A N Hamir

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. pmc Ablation of prion protein immunoreactivity by heating in saturated calcium hydroxide
    Justin J Greenlee
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, 2300 Dayton Avenue, Ames, IA, USA, 50010
    BMC Res Notes 1:99. 2008
  2. doi request reprint Experimental transmission of chronic wasting disease (CWD) of elk (Cervus elaphus nelsoni), white-tailed deer (Odocoileus virginianus), and mule deer (Odocoileus hemionus hemionus) to white-tailed deer by intracerebral route
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    Vet Pathol 45:297-306. 2008
  3. doi request reprint Experimental transmission of US scrapie agent by nasal, peritoneal, and conjunctival routes to genetically susceptible sheep
    A N Hamir
    National Disease Center, ARS, USDA, Ames, IA 50010, USA
    Vet Pathol 45:7-11. 2008
  4. doi request reprint Preliminary observations on the experimental transmission of chronic wasting disease (CWD) from elk and white-tailed deer to fallow deer
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, P O Box 70, Ames, IA 50010, USA
    J Comp Pathol 138:121-30. 2008
  5. doi request reprint Trophoblast-like cells in the tissues of porcupines (Erethizon dorsatum)
    A N Hamir
    National Animal Disease Center, ARS USDA, 2300 Dayton AvenuePO Box 70, Ames, IA 50010, USA
    Vet Pathol 45:409-11. 2008
  6. ncbi request reprint Wasting and neurologic signs in a white-tailed deer (Odocoileus virginianus) not associated with abnormal prion protein
    Amir N Hamir
    National Animal Disease Center, USDA, Ames, Iowa 50010, USA
    J Wildl Dis 44:1045-50. 2008
  7. doi request reprint Diagnostic exercise: astrocytoma with involvement of medulla oblongata, spinal cord, and spinal nerves in a raccoon (Procyon lotor)
    A N Hamir
    College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA
    Vet Pathol 45:949-51. 2008
  8. doi request reprint Serial passage of sheep scrapie inoculum in Suffolk sheep
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    Vet Pathol 46:39-44. 2009
  9. ncbi request reprint Experimental oral transmission of United States origin scrapie to neonatal sheep
    Amir N Hamir
    US Department of Agriculture, National Animal Disease Center, Agricultural Research Service, USDA, Ames, IA 50010, USA
    J Vet Diagn Invest 21:64-8. 2009
  10. ncbi request reprint Preliminary findings on the experimental transmission of chronic wasting disease agent of mule deer to cattle
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    J Vet Diagn Invest 13:91-6. 2001

Detail Information

Publications47

  1. pmc Ablation of prion protein immunoreactivity by heating in saturated calcium hydroxide
    Justin J Greenlee
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, 2300 Dayton Avenue, Ames, IA, USA, 50010
    BMC Res Notes 1:99. 2008
    ....
  2. doi request reprint Experimental transmission of chronic wasting disease (CWD) of elk (Cervus elaphus nelsoni), white-tailed deer (Odocoileus virginianus), and mule deer (Odocoileus hemionus hemionus) to white-tailed deer by intracerebral route
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    Vet Pathol 45:297-306. 2008
    ..However, this observation does not imply that these CWD agents would necessarily behave similarly in other recipient species...
  3. doi request reprint Experimental transmission of US scrapie agent by nasal, peritoneal, and conjunctival routes to genetically susceptible sheep
    A N Hamir
    National Disease Center, ARS, USDA, Ames, IA 50010, USA
    Vet Pathol 45:7-11. 2008
    ..These results indicate that the upper respiratory tract, specifically the pharyngeal tonsil, may serve as a portal of entry for prion protein in scrapie-infected environments...
  4. doi request reprint Preliminary observations on the experimental transmission of chronic wasting disease (CWD) from elk and white-tailed deer to fallow deer
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, P O Box 70, Ames, IA 50010, USA
    J Comp Pathol 138:121-30. 2008
    ..Four years after CWD inoculation, the remaining five inoculated and two control deer are alive and apparently healthy...
