A N Hamir

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. ncbi request reprint Second passage of sheep scrapie and transmissible mink encephalopathy (TME) agents in raccoons (Procyon lotor)
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, Ames, IA 50010, USA
    Vet Pathol 42:844-51. 2005
  2. ncbi request reprint Severe biliary hyperplasia associated with liver fluke infection in an adult alpaca
    A N Hamir
    National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, IA 50010, USA
    Vet Pathol 39:592-4. 2002
  3. pmc Failure to detect abnormal prion protein and scrapie-associated fibrils 6 wk after intracerebral inoculation of genetically susceptible sheep with scrapie agent
    Amir N Hamir
    National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, Iowa 50010, USA
    Can J Vet Res 66:289-94. 2002
  4. ncbi request reprint Preliminary observations on the experimental transmission of scrapie to elk (Cervus elaphus nelsoni) by intracerebral inoculation
    A N Hamir
    National Animal Disease Center, Agricultural Research Service, United States Department of Agricultural, Ames, IA 50010, USA
    Vet Pathol 40:81-5. 2003
  5. ncbi request reprint Failure to detect prion protein (PrPres) by immunohistochemistry in striated muscle tissues of animals experimentally inoculated with agents of transmissible spongiform encephalopathy
    A N Hamir
    National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    Vet Pathol 41:78-81. 2004
  6. ncbi request reprint Susceptibility of cattle to first-passage intracerebral inoculation with chronic wasting disease agent from white-tailed deer
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    Vet Pathol 44:487-93. 2007
  7. pmc Neuronal vacuolation in an adult ferret
    Amir N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Road, P O Box 70, Ames, Iowa 50010, USA
    Can Vet J 48:389-91. 2007
  8. ncbi request reprint Transmission of chronic wasting disease of mule deer to Suffolk sheep following intracerebral inoculation
    Amir N Hamir
    National Animal Disease Center, Agricultural Research Center, U S Department of Agriculture, Ames, IA 50010, USA
    J Vet Diagn Invest 18:558-65. 2006
  9. pmc Observation of Helicobacter-like organisms in gastric mucosa of grey foxes (Urocyon cinereoargenteus) and bobcats (Lynx rufus)
    Amir N Hamir
    National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, 2300 Dayton Road, PO Box 70, Ames, Iowa 50010, USA
    Can J Vet Res 68:154-6. 2004
  10. ncbi request reprint Abnormal prion protein in ectopic lymphoid tissue in a kidney of an asymptomatic white-tailed deer experimentally inoculated with the agent of chronic wasting disease
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    Vet Pathol 43:367-9. 2006

Detail Information

Publications66

  1. ncbi request reprint Second passage of sheep scrapie and transmissible mink encephalopathy (TME) agents in raccoons (Procyon lotor)
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, Ames, IA 50010, USA
    Vet Pathol 42:844-51. 2005
    ....
  2. ncbi request reprint Severe biliary hyperplasia associated with liver fluke infection in an adult alpaca
    A N Hamir
    National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, IA 50010, USA
    Vet Pathol 39:592-4. 2002
    ..The severe biliary hyperplasia was unusual, and it was not clear whether it was caused by an aberrant host response to the parasitic infection or whether it was an unrelated event...
  3. pmc Failure to detect abnormal prion protein and scrapie-associated fibrils 6 wk after intracerebral inoculation of genetically susceptible sheep with scrapie agent
    Amir N Hamir
    National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, Iowa 50010, USA
    Can J Vet Res 66:289-94. 2002
    ..From these findings, it is presumed that until host amplification has occurred, the concentration of PrPres in inoculum is insufficient for detection by currently available techniques...
  4. ncbi request reprint Preliminary observations on the experimental transmission of scrapie to elk (Cervus elaphus nelsoni) by intracerebral inoculation
    A N Hamir
    National Animal Disease Center, Agricultural Research Service, United States Department of Agricultural, Ames, IA 50010, USA
    Vet Pathol 40:81-5. 2003
    ....
