David M Weiner

Summary

Affiliation: ACADIA Pharmaceuticals
Country: USA

Publications

  1. ncbi request reprint 5-hydroxytryptamine2A receptor inverse agonists as antipsychotics
    D M Weiner
    ACADIA Pharmaceuticals Inc, San Diego, California 92121, USA
    J Pharmacol Exp Ther 299:268-76. 2001
  2. ncbi request reprint The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine
    D M Weiner
    ACADIA Pharmaceuticals, Inc, 3911 Sorrento Valley Boulevard, San Diego, CA, USA
    Psychopharmacology (Berl) 177:207-16. 2004
  3. ncbi request reprint Psychosis of Parkinson's disease: serotonin 2A receptor inverse agonists as potential therapeutics
    David M Weiner
    ACADIA Pharmaceuticals Inc, 3911 Sorrento Valley Boulevard, San Diego, CA 92121, USA
    Curr Opin Investig Drugs 4:815-9. 2003
  4. ncbi request reprint The effects of food on the pharmacokinetics of a formulated ACP-103 tablet in healthy volunteers
    Kimberly E Vanover
    ACADIA Pharmaceuticals, Inc, San Diego, CA, USA
    J Clin Pharmacol 47:915-9. 2007
  5. ncbi request reprint Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist
    Kimberly E Vanover
    ACADIA Pharmaceuticals Inc, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 317:910-8. 2006
  6. ncbi request reprint Pharmacology of N-desmethylclozapine
    Jelveh Lameh
    ACADIA Pharmaceuticals Inc, San Diego, California, USA
    Pharmacol Ther 115:223-31. 2007
  7. ncbi request reprint Integrative functional assays, chemical genomics and high throughput screening: harnessing signal transduction pathways to a common HTS readout
    Ethan S Burstein
    ACADIA Pharmaceuticals, Inc, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
    Curr Pharm Des 12:1717-29. 2006
  8. pmc A 5-HT2A receptor inverse agonist, ACP-103, reduces tremor in a rat model and levodopa-induced dyskinesias in a monkey model
    Kimberly E Vanover
    ACADIA Pharmaceuticals Inc, San Diego, CA, USA
    Pharmacol Biochem Behav 90:540-4. 2008
  9. ncbi request reprint Pharmacological characterization of AC-90179 [2-(4-methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide hydrochloride]: a selective serotonin 2A receptor inverse agonist
    Kimberly E Vanover
    ACADIA Pharmaceuticals, Inc, 3911 Sorrento Valley Boulevard, San Diego, CA 92121 1402, USA
    J Pharmacol Exp Ther 310:943-51. 2004
  10. ncbi request reprint Pharmacokinetics, tolerability, and safety of ACP-103 following single or multiple oral dose administration in healthy volunteers
    Kimberly E Vanover
    ACADIA Pharmaceuticals Inc, San Diego, California, USA
    J Clin Pharmacol 47:704-14. 2007