  5. doi request reprint Trophoblast-like cells in the tissues of porcupines (Erethizon dorsatum)
    A N Hamir
    National Animal Disease Center, ARS USDA, 2300 Dayton AvenuePO Box 70, Ames, IA 50010, USA
    Vet Pathol 45:409-11. 2008
    ..Morphologically these cells were typical of uterine epitheloid trophoblasts. This is the first record of the presence of trophoblast-like cells in nongenital tissues of porcupines...
  6. ncbi request reprint Wasting and neurologic signs in a white-tailed deer (Odocoileus virginianus) not associated with abnormal prion protein
    Amir N Hamir
    National Animal Disease Center, USDA, Ames, Iowa 50010, USA
    J Wildl Dis 44:1045-50. 2008
    ..Such a case should be considered in a differential diagnosis of CWD of white-tailed deer...
  7. doi request reprint Diagnostic exercise: astrocytoma with involvement of medulla oblongata, spinal cord, and spinal nerves in a raccoon (Procyon lotor)
    A N Hamir
    College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA
    Vet Pathol 45:949-51. 2008
    ..This appears to be the only reported case of astrocytoma that involved multiple anatomic sites in the central nervous system of this raccoon...
  8. doi request reprint Serial passage of sheep scrapie inoculum in Suffolk sheep
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    Vet Pathol 46:39-44. 2009
    ....
  9. ncbi request reprint Experimental oral transmission of United States origin scrapie to neonatal sheep
    Amir N Hamir
    US Department of Agriculture, National Animal Disease Center, Agricultural Research Service, USDA, Ames, IA 50010, USA
    J Vet Diagn Invest 21:64-8. 2009
    ....
  10. ncbi request reprint Preliminary findings on the experimental transmission of chronic wasting disease agent of mule deer to cattle
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    J Vet Diagn Invest 13:91-6. 2001
    ..These preliminary findings demonstrate that diagnostic techniques currently used for bovine spongiform encephalopathy (BSE) surveillance would also detect CWD in cattle should it occur naturally...
  11. ncbi request reprint Characterization of a Sarcocystis neurona isolate (SN6) from a naturally infected horse from Oregon
    J P Dubey
    United States Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Maryland 20705 2350, USA
    J Eukaryot Microbiol 46:500-6. 1999
    ..neurona schizonts and merozoites were found in encephalitic lesions. The parasite in tissue sections of mice reacted with S. neurona-specific antibodies and S. neurona was reisolated from the brain of knockout mice...
  12. ncbi request reprint Polymorphisms of the prion gene promoter region that influence classical bovine spongiform encephalopathy susceptibility are not applicable to other transmissible spongiform encephalopathies in cattle
    B W Brunelle
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, ARS, Ames, IA 50010, USA
    J Anim Sci 85:3142-7. 2007
    ..This genetic discrepancy demonstrates that atypical BSE progresses differently in the host relative to classical BSE. These results are consistent with the notion that atypical BSE originates spontaneously in cattle...
  13. ncbi request reprint Susceptibility of cattle to first-passage intracerebral inoculation with chronic wasting disease agent from white-tailed deer
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    Vet Pathol 44:487-93. 2007
    ..Also, the absence of SE and a distinctive IHC pattern of CWDwtd and CWDmd in cattle suggests that it should be possible to distinguish these conditions from other TSEs that have been experimentally transmitted to cattle...
  14. ncbi request reprint Experimental second passage of chronic wasting disease (CWD(mule deer)) agent to cattle
    A N Hamir
    Agricultural Research Service, United States Department of Agriculture, National Animal Disease Center, 2300 Dayton Avenue, P O Box 70, Ames, IA 50010, USA
    J Comp Pathol 134:63-9. 2006
    ....
  15. ncbi request reprint Experimental inoculation of scrapie and chronic wasting disease agents in raccoons (Procyon lotor)
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    Vet Rec 153:121-3. 2003
  16. doi request reprint Retinal function and morphology are altered in cattle infected with the prion disease transmissible mink encephalopathy
    J D Smith
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA, USA
    Vet Pathol 46:810-8. 2009
    ..Our results support future efforts to focus on the retina for the development of new strategies for the diagnosis of TSEs...
