R Scott Bitner

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. ncbi request reprint Alpha-7 nicotinic receptor expression by two distinct cell types in the dorsal raphe nucleus and locus coeruleus of rat
    R S Bitner
    Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, Building AP9A LL D 4N5, 100 Abbott Park Rd, Abbott Park, IL 60064 3500, USA
    Brain Res 938:45-54. 2002
  2. ncbi request reprint A-85380: a pharmacological probe for the preclinical and clinical investigation of the alphabeta neuronal nicotinic acetylcholine receptor
    Lynne E Rueter
    Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL, USA
    CNS Drug Rev 12:100-12. 2006
  3. doi request reprint Cyclic AMP response element-binding protein (CREB) phosphorylation: a mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics
    R Scott Bitner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, United States
    Biochem Pharmacol 83:705-14. 2012
  4. pmc Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord
    Younglim Lee
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Mol Pain 7:39. 2011
  5. doi request reprint In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer's disease
    R Scott Bitner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Neuropharmacology 60:460-6. 2011
  6. doi request reprint In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease
    R Scott Bitner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Pharmacol Exp Ther 334:875-86. 2010
  7. doi request reprint Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo
    Robert S Bitner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Brain Res 1265:65-74. 2009
  8. ncbi request reprint Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways
    Robert S Bitner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Neurosci 27:10578-87. 2007
  9. ncbi request reprint Reduced nicotinic receptor-mediated antinociception following in vivo antisense knock-down in rat
    R S Bitner
    Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, Building AP9A LL D 4N5 60064 3500, Abbott Park, IL, USA
    Brain Res 871:66-74. 2000
  10. ncbi request reprint Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation
    Robert S Bitner
    Abbott Laboratories, Neuroscience Research, Abbott Park, IL 60064 3500, USA
    Neuropharmacology 50:521-31. 2006

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Alpha-7 nicotinic receptor expression by two distinct cell types in the dorsal raphe nucleus and locus coeruleus of rat
    R S Bitner
    Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, Building AP9A LL D 4N5, 100 Abbott Park Rd, Abbott Park, IL 60064 3500, USA
    Brain Res 938:45-54. 2002
    ..In addition, there appears to be a small-diameter cell-type in both the DRN and LC, possibly a GABAergic interneuron, expressing alpha 7 that may be regulated by neurotoxic injury...
  2. ncbi request reprint A-85380: a pharmacological probe for the preclinical and clinical investigation of the alphabeta neuronal nicotinic acetylcholine receptor
    Lynne E Rueter
    Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL, USA
    CNS Drug Rev 12:100-12. 2006
    ..Although not developed as a therapeutic agent, A-85380 has proven to be an important component in the development of novel nAChR ligands for the treatment of pain and other disorders...
  3. doi request reprint Cyclic AMP response element-binding protein (CREB) phosphorylation: a mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics
    R Scott Bitner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, United States
    Biochem Pharmacol 83:705-14. 2012
    ....
  4. pmc Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord
    Younglim Lee
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Mol Pain 7:39. 2011
    ..In the present studies, induction of central sensitization as indicated by spinal dorsal horn MAPK activation, specifically ERK and p38 phosphorylation, was assessed in the MIA-OA model...
  5. doi request reprint In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer's disease
    R Scott Bitner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Neuropharmacology 60:460-6. 2011
    ....
  6. doi request reprint In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease
    R Scott Bitner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Pharmacol Exp Ther 334:875-86. 2010
    ....
  7. doi request reprint Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo
    Robert S Bitner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Brain Res 1265:65-74. 2009
    ....
  8. ncbi request reprint Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways
    Robert S Bitner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Neurosci 27:10578-87. 2007
    ....
  9. ncbi request reprint Reduced nicotinic receptor-mediated antinociception following in vivo antisense knock-down in rat
    R S Bitner
    Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, Building AP9A LL D 4N5 60064 3500, Abbott Park, IL, USA
    Brain Res 871:66-74. 2000
    ..However, these data do not eliminate the possibility that other nicotinic subunit combinations may also play a role in antinociception produced by nAChR activation...
  10. ncbi request reprint Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation
    Robert S Bitner
    Abbott Laboratories, Neuroscience Research, Abbott Park, IL 60064 3500, USA
    Neuropharmacology 50:521-31. 2006
    ..These findings provide additional evidence that the PVN may be a site of dopamine D4 receptor-mediated proerectile activity...