  5. ncbi request reprint Failure to detect prion protein (PrPres) by immunohistochemistry in striated muscle tissues of animals experimentally inoculated with agents of transmissible spongiform encephalopathy
    A N Hamir
    National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    Vet Pathol 41:78-81. 2004
    ..Further testing of muscle tissues is needed to confirm the findings of the present study...
  6. ncbi request reprint Susceptibility of cattle to first-passage intracerebral inoculation with chronic wasting disease agent from white-tailed deer
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    Vet Pathol 44:487-93. 2007
    ..Also, the absence of SE and a distinctive IHC pattern of CWDwtd and CWDmd in cattle suggests that it should be possible to distinguish these conditions from other TSEs that have been experimentally transmitted to cattle...
  7. pmc Neuronal vacuolation in an adult ferret
    Amir N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Road, P O Box 70, Ames, Iowa 50010, USA
    Can Vet J 48:389-91. 2007
    ..Extensive neuronal vacuolation was observed. Since the brain was negative for protease-resistant protein prion (PrP'"), it was concluded that this was not a case of transmissible spongiform encephalopathy...
  8. ncbi request reprint Transmission of chronic wasting disease of mule deer to Suffolk sheep following intracerebral inoculation
    Amir N Hamir
    National Animal Disease Center, Agricultural Research Center, U S Department of Agriculture, Ames, IA 50010, USA
    J Vet Diagn Invest 18:558-65. 2006
    ..These findings demonstrate that transmission of the CWDmd agent to sheep via the intracerebral route is possible. Interestingly, the host genotype may play a notable part in successful transmission and incubation period of CWDmd...
  9. pmc Observation of Helicobacter-like organisms in gastric mucosa of grey foxes (Urocyon cinereoargenteus) and bobcats (Lynx rufus)
    Amir N Hamir
    National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, 2300 Dayton Road, PO Box 70, Ames, Iowa 50010, USA
    Can J Vet Res 68:154-6. 2004
    ..The organisms associated with bobcats appeared to be more tightly coiled than those seen in grey foxes. The presence of Helicobacter-like organisms in the gastric mucosa of grey foxes has not previously been described...
  10. ncbi request reprint Abnormal prion protein in ectopic lymphoid tissue in a kidney of an asymptomatic white-tailed deer experimentally inoculated with the agent of chronic wasting disease
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    Vet Pathol 43:367-9. 2006
    ..The demonstration of PrPres in lymphoid tissue in the kidney of this deer corroborates a recently published finding of PrPres in lymphoid follicles of organs other than CNS and lymphoid tissues in laboratory animals with TSE (scrapie)...
  11. ncbi request reprint First and second cattle passage of transmissible mink encephalopathy by intracerebral inoculation
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton AvenuePO Box 70, Ames, IA 50010, USA
    Vet Pathol 43:118-26. 2006
    ..However, it would be a diagnostic challenge to differentiate TME in cattle from BSE by clinical signs, neuropathology, or the presence of PrP(res) by IHC and WB...
  12. pmc Experimental transmission of scrapie agent to susceptible sheep by intralingual or intracerebral inoculation
    Amir N Hamir
    National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, 2300 Dayton Avenue, PO Box 70, Ames, Iowa 50010, USA
    Can J Vet Res 72:63-7. 2008
    ..However, before this method can be recommended for inoculation of TSE agents, research needs to show that other TSE agents can also transmit disease via the tongue...
  13. ncbi request reprint Naturally occurring spirochetes in the colonic mucosa of raccoons (Procyon lotor)
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    Vet Pathol 38:233-6. 2001
    ..5 microm in diameter). The slender spirochete did not resemble any of the known spirochete genera and failed to grow on medium used to propagate oral treponemes and members of the genus Brachyspira...
  14. ncbi request reprint Cerebral larva migrans in a raccoon (Procyon lotor)
    A N Hamir
    National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USA
    Vet Pathol 36:618-20. 1999
    ..Morphologic characteristics indicated that the nematode was an ascarid larva. However, it was smaller than the larva of Baylisascaris sp. This appears to be the first documented case of cerebral larva migrans in a raccoon...
