Sean H Adams

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. pmc Comparative effects of fructose and glucose on lipogenic gene expression and intermediary metabolism in HepG2 liver cells
    Kristin M Hirahatake
    Department of Nutrition, University of California Davis, Davis, California, United States of America
    PLoS ONE 6:e26583. 2011
  2. pmc Gamma-synuclein is an adipocyte-neuron gene coordinately expressed with leptin and increased in human obesity
    Pieter J Oort
    USDA Agricultural Research Service Western Human Nutrition Research Center, Davis, CA 95616, USA
    J Nutr 138:841-8. 2008
  3. pmc Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARgamma and Identification of TUSC5 Coding Variants in Lean and Obese Humans
    Trina A Knotts
    Obesity and Metabolism Research Unit, USDA Agricultural Research Service Western Human Nutrition Research Center, Davis, CA 95616, USA
    PPAR Res 2009:867678. 2009
  4. pmc Long-chain fatty acid combustion rate is associated with unique metabolite profiles in skeletal muscle mitochondria
    Erin L Seifert
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 5:e9834. 2010
  5. pmc Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin
    Caitlin Campbell
    USDA ARS Western Human Nutrition Research Center, Davis, California, United States of America
    PLoS ONE 9:e84260. 2014
  6. pmc Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women
    Oliver Fiehn
    Genome Center, University of California Davis, Davis, California, United States of America
    PLoS ONE 5:e15234. 2010
  7. pmc Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state
    Sean H Adams
    Obesity and Metabolism Research Unit, USDA Agricultural Research Service Western Human Nutrition Research Center, and Department of Nutrition, University of California, Davis, CA, USA
    Adv Nutr 2:445-56. 2011
  8. pmc A high calcium diet containing nonfat dry milk reduces weight gain and associated adipose tissue inflammation in diet-induced obese mice when compared to high calcium alone
    Anthony P Thomas
    Department of Nutrition, University of California, One Shields Avenue, Davis, CA, USA
    Nutr Metab (Lond) 9:3. 2012
  9. pmc Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women
    Sean H Adams
    USDA Agricultural Research Service Western Human Nutrition Research Center, USA
    J Nutr 139:1073-81. 2009
  10. pmc Muscle uncoupling protein 3 overexpression mimics endurance training and reduces circulating biomarkers of incomplete β-oxidation
    Celine Aguer
    2M E H, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada
    FASEB J 27:4213-25. 2013

