Kimberly E Vanover

Summary

Affiliation: ACADIA Pharmaceuticals
Country: USA

Publications

  1. ncbi request reprint Neuroactive steroids attenuate cocaine-induced sucrose intake in rats, but not cocaine-induced hyperactivity in mice
    K E Vanover
    ACADIA Pharmaceuticals, San Diego, CA 92121 1402, USA
    Psychopharmacology (Berl) 149:269-76. 2000
  2. ncbi request reprint Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist
    Kimberly E Vanover
    ACADIA Pharmaceuticals Inc, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 317:910-8. 2006
  3. ncbi request reprint Pharmacological characterization of AC-90179 [2-(4-methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide hydrochloride]: a selective serotonin 2A receptor inverse agonist
    Kimberly E Vanover
    ACADIA Pharmaceuticals, Inc, 3911 Sorrento Valley Boulevard, San Diego, CA 92121 1402, USA
    J Pharmacol Exp Ther 310:943-51. 2004
  4. ncbi request reprint Psychiatric Drug Discovery & Development--SRI Conference. 23-24 June 2003, Princeton, NJ, USA
    Kimberly E Vanover
    ACADIA Pharmaceuticals Inc, 3911 Sorrento Valley Boulevard, San Diego, CA 92121, USA
    IDrugs 6:739-42. 2003
  5. ncbi request reprint Behavioral characterization of Co 134444 (3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha- pregnan-20-one), a novel sedative-hypnotic neuroactive steroid
    K E Vanover
    CoCensys, Inc, Irvine, CA 92618, USA
    Psychopharmacology (Berl) 155:285-91. 2001
  6. ncbi request reprint Effects of benzodiazepine receptor ligands and ethanol in rats trained to discriminate pregnanolone
    K E Vanover
    CoCensys, Irvine, CA 92618, USA
    Pharmacol Biochem Behav 67:483-7. 2000
  7. ncbi request reprint Characterization of the anxiolytic properties of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3alpha, 21-dihydroxy-3beta-trifluoromethyl-19-nor-5beta-pregnan-20-one), a selective modulator of gamma-aminobutyric acid(A) receptors
    K E Vanover
    CoCensys, Inc, Irvine, California, USA
    J Pharmacol Exp Ther 295:337-45. 2000
  8. ncbi request reprint The effects of food on the pharmacokinetics of a formulated ACP-103 tablet in healthy volunteers
    Kimberly E Vanover
    ACADIA Pharmaceuticals, Inc, San Diego, CA, USA
    J Clin Pharmacol 47:915-9. 2007
  9. ncbi request reprint ACP-103, a 5-hydroxytryptamine 2A receptor inverse agonist, improves the antipsychotic efficacy and side-effect profile of haloperidol and risperidone in experimental models
    Luis R Gardell
    ACADIA Pharmaceuticals, Inc, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 322:862-70. 2007
  10. doi request reprint Antipsychotic-like behavioral effects and cognitive enhancement by a potent and selective muscarinic M-sub-1 receptor agonist, AC-260584
    Kimberly E Vanover
    ACADIA Pharmaceuticals Inc, San Diego, CA, USA
    Behav Neurosci 122:570-5. 2008