  15. ncbi request reprint Myocarditis and encephalitis associated with Sarcocystis neurona infection in raccoons (Procyon lotor)
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    Vet Parasitol 95:335-40. 2001
    ..neurona in the current study is of interest. Pathologists should consider the possible association of S. neurona with myocardial inflammation in other S. neurona susceptible animals...
  16. ncbi request reprint Preliminary observations of genetic susceptibility of elk (Cervus elaphus nelsoni) to chronic wasting disease by experimental oral inoculation
    Amir N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    J Vet Diagn Invest 18:110-4. 2006
    ..All 4 LL elk are alive at PI year 4 and are clinically normal, which suggests that 132LL elk may have reduced susceptibility to oral infection with CWD-infected material or may have prolonged incubation time...
  17. ncbi request reprint Characterization of a Sarcocystis neurona isolate (SN6) from a naturally infected horse from Oregon
    J P Dubey
    United States Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Maryland 20705 2350, USA
    J Eukaryot Microbiol 46:500-6. 1999
    ..neurona schizonts and merozoites were found in encephalitic lesions. The parasite in tissue sections of mice reacted with S. neurona-specific antibodies and S. neurona was reisolated from the brain of knockout mice...
  18. doi request reprint Experimental transmission of chronic wasting disease (CWD) of elk (Cervus elaphus nelsoni), white-tailed deer (Odocoileus virginianus), and mule deer (Odocoileus hemionus hemionus) to white-tailed deer by intracerebral route
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    Vet Pathol 45:297-306. 2008
    ..However, this observation does not imply that these CWD agents would necessarily behave similarly in other recipient species...
  19. ncbi request reprint Preliminary findings on the experimental transmission of chronic wasting disease agent of mule deer to cattle
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    J Vet Diagn Invest 13:91-6. 2001
    ..These preliminary findings demonstrate that diagnostic techniques currently used for bovine spongiform encephalopathy (BSE) surveillance would also detect CWD in cattle should it occur naturally...
  20. ncbi request reprint Polymorphisms of the prion gene promoter region that influence classical bovine spongiform encephalopathy susceptibility are not applicable to other transmissible spongiform encephalopathies in cattle
    B W Brunelle
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, ARS, Ames, IA 50010, USA
    J Anim Sci 85:3142-7. 2007
    ..This genetic discrepancy demonstrates that atypical BSE progresses differently in the host relative to classical BSE. These results are consistent with the notion that atypical BSE originates spontaneously in cattle...
  21. doi request reprint Preliminary observations on the experimental transmission of chronic wasting disease (CWD) from elk and white-tailed deer to fallow deer
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, P O Box 70, Ames, IA 50010, USA
    J Comp Pathol 138:121-30. 2008
    ..Four years after CWD inoculation, the remaining five inoculated and two control deer are alive and apparently healthy...
  22. ncbi request reprint Experimental second passage of chronic wasting disease (CWD(mule deer)) agent to cattle
    A N Hamir
    Agricultural Research Service, United States Department of Agriculture, National Animal Disease Center, 2300 Dayton Avenue, P O Box 70, Ames, IA 50010, USA
    J Comp Pathol 134:63-9. 2006
    ....
  23. doi request reprint Serial passage of sheep scrapie inoculum in Suffolk sheep
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    Vet Pathol 46:39-44. 2009
    ....
  24. ncbi request reprint Characteristics of a recent isolate of Sarcocystis neurona (SN7) from a horse and loss of pathogenicity of isolates SN6 and SN7 by passages in cell culture
    J P Dubey
    United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Beltsville Agricultural Research Center, MD 20705 2350, USA
    Vet Parasitol 95:155-66. 2001
    ..These results suggest that prolonged passage in cell culture may affect the pathogenicity of some isolates of S. neurona...