  11. ncbi request reprint Selective H3 receptor (H3R) blockade: broad efficacy in cognition and schizophrenia
    G B Fox
    Neuroscience Research, Abbott Laboratories, AP9A, Global Pharmaceutical Research and Development, Abbott Park, Illinois 60064, USA
    Inflamm Res 54:S23-4. 2005
  12. doi request reprint Acute inhibition of 11beta-hydroxysteroid dehydrogenase type-1 improves memory in rodent models of cognition
    Eric G Mohler
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Neurosci 31:5406-13. 2011
    ..These studies suggest that selective HSD1 inhibitors work through a novel, noncholinergic mechanism to facilitate cognitive processing...
  13. pmc The histamine H3 receptor: an attractive target for the treatment of cognitive disorders
    T A Esbenshade
    Division of Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Br J Pharmacol 154:1166-81. 2008
    ..The discovery of effective H3 antagonists as therapeutic agents for the novel treatment of cognitive disorders will only be accomplished through continued research efforts that further our insights into the functions of the H3 receptor...
  14. ncbi request reprint Distinctions and contradistinctions between antiobesity histamine H(3) receptor (H (3)R) antagonists compared to cognition-enhancing H (3) receptor antagonists
    A A Hancock
    Department R4MN, AP9A 3, Abbott Laboratories, Global Pharmaceutical Research and Development, 100 Abbott Park Road, Abbott Park, IL, 60064 6125, USA
    Inflamm Res 55:S42-4. 2006
  15. ncbi request reprint Dissociation between post-surgical pain behaviors and spinal Fos-like immunoreactivity in the rat
    Chang Z Zhu
    Neuroscience Research, Global Pharmaceutical Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 3500, USA
    Eur J Pharmacol 531:108-17. 2006
    ....
  16. ncbi request reprint Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM
    Steve McGaraughty
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Neurophysiol 90:2702-10. 2003
    ..These results suggest that supraspinal VR1 receptors in the dPAG contribute to descending modulation of nociception...
  17. doi request reprint Mice expressing the Swedish APP mutation on a 129 genetic background demonstrate consistent behavioral deficits and pathological markers of Alzheimer's disease
    Nathan R Rustay
    Neuroscience Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Rd, Bldg AP4 2, Abbott Park, IL 60064, USA
    Brain Res 1311:136-47. 2010
    ..These results indicate that mice on the 129 genetic background may generate more consistent and robust behavioral differences, providing a useful model for testing therapeutic agents for Alzheimer's disease...
  18. doi request reprint Localization of histamine H4 receptors in the central nervous system of human and rat
    Marina I Strakhova
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Department R4MN, Abbott Park, Illinois 60064, USA
    Brain Res 1250:41-8. 2009
    ..Our observations provide evidence of the H(4) presence in both human and rodent CNS and offer some insight into possible role of H(4) in itch and pain...
  19. ncbi request reprint Alpha4beta2 nicotinic receptor stimulation contributes to the effects of nicotine in the DBA/2 mouse model of sensory gating
    Richard J Radek
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Dept R4N5, AP9A LL, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Psychopharmacology (Berl) 187:47-55. 2006
    ..This effect of nicotine has been attributed to activation of the alpha7 nicotinic acetylcholine receptor (nAChR) subtype...
  20. ncbi request reprint Antisense knockdown of the rat alpha7 nicotinic acetylcholine receptor produces spatial memory impairment
    Peter Curzon
    Neuroscience Research, Abbott Laboratories GPRD, Abbott Park, IL 60064 6115, United States
    Neurosci Lett 410:15-9. 2006
    ....
  21. ncbi request reprint Identification of novel H3 receptor (H3R) antagonists with cognition enhancing properties in rats
    G B Fox
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, AP9A, R4N5, 100 Abbott Park Rd, Abbott Park, Illinois 60064 6115, USA
    Inflamm Res 52:S31-2. 2003
  22. ncbi request reprint Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity
    William J Giardina
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064 6125, USA
    Epilepsia 46:1349-61. 2005
    ..The objective of this study was to characterize the antiseizure and safety profiles of ABT-769 [(R)-N-(2 amino-2-oxoethyl)spiro[2,5]octane-1-carboxamide]...
  23. pmc The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons
    Roxana C Sinjoanu
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neurochem Int 53:79-88. 2008
    ..Collectively, these results suggest that, indeed, specific calpain inhibitors could play an important role in the treatment of Alzheimer's disease...
  24. ncbi request reprint Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease
    Stefan Barghorn
    Neuroscience Discovery Research, Abbott GmbH and Co KG, Ludwigshafen, Germany
    J Neurochem 95:834-47. 2005
    ..Selective neutralization of the Abeta globulomer structure epitope is expected to have a high potential for treatment of AD...