Collaborators

Detail Information

Publications27

  1. pmc Comparative effects of fructose and glucose on lipogenic gene expression and intermediary metabolism in HepG2 liver cells
    Kristin M Hirahatake
    Department of Nutrition, University of California Davis, Davis, California, United States of America
    PLoS ONE 6:e26583. 2011
    ....
  2. pmc Gamma-synuclein is an adipocyte-neuron gene coordinately expressed with leptin and increased in human obesity
    Pieter J Oort
    USDA Agricultural Research Service Western Human Nutrition Research Center, Davis, CA 95616, USA
    J Nutr 138:841-8. 2008
    ..0001; n = 44). Gamma-synuclein protein was observed in rodent and human WAT but not in negative control liver. These results are consistent with the hypothesis that gamma-synuclein plays an important role in adipocyte physiology...
  3. pmc Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARgamma and Identification of TUSC5 Coding Variants in Lean and Obese Humans
    Trina A Knotts
    Obesity and Metabolism Research Unit, USDA Agricultural Research Service Western Human Nutrition Research Center, Davis, CA 95616, USA
    PPAR Res 2009:867678. 2009
    ..These studies firmly establish the murine TUSC5 gene locus as a PPARgamma target, but the significance of Tusc5 in obesity phenotypes or in the pharmacologic actions of PPARgamma agonists in humans remains equivocal...
  4. pmc Long-chain fatty acid combustion rate is associated with unique metabolite profiles in skeletal muscle mitochondria
    Erin L Seifert
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 5:e9834. 2010
    ..We have used unbiased metabolite profiling of mouse muscle mitochondria with the aim of identifying candidate metabolites within or effluxed from mitochondria and that are shifted with LCFA combustion rate...
  5. pmc Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin
    Caitlin Campbell
    USDA ARS Western Human Nutrition Research Center, Davis, California, United States of America
    PLoS ONE 9:e84260. 2014
    ....
  6. pmc Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women
    Oliver Fiehn
    Genome Center, University of California Davis, Davis, California, United States of America
    PLoS ONE 5:e15234. 2010
    ....
  7. pmc Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state
    Sean H Adams
    Obesity and Metabolism Research Unit, USDA Agricultural Research Service Western Human Nutrition Research Center, and Department of Nutrition, University of California, Davis, CA, USA
    Adv Nutr 2:445-56. 2011
    ....
  8. pmc A high calcium diet containing nonfat dry milk reduces weight gain and associated adipose tissue inflammation in diet-induced obese mice when compared to high calcium alone
    Anthony P Thomas
    Department of Nutrition, University of California, One Shields Avenue, Davis, CA, USA
    Nutr Metab (Lond) 9:3. 2012
    ..abstract:..
  9. pmc Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women
    Sean H Adams
    USDA Agricultural Research Service Western Human Nutrition Research Center, USA
    J Nutr 139:1073-81. 2009
    ....
  10. pmc Muscle uncoupling protein 3 overexpression mimics endurance training and reduces circulating biomarkers of incomplete β-oxidation
    Celine Aguer
    2M E H, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada
    FASEB J 27:4213-25. 2013
    ....
  11. doi request reprint A dairy-based high calcium diet improves glucose homeostasis and reduces steatosis in the context of preexisting obesity
    Anthony P Thomas
    Graduate Group in Nutritional Biology and Department of Nutrition, University of California, Davis Department of Nutrition, University of California, Davis, California, USA
    Obesity (Silver Spring) 21:E229-35. 2013
    ..Furthermore, interpretations have been confounded historically by differences in body weight gain among DIO animals fed dairy-based protein or high Ca...
  12. ncbi request reprint Characterization of Tusc5, an adipocyte gene co-expressed in peripheral neurons
    Pieter J Oort
    USDA Agricultural Research Service Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA
    Mol Cell Endocrinol 276:24-35. 2007
    ..Characterization of such links is important for clarifying the molecular basis for adipocyte proliferation and could have implications for understanding the biology of metabolic disease-related neuropathies...
  13. pmc Association between subcutaneous white adipose tissue and serum 25-hydroxyvitamin D in overweight and obese adults
    Brian D Piccolo
    Department of Nutrition and Graduate Group in Nutritional Biology, University of California, One Shields Avenue, Davis, CA 95616, USA
    Nutrients 5:3352-66. 2013
    ..Weight loss alone is not sufficient to increase serum 25(OH)D and increases in dietary or dermal biosynthesis of vitamin D appear to be the most critical contributors to in vitamin D status. ..
  14. pmc Dairy food consumption and meal-induced cortisol response interacted to influence weight loss in overweight women undergoing a 12-week, meal-controlled, weight loss intervention
    Megan G Witbracht
    Department of Nutrition, University of California, Davis, CA, USA
    J Nutr 143:46-52. 2013
    ..The AD treatment prevented the latter. Furthermore, certain phenotypic markers of HPA axis function may help to expose the weight-reducing effects of consuming dairy food...
  15. doi request reprint Inflammatory phenotyping identifies CD11d as a gene markedly induced in white adipose tissue in obese rodents and women
    Anthony P Thomas