  17. ncbi request reprint Second passage of sheep scrapie and transmissible mink encephalopathy (TME) agents in raccoons (Procyon lotor)
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, Ames, IA 50010, USA
    Vet Pathol 42:844-51. 2005
    ....
  18. ncbi request reprint Diagnosis of preclinical and subclinical scrapie in a naturally infected sheep flock utilizing currently available postmortem diagnostic techniques
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    J Vet Diagn Invest 13:152-4. 2001
    ..An additional ewe, which did not have histopathologic changes in the brain but was positive by IHC and western blot,was considered a preclinical case of scrapie. None of the sheep had amyloid in the brain stem...
  19. ncbi request reprint Abnormal prion protein in ectopic lymphoid tissue in a kidney of an asymptomatic white-tailed deer experimentally inoculated with the agent of chronic wasting disease
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    Vet Pathol 43:367-9. 2006
    ..The demonstration of PrPres in lymphoid tissue in the kidney of this deer corroborates a recently published finding of PrPres in lymphoid follicles of organs other than CNS and lymphoid tissues in laboratory animals with TSE (scrapie)...
  20. ncbi request reprint Preliminary observations on the experimental transmission of scrapie to elk (Cervus elaphus nelsoni) by intracerebral inoculation
    A N Hamir
    National Animal Disease Center, Agricultural Research Service, United States Department of Agricultural, Ames, IA 50010, USA
    Vet Pathol 40:81-5. 2003
    ....
  21. ncbi request reprint First and second cattle passage of transmissible mink encephalopathy by intracerebral inoculation
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton AvenuePO Box 70, Ames, IA 50010, USA
    Vet Pathol 43:118-26. 2006
    ..However, it would be a diagnostic challenge to differentiate TME in cattle from BSE by clinical signs, neuropathology, or the presence of PrP(res) by IHC and WB...
  22. doi request reprint Characterization of a US sheep scrapie isolate with short incubation time
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA, USA
    Vet Pathol 46:1205-12. 2009
    ..This indicates that inoculum No. x124 appears to induce scrapie in shorter time than inoculum No. 13-7, especially in sheep homozygous or heterozygous for valine at codon 136...
  23. ncbi request reprint Use of capillary electrophoresis and fluorescent labeled peptides to detect the abnormal prion protein in the blood of animals that are infected with a transmissible spongiform encephalopathy
    M J Schmerr
    National Animal Disease Center, MWA, ARS, US Department of Agriculture, Ames, IA 50010, USA
    J Chromatogr A 853:207-14. 1999
    ..This assay makes a pre-clinical assay possible for these diseases and could be adapted to test for the abnormal prion protein in process materials that are used for manufacture of pharmaceuticals and products for human consumption...
  24. ncbi request reprint Exposure of sheep scrapie brain homogenate to rumen-simulating conditions does not result in a reduction of PrP(Sc) levels
    E M Nicholson
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010, USA
    Lett Appl Microbiol 44:631-6. 2007
    ..Experiments were designed to evaluate the potential of rumen-simulating conditions to reduce PrP(Sc) levels...
  25. pmc Resistance of cattle to scrapie by the oral route
    R C Cutlip
    Agricultural Research Service, National Animal Disease Center, United States Department of Agriculture, Ames, Iowa 50010
    Can J Vet Res 65:131-2. 2001
    ..This work indicates that cattle are highly resistant to North American scrapie by the oral route...
  26. ncbi request reprint Idiopathic disseminated intracytoplasmic neuronal vacuolation in a neonatal Holstein calf born in the USA
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    J Vet Diagn Invest 13:349-51. 2001
    ..These results indicate that the clinical signs in this calf were not associated with transmissible spongiform encephalopathy. Neuronal vacuolation has not previously been documented in calves...
