G Schluckebier

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. ncbi request reprint Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria
    D E Bussiere
    Laboratory of Protein Crystallography, Department of Scientific Information, Analysis and Management, Abbott Laboratories, Abbott Park, Illinois 60064 3500, USA
    Biochemistry 37:7103-12. 1998
  2. ncbi request reprint The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism
    G Schluckebier
    Abbott Laboratories, D46Y AP 10, 100 Abbott Park Road, Abbott Park, IL, 60064, USA
    J Mol Biol 289:277-91. 1999

Detail Information

Publications2

  1. ncbi request reprint Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria
    D E Bussiere
    Laboratory of Protein Crystallography, Department of Scientific Information, Analysis and Management, Abbott Laboratories, Abbott Park, Illinois 60064 3500, USA
    Biochemistry 37:7103-12. 1998
    ..ErmC' exhibits the conserved structural motifs previously found in the SAM-binding domain of other methyltransferases. A model of SAM bound to ErmC' is presented which is consistent with the motif conservation among MTases...
  2. ncbi request reprint The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism
    G Schluckebier
    Abbott Laboratories, D46Y AP 10, 100 Abbott Park Road, Abbott Park, IL, 60064, USA
    J Mol Biol 289:277-91. 1999
    ..A model for the transition-state based on the atomic details of the active site is consistent with a one-step methyl-transfer mechanism and might serve as a first step towards the design of potent Erm inhibitors...