Anthony V Capuco

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. doi request reprint Bovine mammary stem cells: cell biology meets production agriculture
    A V Capuco
    Bovine Functional Genomics Laboratory, USDA ARS, Beltsville, MD 20705, USA
    Animal 6:382-93. 2012
  2. pmc In vitro expansion of the mammary stem/progenitor cell population by xanthosine treatment
    Ratan K Choudhary
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD, USA
    BMC Cell Biol 13:14. 2012
  3. ncbi request reprint Identification of putative bovine mammary epithelial stem cells by their retention of labeled DNA strands
    Anthony V Capuco
    Bovine Functional Genomics Laboratory, USDA ARS, Beltsville, MD 20705, USA
    Exp Biol Med (Maywood) 232:1381-90. 2007
  4. doi request reprint Regulation of mammary gland sensitivity to thyroid hormones during the transition from pregnancy to lactation
    A V Capuco
    Bovine Functional Genomics Laboratory, USDA ARS, Powder Mill Road, BARC East, Beltsville, MD 20705, USA
    Exp Biol Med (Maywood) 233:1309-14. 2008
  5. doi request reprint Neither bovine somatotropin nor growth hormone-releasing factor alters expression of thyroid hormone receptors in liver and mammary tissues
    A V Capuco
    Bovine Functional Genomics Laboratory, USDA ARS, Beltsville, MD 20705, USA
    J Dairy Sci 94:4915-21. 2011
  6. doi request reprint In vivo expansion of the mammary stem/ progenitor cell population by xanthosine infusion
    Anthony V Capuco
    Bovine Functional Genomics Laboratory, USDA ARS, Beltsville, MD 20705
    Exp Biol Med (Maywood) 234:475-82. 2009
  7. pmc The origin and evolution of lactation
    Anthony V Capuco
    USDA ARS, Bovine Functional Genomics Laboratory, Powder Mill, BARC East, Beltsville, MD 20705, USA
    J Biol 8:37. 2009
  8. pmc Effects of increased milking frequency on gene expression in the bovine mammary gland
    Erin E Connor
    Bovine Functional Genomics Laboratory, USDA ARS, Beltsville Agricultural Research Center, 10300 Baltimore Avenue, Beltsville, MD 20705, USA
    BMC Genomics 9:362. 2008
  9. doi request reprint A sentinel function for teat tissues in dairy cows: dominant innate immune response elements define early response to E. coli mastitis
    Manuela Rinaldi
    USDA ARS, Beltsville, MD 20705, USA
    Funct Integr Genomics 10:21-38. 2010
  10. ncbi request reprint Identification of estrogen-responsive genes in the parenchyma and fat pad of the bovine mammary gland by microarray analysis
    Robert W Li
    Bovine Functional Genomics Laboratory, United States Department of Agriculture Agricultural Research Service, Beltsville, Maryland 20705, USA
    Physiol Genomics 27:42-53. 2006

Collaborators

Detail Information

Publications42

  1. doi request reprint Bovine mammary stem cells: cell biology meets production agriculture
    A V Capuco
    Bovine Functional Genomics Laboratory, USDA ARS, Beltsville, MD 20705, USA
    Animal 6:382-93. 2012
    ..The exciting possibility that stem cell expansion can influence milk production is currently under investigation...
  2. pmc In vitro expansion of the mammary stem/progenitor cell population by xanthosine treatment
    Ratan K Choudhary
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD, USA
    BMC Cell Biol 13:14. 2012
    ..The objective of this study was to determine if treating primary cultures of bovine mammary epithelial cells (MEC) with xanthosine increases the stem/progenitor cell population by promoting symmetrical division of mammary stem cells...
  3. ncbi request reprint Identification of putative bovine mammary epithelial stem cells by their retention of labeled DNA strands
    Anthony V Capuco
    Bovine Functional Genomics Laboratory, USDA ARS, Beltsville, MD 20705, USA
    Exp Biol Med (Maywood) 232:1381-90. 2007
    ..Continuing studies will address the usefulness of this technique to identify bovine mammary stem cells and to facilitate studies of stem cell biology...