  27. ncbi request reprint Retinal cell types are differentially affected in sheep with scrapie
    J D Smith
    Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50010, USA
    J Comp Pathol 138:12-22. 2008
    ..These results demonstrate alterations of immunoreactivity patterns for proteins associated with specific cell types in retinas with PrP(Sc) accumulation, despite an absence of microscopical evidence of retinal degeneration...
  28. ncbi request reprint Myocarditis and encephalitis associated with Sarcocystis neurona infection in raccoons (Procyon lotor)
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    Vet Parasitol 95:335-40. 2001
    ..neurona in the current study is of interest. Pathologists should consider the possible association of S. neurona with myocardial inflammation in other S. neurona susceptible animals...
  29. ncbi request reprint Abnormal prion accumulation associated with retinal pathology in experimentally inoculated scrapie-affected sheep
    J J Greenlee
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA Agricultural Research Service, 2300 Dayton Ave, Ames, IA 50010, USA
    Vet Pathol 43:733-9. 2006
    ..This is the first report of a prion disease in a natural host that describes the accumulation of PrP(Sc) in retina associated with retinal pathology in the absence of overt morphologic changes indicative of retinal degeneration...
  30. ncbi request reprint Failure to detect prion protein (PrPres) by immunohistochemistry in striated muscle tissues of animals experimentally inoculated with agents of transmissible spongiform encephalopathy
    A N Hamir
    National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    Vet Pathol 41:78-81. 2004
    ..Further testing of muscle tissues is needed to confirm the findings of the present study...
  31. ncbi request reprint Campylobacter jejuni and Arcobacter species associated with intussusception in a raccoon (Procyon lotor)
    A N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Road, Ames, IA 50010, USA
    Vet Rec 155:338-40. 2004
  32. doi request reprint Spontaneous idiopathic arteritis of the testicular artery in raccoons (Procyon lotor)
    A N Hamir
    National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA, USA
    Vet Pathol 46:1129-32. 2009
    ..To our knowledge multifocal arteritis confined to the testicular artery has not previously been documented in raccoons...
  33. ncbi request reprint Experimental toxoplasmosis in budgerigars (Melopsittacus undulatus)
    J P Dubey
    Animal and Natural Resources Institute, Agricultural Research Service, United States Department of Agriculture, Beltsville, Maryland 20705 2350, USA
    J Parasitol 88:514-9. 2002
    ..The control budgerigars remained clinically normal and showed no evidence of T. gondii exposure. These results indicate that, compared to other passerines, budgerigars are relatively resistant to clinical toxoplasmosis...
  34. ncbi request reprint Sarcocystis neurona infections in raccoons (Procyon lotor): evidence for natural infection with sarcocysts, transmission of infection to opossums (Didelphis virginiana), and experimental induction of neurologic disease in raccoons
    J P Dubey
    United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Parasite Biology, Epidemiology and Systematics Laboratory, Building 1001, Beltsville, MD 20705 2350, USA
    Vet Parasitol 100:117-29. 2001
    ..neurona-associated encephalomyelitis was found in raccoons killed 14 and 22 days after feeding sporocysts; schizonts and merozoites were seen in encephalitic lesions...
  35. ncbi request reprint Acute fatal toxoplasmosis in squirrels (Sciurus carolensis) with bradyzoites in visceral tissues
    J P Dubey
    United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Animal Parasitic Diseases Laboratory, Beltsville, Maryland 20705 2350, USA
    J Parasitol 92:658-9. 2006
    ..Tissue cysts were seen in several organs, including lung alveoli. The presence of tissue cysts in alveoli of pet squirrels maybe of public health concern if tissue cysts excreted in nasal secretions are swallowed by children...
  36. ncbi request reprint Sarcocystis mephitisi n. sp. (Protozoa: Sarcocystidae), Sarcocystis neurona-like and Toxoplasma-like infections in striped skunks (Mephitis mephitis)
    J P Dubey
    Parasite Biology, Epidemiology and Systematics Laboratory, Animal and Natural Resources Institute, United States Department of Agriculture, Beltsville, Maryland 20705 2350, USA
    J Parasitol 88:113-7. 2002
    ..These sarcocysts were structurally similar to S. neurona sarcocysts. A Toxoplasma gondii-like tissue cyst was found in a section of tongue of 1 of the 4 skunks...
