal system underlies the motor behavioral deficits observed in the middle-aged rats... - Qualitative versus quantitative caloric intake: are they equivalent paths to successful aging?Gemma Casadesus
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Rm 919, Boston, MA 02111, USA
Neurobiol Aging 23:747-69. 2002..The two interventions will be compared and contrasted in terms of their effectiveness, safety, and generalization capacity for human treatment... - Dietary polyunsaturated fatty acids improve cholinergic transmission in the aged brainLauren Meredith Willis
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA
Genes Nutr 4:309-14. 2009..The data reviewed herein indicate that, at least in animal studies, inclusion of PUFAs in the diet can improve cholinergic transmission in the brain, possibly leading to improvements in cognitive functioning... - The nitrone spin trap PBN alters the cellular response to H(2)O(2): activation of the EGF receptor/ERK pathwayWaleed N Hassan
Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Free Radic Biol Med 32:551-61. 2002..These data suggest a model in which PBN attenuates H(2)O(2)-induced Ca(+2) entry, yet magnifies or alters Ca(+2) action, resulting in the activation of the EGF receptor/ERK pathway...