  4. doi request reprint Regulation of mammary gland sensitivity to thyroid hormones during the transition from pregnancy to lactation
    A V Capuco
    Bovine Functional Genomics Laboratory, USDA ARS, Powder Mill Road, BARC East, Beltsville, MD 20705, USA
    Exp Biol Med (Maywood) 233:1309-14. 2008
    ..Data suggest that increased expression of mammary TRbeta1 and DIO2, and decreased RXRalpha, provide a mechanism to increase thyroid hormone activity within the mammary gland during lactation...
  5. doi request reprint Neither bovine somatotropin nor growth hormone-releasing factor alters expression of thyroid hormone receptors in liver and mammary tissues
    A V Capuco
    Bovine Functional Genomics Laboratory, USDA ARS, Beltsville, MD 20705, USA
    J Dairy Sci 94:4915-21. 2011
    ..Data do not support the hypothesis that administration of bST or bGRF alters sensitivity of mammary tissue by changing expression of thyroid hormone receptors...
  6. doi request reprint In vivo expansion of the mammary stem/ progenitor cell population by xanthosine infusion
    Anthony V Capuco
    Bovine Functional Genomics Laboratory, USDA ARS, Beltsville, MD 20705
    Exp Biol Med (Maywood) 234:475-82. 2009
    ..This is the first demonstration of an in vivo treatment to increase the endogenous population of mammary stem cells, with utility for biomedical research and dairy management...
  7. pmc The origin and evolution of lactation
    Anthony V Capuco
    USDA ARS, Bovine Functional Genomics Laboratory, Powder Mill, BARC East, Beltsville, MD 20705, USA
    J Biol 8:37. 2009
    ..The recent assembly of the bovine genome and a report in Genome Biology that links the milk and lactation data of bovine and other mammalian genomes will help biologists investigate this economically and medically important feature...
  8. pmc Effects of increased milking frequency on gene expression in the bovine mammary gland
    Erin E Connor
    Bovine Functional Genomics Laboratory, USDA ARS, Beltsville Agricultural Research Center, 10300 Baltimore Avenue, Beltsville, MD 20705, USA
    BMC Genomics 9:362. 2008
    ....
  9. doi request reprint A sentinel function for teat tissues in dairy cows: dominant innate immune response elements define early response to E. coli mastitis
    Manuela Rinaldi
    USDA ARS, Beltsville, MD 20705, USA
    Funct Integr Genomics 10:21-38. 2010
    ..Data support an important sentinel function for the teat, as these tissues responded rapidly and intensely, with production of cytokines and antimicrobial peptides...
  10. ncbi request reprint Identification of estrogen-responsive genes in the parenchyma and fat pad of the bovine mammary gland by microarray analysis
    Robert W Li
    Bovine Functional Genomics Laboratory, United States Department of Agriculture Agricultural Research Service, Beltsville, Maryland 20705, USA
    Physiol Genomics 27:42-53. 2006
    ..The distinctive expression patterns regulated by estrogen in parenchyma and fat pad shed light on the need for both tissues to obtain normal mammary development...
  11. ncbi request reprint Discovery and profiling of bovine microRNAs from immune-related and embryonic tissues
    Luiz L Coutinho
    United States Department of Agriculture, Agricultural Research Center, Beltsville Area Research Center, Beltsville, Maryland 20705, USA
    Physiol Genomics 29:35-43. 2007
    ..These results support the premise that species differences in regulation of gene expression by miR occur primarily at the level of expression and processing...
  12. ncbi request reprint Canonical pathways and networks regulated by estrogen in the bovine mammary gland
    Robert W Li
    Animal and Natural Resources Institute, United States Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705, USA
    Funct Integr Genomics 8:55-68. 2008
    ....
  13. ncbi request reprint Chromosomal mapping and quantitative analysis of estrogen-related receptor alpha-1, estrogen receptors alpha and beta and progesterone receptor in the bovine mammary gland
    E E Connor
    Bovine Functional Genomics Laboratory, USDA ARS, Beltsville, Maryland 20705, USA
    J Endocrinol 185:593-603. 2005
    ..Our results demonstrate the presence of ERalpha, PR and ERRalpha during all physiological stages, and suggest a functional role for ERRalpha and a relative lack of a role for ERbeta in bovine mammary gland development and lactation...
