Liping Huang

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. ncbi request reprint The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus
    Liping Huang
    Agricultural Research Service, United States Department of Agriculture, Western Human Nutrition Research Center, University of California at Davis, 95616, USA
    J Biol Chem 280:15456-63. 2005
  2. ncbi request reprint A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein
    Liping Huang
    United States Department of Agriculture, Agriculture Research Service, Western Human Nutrition Research Center, Davis, CA, USA
    FEBS J 274:3986-97. 2007
  3. ncbi request reprint Functional characterization of a novel mammalian zinc transporter, ZnT6
    Liping Huang
    Western Human Nutrition Research Center Agriculture Research Service United States Department of Agriculture and the Department of Nutrition and the Rowe Program in Genetics, University of California, Davis, California 95616, USA
    J Biol Chem 277:26389-95. 2002
  4. pmc Znt7-null mice are more susceptible to diet-induced glucose intolerance and insulin resistance
    Liping Huang
    United States Department of Agriculture Agricultural Research Service Western Human Nutrition Research Center, Obesity and Metabolism Research Unit, Davis, California 95616, USA
    J Biol Chem 287:33883-96. 2012
  5. ncbi request reprint Znt7 (Slc30a7)-deficient mice display reduced body zinc status and body fat accumulation
    Liping Huang
    United States Department of Agriculture Agriculture Research Service Western Human Nutrition Research Center, Rowe Program in Genetics, University of California, Davis, California 95616, USA
    J Biol Chem 282:37053-63. 2007
  6. ncbi request reprint ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus
    Catherine P Kirschke
    Western Human Nutrition Research Center, Agriculture Research Service, United States Department of Agriculture, Davis, California 95616, USA
    J Biol Chem 278:4096-102. 2003
  7. doi request reprint The SLC30 family of zinc transporters - a review of current understanding of their biological and pathophysiological roles
    Liping Huang
    USDA ARS Western Human Nutrition Research Center and Department of Nutrition, University of California Davis, 430 West Health Sciences Drive, Davis, CA 95616, USA
    Mol Aspects Med 34:548-60. 2013
  8. ncbi request reprint Immunohistochemical analysis of ZnT1, 4, 5, 6, and 7 in the mouse gastrointestinal tract
    Yan Yiu Yu
    Department of Nutrition, University of California at Davis, Davis, California, USA
    J Histochem Cytochem 55:223-34. 2007
  9. ncbi request reprint Investigation of lymphocyte gene expression for use as biomarkers for zinc status in humans
    Karl B Andree
    Western Human Nutrition Research Center, Agriculture Research Service, U S Department of Agriculture, USA
    J Nutr 134:1716-23. 2004
  10. ncbi request reprint Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription
    Liping Huang
    USDA, ARS, Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, USA
    Exp Cell Res 316:2630-43. 2010

Collaborators

Detail Information

Publications39

  1. ncbi request reprint The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus
    Liping Huang
    Agricultural Research Service, United States Department of Agriculture, Western Human Nutrition Research Center, University of California at Davis, 95616, USA
    J Biol Chem 280:15456-63. 2005
    ..Our study demonstrates that ZIP7 is a functional zinc transporter that acts by transporting zinc from the Golgi apparatus to the cytoplasm of the cell...
  2. ncbi request reprint A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein
    Liping Huang
    United States Department of Agriculture, Agriculture Research Service, Western Human Nutrition Research Center, Davis, CA, USA
    FEBS J 274:3986-97. 2007
    ....
  3. ncbi request reprint Functional characterization of a novel mammalian zinc transporter, ZnT6
    Liping Huang
    Western Human Nutrition Research Center Agriculture Research Service United States Department of Agriculture and the Department of Nutrition and the Rowe Program in Genetics, University of California, Davis, California 95616, USA
    J Biol Chem 277:26389-95. 2002
    ..The results from this report, combined with those from other studies, suggest that the intracellular zinc homeostasis is mediated by many ZnT proteins, which act in tissue-, cell-, and organelle-specific manners...
  4. pmc Znt7-null mice are more susceptible to diet-induced glucose intolerance and insulin resistance
    Liping Huang
    United States Department of Agriculture Agricultural Research Service Western Human Nutrition Research Center, Obesity and Metabolism Research Unit, Davis, California 95616, USA
    J Biol Chem 287:33883-96. 2012
    ..We conclude that a combination of decreased insulin secretion and increased insulin resistance accounts for the glucose intolerance observed in Znt7 KO mice...
