Research Topics
| Ranajit PalSummaryAffiliation: Advanced BioScience Laboratories Country: USA Publications
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Detail Information
Publications
Virological and molecular characterization of a simian human immunodeficiency virus (SHIV) encoding the envelope and reverse transcriptase genes from HIV-1Ranajit Pal
Advanced BioScience Laboratories Inc, Rockville, MD 20850, USA
Virology 432:173-83. 2012..Inhibition of RT Env SHIV by RT and entry inhibitors and ease of in vivo transmission make it a useful model for testing the efficacy of combinations of entry and RT inhibitors in nonhuman primates...
Immunization of rhesus macaques with a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine elicits protective antibody response against simian human immunodeficiency virus of R5 phenotypeRanajit Pal
Department of Cell Biology, Advanced BioScience Laboratories, Kensington, MD 20895, USA
Virology 348:341-53. 2006....- Characterization of vaginal transmission of a simian human immunodeficiency virus (SHIV) encoding the reverse transcriptase gene from HIV-1 in Chinese rhesus macaquesRanajit Pal
Advanced BioScience Laboratories Inc, Kensington, MD 20895, USA
Virology 386:102-8. 2009..The vaginal transmission of RT SHIV demonstrated here suggests this virus may possibly be used in the nonhuman primate model for limited evaluation of RT inhibitors applied vaginally... - Definitive toxicology and biodistribution study of a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 (HIV-1) vaccine in rabbitsRanajit Pal
Department of Cell Biology, Advanced BioScience Laboratories, 5510 Nicholson Lane, Kensington, MD 20895, USA
Vaccine 24:1225-34. 2006..These studies demonstrate that a novel polyvalent DNA prime/protein boost vaccine lacks signs of toxicity and DNA integration in a rabbit model, and immunogenicity and toxicology data support clinical testing of the vaccine in humans... 
Polyvalent DNA prime and envelope protein boost HIV-1 vaccine elicits humoral and cellular responses and controls plasma viremia in rhesus macaques following rectal challenge with an R5 SHIV isolateRanajit Pal
Advanced BioScience Laboratories, Kensington, MD 20895, USA
J Med Primatol 34:226-36. 2005....- HIV-1 Env vaccine comprised of electroporated DNA and protein co-administered with TalabostatAnthony D Cristillo
Advanced BioScience Laboratories, Inc, 5510 Nicholson Lane, Kensington, MD 20895, USA
Biochem Biophys Res Commun 370:22-6. 2008..Induction of CD8(+) and CD4(+) T cells and functional CTL activity was noted. These results highlight the potential use of orally administered Talabostat for efficient protein boosting of antibody and T-cell responses primed by DNA... - Characterization of a SHIV162P3 variant evolved in an infected rhesus macaque with persistent plasma viremiaHye Kyung Chung
Department of Cell Biology, Advanced BioScience Laboratories, Inc, Kensington, MD 20895, USA
Virus Res 151:229-34. 2010..These results demonstrate that evolution of the envelope in SHIV-infected macaques may lead to the emergence of a viral variant with altered immunological characteristics... - HIV-1 prophylactic vaccine comprised of topical DermaVir prime and protein boost elicits cellular immune responses and controls pathogenic R5 SHIV162P3Anthony D Cristillo
Advanced BioScience Laboratories, Inc, 5510 Nicholson Lane, Kensington, MD 20895, USA
Virology 366:197-211. 2007..Overall, the topical DermaVir/protein vaccination yields central memory T cell responses and facilitates control of pathogenic SHIV infection... - Molecular methods for evaluation of virological status of nonhuman primates challenged with simian immunodeficiency or simian-human immunodeficiency virusesEun Mi Lee
Advanced BioScience Laboratories, Inc, Kensington, MD 20895, United States
J Virol Methods 163:287-94. 2010..These results suggest that simultaneous application of real-time NASBA and PCR assays provides quantitative evaluation of challenge outcome in macaques... - Preclinical evaluation of cellular immune responses elicited by a polyvalent DNA prime/protein boost HIV-1 vaccineAnthony D Cristillo