  14. ncbi request reprint Concurrent pregnancy retards mammary involution: effects on apoptosis and proliferation of the mammary epithelium after forced weaning of mice
    Anthony V Capuco
    Gene Evaluation and Mapping Laboratory, U S Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705, USA
    Biol Reprod 66:1471-6. 2002
    ....
  15. ncbi request reprint Adrenomedullin (AM) and adrenomedullin binding protein (AM-BP) in the bovine mammary gland and milk: Effects of stage of lactation and experimental intramammary E. coli infection
    Ted H Elsasser
    USDA ARS, Growth Biology Laboratory, Beltsville, MD 20705, US
    Domest Anim Endocrinol 32:138-54. 2007
    ....
  16. ncbi request reprint Visceral tissue growth and proliferation during the bovine lactation cycle
    R L Baldwin
    Growth Biology Laboratory, ARS, US Department of Agriculture, Belltsville, MD 20705, USA
    J Dairy Sci 87:2977-86. 2004
    ..Mass of visceral tissues increase to meet the energetic demands of lactation and that increased absorption capacity of the intestines is achieved by hyperplastic growth of the intestinal epithelium...
  17. ncbi request reprint Cell proliferation in bovine mammary epithelium: identification of the primary proliferative cell population
    S Ellis
    Gene Evaluation and Mapping Laboratory, USDA Agricultural Research Center, Building 200, BARC East, 20705, Beltsville, MD 20705, USA
    Tissue Cell 34:155-63. 2002
    ..These results strongly support the concept that lightly staining mammary parenchymal cells are the primary proliferative cell population...
  18. ncbi request reprint Regulation of gene expression in the bovine mammary gland by ovarian steroids
    E E Connor
    Bovine Functional Genomics Laboratory, USDA, ARS, Beltsville, MD 20705 2350, USA
    J Dairy Sci 90:E55-65. 2007
    ..Continuing studies using advanced molecular techniques should assist in elucidating the complex regulation of mammary function at the transcript level...
  19. ncbi request reprint Mammary involution in dairy animals
    A V Capuco
    Gene Evaluation and Mapping Laboratory, USDA ARS, Beltsville, Maryland 20705, USA
    J Mammary Gland Biol Neoplasia 4:137-44. 1999
    ..The ability to manipulate apoptosis and cell proliferation during the nonlactating period and during lactation is expected to provide enormous benefits to the dairy industry...
  20. doi request reprint Characterization of glucagon-like peptide 2 pathway member expression in bovine gastrointestinal tract
    E E Connor
    Beltsville Agricultural Research Center, USDA ARS, Beltsville, MD 20705, USA
    J Dairy Sci 93:5167-78. 2010
    ..Our findings support a functional role of the GLP-2 pathway in bovine GIT and the potential for use of GLP-2 as a therapy to improve intestinal function and nutrient absorption in ruminants...
  21. ncbi request reprint Postnatal mammary ductal growth: three-dimensional imaging of cell proliferation, effects of estrogen treatment, and expression of steroid receptors in prepubertal calves
    A V Capuco
    Gene Evaluation and Mapping Laboratory, USDA ARS, Beltsville, MD 20705, USA
    Tissue Cell 34:143-54. 2002
    ....
  22. ncbi request reprint Mammary cell number, proliferation, and apoptosis during a bovine lactation: relation to milk production and effect of bST
    A V Capuco
    Gene Evaluation and Mapping Laboratory, USDA ARS, Beltsville, MD 20705, USA
    J Dairy Sci 84:2177-87. 2001
    ..A change in the ratio of epithelial proliferation to cell death during lactation will affect the persistency of lactation...
  23. ncbi request reprint Effect of mastitis on milk perchlorate concentrations in dairy cows
    D D Bannerman
    Bovine Functional Genomics Laboratory, USDA, ARS, Beltsville, MD 20705, USA
    J Dairy Sci 89:3011-9. 2006
    ..The overall finding that mastitis results in lower milk perchlorate concentrations suggests that changes in udder health do not necessitate increased screening of milk for perchlorate...
