Ranajit Pal

Summary

Affiliation: Advanced BioScience Laboratories
Country: USA

Publications

  1. pmc Induction of mucosal and systemic antibody and T-cell responses following prime-boost immunization with novel adjuvanted human immunodeficiency virus-1-vaccine formulations
    Anthony D Cristillo
    Advanced BioScience Laboratories Inc, 5510 Nicholson Lane, Kensington, MD 20895, USA
    J Gen Virol 92:128-40. 2011
  2. doi Virological and molecular characterization of a simian human immunodeficiency virus (SHIV) encoding the envelope and reverse transcriptase genes from HIV-1
    Ranajit Pal
    Advanced BioScience Laboratories Inc, Rockville, MD 20850, USA
    Virology 432:173-83. 2012
  3. ncbi Immunization of rhesus macaques with a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine elicits protective antibody response against simian human immunodeficiency virus of R5 phenotype
    Ranajit Pal
    Department of Cell Biology, Advanced BioScience Laboratories, Kensington, MD 20895, USA
    Virology 348:341-53. 2006
  4. doi Characterization of vaginal transmission of a simian human immunodeficiency virus (SHIV) encoding the reverse transcriptase gene from HIV-1 in Chinese rhesus macaques
    Ranajit Pal
    Advanced BioScience Laboratories Inc, Kensington, MD 20895, USA
    Virology 386:102-8. 2009
  5. ncbi Definitive toxicology and biodistribution study of a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 (HIV-1) vaccine in rabbits
    Ranajit Pal
    Department of Cell Biology, Advanced BioScience Laboratories, 5510 Nicholson Lane, Kensington, MD 20895, USA
    Vaccine 24:1225-34. 2006
  6. pmc Polyvalent DNA prime and envelope protein boost HIV-1 vaccine elicits humoral and cellular responses and controls plasma viremia in rhesus macaques following rectal challenge with an R5 SHIV isolate
    Ranajit Pal
    Advanced BioScience Laboratories, Kensington, MD 20895, USA
    J Med Primatol 34:226-36. 2005
  7. doi HIV-1 Env vaccine comprised of electroporated DNA and protein co-administered with Talabostat
    Anthony D Cristillo
    Advanced BioScience Laboratories, Inc, 5510 Nicholson Lane, Kensington, MD 20895, USA
    Biochem Biophys Res Commun 370:22-6. 2008
  8. ncbi Preclinical evaluation of cellular immune responses elicited by a polyvalent DNA prime/protein boost HIV-1 vaccine
    Anthony D Cristillo
    Advanced BioScience Laboratories, Department of Cell Biology, 5510 Nicholson Lane, Kensington, MD 20895, USA
    Virology 346:151-68. 2006
  9. doi Molecular methods for evaluation of virological status of nonhuman primates challenged with simian immunodeficiency or simian-human immunodeficiency viruses
    Eun Mi Lee
    Advanced BioScience Laboratories, Inc, Kensington, MD 20895, United States
    J Virol Methods 163:287-94. 2010
  10. doi Characterization of a SHIV162P3 variant evolved in an infected rhesus macaque with persistent plasma viremia
    Hye Kyung Chung
    Department of Cell Biology, Advanced BioScience Laboratories, Inc, Kensington, MD 20895, USA
    Virus Res 151:229-34. 2010