Advanced BioScience Laboratories, Department of Cell Biology, 5510 Nicholson Lane, Kensington, MD 20895, USA
Virology 346:151-68. 2006.... - Cellular gene expression profiles in rhesus macaques challenged mucosally with a pathogenic R5 tropic simian human immunodeficiency virus isolateHye Kyung Chung
Advanced BioScience Laboratories, Inc, Kensington, Maryland 20895, USA
Viral Immunol 21:411-23. 2008..Using the paired LPE test, 59 genes with p values <0.01 were identified and specific differences in the gene expression profiles in PBMCs from controllers versus non-controllers were detected... - Induction of mucosal and systemic antibody and T-cell responses following prime-boost immunization with novel adjuvanted human immunodeficiency virus-1-vaccine formulationsAnthony D Cristillo
Advanced BioScience Laboratories Inc, 5510 Nicholson Lane, Kensington, MD 20895, USA
J Gen Virol 92:128-40. 2011.... - Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-human immunodeficiency virus SHIVKU2 RNA levelsRanajit Pal
Advanced BioScience Laboratories, Inc, Kensington, Maryland 20895, USA
J Virol 80:3732-42. 2006..Thus, systemic immunization with ALVAC-HIV-1 vaccine candidates elicits anti-HIV-1 immune responses able to contain virus replication also at mucosal sites in macaques... - Persistent antibody and T cell responses induced by HIV-1 DNA vaccine delivered by electroporationAnthony D Cristillo
Advanced BioScience Laboratories, Inc, Department of Cell Biology, 5510 Nicholson Lane, Kensington, MD 20895, USA
Biochem Biophys Res Commun 366:29-35. 2008..These findings highlight efficient priming of immune responses by electroporated DNA that in conjunction with protein boost may give rise to long-term immunity in immunized hosts... - Characterization of a simian human immunodeficiency virus encoding the envelope gene from the CCR5-tropic HIV-1 Ba-LRanajit Pal
Advanced BioScience Laboratories, Kensington, Maryland, USA
J Acquir Immune Defic Syndr 33:300-7. 2003..The envelope gene of SHIV Ba-L revealed a very little genetic drift during in vivo passage. SHIV Ba-L provides a potentially useful model for R5 HIV-1 infection of humans... - The safety and tolerability of an HIV-1 DNA prime-protein boost vaccine (DP6-001) in healthy adult volunteersJeffrey S Kennedy
Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, USA
Vaccine 26:4420-4. 2008..Questions remain regarding the cause of the vasculitis, but the unique DTH observation may have contributed to the high level of immune responses previously reported for this vaccine... - Comparative study of Tat vaccine regimens in Mauritian cynomolgus and Indian rhesus macaques: influence of Mauritian MHC haplotypes on susceptibility/resistance to SHIV(89.6P) infectionRuth H Florese
Vaccine Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Vaccine 26:3312-21. 2008..Although protection here was limited, Tat-based vaccines incorporating other HIV components have shown greater efficacy. Combination strategies should be further explored... - Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteersShixia Wang
Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
Vaccine 26:1098-110. 2008.... - Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteersShixia Wang
Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
Vaccine 26:3947-57. 2008.... - Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelopeSusan W Barnett
Novartis Vaccines and Diagnostics, Inc, 4560 Horton Street, Emeryville, California 94608, USA
AIDS 22:339-48. 2008..Worldwide, the majority of human immunodeficiency virus (HIV) infections occur by heterosexual transmission. Thus, the development of a vaccine that can prevent intravaginal HIV infection is an important goal of AIDS vaccine research... - Antibodies to CD4-induced sites in HIV gp120 correlate with the control of SHIV challenge in macaques vaccinated with subunit immunogensAnthony Devico
Basic Research and Vaccine and Epidemiology Divisions, Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 104:17477-82. 2007..Collectively, these data suggest that antibodies to CD4i epitopes may play a role in controlling SHIV infection and provide insights for HIV vaccine development... - Crosslinked HIV-1 envelope-CD4 receptor complexes elicit broadly cross-reactive neutralizing antibodies in rhesus macaquesTimothy Fouts
Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard Street, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 99:11842-7. 2002.... - Correlation between viral RNA levels but not immune responses in plasma and tissues of macaques with long-standing SIVmac251 infectionMarcin Moniuszko
Animal Models and Retroviral Vaccines Section, National Cancer Institute, 41/D804, Bethesda, MD 20892, USA
Virology 333:159-68. 2005..These results may imply that there are differences in the immunological pressure exerted by cytotoxic T lymphocytes (CTLs) in tissue compartments of SIVmac251-infected macaques... - Impact of vaccine-induced mucosal high-avidity CD8+ CTLs in delay of AIDS viral dissemination from mucosaIgor M Belyakov
Vaccine Branch, National Cancer Institute, Bethesda, MD 20892, USA
Blood 107:3258-64. 2006.... - Polyvalent HIV-1 Env vaccine formulations delivered by the DNA priming plus protein boosting approach are effective in generating neutralizing antibodies against primary human immunodeficiency virus type 1 isolates from subtypes A, B, C, D and EShixia Wang
Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Lazare Research Building, Worcester, MA 01605, USA
Virology 350:34-47. 2006.... - Oral delivery of replication-competent adenovirus vectors is well tolerated by SIV- and SHIV-infected rhesus macaquesV Rául Gómez-Román
NIH, NCI, Vaccine Branch, Bethesda, MD 20892, USA
Vaccine 24:5064-72. 2006..Oral delivery of the replicating Ad vector was safe and well tolerated by SHIV- and SIV-infected hosts. Oral enteric-coated tablets may prove safe for administering replicating Ad-vectored vaccines in areas with high HIV prevalence... - Durable protection of rhesus macaques immunized with a replicating adenovirus-SIV multigene prime/protein boost vaccine regimen against a second SIVmac251 rectal challenge: role of SIV-specific CD8+ T cell responsesNina V Malkevitch
Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, 41 Medlars Drive MSC 5065, Building 41, Room D804, Bethesda, MD 20892-5065, USA
Virology 353:83-98. 2006..Overall, cellular immunity induced by vaccination and/or low-level, inapparent viremia post-first SIV(mac251) challenge, was associated with durable protection against re-challenge... - A replication-competent adenovirus-human immunodeficiency virus (Ad-HIV) tat and Ad-HIV env priming/Tat and envelope protein boosting regimen elicits enhanced protective efficacy against simian/human immunodeficiency virus SHIV89.6P challenge in rhesus maThorsten Demberg
Vaccine Branch, National Cancer Institute NIH, 41 Medlars Drive, Building 41, Bethesda, MD 20892 5065, USA
J Virol 81:3414-27. 2007..Since prechallenge anti-Env antibodies lacked SHIV(89.6P)-neutralizing activity, other functional anti-Env and anti-Tat activities are under investigation, as is a possible synergy between the Tat and Env immunogens... - Evaluation of -2 RANTES vaginal microbicide formulations in a nonhuman primate simian/human immunodeficiency virus (SHIV) challenge modelTina Kish Catalone
Division of Basic Science, Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
AIDS Res Hum Retroviruses 23:33-42. 2007..In comparison, liposomal agents such as Novasomes 7474 provide comparatively robust protection against vaginal transmission... - Recombinant canarypox vaccine-elicited CTL specific for dominant and subdominant simian immunodeficiency virus epitopes in rhesus monkeysSampa Santra
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
J Immunol 168:1847-53. 2002..The later emerging CTL response specific for the subdominant epitope may contribute to the control of viral replication in the setting of chronic infection... - High frequency of virus-specific CD8+ T cells in the central nervous system of macaques chronically infected with simian immunodeficiency virus SIVmac251Marcin Moniuszko
Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, Maryland 20892-5055, USA
J Virol 77:12346-51. 2003..These data suggest that this Gag-specific response may contribute to the containment of viral replication in this locale...