  24. ncbi request reprint Prolactin and growth hormone stimulation of lactation in mice requires thyroid hormones
    A V Capuco
    Gene Evaluation and Mapping Laboratory, United States Department of Agriculture, Agricultural Research Service, Livestock and Poultry Sciences Institute, Beltsville, Maryland 20705, USA
    Proc Soc Exp Biol Med 221:345-51. 1999
    ..Data show that thyroid hormones are necessary for a galactopoietic response to GH and PRL and demonstrate a unique organ-specific regulation of 5'D by galactopoietic hormones...
  25. ncbi request reprint Lactation persistency: insights from mammary cell proliferation studies
    A V Capuco
    Gene Evaluation and Mapping Laboratory, Animal and Natural Resources Institute, USDA, ARS, Beltsville, MD 20705, USA
    J Anim Sci 81:18-31. 2003
    ..Characterization of these cells may provide a means to regulate mammary cell proliferation and thus to enhance persistency, reduce the effects of mastitis, and decrease the necessity for a dry period...
  26. pmc Fate of dietary perchlorate in lactating dairy cows: Relevance to animal health and levels in the milk supply
    A V Capuco
    Bovine Functional Genomics Laboratory, Environmental Quality Laboratory, and Veterinary Services, U S Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705, USA
    Proc Natl Acad Sci U S A 102:16152-7. 2005
    ..Data presented are important for assessing the environmental impact on perchlorate concentrations in milk and potential for relevance to human health...
  27. ncbi request reprint Molecular cloning, expression and radiation hybrid mapping of the bovine deiodinase type II (DIO2) and deiodinase type III (DIO3) genes
    E E Connor
    Beltsville Agricultural Research Center, ARS, USDA, 10300 Baltimore Ave, Beltsville, MD 20705, USA
    Anim Genet 36:240-3. 2005
    ..Results of this work will aid in the study of deiodinase gene expression and thyroid hormone regulation in cattle...
  28. ncbi request reprint Characterization of open reading frame-expressed sequence tags generated from Bos indicus and B. taurus mammary gland cDNA libraries
    A F da Mota
    USDA, ARS Bovine Functional Genomics Laboratory, Beltsville Agricultural Research Institute BARC East, Beltsville, MD, USA
    Anim Genet 35:213-9. 2004
    ....
  29. ncbi request reprint Bovine mammary progenitor cells: current concepts and future directions
    A V Capuco
    Bovine Functional Genomics Laboratory, USDA ARS, Beltsville, MD 20705, USA
    J Mammary Gland Biol Neoplasia 10:5-15. 2005
    ....
  30. ncbi request reprint Effect of bovine somatotropin and rumen-undegradable protein on mammary growth of prepubertal dairy heifers and subsequent milk production
    A V Capuco
    Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, USDA ARS, Beltsville, MD 20705, USA
    J Dairy Sci 87:3762-9. 2004
    ..Neither deleterious effects of increased rates of gain nor positive effects of bST were evident in prepubertal mammary growth. Subsequent milk production and composition was not different among treatments...
  31. ncbi request reprint Effect of somatotropin on thyroid hormones and cytokines in lactating dairy cows during ad libitum and restricted feed intake
    A V Capuco
    Gene Evaluation and Mapping Laboratory, USDA ARS, Beltsville, MD 20705, USA
    J Dairy Sci 84:2430-9. 2001
    ..Short-term treatment with bST did not influence thyroid hormone metabolism in lactating cows in positive or negative energy balance...
  32. pmc Comparison of the transcriptomes of long-term label retaining-cells and control cells microdissected from mammary epithelium: an initial study to characterize potential stem/progenitor cells
    Ratan K Choudhary
    Department of Animal and Avian Sciences, University of Maryland College Park, MD, USA
    Front Oncol 3:21. 2013
    ..Insights into the biology of stem cells will be gained by confirmation and characterization of candidate MaSC markers identified in this study...
  33. ncbi request reprint Expression of lysostaphin in milk of transgenic mice affects the growth of neonates
    Abhijit Mitra
    Gene Evaluation and Mapping Laboratory, Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705, USA
    Transgenic Res 12:597-605. 2003
    ....
