Affiliation: Abbott Laboratories
- Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteriaD E Bussiere
Laboratory of Protein Crystallography, Department of Scientific Information, Analysis and Management, Abbott Laboratories, Abbott Park, Illinois 60064 3500, USA
Biochemistry 37:7103-12. 1998..ErmC' exhibits the conserved structural motifs previously found in the SAM-binding domain of other methyltransferases. A model of SAM bound to ErmC' is presented which is consistent with the motif conservation among MTases...
- The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanismG Schluckebier
Abbott Laboratories, D46Y AP 10, 100 Abbott Park Road, Abbott Park, IL, 60064, USA
J Mol Biol 289:277-91. 1999..A model for the transition-state based on the atomic details of the active site is consistent with a one-step methyl-transfer mechanism and might serve as a first step towards the design of potent Erm inhibitors...