Collaborators

Detail Information

Publications31

  1. pmc Induction of mucosal and systemic antibody and T-cell responses following prime-boost immunization with novel adjuvanted human immunodeficiency virus-1-vaccine formulations
    Anthony D Cristillo
    Advanced BioScience Laboratories Inc, 5510 Nicholson Lane, Kensington, MD 20895, USA
    J Gen Virol 92:128-40. 2011
    ....
  2. doi Virological and molecular characterization of a simian human immunodeficiency virus (SHIV) encoding the envelope and reverse transcriptase genes from HIV-1
    Ranajit Pal
    Advanced BioScience Laboratories Inc, Rockville, MD 20850, USA
    Virology 432:173-83. 2012
    ..Inhibition of RT Env SHIV by RT and entry inhibitors and ease of in vivo transmission make it a useful model for testing the efficacy of combinations of entry and RT inhibitors in nonhuman primates...
  3. ncbi Immunization of rhesus macaques with a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine elicits protective antibody response against simian human immunodeficiency virus of R5 phenotype
    Ranajit Pal
    Department of Cell Biology, Advanced BioScience Laboratories, Kensington, MD 20895, USA
    Virology 348:341-53. 2006
    ....
  4. doi Characterization of vaginal transmission of a simian human immunodeficiency virus (SHIV) encoding the reverse transcriptase gene from HIV-1 in Chinese rhesus macaques
    Ranajit Pal
    Advanced BioScience Laboratories Inc, Kensington, MD 20895, USA
    Virology 386:102-8. 2009
    ..The vaginal transmission of RT SHIV demonstrated here suggests this virus may possibly be used in the nonhuman primate model for limited evaluation of RT inhibitors applied vaginally...
  5. ncbi Definitive toxicology and biodistribution study of a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 (HIV-1) vaccine in rabbits
    Ranajit Pal
    Department of Cell Biology, Advanced BioScience Laboratories, 5510 Nicholson Lane, Kensington, MD 20895, USA
    Vaccine 24:1225-34. 2006
    ..These studies demonstrate that a novel polyvalent DNA prime/protein boost vaccine lacks signs of toxicity and DNA integration in a rabbit model, and immunogenicity and toxicology data support clinical testing of the vaccine in humans...
  6. pmc Polyvalent DNA prime and envelope protein boost HIV-1 vaccine elicits humoral and cellular responses and controls plasma viremia in rhesus macaques following rectal challenge with an R5 SHIV isolate
    Ranajit Pal
    Advanced BioScience Laboratories, Kensington, MD 20895, USA
    J Med Primatol 34:226-36. 2005
    ....
  7. doi HIV-1 Env vaccine comprised of electroporated DNA and protein co-administered with Talabostat
    Anthony D Cristillo
    Advanced BioScience Laboratories, Inc, 5510 Nicholson Lane, Kensington, MD 20895, USA
    Biochem Biophys Res Commun 370:22-6. 2008
    ..Induction of CD8(+) and CD4(+) T cells and functional CTL activity was noted. These results highlight the potential use of orally administered Talabostat for efficient protein boosting of antibody and T-cell responses primed by DNA...
  8. ncbi Preclinical evaluation of cellular immune responses elicited by a polyvalent DNA prime/protein boost HIV-1 vaccine
    Anthony D Cristillo
    Advanced BioScience Laboratories, Department of Cell Biology, 5510 Nicholson Lane, Kensington, MD 20895, USA
    Virology 346:151-68. 2006
    ....
  9. doi Molecular methods for evaluation of virological status of nonhuman primates challenged with simian immunodeficiency or simian-human immunodeficiency viruses
    Eun Mi Lee
    Advanced BioScience Laboratories, Inc, Kensington, MD 20895, United States
    J Virol Methods 163:287-94. 2010
    ..These results suggest that simultaneous application of real-time NASBA and PCR assays provides quantitative evaluation of challenge outcome in macaques...
  10. doi Characterization of a SHIV162P3 variant evolved in an infected rhesus macaque with persistent plasma viremia
    Hye Kyung Chung
    Department of Cell Biology, Advanced BioScience Laboratories, Inc, Kensington, MD 20895, USA
    Virus Res 151:229-34. 2010
    ..These results demonstrate that evolution of the envelope in SHIV-infected macaques may lead to the emergence of a viral variant with altered immunological characteristics...
  11. ncbi HIV-1 prophylactic vaccine comprised of topical DermaVir prime and protein boost elicits cellular immune responses and controls pathogenic R5 SHIV162P3