  34. ncbi request reprint Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index
    Tad S Sonstegard
    USDA, ARS, Beltsville Agricultural Research Center, Beltsville, Maryland 20705, USA
    Mamm Genome 13:373-9. 2002
    ..These results demonstrate that bovine sequence expression data serve as a resource for characterizing mammalian transcriptomes and identifying those genes potentially unique to ruminants...
  35. doi request reprint Exploring the host transcriptome for mechanisms underlying protective immunity and resistance to nematode infections in ruminants
    Robert W Li
    USDA ARS, Bovine Functional Genomics Laboratory, Beltsville, MD, USA
    Vet Parasitol 190:1-11. 2012
    ..This review summarizes recent progress and limitations of understanding regulatory genetic networks and biological pathways that affect host resistance and susceptibility to nematode infection in ruminants...
  36. pmc Characterization of the abomasal transcriptome for mechanisms of resistance to gastrointestinal nematodes in cattle
    Robert W Li
    Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, USDA ARS, Beltsville, MD 20705, USA
    Vet Res 42:114. 2011
    ..Our results provide insights into the development of host immunity to gastrointestinal nematode infection and will facilitate understanding of mechanism underlying host resistance...
  37. ncbi request reprint Predicting perchlorate exposure in milk from concentrations in dairy feed
    Clifford P Rice
    Environmental Management and Byproduct Utilization Laboratory, USDA, Agricultural Research Service, Beltsville, Maryland 20715, USA
    J Agric Food Chem 55:8806-13. 2007
    ..The study suggests that reducing perchlorate concentration in dairy feed may reduce perchlorate concentrations in milk as well as the potential to reduce human exposure to perchlorate in milk...
  38. ncbi request reprint Changes in secretory cell turnover, and mitochondrial oxidative damage in the mouse mammary gland during a single prolonged lactation cycle suggest the possibility of accelerated cellular aging
    Darryl L Hadsell
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston TX, 77030 USA
    Exp Gerontol 41:271-81. 2006
    ..The results suggest that a single prolonged lactation cycle may replicate on an accelerated basis some of the changes that occur with a lifetime of aging in organs possessing more stable cell populations...
  39. ncbi request reprint Expression of cytosolic NADP+-dependent isocitrate dehydrogenase in bovine mammary epithelium: Modulation by regulators of differentiation and metabolic effectors
    WenJing Liu
    Laboratory of Mammary Gland Biology, Department of Nutritional Sciences, University of Arizona, Tucson, Arizona 85724, USA
    Exp Biol Med (Maywood) 231:599-610. 2006
    ..Taken together, our data suggest that the expression of IDH1 in bovine mammary epithelium is modulated by regulators of differentiation including extracellular matrix and lactogenic hormones as well as metabolic effectors...
  40. doi request reprint Involvement of connective tissue growth factor (CTGF) in insulin-like growth factor-I (IGF1) stimulation of proliferation of a bovine mammary epithelial cell line
    Yinli Zhou
    Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Domest Anim Endocrinol 35:180-9. 2008
    ....
  41. ncbi request reprint Apoptosis of bovine neutrophils during mastitis experimentally induced with Escherichia coli or endotoxin
    Kaat Van Oostveldt
    University of Ghent, Faculty of Veterinary Medicine, Department of Physiology, Biochemistry and Biometrics, Merelbeke, Belgium
    Am J Vet Res 63:448-53. 2002
    ..To determine whether apoptosis of neutrophils was accelerated during mastits experimentally induced by use of Escherichia coli or E coli endotoxin and whether differences were apparent in the response to E coli or endotoxin...
  42. ncbi request reprint Evaluation of L-selectin expression and assessment of protein tyrosine phosphorylation in bovine polymorphonuclear neutrophil leukocytes around parturition
    Erica Monfardini
    Department of Physiology, Biochemistry and Biometrics, Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium
    Vet Res 33:271-81. 2002
    ..Reduced PMN function during the periparturient period could be related to reduced L-selectin adhesion molecules on the cell surface, and to modulation in the phosphorylation of functionally important molecules...