  5. ncbi request reprint Znt7 (Slc30a7)-deficient mice display reduced body zinc status and body fat accumulation
    Liping Huang
    United States Department of Agriculture Agriculture Research Service Western Human Nutrition Research Center, Rowe Program in Genetics, University of California, Davis, California 95616, USA
    J Biol Chem 282:37053-63. 2007
    ..Furthermore, the reduced body weight gain of the mutant mice was largely due to the decrease in body fat accumulation. We conclude that ZNT7 has essential functions in dietary zinc absorption and in regulation of body adiposity...
  6. ncbi request reprint ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus
    Catherine P Kirschke
    Western Human Nutrition Research Center, Agriculture Research Service, United States Department of Agriculture, Davis, California 95616, USA
    J Biol Chem 278:4096-102. 2003
    ..Exposure of the ZnT7-expressing Chinese hamster ovary (CHO) cells to zinc causes an accumulation of zinc in the Golgi apparatus, suggesting that ZnT7 facilitates zinc transport from the cytoplasm into the Golgi apparatus...
  7. doi request reprint The SLC30 family of zinc transporters - a review of current understanding of their biological and pathophysiological roles
    Liping Huang
    USDA ARS Western Human Nutrition Research Center and Department of Nutrition, University of California Davis, 430 West Health Sciences Drive, Davis, CA 95616, USA
    Mol Aspects Med 34:548-60. 2013
    ..Ten members of the ZnT family have been identified so far. Here we give a review of these advances and discuss the pathological implications and future preventive or therapeutic applications of ZnTs...
  8. ncbi request reprint Immunohistochemical analysis of ZnT1, 4, 5, 6, and 7 in the mouse gastrointestinal tract
    Yan Yiu Yu
    Department of Nutrition, University of California at Davis, Davis, California, USA
    J Histochem Cytochem 55:223-34. 2007
    ..Expression of ZnT proteins in the absorptive epithelial cell of the gastrointestinal tract suggests that ZnT proteins may play important roles in zinc absorption and endogenous zinc secretion...
  9. ncbi request reprint Investigation of lymphocyte gene expression for use as biomarkers for zinc status in humans
    Karl B Andree
    Western Human Nutrition Research Center, Agriculture Research Service, U S Department of Agriculture, USA
    J Nutr 134:1716-23. 2004
    ..ZNT1 expression was not affected by taking the zinc supplement. These data suggest a potential application of ZIP1 as a biomarker of zinc status in humans...
  10. ncbi request reprint Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription
    Liping Huang
    USDA, ARS, Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, USA
    Exp Cell Res 316:2630-43. 2010
    ..Together, the data strongly suggest that ZnT7 plays an important role in regulating insulin expression by modulating Mtf1 transcriptional activity...
  11. doi request reprint Dietary strawberry powder reduces blood glucose concentrations in obese and lean C57BL/6 mice, and selectively lowers plasma C-reactive protein in lean mice
    Mardi A Parelman
    Department of Nutrition, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Br J Nutr 108:1789-99. 2012
    ..These results, although modest, support a promising role for dietary strawberries in reducing the risks associated with obesity and diabetes, and regulating the levels of inflammatory markers in non-obese individuals...
  12. ncbi request reprint Expression of the ZNT (SLC30) family members in the epithelium of the mouse prostate during sexual maturation
    Catherine P Kirschke
    USDA, ARS, Western Human Nutrition Research Center, UC Davis, 430 West Health Sciences Drive, Davis, CA, 95616, USA
    J Mol Histol 39:359-70. 2008
    ....
  13. doi request reprint A null-mutation in the Znt7 gene accelerates prostate tumor formation in a transgenic adenocarcinoma mouse prostate model
    Surapun Tepaamorndech
    Genetics Graduate Group, University of California at Davis, 95616, United States
    Cancer Lett 308:33-42. 2011
    ..Furthermore, apoptosis was reduced in the prostates of TRAMP/Znt7(-/-) mice. In conclusion, a null-mutation of the Znt7 gene accelerates prostate tumor formation in TRAMP mice...
  14. ncbi request reprint Linking cellular zinc status to body weight and fat mass: mapping quantitative trait loci in Znt7 knockout mice
    Surapun Tepaamorndech
    Integrative Genetics and Genomics Graduate Group, University of California Davis, One Shields Avenue, Davis, CA, 95616, USA
    Mamm Genome 25:335-53. 2014
    ..63) for body weight and fat accumulation were detected in Znt7 KO and WT mice. In conclusion, the QTLs identified in this study may provide new hints to uncover the genes linking cellular zinc status to growth and body fat accumulation. ..