  25. doi request reprint Retinal function and morphology are altered in cattle infected with the prion disease transmissible mink encephalopathy
    J D Smith
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA, USA
    Vet Pathol 46:810-8. 2009
    ..Our results support future efforts to focus on the retina for the development of new strategies for the diagnosis of TSEs...
  26. ncbi request reprint Idiopathic disseminated intracytoplasmic neuronal vacuolation in a neonatal Holstein calf born in the USA
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    J Vet Diagn Invest 13:349-51. 2001
    ..These results indicate that the clinical signs in this calf were not associated with transmissible spongiform encephalopathy. Neuronal vacuolation has not previously been documented in calves...
  27. doi request reprint Experimental transmission of US scrapie agent by nasal, peritoneal, and conjunctival routes to genetically susceptible sheep
    A N Hamir
    National Disease Center, ARS, USDA, Ames, IA 50010, USA
    Vet Pathol 45:7-11. 2008
    ..These results indicate that the upper respiratory tract, specifically the pharyngeal tonsil, may serve as a portal of entry for prion protein in scrapie-infected environments...
  28. ncbi request reprint Experimental inoculation of scrapie and chronic wasting disease agents in raccoons (Procyon lotor)
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    Vet Rec 153:121-3. 2003
  29. ncbi request reprint Diagnosis of preclinical and subclinical scrapie in a naturally infected sheep flock utilizing currently available postmortem diagnostic techniques
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    J Vet Diagn Invest 13:152-4. 2001
    ..An additional ewe, which did not have histopathologic changes in the brain but was positive by IHC and western blot,was considered a preclinical case of scrapie. None of the sheep had amyloid in the brain stem...
  30. doi request reprint Characterization of a US sheep scrapie isolate with short incubation time
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA, USA
    Vet Pathol 46:1205-12. 2009
    ..This indicates that inoculum No. x124 appears to induce scrapie in shorter time than inoculum No. 13-7, especially in sheep homozygous or heterozygous for valine at codon 136...
  31. ncbi request reprint Use of capillary electrophoresis and fluorescent labeled peptides to detect the abnormal prion protein in the blood of animals that are infected with a transmissible spongiform encephalopathy
    M J Schmerr
    National Animal Disease Center, MWA, ARS, US Department of Agriculture, Ames, IA 50010, USA
    J Chromatogr A 853:207-14. 1999
    ..This assay makes a pre-clinical assay possible for these diseases and could be adapted to test for the abnormal prion protein in process materials that are used for manufacture of pharmaceuticals and products for human consumption...
  32. pmc Resistance of cattle to scrapie by the oral route
    R C Cutlip
    Agricultural Research Service, National Animal Disease Center, United States Department of Agriculture, Ames, Iowa 50010
    Can J Vet Res 65:131-2. 2001
    ..This work indicates that cattle are highly resistant to North American scrapie by the oral route...
  33. ncbi request reprint Exposure of sheep scrapie brain homogenate to rumen-simulating conditions does not result in a reduction of PrP(Sc) levels
    E M Nicholson
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010, USA
    Lett Appl Microbiol 44:631-6. 2007
    ..Experiments were designed to evaluate the potential of rumen-simulating conditions to reduce PrP(Sc) levels...
  34. ncbi request reprint Sarcocystis mephitisi n. sp. (Protozoa: Sarcocystidae), Sarcocystis neurona-like and Toxoplasma-like infections in striped skunks (Mephitis mephitis)
    J P Dubey
    Parasite Biology, Epidemiology and Systematics Laboratory, Animal and Natural Resources Institute, United States Department of Agriculture, Beltsville, Maryland 20705 2350, USA
    J Parasitol 88:113-7. 2002
    ..These sarcocysts were structurally similar to S. neurona sarcocysts. A Toxoplasma gondii-like tissue cyst was found in a section of tongue of 1 of the 4 skunks...
  35. ncbi request reprint Transmission of transmissible mink encephalopathy to raccoons (Procyon lotor) by intracerebral inoculation
    Amir N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    J Vet Diagn Invest 16:57-63. 2004
    ..Further studies, such as the incubation periods of bovine spongiform encephalopathy and other isolates of scrapie, CWD, and TME in raccoons, are needed before the model can be further characterized for differentiation of TSE agents...
