B W Murray

Summary

Affiliation: Agouron Pharmaceuticals
Country: USA

Publications

  1. ncbi Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho-Tie2
    B W Murray
    Pfizer Global Research and Development La Jolla Laboratories, 4215 Sorrento Valley Boulevard, La Jolla, California 92121, USA
    Biochemistry 40:10243-53. 2001
  2. pmc IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex
    F Mercurio
    Signal Pharmaceuticals, Inc, San Diego, California 92121, USA
    Mol Cell Biol 19:1526-38. 1999
  3. ncbi Mechanism and specificity of human alpha-1,3-fucosyltransferase V
    B W Murray
    Department of Chemistry, Scripps Research Institute, La Jolla, California 92037, USA
    Biochemistry 35:11183-95. 1996
  4. ncbi p38-2, a novel mitogen-activated protein kinase with distinct properties
    B Stein
    Signal Pharmaceuticals Inc, San Diego, California 92121, USA
    J Biol Chem 272:19509-17. 1997
  5. ncbi IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation
    F Mercurio
    Signal Pharmaceuticals, Inc, 5555 Oberlin Drive, San Diego, CA 92121, USA
    Science 278:860-6. 1997
  6. ncbi Genome organization of glutamine synthetase genes in rainbow trout (Oncorhynchus mykiss)
    K Gharbi
    Department of Integrative Biology, University of Guelph, Guelph, Canada
    Cytogenet Genome Res 116:113-5. 2007

Collaborators

Detail Information

Publications6

  1. ncbi Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho-Tie2
    B W Murray
    Pfizer Global Research and Development La Jolla Laboratories, 4215 Sorrento Valley Boulevard, La Jolla, California 92121, USA
    Biochemistry 40:10243-53. 2001
    ..Tie2 activation perturbs catalytic residue ionizations, shifts the rate-limiting step to almost exclusive diffusion-control, and transforms the kinase into a more perfect catalyst...
  2. pmc IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex
    F Mercurio
    Signal Pharmaceuticals, Inc, San Diego, California 92121, USA
    Mol Cell Biol 19:1526-38. 1999
    ..IKKAP1 therefore appears to mediate an essential step of the NF-kappaB signal transduction cascade. Heterogeneity of IKK complexes in vivo may provide a mechanism for differential regulation of NF-kappaB activation...
  3. ncbi Mechanism and specificity of human alpha-1,3-fucosyltransferase V
    B W Murray
    Department of Chemistry, Scripps Research Institute, La Jolla, California 92037, USA
    Biochemistry 35:11183-95. 1996
    ..The role of charge and distance in the synergistic inhibitory effect by the combination of GDP, an aza sugar, and the acceptor sugar was probed. A mechanism for fucosyl transfer incorporating these findings is proposed and discussed...
  4. ncbi p38-2, a novel mitogen-activated protein kinase with distinct properties
    B Stein
    Signal Pharmaceuticals Inc, San Diego, California 92121, USA
    J Biol Chem 272:19509-17. 1997
    ..A sequential kinetic mechanism of p38-2 is suggested by steady state kinetic analysis. In conclusion, p38-2 may be an important component of the stress response required for the homeostasis of a cell...
  5. ncbi IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation
    F Mercurio
    Signal Pharmaceuticals, Inc, 5555 Oberlin Drive, San Diego, CA 92121, USA
    Science 278:860-6. 1997
    ..Mutant versions of IKK-2 had pronounced effects on RelA nuclear translocation and NF-kappaB-dependent reporter activity, consistent with a critical role for the IKK kinases in the NF-kappaB signaling pathway...
  6. ncbi Genome organization of glutamine synthetase genes in rainbow trout (Oncorhynchus mykiss)
    K Gharbi
    Department of Integrative Biology, University of Guelph, Guelph, Canada
    Cytogenet Genome Res 116:113-5. 2007
    ..In contrast, there is at present no further evidence that RT-24 and RT-08 share ancestrally homologous segments and additional genomic studies will be needed to clarify the evolutionary origin of genes coding for GS01 and GS03...