Detail Information

Publications19

  1. ncbi request reprint 5-hydroxytryptamine2A receptor inverse agonists as antipsychotics
    D M Weiner
    ACADIA Pharmaceuticals Inc, San Diego, California 92121, USA
    J Pharmacol Exp Ther 299:268-76. 2001
    ..The behavioral pharmacology of AC-90179 is characteristic of an atypical antipsychotic agent...
  2. ncbi request reprint The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine
    D M Weiner
    ACADIA Pharmaceuticals, Inc, 3911 Sorrento Valley Boulevard, San Diego, CA, USA
    Psychopharmacology (Berl) 177:207-16. 2004
    ..Despite its unique clinical actions, no specific molecular mechanism responsible for these actions has yet been described...
  3. ncbi request reprint Psychosis of Parkinson's disease: serotonin 2A receptor inverse agonists as potential therapeutics
    David M Weiner
    ACADIA Pharmaceuticals Inc, 3911 Sorrento Valley Boulevard, San Diego, CA 92121, USA
    Curr Opin Investig Drugs 4:815-9. 2003
    ....
  4. ncbi request reprint The effects of food on the pharmacokinetics of a formulated ACP-103 tablet in healthy volunteers
    Kimberly E Vanover
    ACADIA Pharmaceuticals, Inc, San Diego, CA, USA
    J Clin Pharmacol 47:915-9. 2007
  5. ncbi request reprint Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist
    Kimberly E Vanover
    ACADIA Pharmaceuticals Inc, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 317:910-8. 2006
    ..6% oral bioavailability in rats. Thus, ACP-103 is a potent, efficacious, orally active 5-HT(2A) receptor inverse agonist with a behavioral pharmacological profile consistent with utility as an antipsychotic agent...
  6. ncbi request reprint Pharmacology of N-desmethylclozapine
    Jelveh Lameh
    ACADIA Pharmaceuticals Inc, San Diego, California, USA
    Pharmacol Ther 115:223-31. 2007
    ..We also consider whether NDMC, in its own right, might be a superior antipsychotic drug...
  7. ncbi request reprint Integrative functional assays, chemical genomics and high throughput screening: harnessing signal transduction pathways to a common HTS readout
    Ethan S Burstein
    ACADIA Pharmaceuticals, Inc, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
    Curr Pharm Des 12:1717-29. 2006
    ..Here we review strategies for building homogeneous assay platforms across large gene families by redirecting and/or amplifying signal transduction pathways...
  8. pmc A 5-HT2A receptor inverse agonist, ACP-103, reduces tremor in a rat model and levodopa-induced dyskinesias in a monkey model
    Kimberly E Vanover
    ACADIA Pharmaceuticals Inc, San Diego, CA, USA
    Pharmacol Biochem Behav 90:540-4. 2008
    ..These data suggest that ACP-103 may have the potential to reduce tremor and levodopa-induced dyskinesias in Parkinson's disease...
  9. ncbi request reprint Pharmacological characterization of AC-90179 [2-(4-methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide hydrochloride]: a selective serotonin 2A receptor inverse agonist
    Kimberly E Vanover
    ACADIA Pharmaceuticals, Inc, 3911 Sorrento Valley Boulevard, San Diego, CA 92121 1402, USA
    J Pharmacol Exp Ther 310:943-51. 2004
    ..Taken together, a compound with a similar pharmacological profile as AC-90179 and with increased oral bioavailability may have potential for the treatment of psychosis...
  10. ncbi request reprint Pharmacokinetics, tolerability, and safety of ACP-103 following single or multiple oral dose administration in healthy volunteers
    Kimberly E Vanover
    ACADIA Pharmaceuticals Inc, San Diego, California, USA
    J Clin Pharmacol 47:704-14. 2007
    ..The half-life of ACP-103 was approximately 55 hours, with a t(max) at 6 hours. ACP-103 was well tolerated at single doses up to and including 300 mg and multiple doses up to 100 mg once daily for 14 days...
  11. ncbi request reprint Pharmacology of polymorphic variants of the human 5-HT1A receptor
    Andria L Del Tredici
    ACADIA Pharmaceuticals, 3911 Sorrento Valley Blvd, San Diego, CA 92121 1402, USA
    Biochem Pharmacol 67:479-90. 2004
    ..Furthermore, individuals that potentially harbor the A50V polymorphism might display aberrant affective behaviors and altered responses to drugs targeting the 5-HT1A receptor...
  12. ncbi request reprint Distribution analysis of nonsynonymous polymorphisms within the G-protein-coupled receptor gene family
    Andria Lee
    ACADIA Pharmaceuticals, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
    Genomics 81:245-8. 2003
    ..This finding reflects the relative importance of these domains to GPCR function and implies different biological characteristics for the two sets of human polymorphisms...
  13. ncbi request reprint Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist
    E S Burstein
    ACADIA Pharmaceuticals, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 315:1278-87. 2005
    ....
  14. ncbi request reprint Functional screening of drug target genes: m1 muscarinic acetylcholine receptor phenotypes in degenerative dementias
    David M Weiner
    ACADIA Pharmaceuticals, Inc, San Diego, California 92121, USA
    Am J Pharmacogenomics 4:119-28. 2004
    ..We report on the development of a novel phenotypic screening process that combines high-throughput molecular cloning techniques with functional expression utilizing the cell-based assay R-SAT...
  15. ncbi request reprint Molecular cloning and pharmacology of functionally distinct isoforms of the human histamine H(3) receptor
    P Wellendorph
    ACADIA Pharmaceuticals Inc, San Diego, CA 92121, USA
    Neuropharmacology 42:929-40. 2002
    ....
  16. ncbi request reprint Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6
    David A Shapiro
    Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, Ohio 44106 4935, USA
    J Biol Chem 277:11441-9. 2002
    ..L. Roth and D. A. Shapiro (2001) Expert Opin. Ther. Targets 5, 685-695) and others, that this may represent a general mechanism of activation for many, but not all, G-protein-coupled receptors...
  17. ncbi request reprint PET analysis of the 5-HT2A receptor inverse agonist ACP-103 in human brain
    Anna Lena Nordstrom
    Karolinska University Hospital, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Int J Neuropsychopharmacol 11:163-71. 2008
    ..In conclusion, administration of ACP-103 to healthy volunteers was found to be safe and well tolerated, and single oral doses as low as 10 mg were found to fully saturate 5-HT2A receptors in human brain as determined by PET...
  18. ncbi request reprint Loss-of-function polymorphic variants of the human angiotensin II type 1 receptor
    Jakob Lerche Hansen
    Laboratory of Molecular Cardiology, The Heart Centre and Copenhagen Heart Arrhythmia Research Centre, Copenhagen University Hospital Section 9312, and the Faculty of Health, University of Copenhagen, Denmark
    Mol Pharmacol 65:770-7. 2004
    ..These data demonstrate that polymorphic variation in the human AT1 receptor induces loss of functional phenotypes, which may constitute the molecular basis of variability of AT1 receptor-mediated physiological responses...
  19. doi request reprint The human angiotensin AT(1) receptor supports G protein-independent extracellular signal-regulated kinase 1/2 activation and cellular proliferation
    Jakob Lerche Hansen
    Laboratory for Molecular Cardiology, The Danish National Research Foundation Centre for Cardiac Arrhythmia, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Eur J Pharmacol 590:255-63. 2008
    ..The realization of G protein-independent signalling by the human angiotensin AT(1) receptor has clear pharmacological implications for development of drugs with pathway-specific actions and defined biological outcomes...