    Anthony D Cristillo
    Advanced BioScience Laboratories, Inc, 5510 Nicholson Lane, Kensington, MD 20895, USA
    Virology 366:197-211. 2007
    ..Overall, the topical DermaVir/protein vaccination yields central memory T cell responses and facilitates control of pathogenic SHIV infection...
  12. pmc Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-human immunodeficiency virus SHIVKU2 RNA levels
    Ranajit Pal
    Advanced BioScience Laboratories, Inc, Kensington, Maryland 20895, USA
    J Virol 80:3732-42. 2006
    ..Thus, systemic immunization with ALVAC-HIV-1 vaccine candidates elicits anti-HIV-1 immune responses able to contain virus replication also at mucosal sites in macaques...
  13. pmc Cellular gene expression profiles in rhesus macaques challenged mucosally with a pathogenic R5 tropic simian human immunodeficiency virus isolate
    Hye Kyung Chung
    Advanced BioScience Laboratories, Inc, Kensington, Maryland 20895, USA
    Viral Immunol 21:411-23. 2008
    ..Using the paired LPE test, 59 genes with p values <0.01 were identified and specific differences in the gene expression profiles in PBMCs from controllers versus non-controllers were detected...
  14. ncbi Persistent antibody and T cell responses induced by HIV-1 DNA vaccine delivered by electroporation
    Anthony D Cristillo
    Advanced BioScience Laboratories, Inc, Department of Cell Biology, 5510 Nicholson Lane, Kensington, MD 20895, USA
    Biochem Biophys Res Commun 366:29-35. 2008
    ..These findings highlight efficient priming of immune responses by electroporated DNA that in conjunction with protein boost may give rise to long-term immunity in immunized hosts...
  15. ncbi Characterization of a simian human immunodeficiency virus encoding the envelope gene from the CCR5-tropic HIV-1 Ba-L
    Ranajit Pal
    Advanced BioScience Laboratories, Kensington, Maryland, USA
    J Acquir Immune Defic Syndr 33:300-7. 2003
    ..The envelope gene of SHIV Ba-L revealed a very little genetic drift during in vivo passage. SHIV Ba-L provides a potentially useful model for R5 HIV-1 infection of humans...
  16. pmc The safety and tolerability of an HIV-1 DNA prime-protein boost vaccine (DP6-001) in healthy adult volunteers
    Jeffrey S Kennedy
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, USA
    Vaccine 26:4420-4. 2008
    ..Questions remain regarding the cause of the vasculitis, but the unique DTH observation may have contributed to the high level of immune responses previously reported for this vaccine...
  17. pmc Comparative study of Tat vaccine regimens in Mauritian cynomolgus and Indian rhesus macaques: influence of Mauritian MHC haplotypes on susceptibility/resistance to SHIV(89.6P) infection
    Ruth H Florese
    Vaccine Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Vaccine 26:3312-21. 2008
    ..Although protection here was limited, Tat-based vaccines incorporating other HIV components have shown greater efficacy. Combination strategies should be further explored...
  18. pmc Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers
    Shixia Wang
    Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Vaccine 26:1098-110. 2008
    ....
  19. pmc Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers
    Shixia Wang
    Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Vaccine 26:3947-57. 2008
    ....
  20. doi Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelope
    Susan W Barnett
    Novartis Vaccines and Diagnostics, Inc, 4560 Horton Street, Emeryville, California 94608, USA
    AIDS 22:339-48. 2008
    ..Worldwide, the majority of human immunodeficiency virus (HIV) infections occur by heterosexual transmission. Thus, the development of a vaccine that can prevent intravaginal HIV infection is an important goal of AIDS vaccine research...
  21. pmc Antibodies to CD4-induced sites in HIV gp120 correlate with the control of SHIV challenge in macaques vaccinated with subunit immunogens
    Anthony Devico
    Basic Research and Vaccine and Epidemiology Divisions, Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 104:17477-82. 2007
    ..Collectively, these data suggest that antibodies to CD4i epitopes may play a role in controlling SHIV infection and provide insights for HIV vaccine development...
