J Ruth Wu-Wong

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. ncbi S-0139 (Shionogi)
    J Ruth Wu-Wong
    Abbott Laboratories, Santa Clara, CA 95054, USA
    Curr Opin Investig Drugs 3:1051-6. 2002
  2. ncbi Endothelin stimulates glucose uptake and GLUT4 translocation via activation of endothelin ETA receptor in 3T3-L1 adipocytes
    J R Wu-Wong
    Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064 3500, USA
    J Biol Chem 274:8103-10. 1999
  3. ncbi Vitamin D analogs as therapeutic agents: a clinical study update
    J Ruth Wu-Wong
    Abbott Laboratories, R4CM Building AP52, 200 Abbott Park Rd, Abbott Park, IL 60064, USA
    Curr Opin Investig Drugs 5:320-6. 2004
  4. ncbi Cardiovascular disease in chronic kidney failure: is there a role for vitamin D analogs?
    J Ruth Wu-Wong
    Abbott Laboratories, R4CM Building AP52, 200 Abbott Park Road, Abbott Park, IL 60064, USA
    Curr Opin Investig Drugs 6:245-54. 2005
  5. ncbi Effects of Vitamin D analogs on gene expression profiling in human coronary artery smooth muscle cells
    J Ruth Wu-Wong
    Abbott Laboratories, R4CM, AP52, 200 Abbott Park Rd, Abbott Park, IL 60064, USA
    Atherosclerosis 186:20-8. 2006
  6. ncbi The potential for vitamin D receptor activation in cardiovascular research
    Jinshyun Ruth Wu-Wong
    R46R, AP9, Abbott Laboratories, Abbott Park, IL 60064, USA
    Expert Opin Investig Drugs 16:407-11. 2007
  7. ncbi Vitamin D analogs modulate the expression of plasminogen activator inhibitor-1, thrombospondin-1 and thrombomodulin in human aortic smooth muscle cells
    J Ruth Wu-Wong
    Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    J Vasc Res 44:11-8. 2007
  8. ncbi Effects of vitamin D analogs on the expression of plasminogen activator inhibitor-1 in human vascular cells
    J Ruth Wu-Wong
    Abbott Laboratories, R4CM, AP52, 200 Abbott Park Rd, Abbott Park, IL 60064, Unites States
    Thromb Res 118:709-14. 2006
  9. ncbi Cardiovascular disease in chronic kidney failure: the role of VDR activators
    J Ruth Wu-Wong
    Curr Opin Investig Drugs 7:206-13. 2006
  10. ncbi Role of phosphorus and vitamin D analogs in the pathogenesis of vascular calcification
    J Ruth Wu-Wong
    Abbott Laboratories, R4CM, AP52, 200 Abbott Park Rd, Abbott Park, IL 60064, USA
    J Pharmacol Exp Ther 318:90-8. 2006