  36. ncbi request reprint Retinal cell types are differentially affected in sheep with scrapie
    J D Smith
    Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50010, USA
    J Comp Pathol 138:12-22. 2008
    ..These results demonstrate alterations of immunoreactivity patterns for proteins associated with specific cell types in retinas with PrP(Sc) accumulation, despite an absence of microscopical evidence of retinal degeneration...
  37. ncbi request reprint Campylobacter jejuni and Arcobacter species associated with intussusception in a raccoon (Procyon lotor)
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Road, Ames, IA 50010, USA
    Vet Rec 155:338-40. 2004
  38. ncbi request reprint Sarcocystis neurona infections in raccoons (Procyon lotor): evidence for natural infection with sarcocysts, transmission of infection to opossums (Didelphis virginiana), and experimental induction of neurologic disease in raccoons
    J P Dubey
    United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Parasite Biology, Epidemiology and Systematics Laboratory, Building 1001, Beltsville, MD 20705 2350, USA
    Vet Parasitol 100:117-29. 2001
    ..neurona-associated encephalomyelitis was found in raccoons killed 14 and 22 days after feeding sporocysts; schizonts and merozoites were seen in encephalitic lesions...
  39. pmc Preclinical diagnosis of scrapie by immunohistochemistry of third eyelid lymphoid tissue
    K I O'Rourke
    Animal Disease Research Unit, Animal Research Service, U S Department of Agriculture, College of Veterinary Medicine, Washington State University, Pullman 99164 6630, USA
    J Clin Microbiol 38:3254-9. 2000
    ..Immunohistochemistry assay of routinely formalin-fixed lymphoid tissues with a cocktail of pan-specific MAbs is a practical, readily standardized live-animal and preclinical test for ovine scrapie...
  40. ncbi request reprint Elk with a long incubation prion disease phenotype have a unique PrPd profile
    Katherine I O'Rourke
    United States Department of Agriculture, Agricultural Research Service, Animal Disease Research Unit, Pullman, Washington 99164, USA
    Neuroreport 18:1935-8. 2007
    ..We now report that elk lacking the predisposing 132-methionine allele develop chronic wasting disease after a long incubation period and display a novel PrP folding pattern...
  41. ncbi request reprint Transmission of sheep scrapie to elk (Cervus elaphus nelsoni) by intracerebral inoculation: final outcome of the experiment
    Amir N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    J Vet Diagn Invest 16:316-21. 2004
    ..Based on morphologic and IHC findings, the experimentally induced SE cannot be distinguished from chronic wasting disease of elk with currently available diagnostic techniques...
  42. ncbi request reprint Experimental transmission of sheep scrapie by intracerebral and oral routes to genetically susceptible Suffolk sheep in the United States
    Amir N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    J Vet Diagn Invest 17:3-9. 2005
    ..Three of the 4 clinically normal sheep were positive at 15, 20, and 49 months PI by PrPres immunohistochemistry...
  43. doi request reprint Cartilaginous metaplasia in the sclera of Suffolk sheep
    J D Smith
    Virus and Prion Research Unit, USDA ARS National Animal Disease Center, 1920 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    Vet Pathol 48:827-9. 2011
    ..7% of eyes examined, respectively. The clinical significance of this previously unreported finding is unknown...
  44. ncbi request reprint Abnormal prion accumulation associated with retinal pathology in experimentally inoculated scrapie-affected sheep
    J J Greenlee
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA Agricultural Research Service, 2300 Dayton Ave, Ames, IA 50010, USA
    Vet Pathol 43:733-9. 2006
    ..This is the first report of a prion disease in a natural host that describes the accumulation of PrP(Sc) in retina associated with retinal pathology in the absence of overt morphologic changes indicative of retinal degeneration...