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Neuroactive steroids attenuate cocaine-induced sucrose intake in rats, but not cocaine-induced hyperactivity in mice
    K E Vanover
    ACADIA Pharmaceuticals, San Diego, CA 92121 1402, USA
    Psychopharmacology (Berl) 149:269-76. 2000
    ....
  2. ncbi request reprint Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist
    Kimberly E Vanover
    ACADIA Pharmaceuticals Inc, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 317:910-8. 2006
    ..6% oral bioavailability in rats. Thus, ACP-103 is a potent, efficacious, orally active 5-HT(2A) receptor inverse agonist with a behavioral pharmacological profile consistent with utility as an antipsychotic agent...
  3. ncbi request reprint Pharmacological characterization of AC-90179 [2-(4-methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide hydrochloride]: a selective serotonin 2A receptor inverse agonist
    Kimberly E Vanover
    ACADIA Pharmaceuticals, Inc, 3911 Sorrento Valley Boulevard, San Diego, CA 92121 1402, USA
    J Pharmacol Exp Ther 310:943-51. 2004
    ..Taken together, a compound with a similar pharmacological profile as AC-90179 and with increased oral bioavailability may have potential for the treatment of psychosis...
  4. ncbi request reprint Psychiatric Drug Discovery & Development--SRI Conference. 23-24 June 2003, Princeton, NJ, USA
    Kimberly E Vanover
    ACADIA Pharmaceuticals Inc, 3911 Sorrento Valley Boulevard, San Diego, CA 92121, USA
    IDrugs 6:739-42. 2003
  5. ncbi request reprint Behavioral characterization of Co 134444 (3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha- pregnan-20-one), a novel sedative-hypnotic neuroactive steroid
    K E Vanover
    CoCensys, Inc, Irvine, CA 92618, USA
    Psychopharmacology (Berl) 155:285-91. 2001
    ..Neuroactive steroids have been shown to exhibit a wide range of behavioral activities that are similar but not identical to those of benzodiazepines. These activities include anticonvulsant, anxiolytic and sedative-hypnotic effects...
  6. ncbi request reprint Effects of benzodiazepine receptor ligands and ethanol in rats trained to discriminate pregnanolone
    K E Vanover
    CoCensys, Irvine, CA 92618, USA
    Pharmacol Biochem Behav 67:483-7. 2000
    ..The results are consistent with GABA(A) receptor mediation of the discriminative stimulus effects of pregnanolone. The effects on response rates suggest subtle differentiation among the GABA(A) receptor-mediated cues...
  7. ncbi request reprint Characterization of the anxiolytic properties of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3alpha, 21-dihydroxy-3beta-trifluoromethyl-19-nor-5beta-pregnan-20-one), a selective modulator of gamma-aminobutyric acid(A) receptors
    K E Vanover
    CoCensys, Inc, Irvine, California, USA
    J Pharmacol Exp Ther 295:337-45. 2000
    ....
  8. ncbi request reprint The effects of food on the pharmacokinetics of a formulated ACP-103 tablet in healthy volunteers
    Kimberly E Vanover
    ACADIA Pharmaceuticals, Inc, San Diego, CA, USA
    J Clin Pharmacol 47:915-9. 2007
  9. ncbi request reprint ACP-103, a 5-hydroxytryptamine 2A receptor inverse agonist, improves the antipsychotic efficacy and side-effect profile of haloperidol and risperidone in experimental models
    Luis R Gardell
    ACADIA Pharmaceuticals, Inc, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 322:862-70. 2007
    ..These data indicate that utilizing ACP-103 as an adjunctive therapy to currently used APDs may result in enhanced antipsychotic efficacy while reducing adverse effects including those attributable to D(2) receptor antagonism...
  10. doi request reprint Antipsychotic-like behavioral effects and cognitive enhancement by a potent and selective muscarinic M-sub-1 receptor agonist, AC-260584
    Kimberly E Vanover
    ACADIA Pharmaceuticals Inc, San Diego, CA, USA
    Behav Neurosci 122:570-5. 2008
    ..These data indicate that AC-260584 has a behavioral profile consistent with antipsychotic-like efficacy with the potential to improve cognitive performance and shows reduced liability for extrapyramidal symptoms...
  11. pmc A 5-HT2A receptor inverse agonist, ACP-103, reduces tremor in a rat model and levodopa-induced dyskinesias in a monkey model
    Kimberly E Vanover
    ACADIA Pharmaceuticals Inc, San Diego, CA, USA
    Pharmacol Biochem Behav 90:540-4. 2008
    ..These data suggest that ACP-103 may have the potential to reduce tremor and levodopa-induced dyskinesias in Parkinson's disease...
  12. ncbi request reprint Pharmacology of N-desmethylclozapine
    Jelveh Lameh
    ACADIA Pharmaceuticals Inc, San Diego, California, USA
    Pharmacol Ther 115:223-31. 2007
    ..We also consider whether NDMC, in its own right, might be a superior antipsychotic drug...
  13. ncbi request reprint Psychosis of Parkinson's disease: serotonin 2A receptor inverse agonists as potential therapeutics
    David M Weiner
    ACADIA Pharmaceuticals Inc, 3911 Sorrento Valley Boulevard, San Diego, CA 92121, USA
    Curr Opin Investig Drugs 4:815-9. 2003
    ....
  14. ncbi request reprint Pharmacokinetics, tolerability, and safety of ACP-103 following single or multiple oral dose administration in healthy volunteers
    Kimberly E Vanover
    ACADIA Pharmaceuticals Inc, San Diego, California, USA
    J Clin Pharmacol 47:704-14. 2007
    ..The half-life of ACP-103 was approximately 55 hours, with a t(max) at 6 hours. ACP-103 was well tolerated at single doses up to and including 300 mg and multiple doses up to 100 mg once daily for 14 days...
  15. ncbi request reprint PET analysis of the 5-HT2A receptor inverse agonist ACP-103 in human brain
    Anna Lena Nordstrom
    Karolinska University Hospital, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Int J Neuropsychopharmacol 11:163-71. 2008
    ..In conclusion, administration of ACP-103 to healthy volunteers was found to be safe and well tolerated, and single oral doses as low as 10 mg were found to fully saturate 5-HT2A receptors in human brain as determined by PET...