Collaborators

Detail Information

Publications32

  1. ncbi S-0139 (Shionogi)
    J Ruth Wu-Wong
    Abbott Laboratories, Santa Clara, CA 95054, USA
    Curr Opin Investig Drugs 3:1051-6. 2002
    ..In August 1999, Lehman Brothers gave S-0139 a 10% probability of reaching the market with an expected launch in 2005. Sales were expected to peak at US $50 million in 2012 [349228]...
  2. ncbi Endothelin stimulates glucose uptake and GLUT4 translocation via activation of endothelin ETA receptor in 3T3-L1 adipocytes
    J R Wu-Wong
    Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064 3500, USA
    J Biol Chem 274:8103-10. 1999
    ..Genistein (100 microM), an inhibitor of tyrosine kinases, inhibited ET-1-stimulated glucose uptake. Our results show that ET-1 stimulates GLUT4 translocation and glucose uptake in 3T3-L1 adipocytes via activation of ETA receptor...
  3. ncbi Vitamin D analogs as therapeutic agents: a clinical study update
    J Ruth Wu-Wong
    Abbott Laboratories, R4CM Building AP52, 200 Abbott Park Rd, Abbott Park, IL 60064, USA
    Curr Opin Investig Drugs 5:320-6. 2004
    ..This review discusses recent progress on the use of vitamin D and its analogs in the management of HPT secondary to chronic renal disease...
  4. ncbi Cardiovascular disease in chronic kidney failure: is there a role for vitamin D analogs?
    J Ruth Wu-Wong
    Abbott Laboratories, R4CM Building AP52, 200 Abbott Park Road, Abbott Park, IL 60064, USA
    Curr Opin Investig Drugs 6:245-54. 2005
    ..This review discusses recent data regarding the role of vitamin D and its analogs in the CVD associated with CKD...
  5. ncbi Effects of Vitamin D analogs on gene expression profiling in human coronary artery smooth muscle cells
    J Ruth Wu-Wong
    Abbott Laboratories, R4CM, AP52, 200 Abbott Park Rd, Abbott Park, IL 60064, USA
    Atherosclerosis 186:20-8. 2006
    ..This study identified genes not previously known to be regulated by VDR, providing insight into understanding the role of VDR on regulating smooth muscle cell growth, thrombogenicity, fibrinolysis and endothelial regeneration...
  6. ncbi The potential for vitamin D receptor activation in cardiovascular research
    Jinshyun Ruth Wu-Wong
    R46R, AP9, Abbott Laboratories, Abbott Park, IL 60064, USA
    Expert Opin Investig Drugs 16:407-11. 2007
    ..Recent clinical observations show that VDR therapy reduces mortality and morbidity in chronic kidney disease. Preclinical studies demonstrate that VDR is likely to be involved in the cardiovascular pathophysiology...
  7. ncbi Vitamin D analogs modulate the expression of plasminogen activator inhibitor-1, thrombospondin-1 and thrombomodulin in human aortic smooth muscle cells
    J Ruth Wu-Wong
    Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    J Vasc Res 44:11-8. 2007
    ..Plasminogen activator inhibitor-1 (PAI-1), thrombospondin-1 (THBS1) and thrombomodulin (TM) are involved in atherothrombosis. Vitamin D receptor agonists (VDRAs) provide survival/cardiovascular benefits for chronic kidney disease patients...
  8. ncbi Effects of vitamin D analogs on the expression of plasminogen activator inhibitor-1 in human vascular cells
    J Ruth Wu-Wong
    Abbott Laboratories, R4CM, AP52, 200 Abbott Park Rd, Abbott Park, IL 60064, Unites States
    Thromb Res 118:709-14. 2006
    ..Plasminogen activator inhibitor-1 (PAI-1) is one of the risk markers for coronary artery disease...
  9. ncbi Cardiovascular disease in chronic kidney failure: the role of VDR activators
    J Ruth Wu-Wong
    Curr Opin Investig Drugs 7:206-13. 2006
    ..In this review, we discuss recent preclinical and clinical data regarding the role of VDR and its ligands in the cardiovascular system...
  10. ncbi Role of phosphorus and vitamin D analogs in the pathogenesis of vascular calcification
    J Ruth Wu-Wong
    Abbott Laboratories, R4CM, AP52, 200 Abbott Park Rd, Abbott Park, IL 60064, USA
    J Pharmacol Exp Ther 318:90-8. 2006
    ....
  11. ncbi Vitamin D receptor (VDR) localization in human promyelocytic leukemia cells
    J Ruth Wu-Wong
    Abbott Laboratories, Abbott Park, IL 60064, USA
    Leuk Lymphoma 47:727-32. 2006
    ..These results suggest that binding of vitamin D analogs to VDR induced receptor translocation into the nucleus, which stabilizes the receptor, resulting in an accumulation of the VDR protein...
  12. ncbi Endothelin receptor antagonists as therapeutic agents for cancer
    J Ruth Wu-Wong
    Abbott Laboratories, Santa Clara, CA 95054, USA
    Curr Opin Investig Drugs 3:1234-9. 2002
    ..This paper reviews recent studies on the role of the ET system in tumorigenesis and provides an update on the recent development of ET receptor antagonists, in clinical studies for cancer...
  13. ncbi Vascular calcification in chronic kidney failure: role of vitamin D receptor
    J Ruth Wu-Wong
    Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    Curr Opin Investig Drugs 8:237-47. 2007
    ....
  14. ncbi Endothelin-stimulated glucose uptake: effects of intracellular Ca(2+), cAMP and glucosamine
    Jinshyun R Wu-Wong
    Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL, U S A
    Clin Sci (Lond) 103:418S-423S. 2002
    ..These results suggest that ET-1-induced glucose uptake is independent of its effects on modulating intracellular Ca(2+) and cAMP levels, but is likely linked to the hexosamine biosynthetic pathway...
  15. ncbi Extracellular signal-regulated kinases are involved in the antiapoptotic effect of endothelin-1
    J R Wu-Wong
    Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois, USA
    J Pharmacol Exp Ther 293:514-21. 2000
    ..These results suggest that the ERK1/2 pathway is activated by ET-1, and blocking this pathway abolishes the antiapoptotic effect of ET-1...
