Research TopicsSpecies | C LaiSummaryAffiliation: Affymetrix Inc Country: USA Publications
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Publications
quemao, a Drosophila bristle locus, encodes geranylgeranyl pyrophosphate synthaseC Lai
Center for Population Biology, University of California, Davis, California 95616, USA
Genetics 149:1051-61. 1998..An EMS-induced qm nonsense mutation at the 12th codon leads to recessive lethality at the first larval instar, indicating the essential role of qm in the isoprenoid biosynthesis of insects...
A homologue of the 19 kDa signal recognition particle protein locus in Drosophila melanogasterC Lai
Center for Population Biology, University of California, Davis 95616, USA
Gene 203:59-63. 1997..The most conserved amino acid residues across these species are located at those sites required for in vitro association with the 7S RNA component of the SRP...- Structure and expression of the Tyro 10 receptor tyrosine kinaseC Lai
Molecular Neurobiology Laboratory, Salk Institute, La Jolla, CA 92037
Oncogene 9:877-83. 1994..These appear to be structural features of a distinct receptor PTK sub-family, in that they are also found in the recently-described discoidin domain receptor (DDR)... - Linkage disequilibrium mapping of molecular polymorphisms at the scabrous locus associated with naturally occurring variation in bristle number in Drosophila melanogasterR F Lyman
Department of Genetics, North Carolina State University, Raleigh 27695, USA
Genet Res 74:303-11. 1999..Three sites in regulatory regions were associated with female-specific variation in abdominal bristle number, one of which was an SSCP site in the region of the gene associated with regulation of sca in embryonic abdominal segments... - Naturally occurring variation in bristle number and DNA polymorphisms at the scabrous locus of Drosophila melanogasterC Lai
Center for Population Biology, University of California at Davis 95616
Science 266:1697-702. 1994.... - Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinasesK L Carraway
Department of Cell Biology, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215, USA
Nature 387:512-6. 1997..Our results indicate that NRG-1 and NRG-2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biochemical responses in cells... - An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous systemC Lai
Molecular Neurobiology Laboratory, Salk Institute, La Jolla, California 92037
Neuron 6:691-704. 1991..Together with recent studies in invertebrates, these data are consistent with the hypothesis that protein-tyrosine kinases play a central role in neural development... - Genetic interactions between mei-S332 and ord in the control of sister-chromatid cohesionS E Bickel
Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Genetics 150:1467-76. 1998..Our results suggest that a balance between the activity of mei-S332 and ord is required for proper regulation of meiotic cohesion and demonstrate that additional proteins must be functioning to ensure mitotic sister-chromatid cohesion... - Tyro-3 family receptors are essential regulators of mammalian spermatogenesisQ Lu
Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
Nature 398:723-8. 1999..Additional observations indicate that these receptors may also be essential for the tropic maintenance of diverse cell types in the mature nervous, immune and reproductive systems... - An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptorsH Kong
Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York, USA
J Neurosci 21:176-85. 2001.... - Mapping and characterization of P-element-induced mutations at quantitative trait loci in Drosophila melanogasterC Lai
Department of Genetics, University of Edinburgh
Genet Res 61:177-93. 1993.... - The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25A Polvi
Department of Pathology, University of Helsinki, Finland
Gene 134:289-93. 1993..Abundant levels of the 4.2-kb TYRO3 mRNA were detected in human brain, and lower levels in other human tissues. TYRO3 and TYRO3P were both assigned to human chromosome 15q14-q25 by analysis of DNAs from somatic cell hybrids... - The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinasesT N Stitt
Regeneron Pharmaceuticals, Incorporated, Tarrytown, New York 10591
Cell 80:661-70. 1995.... - Mapping of the receptor protein-tyrosine kinase 10 to human chromosome 1q21-q23 and mouse chromosome 1H1-5 by fluorescence in situ hybridizationS Edelhoff
Department of Pathology, University of Washington School of Medicine, Seattle 98195, USA
Genomics 25:337-9. 1995 - Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptorM Gassmann
Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
Nature 378:390-4. 1995.... - Structural characterization of a heterogeneous family of rat brain mRNAsA P Tsou
Mol Cell Biol 6:768-78. 1986..Polyadenylation occurs at either of two sites. This complicated family of 88 RNAs encodes two novel putative proteins that differ at their C termini... - Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelinK A Nave
Proc Natl Acad Sci U S A 84:5665-9. 1987..DM-20 mRNA is expressed in rat brain with approximately 50% abundance relative to PLP mRNA and appears to be developmentally coregulated... - Two forms of 1B236/myelin-associated glycoprotein, a cell adhesion molecule for postnatal neural development, are produced by alternative splicingC Lai
Proc Natl Acad Sci U S A 84:4337-41. 1987..The N terminus consists of five domains related in sequence to each other and to immunoglobulin-like molecules, especially the neural cell adhesion molecule N-CAM, suggesting a common structure for cell adhesion molecules... - Nucleotide sequences of two mRNAs for rat brain myelin proteolipid proteinR J Milner
Cell 42:931-9. 1985..Mouse and monkey utilize the 3200 but not the 1600 nucleotide mRNA, suggesting that there is no functional necessity for two sizes of rat PLP mRNAs... - Stimulation of acetylcholine receptor transcription by neuregulin-2 requires an N-box response element and is regulated by alternative splicingO N Ponomareva
Section of Neurobiology, University of Texas at Austin, Austin, TX 78712, USA
Neuroscience 134:495-503. 2005..We also show that unique Nrg-2 isoforms are differentially distributed between spinal cord and skeletal muscle, the tissues that harbor the cellular components of the neuromuscular synapse...