  45. doi request reprint Diagnostic exercise: astrocytoma with involvement of medulla oblongata, spinal cord, and spinal nerves in a raccoon (Procyon lotor)
    A N Hamir
    College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA
    Vet Pathol 45:949-51. 2008
    ..This appears to be the only reported case of astrocytoma that involved multiple anatomic sites in the central nervous system of this raccoon...
  46. ncbi request reprint Western blot detection of PrP Sc in archived paraffin-embedded brainstem from scrapie-affected sheep
    Robert A Kunkle
    National Animal Disease Center, US Department of Agriculture, Animal Research Service, Ames, IA 50010, USA
    J Vet Diagn Invest 20:522-6. 2008
    ..The present article describes a method to conduct a WB assay from the same paraffin-embedded brainstem sample used for the IHC diagnosis of experimentally induced sheep scrapie...
  47. ncbi request reprint Experimental oral transmission of United States origin scrapie to neonatal sheep
    Amir N Hamir
    US Department of Agriculture, National Animal Disease Center, Agricultural Research Service, USDA, Ames, IA 50010, USA
    J Vet Diagn Invest 21:64-8. 2009
    ....
  48. ncbi request reprint Age-related lesions in laboratory-confined raccoons (Procyon lotor) inoculated with the agent of chronic wasting disease of mule deer
    Amir N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, P O Box 70, Ames, IA 50010, USA
    J Vet Diagn Invest 19:680-6. 2007
    ..The latter 2 pathologic conditions were not previously reported in raccoons...
  49. ncbi request reprint Detection of the disease-associated isoform of the prion protein in formalin-fixed tissues by Western blot
    Eric M Nicholson
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010, USA
    J Vet Diagn Invest 19:548-52. 2007
    ..The approach requires only minimal modification of existing Western-blot procedures and could readily be incorporated into existing detection schemes for confirmatory purposes when fresh or frozen tissues are unavailable...
  50. ncbi request reprint Wasting and neurologic signs in a white-tailed deer (Odocoileus virginianus) not associated with abnormal prion protein
    Amir N Hamir
    National Animal Disease Center, USDA, Ames, Iowa 50010, USA
    J Wildl Dis 44:1045-50. 2008
    ..Such a case should be considered in a differential diagnosis of CWD of white-tailed deer...
  51. ncbi request reprint Identification and characterization of two bovine spongiform encephalopathy cases diagnosed in the United States
    Jürgen A Richt
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, Iowa 50010, USA
    J Vet Diagn Invest 19:142-54. 2007
    ..Sequencing of the prion protein gene of both BSE-positive animals revealed that the sequences of both animals were within [corrected] the range of the prion protein gene sequence diversity previously reported for cattle...
  52. pmc Production of cattle lacking prion protein
    Jürgen A Richt
    National Animal Disease Center, Agriculture Research Services, United States Department of Agriculture, 2300 Dayton Avenue, Ames, Iowa 50010, USA
    Nat Biotechnol 25:132-8. 2007
    ..PrP(C)-deficient cattle may be a useful model for prion research and could provide industrial bovine products free of prion proteins...
  53. pmc Ablation of prion protein immunoreactivity by heating in saturated calcium hydroxide
    Justin J Greenlee
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, 2300 Dayton Avenue, Ames, IA, USA, 50010
    BMC Res Notes 1:99. 2008
    ....
  54. doi request reprint Spontaneous idiopathic arteritis of the testicular artery in raccoons (Procyon lotor)
    A N Hamir
    National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA, USA
    Vet Pathol 46:1129-32. 2009
    ..To our knowledge multifocal arteritis confined to the testicular artery has not previously been documented in raccoons...
  55. ncbi request reprint Acute fatal toxoplasmosis in squirrels (Sciurus carolensis) with bradyzoites in visceral tissues
    J P Dubey
    United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Animal Parasitic Diseases Laboratory, Beltsville, Maryland 20705 2350, USA
    J Parasitol 92:658-9. 2006
    ..Tissue cysts were seen in several organs, including lung alveoli. The presence of tissue cysts in alveoli of pet squirrels maybe of public health concern if tissue cysts excreted in nasal secretions are swallowed by children...
