C Lai

Summary

Affiliation: Affymetrix Inc
Country: USA

Publications

  1. pmc quemao, a Drosophila bristle locus, encodes geranylgeranyl pyrophosphate synthase
    C Lai
    Center for Population Biology, University of California, Davis, California 95616, USA
    Genetics 149:1051-61. 1998
  2. ncbi request reprint A homologue of the 19 kDa signal recognition particle protein locus in Drosophila melanogaster
    C Lai
    Center for Population Biology, University of California, Davis 95616, USA
    Gene 203:59-63. 1997
  3. ncbi request reprint Structure and expression of the Tyro 10 receptor tyrosine kinase
    C Lai
    Molecular Neurobiology Laboratory, Salk Institute, La Jolla, CA 92037
    Oncogene 9:877-83. 1994
  4. ncbi request reprint Linkage disequilibrium mapping of molecular polymorphisms at the scabrous locus associated with naturally occurring variation in bristle number in Drosophila melanogaster
    R F Lyman
    Department of Genetics, North Carolina State University, Raleigh 27695, USA
    Genet Res 74:303-11. 1999
  5. ncbi request reprint Naturally occurring variation in bristle number and DNA polymorphisms at the scabrous locus of Drosophila melanogaster
    C Lai
    Center for Population Biology, University of California at Davis 95616
    Science 266:1697-702. 1994
  6. ncbi request reprint Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases
    K L Carraway
    Department of Cell Biology, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215, USA
    Nature 387:512-6. 1997
  7. ncbi request reprint An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system
    C Lai
    Molecular Neurobiology Laboratory, Salk Institute, La Jolla, California 92037
    Neuron 6:691-704. 1991
  8. pmc Genetic interactions between mei-S332 and ord in the control of sister-chromatid cohesion
    S E Bickel
    Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Genetics 150:1467-76. 1998
  9. ncbi request reprint Tyro-3 family receptors are essential regulators of mammalian spermatogenesis
    Q Lu
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 398:723-8. 1999
  10. ncbi request reprint An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors
    H Kong
    Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York, USA
    J Neurosci 21:176-85. 2001

Collaborators

  • T F Mackay
  • Terry Orr Weaver
  • A D Long
  • O N Ponomareva
  • H Kong
  • Q Lu
  • R F Lyman
  • J L Weber
  • M Gassmann
  • G Lemke
  • S E Bickel
  • R Dakour
  • T D Raabe
  • H Ma
  • M Rimer
  • K L Carraway
  • F Casagranda
  • M Gore
  • R Klein
  • M V Chao
  • J Boulter
  • T N Stitt
  • S Edelhoff
  • S Boast
  • Q Zhang
  • T Camenisch
  • H S Earp
  • M K Skinner
  • S P Goff
  • G K Matsushima
  • T L Orr-Weaver
  • D P Moore
  • J Ledesma
  • N Yu
  • M J Unger
  • A Polvi
  • C M Disteche
  • H Simon
  • D Orioli
  • G Conn
  • J Fisher
  • P F Jones
  • D R Gies
  • J Bruno
  • K Mattsson
  • C Radziejewski
  • K Huebner
  • R D Nicholls
  • K A Nave
  • R J Milner
  • R A Spritz
  • K Alitalo
  • L C Guida
  • E Armstrong
  • J G Sutcliffe
  • A P Tsou
  • P Danielson
  • F E Bloom
  • D J Noonan
  • J Ogata
  • D Lenoir