  16. ncbi Endothelin stimulates glucose uptake via activation of endothelin-A receptor in neonatal rat cardiomyocytes
    J R Wu-Wong
    Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois, USA
    J Cardiovasc Pharmacol 36:S179-83. 2000
    ..Our results show that ET-1 stimulates glucose uptake in neonatal rat cardiomyocytes via activation of the ET(A)-receptor...
  17. ncbi Identification and characterization of A-105972, an antineoplastic agent
    J R Wu-Wong
    Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Cancer Res 61:1486-92. 2001
    ..A-105972 and its analogues may be useful for treating cell proliferative disorders such as cancer...
  18. ncbi Sitaxsentan (ICOS-Texas Biotechnology)
    J R Wu-Wong
    Abbott Laboratories, Santa Clara, CA 95054, USA
    Curr Opin Investig Drugs 2:531-6. 2001
    ..US-05591761 was issued to Texas in January 1997, covering TBC-11251 and several related isomers [2309301...
  19. ncbi VDR-mediated gene expression patterns in resting human coronary artery smooth muscle cells
    J Ruth Wu-Wong
    Department of Integrative Pharmacology, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Cell Biochem 100:1395-405. 2007
    ..This study provides insight into understanding the role of VDR in regulating gene expression in resting smooth muscle cells...
  20. ncbi Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: in vitro studies
    J Ruth Wu-Wong
    Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064, U S A
    Clin Sci (Lond) 103:107S-111S. 2002
    ....
  21. ncbi Elevated phosphorus modulates vitamin D receptor-mediated gene expression in human vascular smooth muscle cells
    J Ruth Wu-Wong
    Abbott Laboratories, Abbott Park, Illinois, USA
    Am J Physiol Renal Physiol 293:F1592-604. 2007
    ..Our results demonstrate for the first time that elevated Pi affects VDR-mediated gene expression in human coronary artery SMCs and the effect is not limited to VDR in SMCs...
  22. ncbi Differential inhibition of renin mRNA expression by paricalcitol and calcitriol in C57/BL6 mice
    Ryan M Fryer
    Integrative Pharmacology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6119, USA
    Nephron Physiol 106:p76-81. 2007
    ..Vitamin D receptor activators (VDRAs) may suppress renin expression and VDR-mediated renin inhibitors may offer a novel mechanism to control the RAS...
  23. ncbi Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: ex vivo and in vivo studies
    Jerry L Wessale
    Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064, U S A
    Clin Sci (Lond) 103:112S-117S. 2002
    ....
  24. ncbi Expression of VDR and CYP24A1 mRNA in human tumors
    Mark G Anderson
    Abbott Laboratories, R4CM, AP52, 200 Abbott Park Rd, Abbott Park, IL 60064, USA
    Cancer Chemother Pharmacol 57:234-40. 2006
    ..These data suggest that the VDR signaling pathway may be compromised via the modulation of CYP24A1 and VDR in human tumors...
  25. doi Two novel vitamin D receptor modulators with similar structures exhibit different hypercalcemic effects in 5/6 nephrectomized uremic rats
    J Ruth Wu-Wong
    Vidasym, Chicago, IL, USA
    Am J Nephrol 37:310-9. 2013
    ..Hypercalcemia leads to the need for frequent drug dose titration and serum calcium (Ca) monitoring. A VDRM with a wider therapeutic index and beneficial CV effects will be clinically useful...
  26. ncbi Differential effects of Vitamin D analogs on bone formation and resorption
    Masaki Nakane
    Abbott Laboratories, R4CM, AP52, 200 Abbott Park Rd, Abbott Park, IL 60064 6217, USA
    J Steroid Biochem Mol Biol 98:72-7. 2006
    ....
  27. ncbi Effect of castration on endothelin receptors
    Robert J Padley
    Pharmaceutical Products Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, U S A
    Clin Sci (Lond) 103:442S-445S. 2002
    ....
  28. ncbi Systemic activation of the calcium sensing receptor produces acute effects on vascular tone and circulatory function in uremic and normal rats: focus on central versus peripheral control of vascular tone and blood pressure by cinacalcet
    Ryan M Fryer
    Integrative Pharmacology, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6119, USA
    J Pharmacol Exp Ther 323:217-26. 2007
    ..Moreover, subsequent mechanistic studies suggest that increases in MAP produced by cinacalcet may be mediated by reduced tonic NO synthase-dependent NO production subsequent to reductions in blood iCa2+...
  29. ncbi Characterization of a new endothelin receptor ligand by in vitro assays
    J Ruth Wu-Wong
    Abbott Laboratories, Santa Clara, CA, USA
    Methods Mol Biol 206:181-98. 2002
  30. ncbi Differential effects of Vitamin D analogs on calcium transport
    Masaki Nakane
    Abbott Laboratories, Abbott Park, IL 60064, United States
    J Steroid Biochem Mol Biol 103:84-9. 2007
    ..These results suggest that the differential effect of Vitamin D analogs on stimulating intestinal and Caco-2 calcium transport may be in part due to its different effect on stimulating CALB3 and TRPV6 mRNA expression...
  31. doi Differential effects of vitamin d receptor agonists on gene expression in neonatal rat cardiomyocytes
    J Ruth Wu-Wong
    University of Illinois at Chicago, Chicago, IL, 60612, USA
    Cardiovasc Drugs Ther 25:215-22. 2011
    ..Vitamin D receptor (VDR) activation is associated with cardiovascular benefits in chronic kidney disease patients, but whether VDR's hormone and prehormone exhibit similar effects requires more studies...
  32. ncbi Using receptor antagonists in binding studies to characterize a mammalian endothelin receptor
    J Ruth Wu-Wong
    Abbott Laboratories, Santa Clara, CA, USA
    Methods Mol Biol 206:71-91. 2002