  22. pmc Crosslinked HIV-1 envelope-CD4 receptor complexes elicit broadly cross-reactive neutralizing antibodies in rhesus macaques
    Timothy Fouts
    Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard Street, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 99:11842-7. 2002
    ....
  23. ncbi Correlation between viral RNA levels but not immune responses in plasma and tissues of macaques with long-standing SIVmac251 infection
    Marcin Moniuszko
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, 41 D804, Bethesda, MD 20892, USA
    Virology 333:159-68. 2005
    ..These results may imply that there are differences in the immunological pressure exerted by cytotoxic T lymphocytes (CTLs) in tissue compartments of SIVmac251-infected macaques...
  24. pmc Impact of vaccine-induced mucosal high-avidity CD8+ CTLs in delay of AIDS viral dissemination from mucosa
    Igor M Belyakov
    Vaccine Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 107:3258-64. 2006
    ....
  25. ncbi Polyvalent HIV-1 Env vaccine formulations delivered by the DNA priming plus protein boosting approach are effective in generating neutralizing antibodies against primary human immunodeficiency virus type 1 isolates from subtypes A, B, C, D and E
    Shixia Wang
    Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Lazare Research Building, Worcester, MA 01605, USA
    Virology 350:34-47. 2006
    ....
  26. ncbi Oral delivery of replication-competent adenovirus vectors is well tolerated by SIV- and SHIV-infected rhesus macaques
    V Rául Gómez-Román
    NIH, NCI, Vaccine Branch, Bethesda, MD 20892, USA
    Vaccine 24:5064-72. 2006
    ..Oral delivery of the replicating Ad vector was safe and well tolerated by SHIV- and SIV-infected hosts. Oral enteric-coated tablets may prove safe for administering replicating Ad-vectored vaccines in areas with high HIV prevalence...
  27. ncbi Durable protection of rhesus macaques immunized with a replicating adenovirus-SIV multigene prime/protein boost vaccine regimen against a second SIVmac251 rectal challenge: role of SIV-specific CD8+ T cell responses
    Nina V Malkevitch
    Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, 41 Medlars Drive MSC 5065, Building 41, Room D804, Bethesda, MD 20892 5065, USA
    Virology 353:83-98. 2006
    ..Overall, cellular immunity induced by vaccination and/or low-level, inapparent viremia post-first SIV(mac251) challenge, was associated with durable protection against re-challenge...
  28. pmc A replication-competent adenovirus-human immunodeficiency virus (Ad-HIV) tat and Ad-HIV env priming/Tat and envelope protein boosting regimen elicits enhanced protective efficacy against simian/human immunodeficiency virus SHIV89.6P challenge in rhesus ma
    Thorsten Demberg
    Vaccine Branch, National Cancer Institute NIH, 41 Medlars Drive, Building 41, Bethesda, MD 20892 5065, USA
    J Virol 81:3414-27. 2007
    ..Since prechallenge anti-Env antibodies lacked SHIV(89.6P)-neutralizing activity, other functional anti-Env and anti-Tat activities are under investigation, as is a possible synergy between the Tat and Env immunogens...
  29. ncbi Evaluation of -2 RANTES vaginal microbicide formulations in a nonhuman primate simian/human immunodeficiency virus (SHIV) challenge model
    Tina Kish-Catalone
    Division of Basic Science, Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA
    AIDS Res Hum Retroviruses 23:33-42. 2007
    ..In comparison, liposomal agents such as Novasomes 7474 provide comparatively robust protection against vaginal transmission...
  30. ncbi Recombinant canarypox vaccine-elicited CTL specific for dominant and subdominant simian immunodeficiency virus epitopes in rhesus monkeys
    Sampa Santra
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:1847-53. 2002
    ..The later emerging CTL response specific for the subdominant epitope may contribute to the control of viral replication in the setting of chronic infection...
  31. pmc High frequency of virus-specific CD8+ T cells in the central nervous system of macaques chronically infected with simian immunodeficiency virus SIVmac251
    Marcin Moniuszko
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, Maryland 20892 5055, USA
    J Virol 77:12346-51. 2003
    ..These data suggest that this Gag-specific response may contribute to the containment of viral replication in this locale...