Detail Information

Publications20

  1. pmc quemao, a Drosophila bristle locus, encodes geranylgeranyl pyrophosphate synthase
    C Lai
    Center for Population Biology, University of California, Davis, California 95616, USA
    Genetics 149:1051-61. 1998
    ..An EMS-induced qm nonsense mutation at the 12th codon leads to recessive lethality at the first larval instar, indicating the essential role of qm in the isoprenoid biosynthesis of insects...
  2. ncbi request reprint A homologue of the 19 kDa signal recognition particle protein locus in Drosophila melanogaster
    C Lai
    Center for Population Biology, University of California, Davis 95616, USA
    Gene 203:59-63. 1997
    ..The most conserved amino acid residues across these species are located at those sites required for in vitro association with the 7S RNA component of the SRP...
  3. ncbi request reprint Structure and expression of the Tyro 10 receptor tyrosine kinase
    C Lai
    Molecular Neurobiology Laboratory, Salk Institute, La Jolla, CA 92037
    Oncogene 9:877-83. 1994
    ..These appear to be structural features of a distinct receptor PTK sub-family, in that they are also found in the recently-described discoidin domain receptor (DDR)...
  4. ncbi request reprint Linkage disequilibrium mapping of molecular polymorphisms at the scabrous locus associated with naturally occurring variation in bristle number in Drosophila melanogaster
    R F Lyman
    Department of Genetics, North Carolina State University, Raleigh 27695, USA
    Genet Res 74:303-11. 1999
    ..Three sites in regulatory regions were associated with female-specific variation in abdominal bristle number, one of which was an SSCP site in the region of the gene associated with regulation of sca in embryonic abdominal segments...
  5. ncbi request reprint Naturally occurring variation in bristle number and DNA polymorphisms at the scabrous locus of Drosophila melanogaster
    C Lai
    Center for Population Biology, University of California at Davis 95616
    Science 266:1697-702. 1994
    ....
  6. ncbi request reprint Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases
    K L Carraway
    Department of Cell Biology, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215, USA
    Nature 387:512-6. 1997
    ..Our results indicate that NRG-1 and NRG-2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biochemical responses in cells...
  7. ncbi request reprint An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system
    C Lai
    Molecular Neurobiology Laboratory, Salk Institute, La Jolla, California 92037
    Neuron 6:691-704. 1991
    ..Together with recent studies in invertebrates, these data are consistent with the hypothesis that protein-tyrosine kinases play a central role in neural development...
  8. pmc Genetic interactions between mei-S332 and ord in the control of sister-chromatid cohesion
    S E Bickel
    Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Genetics 150:1467-76. 1998
    ..Our results suggest that a balance between the activity of mei-S332 and ord is required for proper regulation of meiotic cohesion and demonstrate that additional proteins must be functioning to ensure mitotic sister-chromatid cohesion...
  9. ncbi request reprint Tyro-3 family receptors are essential regulators of mammalian spermatogenesis
    Q Lu
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 398:723-8. 1999
    ..Additional observations indicate that these receptors may also be essential for the tropic maintenance of diverse cell types in the mature nervous, immune and reproductive systems...
  10. ncbi request reprint An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors
    H Kong
    Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York, USA
    J Neurosci 21:176-85. 2001
    ....
  11. ncbi request reprint Mapping and characterization of P-element-induced mutations at quantitative trait loci in Drosophila melanogaster
    C Lai
    Department of Genetics, University of Edinburgh
    Genet Res 61:177-93. 1993
    ....
  12. ncbi request reprint The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25
    A Polvi
    Department of Pathology, University of Helsinki, Finland
    Gene 134:289-93. 1993
    ..Abundant levels of the 4.2-kb TYRO3 mRNA were detected in human brain, and lower levels in other human tissues. TYRO3 and TYRO3P were both assigned to human chromosome 15q14-q25 by analysis of DNAs from somatic cell hybrids...
  13. ncbi request reprint The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
    T N Stitt
    Regeneron Pharmaceuticals, Incorporated, Tarrytown, New York 10591
    Cell 80:661-70. 1995
    ....
  14. ncbi request reprint Mapping of the receptor protein-tyrosine kinase 10 to human chromosome 1q21-q23 and mouse chromosome 1H1-5 by fluorescence in situ hybridization
    S Edelhoff
    Department of Pathology, University of Washington School of Medicine, Seattle 98195, USA
    Genomics 25:337-9. 1995
  15. ncbi request reprint Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
    M Gassmann
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 378:390-4. 1995
    ....
  16. pmc Structural characterization of a heterogeneous family of rat brain mRNAs
    A P Tsou
    Mol Cell Biol 6:768-78. 1986
    ..Polyadenylation occurs at either of two sites. This complicated family of 88 RNAs encodes two novel putative proteins that differ at their C termini...
  17. pmc Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin
    K A Nave
    Proc Natl Acad Sci U S A 84:5665-9. 1987
    ..DM-20 mRNA is expressed in rat brain with approximately 50% abundance relative to PLP mRNA and appears to be developmentally coregulated...
  18. pmc Two forms of 1B236/myelin-associated glycoprotein, a cell adhesion molecule for postnatal neural development, are produced by alternative splicing
    C Lai
    Proc Natl Acad Sci U S A 84:4337-41. 1987
    ..The N terminus consists of five domains related in sequence to each other and to immunoglobulin-like molecules, especially the neural cell adhesion molecule N-CAM, suggesting a common structure for cell adhesion molecules...
  19. ncbi request reprint Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein
    R J Milner
    Cell 42:931-9. 1985
    ..Mouse and monkey utilize the 3200 but not the 1600 nucleotide mRNA, suggesting that there is no functional necessity for two sizes of rat PLP mRNAs...
  20. ncbi request reprint Stimulation of acetylcholine receptor transcription by neuregulin-2 requires an N-box response element and is regulated by alternative splicing
    O N Ponomareva
    Section of Neurobiology, University of Texas at Austin, Austin, TX 78712, USA
    Neuroscience 134:495-503. 2005
    ..We also show that unique Nrg-2 isoforms are differentially distributed between spinal cord and skeletal muscle, the tissues that harbor the cellular components of the neuromuscular synapse...