Betty Yao

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. ncbi request reprint Direct interaction of STAT4 with the IL-12 receptor
    B B Yao
    Pharmaceutical Products Division, Pharmaceutical Discovery, Abbott Park, Illinois, 60064, USA
    Arch Biochem Biophys 368:147-55. 1999
  2. ncbi request reprint Molecular modeling and pharmacological analysis of species-related histamine H(3) receptor heterogeneity
    B B Yao
    Neuroscience Research, Abbott Laboratories, R4MN, AP9A, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Neuropharmacology 44:773-86. 2003
  3. ncbi request reprint In vitro pharmacological properties of two novel non-imidazole H3 receptor (H3R) antagonists
    B B Yao
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, AP9A, R4MN, 100 Abbott Park Road, Abbott Park, Illinois 60064 6123, USA
    Inflamm Res 52:S45-6. 2003
  4. doi request reprint Endocannabinoid receptor pharmacology
    Betty Yao
    Neuroscience Research, Abbott Laboratories, Abbott Park, IL 60048, USA
    Curr Top Behav Neurosci 1:37-63. 2009
  5. ncbi request reprint Cloning and pharmacological characterization of the monkey histamine H3 receptor
    Betty Bei Yao
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R4MN, AP9A, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Eur J Pharmacol 482:49-60. 2003
  6. ncbi request reprint Molecular and pharmacological characterization of the monkey histamine H(3) receptor
    B B Yao
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Inflamm Res 53:S75-6. 2004
  7. doi request reprint Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and
    Betty B Yao
    Neurological Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R47W, AP9A, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    J Pharmacol Exp Ther 328:141-51. 2009
  8. ncbi request reprint Use of an inverse agonist radioligand [3H]A-317920 reveals distinct pharmacological profiles of the rat histamine H3 receptor
    B Bei Yao
    Neuroscience Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Neuropharmacology 50:468-78. 2006
  9. pmc In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?
    B B Yao
    Neuroscience Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Br J Pharmacol 149:145-54. 2006
  10. doi request reprint Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB₂ receptor agonists for pain management
    Derek W Nelson
    Neurological Diseases Research, Global Pharmaceutical R and D, Abbott, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 22:2604-8. 2012

Detail Information

Publications13

  1. ncbi request reprint Direct interaction of STAT4 with the IL-12 receptor
    B B Yao
    Pharmaceutical Products Division, Pharmaceutical Discovery, Abbott Park, Illinois, 60064, USA
    Arch Biochem Biophys 368:147-55. 1999
    ....
  2. ncbi request reprint Molecular modeling and pharmacological analysis of species-related histamine H(3) receptor heterogeneity
    B B Yao
    Neuroscience Research, Abbott Laboratories, R4MN, AP9A, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Neuropharmacology 44:773-86. 2003
    ..A model has been developed to elucidate the ligand receptor interactions for H(3)Rs, and pharmacological aspects of this model are described...
  3. ncbi request reprint In vitro pharmacological properties of two novel non-imidazole H3 receptor (H3R) antagonists
    B B Yao
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, AP9A, R4MN, 100 Abbott Park Road, Abbott Park, Illinois 60064 6123, USA
    Inflamm Res 52:S45-6. 2003
  4. doi request reprint Endocannabinoid receptor pharmacology
    Betty Yao
    Neuroscience Research, Abbott Laboratories, Abbott Park, IL 60048, USA
    Curr Top Behav Neurosci 1:37-63. 2009
    ..The aim of this chapter is to introduce the cannabinoid receptor pharmacology that will be necessary to appreciate the intricacies of endocannabinoid signaling presented in later chapters...
  5. ncbi request reprint Cloning and pharmacological characterization of the monkey histamine H3 receptor
    Betty Bei Yao
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R4MN, AP9A, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Eur J Pharmacol 482:49-60. 2003
    ....
  6. ncbi request reprint Molecular and pharmacological characterization of the monkey histamine H(3) receptor
    B B Yao
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Inflamm Res 53:S75-6. 2004
  7. doi request reprint Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and
    Betty B Yao
    Neurological Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R47W, AP9A, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    J Pharmacol Exp Ther 328:141-51. 2009
    ..These data demonstrate that A-836339 is a useful tool for use of studying CB(2) receptor pharmacology and for investigation of the role of CB(2) receptor modulation for treatment of pain in preclinical animal models...
  8. ncbi request reprint Use of an inverse agonist radioligand [3H]A-317920 reveals distinct pharmacological profiles of the rat histamine H3 receptor
    B Bei Yao
    Neuroscience Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Neuropharmacology 50:468-78. 2006
    ..These findings show that [(3)H]A-317920 is a potent rat H(3) receptor antagonist radioligand and has utility for studying H(3) receptor pharmacology...
  9. pmc In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?
    B B Yao
    Neuroscience Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Br J Pharmacol 149:145-54. 2006
    ..Based on its in vivo analgesic efficacy, AM1241 has been classified as a CB2-selective agonist. However, in vitro characterization of AM1241 in functional assays has not been reported...
  10. doi request reprint Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB₂ receptor agonists for pain management
    Derek W Nelson
    Neurological Diseases Research, Global Pharmaceutical R and D, Abbott, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 22:2604-8. 2012
    ..Control experiments using a CB(2) antagonist demonstrated the efficacy in the pain models resulted from CB(2) agonism...
  11. pmc Detection of multiple H3 receptor affinity states utilizing [3H]A-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand
    David G Witte
    Neuroscience Research, Dept R4MN, Global Pharmaceutical Research Division, Abbott Laboratories, Bldg AP9A 2, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Br J Pharmacol 148:657-70. 2006
    ..3H]A-349821 competition studies showed significant differences in the proportions and potencies of high- and low-affinity sites across species, providing new information about the fundamental pharmacological nature of H3 receptors...
  12. ncbi request reprint Genetic and pharmacological aspects of histamine H3 receptor heterogeneity
    Arthur A Hancock
    Neuroscience Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6125, USA
    Life Sci 73:3043-72. 2003
    ..The promise of newly available tools to further explore H3 receptor function may provide the insight to bring the promised clinical potential of H3 receptor ligands to realization...
  13. ncbi request reprint Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors
    Sutapa Mukherjee
    Neuroscience Disease Research, Global Pharmaceutical Research and Development, AP9A 3, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    Eur J Pharmacol 505:1-9. 2004
    ..The findings of the pharmacological differences between the human and rat cannabinoid CB2 receptors in this study provide critical information for characterizing cannabinoid ligands in in vivo rodent models for drug discovery purpose...