  15. pmc Differential expression of thrombospondin (THBS1) in tumorigenic and nontumorigenic prostate epithelial cells in response to a chromatin-binding soy peptide
    Alfredo F Galvez
    Center of Excellence in Nutritional Genomics, Department of Molecular and Cellular Biology, University of California Davis, Davis, California 95616, USA
    Nutr Cancer 63:623-36. 2011
    ..Histone hypoacetylation and DNA hypermethylation in the 5' region of THBS1 may explain the inability of lunasin to upregulate this gene in RWPE-2 cells...
  16. ncbi request reprint Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney
    Alaa S Awad
    Department of Medicine, Univ of Virginia, Charlottesville, VA, USA
    Am J Physiol Renal Physiol 290:F1516-24. 2006
    ..The mechanism of protection is not known but may be related to peripheral lymphocyte depletion or direct effects on kidney cells expressing S1P1 receptor...
  17. ncbi request reprint Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers
    Richard D Palmiter
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195, USA
    Pflugers Arch 447:744-51. 2004
    ..No mutations in human counterparts of any of the members of the SLC30 family have been described...
  18. pmc Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cells
    Yuan Ji Day
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 112:883-91. 2003
    ..We conclude that protection from renal IRI by A2AR agonists or endogenous adenosine requires activation of receptors expressed on BM-derived cells...
  19. ncbi request reprint Protection from ischemic liver injury by activation of A2A adenosine receptors during reperfusion: inhibition of chemokine induction
    Yuan Ji Day
    Department of Internal Medicine, Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Gastrointest Liver Physiol 286:G285-93. 2004
    ..We speculate that inhibition of chemokine and cytokine production limits inflammation and contributes to tissue protection by the A(2A)AR agonist ATL146e...
  20. doi request reprint Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain
    Li Hong Zhang
    Department of Histology and Embryology, China Medical University, Shenyang 110001, PR China
    Brain Res Bull 77:55-60. 2008
    ..In conclusion, our data provided significant morphological evidence of zinc ions and ZNTs being actively involved in the pathological processes that lead to plaque formation...
  21. ncbi request reprint Expression of zinc transporter ZnT7 in mouse superior cervical ganglion
    Hui Ling Gao
    Department of Histology and Embryology, China Medical University, Shenyang 110001, PR China
    Auton Neurosci 140:59-65. 2008
    ..These observations support the notion that ZnT7 may participate in zinc transport, storage, and incorporation of zinc into zinc-binding proteins in the Golgi apparatus of mouse SCG neurons...
  22. ncbi request reprint The cellular and subcellular localization of zinc transporter 7 in the mouse spinal cord
    Zhi Hong Chi
    Department of Histology and Embryology, China Medical University, Shenyang, China
    Histol Histopathol 23:781-7. 2008
    ..The present study supports the notion that ZNT7 may function to supply zinc ions to the newly synthesized metalloproteins in the secretory pathway of the spinal neuron and the ependyma cell...
  23. ncbi request reprint Imunoreactivity of zinc transporter 7 (ZNT7) in mouse dorsal root ganglia
    Li Zhang
    Department of Histology and Embryology, China Medical University, Shenyang 110001, PR China
    Brain Res Bull 74:278-83. 2007
    ..These observations strongly suggest that ZNT7 may play an important role in facilitating zinc transport into the Golgi apparatus from the cytosol in the mouse DRG...
  24. ncbi request reprint Abundant expression of zinc transporters in Bergman glia of mouse cerebellum
    Zhan You Wang
    Department of Histology and Embryology, China Medical University, 92 Bei Er Road, Heping District, Shenyang 110001, PR China
    Brain Res Bull 64:441-8. 2005
    ..ZnT6 was undetectable in either the cell bodies or processes in the granular layer. The present results indicate that the Bergman glial cells may play an important role in zinc metabolism in the mouse cerebellar cortex...
  25. ncbi request reprint Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: the role of CD4+ T cells and IFN-gamma
    Yuan Ji Day
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 176:3108-14. 2006
    ..These studies demonstrate that CD4+ IFN-gamma contributes to IRI and that A(2A) agonists mediate protection from IRI through action on CD4+ cells...
  26. ncbi request reprint Localization of ZnT7 and zinc ions in mouse retina--immunohistochemistry and selenium autometallography
    Xin Wang
    Department of Histology and Embryology, China Medical University, Shenyang 110001, PR China
    Brain Res Bull 71:91-6. 2006
    ..These observations strongly suggest that ZnT7 may play critical roles in retinal zinc homeostasis and that chelatable zinc pools may have multiple functions in the retina...
  27. ncbi request reprint NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury
    Li Li
    Department of Medicine, Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 178:5899-911. 2007
    ..The results support the essential role of NKT cells and neutrophils in the innate immune response of renal IRI by mediating neutrophil infiltration and production of IFN-gamma...
