Research Topics
| R Scott BitnerSummaryAffiliation: Abbott Laboratories Country: USA Publications
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Publications
Alpha-7 nicotinic receptor expression by two distinct cell types in the dorsal raphe nucleus and locus coeruleus of ratR S Bitner
Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, Building AP9A LL D 4N5, 100 Abbott Park Rd, Abbott Park, IL 60064 3500, USA
Brain Res 938:45-54. 2002..In addition, there appears to be a small-diameter cell-type in both the DRN and LC, possibly a GABAergic interneuron, expressing alpha 7 that may be regulated by neurotoxic injury...- A-85380: a pharmacological probe for the preclinical and clinical investigation of the alphabeta neuronal nicotinic acetylcholine receptorLynne E Rueter
Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL, USA
CNS Drug Rev 12:100-12. 2006..Although not developed as a therapeutic agent, A-85380 has proven to be an important component in the development of novel nAChR ligands for the treatment of pain and other disorders... 
Cyclic AMP response element-binding protein (CREB) phosphorylation: a mechanistic marker in the development of memory enhancing Alzheimer's disease therapeuticsR Scott Bitner
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, United States
Biochem Pharmacol 83:705-14. 2012....
Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cordYounglim Lee
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
Mol Pain 7:39. 2011..In the present studies, induction of central sensitization as indicated by spinal dorsal horn MAPK activation, specifically ERK and p38 phosphorylation, was assessed in the MIA-OA model...- In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer's diseaseR Scott Bitner
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
Neuropharmacology 60:460-6. 2011.... - In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's diseaseR Scott Bitner
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
J Pharmacol Exp Ther 334:875-86. 2010.... - Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivoRobert S Bitner
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
Brain Res 1265:65-74. 2009.... - Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathwaysRobert S Bitner
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
J Neurosci 27:10578-87. 2007.... - Reduced nicotinic receptor-mediated antinociception following in vivo antisense knock-down in ratR S Bitner
Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, Building AP9A LL D 4N5 60064 3500, Abbott Park, IL, USA
Brain Res 871:66-74. 2000..However, these data do not eliminate the possibility that other nicotinic subunit combinations may also play a role in antinociception produced by nAChR activation... - Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylationRobert S Bitner
Abbott Laboratories, Neuroscience Research, Abbott Park, IL 60064 3500, USA
Neuropharmacology 50:521-31. 2006..These findings provide additional evidence that the PVN may be a site of dopamine D4 receptor-mediated proerectile activity... - Selective H3 receptor (H3R) blockade: broad efficacy in cognition and schizophreniaG B Fox
Neuroscience Research, Abbott Laboratories, AP9A, Global Pharmaceutical Research and Development, Abbott Park, Illinois 60064, USA
Inflamm Res 54:S23-4. 2005 - Acute inhibition of 11beta-hydroxysteroid dehydrogenase type-1 improves memory in rodent models of cognitionEric G Mohler
Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
J Neurosci 31:5406-13. 2011..These studies suggest that selective HSD1 inhibitors work through a novel, noncholinergic mechanism to facilitate cognitive processing... - The histamine H3 receptor: an attractive target for the treatment of cognitive disordersT A Esbenshade
Division of Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
Br J Pharmacol 154:1166-81. 2008..The discovery of effective H3 antagonists as therapeutic agents for the novel treatment of cognitive disorders will only be accomplished through continued research efforts that further our insights into the functions of the H3 receptor... - Distinctions and contradistinctions between antiobesity histamine H(3) receptor (H (3)R) antagonists compared to cognition-enhancing H (3) receptor antagonistsA A Hancock
Department R4MN, AP9A-3, Abbott Laboratories, Global Pharmaceutical Research and Development, 100 Abbott Park Road, Abbott Park, IL, 60064-6125, USA
Inflamm Res 55:S42-4. 2006 - Dissociation between post-surgical pain behaviors and spinal Fos-like immunoreactivity in the ratChang Z Zhu
Neuroscience Research, Global Pharmaceutical Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 3500, USA
Eur J Pharmacol 531:108-17. 2006.... - Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVMSteve McGaraughty
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
J Neurophysiol 90:2702-10. 2003..These results suggest that supraspinal VR1 receptors in the dPAG contribute to descending modulation of nociception... - Mice expressing the Swedish APP mutation on a 129 genetic background demonstrate consistent behavioral deficits and pathological markers of Alzheimer's diseaseNathan R Rustay
Neuroscience Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Rd, Bldg AP4 2, Abbott Park, IL 60064, USA
Brain Res 1311:136-47. 2010..These results indicate that mice on the 129 genetic background may generate more consistent and robust behavioral differences, providing a useful model for testing therapeutic agents for Alzheimer's disease... - Localization of histamine H4 receptors in the central nervous system of human and ratMarina I Strakhova
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Department R4MN, Abbott Park, Illinois 60064, USA
Brain Res 1250:41-8. 2009..Our observations provide evidence of the H(4) presence in both human and rodent CNS and offer some insight into possible role of H(4) in itch and pain... - Alpha4beta2 nicotinic receptor stimulation contributes to the effects of nicotine in the DBA/2 mouse model of sensory gatingRichard J Radek
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Dept R4N5, AP9A LL, 100 Abbott Park Road, Abbott Park, IL 60064, USA
Psychopharmacology (Berl) 187:47-55. 2006..This effect of nicotine has been attributed to activation of the alpha7 nicotinic acetylcholine receptor (nAChR) subtype... - Antisense knockdown of the rat alpha7 nicotinic acetylcholine receptor produces spatial memory impairmentPeter Curzon
Neuroscience Research, Abbott Laboratories GPRD, Abbott Park, IL 60064 6115, United States
Neurosci Lett 410:15-9. 2006.... - Identification of novel H3 receptor (H3R) antagonists with cognition enhancing properties in ratsG B Fox
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, AP9A, R4N5, 100 Abbott Park Rd, Abbott Park, Illinois 60064-6115, USA
Inflamm Res 52:S31-2. 2003 - Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activityWilliam J Giardina
Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064-6125, USA
Epilepsia 46:1349-61. 2005..ABT-769 has a broad-spectrum profile like that of valproic acid. Its profile is clearly different from those of carbamazepine, phenytoin, lamotrigine, topiramate, vigabatrin, and tiagabine... - The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neuronsRoxana C Sinjoanu
Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Neurochem Int 53:79-88. 2008..Collectively, these results suggest that, indeed, specific calpain inhibitors could play an important role in the treatment of Alzheimer's disease... - Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's diseaseStefan Barghorn
Neuroscience Discovery Research, Abbott GmbH and Co KG, Ludwigshafen, Germany
J Neurochem 95:834-47. 2005..Selective neutralization of the Abeta globulomer structure epitope is expected to have a high potential for treatment of AD...