  56. ncbi request reprint Experimental transmission of chronic wasting disease agent from mule deer to cattle by the intracerebral route
    Amir N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    J Vet Diagn Invest 17:276-81. 2005
    ....
  57. ncbi request reprint Resistance of domestic cats to a US sheep scrapie agent by intracerebral route
    Amir N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    J Vet Diagn Invest 14:444-5. 2002
    ..These results indicate that the sheep scrapie agent (G-639-PP) used in this study was not capable of amplifying in cats and therefore was unable to cross the species barrier to produce FSE...
  58. ncbi request reprint Experimental toxoplasmosis in budgerigars (Melopsittacus undulatus)
    J P Dubey
    Animal and Natural Resources Institute, Agricultural Research Service, United States Department of Agriculture, Beltsville, Maryland 20705 2350, USA
    J Parasitol 88:514-9. 2002
    ..The control budgerigars remained clinically normal and showed no evidence of T. gondii exposure. These results indicate that, compared to other passerines, budgerigars are relatively resistant to clinical toxoplasmosis...
  59. ncbi request reprint Meningoencephalitis and pneumonia associated with Cryptococcus neoformans infection in a free-ranging elk in the USA
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    Vet Rec 151:332-3. 2002
  60. doi request reprint Fluorescence-based method, exploiting lipofuscin, for real-time detection of central nervous system tissues on bovine carcasses
    Holger Schönenbrücher
    Virus and Prion Diseases of Livestock Research Unit and Pre Harvest Food Safety and Enteric Disease Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, Iowa 50010, USA
    J Agric Food Chem 56:6220-6. 2008
    ..The presented data are a fundamental basis for the development of a prototype device allowing real-time monitoring of CNS tissue contamination on bovine carcasses and meat cuts...
  61. doi request reprint Trophoblast-like cells in the tissues of porcupines (Erethizon dorsatum)
    A N Hamir
    National Animal Disease Center, ARS USDA, 2300 Dayton AvenuePO Box 70, Ames, IA 50010, USA
    Vet Pathol 45:409-11. 2008
    ..Morphologically these cells were typical of uterine epitheloid trophoblasts. This is the first record of the presence of trophoblast-like cells in nongenital tissues of porcupines...
  62. ncbi request reprint Neuroaxonal dystrophy in raccoons (Procyon lotor) from Iowa
    Amir N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA, USA
    J Vet Diagn Invest 14:175-8. 2002
    ..Because of the apparently high prevalence of this condition at this geographic location, factors other than age (genetic, nutritional, and/or environmental) may influence this degenerative process in the brains of raccoons in Iowa...
  63. doi request reprint A comparison of the fluorescence spectra of murine and bovine central nervous system and other tissues
    Ramkrishna Adhikary
    Department of Chemistry, Iowa State University, Ames, IA, USA
    Photochem Photobiol 85:1322-6. 2009
    ..It is concluded that murine CNS tissue is an appropriate model system for bovine CNS tissue for the development of fluorometric CNS detection assays...
  64. ncbi request reprint West Nile virus infection in reindeer (Rangifer tarandus)
    Mitchell V Palmer
    Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USA
    J Vet Diagn Invest 16:219-22. 2004
    ....
  65. doi request reprint Monitoring the accumulation of lipofuscin in aging murine eyes by fluorescence spectroscopy
    Prasun Mukherjee
    Department of Chemistry, Iowa State University, Ames, IA, USA
    Photochem Photobiol 85:234-8. 2009
    ....
  66. ncbi request reprint Immunohistochemical localization of endothelial and inducible nitric oxide synthase within neurons of cattle with rabies
    Taekyun Shin
    Department of Veterinary Medicine, Cheju National University, Jeju, Republic of Korea
    J Vet Med Sci 66:539-41. 2004
    ..The specific localization of eNOS, but not iNOS, in the Negri bodies suggests that eNOS is involved in the formation of rabies virus inclusion bodies...