  28. ncbi request reprint Cellular and molecular characterization of oxidative stress in olfactory epithelium of Harlequin mutant mouse
    Radhika A Vaishnav
    Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    J Neurosci Res 86:165-82. 2008
    ..Our results strongly support the Hq/Y mutant mouse being a novel model for mechanistic studies of oxidative stress-associated olfactory aging...
  29. ncbi request reprint Selective blockade of lysophosphatidic acid LPA3 receptors reduces murine renal ischemia-reperfusion injury
    Mark D Okusa
    Department of Medicine, University of Virginia, Charlottesville 22908, USA
    Am J Physiol Renal Physiol 285:F565-74. 2003
    ..We conclude that VPC-12249 reduces renal I/R injury predominantly by LPA3 receptor blockade and could serve as a novel compound in the treatment of ischemia acute renal failure...
  30. ncbi request reprint Serologic analysis of anti-porcine endogenous retroviruses immune responses in humans after ex vivo transgenic pig liver perfusion
    Hui Xu
    Nextran Inc, Princeton, NJ 08540, USA
    ASAIO J 49:407-16. 2003
    ..However, analysis of patient serum samples over a 3 to 4 year period has showed no evidence of an immune response to PERV antigens, suggesting a lack of PERV infection...
  31. ncbi request reprint Adenosine A2A receptor activation attenuates inflammation and injury in diabetic nephropathy
    Alaa S Awad
    Department of Medicine, University of Virginia, Charlottesville, USA
    Am J Physiol Renal Physiol 290:F828-37. 2006
    ..These results demonstrate that chronic A(2A)R activation in diabetic rats 1) ameliorates histological and functional changes in kidneys induced by diabetes and 2) causes reduced inflammation associated with diabetic nephropathy...
  32. ncbi request reprint Linear free energy relationships on rate constants for the gas-phase reactions of hydroxyl radicals with PAHs and PCDD/Fs
    Chunli Yan
    Department of Environmental Science and Technology, Dalian University of Technology, Linggong Road 2, Dalian Liaoning Province 116024, PR China
    Chemosphere 61:1523-8. 2005
    ..PAH and PCDD/F molecules with high E(HOMO) and low qH(+) and qC values tend to have high log kOH values. The LFER model indicates the temperature dependence of log kOH is weak...
  33. ncbi request reprint Quantitative structure-property relationships on photolysis of PCDD/Fs adsorbed to spruce (Picea abies (L.) Karst.) needle surfaces under sunlight irradiation
    Junfeng Niu
    Department of Environmental Science and Engineering, POPs Research Center, Tsinghua University, Beijing 100084, PR China
    Chemosphere 58:917-24. 2005
    ..Increasing the number of chlorine atoms and (E(LUMO)-E(HOMO))2 values leads to increase of logt1/2 values of PCDFs...
  34. ncbi request reprint Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages
    Yuan Ji Day
    Div of Nephrology, Box 133, Univ of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 288:F722-31. 2005
    ..We conclude that the full extent of IRI requires macrophages and that A(2A) agonist-mediated tissue protection is independent of activation of macrophage A(2A)Rs...
  35. pmc A novel application of quantile regression for identification of biomarkers exemplified by equine cartilage microarray data
    Liping Huang
    Department of Statistics, 815 Patterson Office Tower, University of Kentucky, Lexington, Kentucky 40508 0027, USA
    BMC Bioinformatics 9:300. 2008
    ..Related experiments can be done to identify tissue-restricted biomarkers, genes with a high level of expression in one tissue compared to other tissue types in the body...
  36. ncbi request reprint Dynamic zinc pools in mouse choroid plexus
    Zhan You Wang
    Department of Neurobiology, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Denmark
    Neuroreport 15:1801-4. 2004
    ..The observations suggests that the choroid plexus is instrumental to regulation of the level of zinc ions in the cerebrospinal fluid...
  37. ncbi request reprint Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition
    Charles P Sevigny
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 178:4240-9. 2007
    ..We conclude that A(2A)R agonists may represent a new class of compounds for induction therapy in organ transplantation...
  38. ncbi request reprint Zinc transporter 7 is located in the cis-Golgi apparatus of mouse choroid epithelial cells
    Zhi Hong Chi
    Department of Histology and Embryology, China Medical University, Shenyang, Liaoning, PR China
    Neuroreport 17:1807-11. 2006
    ..The results support the notion that zinc transporter 7 may participate in the transport of the cytoplasmic zinc into the Golgi apparatus, and may be involved in local packaging of zinc-binding proteins in the mouse choroid plexus...