    Obesity and Metabolism Research Unit, USDA Agricultural Research Service Western Human Nutrition Research Center, Davis, CA 95616, USA
    J Nutr 141:1172-80. 2011
    ....
  16. pmc Acylcarnitines activate proinflammatory signaling pathways
    Jennifer M Rutkowsky
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, California
    Am J Physiol Endocrinol Metab 306:E1378-87. 2014
    ..Thus, acylcarnitines have the potential to activate inflammation, but the specific molecular and tissue target(s) involved remain to be identified. ..
  17. pmc Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats
    Gabriel Paulino
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, 1321 Haring Hall, Vet Med APC, University of California, Davis, 1 Shields Ave, Davis, CA 95616, USA
    Am J Physiol Endocrinol Metab 296:E898-903. 2009
    ..Shifts in the balance between orexigenic and anorexigenic signals within the vagal afferent pathway may influence food intake and body weight gain induced by high fat diets...
  18. pmc Type 2 diabetes associated changes in the plasma non-esterified fatty acids, oxylipins and endocannabinoids
    Dmitry Grapov
    Department of Nutrition, University of California Davis, Davis, California, USA
    PLoS ONE 7:e48852. 2012
    ....
  19. doi request reprint Performance on the Iowa Gambling Task is related to magnitude of weight loss and salivary cortisol in a diet-induced weight loss intervention in overweight women
    Megan G Witbracht
    Department of Nutrition, 1 Shields Ave, University of California, Davis, CA 95616, USA
    Physiol Behav 106:291-7. 2012
    ..These findings underscore the need to further investigate higher cognitive and neuroendocrine pathways that may influence or be altered by the process of dieting and weight loss...
  20. pmc Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways
    Shurong Huang
    Western Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Department of Anatomy, Physiology and Cell Biology, University of California, Davis, CA, USA
    J Lipid Res 53:2002-13. 2012
    ....
  21. pmc Contributions of adipose tissue architectural and tensile properties toward defining healthy and unhealthy obesity
    Denise E Lackey
    Obesity and Metabolism Research Unit, US Department of Agriculture Agricultural Research Service Western Human Nutrition Research Center, Davis, California
    Am J Physiol Endocrinol Metab 306:E233-46. 2014
    ..This is consistent with the hypothesis that WAT ECM physiology is intimately linked to metabolic health in obese humans, and the studies provide new tools to explore this relationship...
  22. pmc Metabolic and endocrine profiles in response to systemic infusion of fructose and glucose in rhesus macaques
    Sean H Adams
    US Department of Agriculture Agricultural Research Service Western Human Nutrition Research Center, University of California, Davis, Davis, California 95616, USA
    Endocrinology 149:3002-8. 2008
    ..e. limited post-fructose insulin excursions and/or hexose-specific differences in adipocyte metabolism) are likely to underlie disparate effects of fructose and glucose to increase circulating leptin concentrations...
  23. ncbi request reprint Prevalence of undiagnosed and inadequately treated type 2 diabetes mellitus, hypertension, and dyslipidemia in morbidly obese patients who present for bariatric surgery
    Rouzbeh Mostaedi
    Department of Surgery, University of California, Davis, 2221 Stockton Boulevard, Cypress Building, Sacramento, CA, 95817, USA
    Obes Surg 24:927-35. 2014
    ..Pharmacotherapy is considered the primary treatment modality for diabetes mellitus (DM), hypertension (HTN), and dyslipidemia (DYS). We sought to investigate the status of DM, HTN, and DYS in patients who seek bariatric surgery...
  24. pmc Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity
    Denise E Lackey
    Obesity and Metabolism Research Unit, United States Department of Agriculture Agricultural Research Service Western Human Nutrition Research Center, Davis, CA 95616, USA
    Am J Physiol Endocrinol Metab 304:E1175-87. 2013
    ....
  25. ncbi request reprint Associations between dairy foods, diabetes, and metabolic health: potential mechanisms and future directions
    Kristin M Hirahatake
    Obesity and Metabolism Research Unit, USDA ARS Western Human Nutrition Research Center, Davis, CA
    Metabolism 63:618-27. 2014
    ..Such experiments would complement epidemiological studies and add to the evidence base for recommendations regarding consumption of dairy products and their individual components...
  26. pmc Dairy Foods in a Moderate Energy Restricted Diet Do Not Enhance Central Fat, Weight, and Intra-Abdominal Adipose Tissue Losses nor Reduce Adipocyte Size or Inflammatory Markers in Overweight and Obese Adults: A Controlled Feeding Study
    Marta D Van Loan
    Obesity and Metabolism Research Unit, Western Human Nutrition Research Center, USDA, ARS, 430 West Health Science Drive, Davis, CA 95616, USA
    J Obes 2011:989657. 2011
    ..Assessment of appetite, hunger, and satiety with followup on weight regain should be considered...
  27. ncbi request reprint PYY[3-36] administration decreases the respiratory quotient and reduces adiposity in diet-induced obese mice
    Sean H Adams
    Department of Pharmacology, Amylin Pharmaceuticals, San Diego, CA, USA
    J Nutr 136:195-201. 2006
    ..Fat loss and reduced RQ highlight the potential for PYY[3-36] to drive increased mobilization of fat stores to help meet energy requirements in this model...