  37. ncbi request reprint Severe biliary hyperplasia associated with liver fluke infection in an adult alpaca
    A N Hamir
    National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, IA 50010, USA
    Vet Pathol 39:592-4. 2002
    ..The severe biliary hyperplasia was unusual, and it was not clear whether it was caused by an aberrant host response to the parasitic infection or whether it was an unrelated event...
  38. ncbi request reprint Naturally occurring spirochetes in the colonic mucosa of raccoons (Procyon lotor)
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    Vet Pathol 38:233-6. 2001
    ..5 microm in diameter). The slender spirochete did not resemble any of the known spirochete genera and failed to grow on medium used to propagate oral treponemes and members of the genus Brachyspira...
  39. pmc Preclinical diagnosis of scrapie by immunohistochemistry of third eyelid lymphoid tissue
    K I O'Rourke
    Animal Disease Research Unit, Animal Research Service, U S Department of Agriculture, College of Veterinary Medicine, Washington State University, Pullman 99164 6630, USA
    J Clin Microbiol 38:3254-9. 2000
    ..Immunohistochemistry assay of routinely formalin-fixed lymphoid tissues with a cocktail of pan-specific MAbs is a practical, readily standardized live-animal and preclinical test for ovine scrapie...
  40. doi request reprint Cartilaginous metaplasia in the sclera of Suffolk sheep
    J D Smith
    Virus and Prion Research Unit, USDA ARS National Animal Disease Center, 1920 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    Vet Pathol 48:827-9. 2011
    ..7% of eyes examined, respectively. The clinical significance of this previously unreported finding is unknown...
  41. ncbi request reprint Characteristics of a recent isolate of Sarcocystis neurona (SN7) from a horse and loss of pathogenicity of isolates SN6 and SN7 by passages in cell culture
    J P Dubey
    United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Beltsville Agricultural Research Center, MD 20705 2350, USA
    Vet Parasitol 95:155-66. 2001
    ..These results suggest that prolonged passage in cell culture may affect the pathogenicity of some isolates of S. neurona...
  42. ncbi request reprint Meningoencephalitis and pneumonia associated with Cryptococcus neoformans infection in a free-ranging elk in the USA
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    Vet Rec 151:332-3. 2002
  43. ncbi request reprint Granulomatous orchitis associated with Histoplasma-like organisms in porcupines (Erethizon dorsatum)
    A N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    Vet Rec 150:251-2. 2002
  44. ncbi request reprint Cerebral larva migrans in a raccoon (Procyon lotor)
    A N Hamir
    National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USA
    Vet Pathol 36:618-20. 1999
    ..Morphologic characteristics indicated that the nematode was an ascarid larva. However, it was smaller than the larva of Baylisascaris sp. This appears to be the first documented case of cerebral larva migrans in a raccoon...
  45. ncbi request reprint Nodular hyperplasia and cysts in thyroid glands of llamas (Lama glama) from north-west USA
    A N Hamir
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Magruder Hall, Corvallis, OR 97331, USA
    Vet Rec 152:507-8. 2003
  46. ncbi request reprint Prevalence of psammoma bodies in meninges and choroid plexuses of raccoons (Procyon lotor) from Parramore Island, Virginia
    A N Hamir
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
    J Vet Diagn Invest 13:76-9. 2001
    ..Although the exact cause of this condition is not known, a primary vascular insult with resultant dystrophic mineralization of the affected vessels is suspected...
  47. pmc The prevalence of interstitial nephritis and leptospirosis in 283 raccoons (Procyon lotor) from 5 different sites in the United States
    A N Hamir
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, Kennett Square, Pennsylvania 19348, USA
    Can Vet J 42:869-71. 2001
    ..Results of this study indicate that although interstitial nephritis was common in raccoons from all locations, the presence of renal leptospiral spirochetes was not...