V Nimmrich

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. pmc Cellular and network mechanisms underlying spontaneous sharp wave-ripple complexes in mouse hippocampal slices
    Nikolaus Maier
    Johannes Müller Institut für Physiologie der Charité, Tucholskystrasse 2, 10117 Berlin, Germany
    J Physiol 550:873-87. 2003
  2. ncbi request reprint Is Alzheimer's disease a result of presynaptic failure? Synaptic dysfunctions induced by oligomeric beta-amyloid
    Volker Nimmrich
    Neuroscience Discovery, GPRD, Abbott, Ludwigshafen, Germany
    Rev Neurosci 20:1-12. 2009
  3. doi request reprint Calcium channel blockers and dementia
    V Nimmrich
    Neuroscience Research, GPRD, AbbVie GmbH, Ludwigshafen, Germany
    Br J Pharmacol 169:1203-10. 2013
  4. ncbi request reprint Establishment of a secondary screening assay for P/Q-type calcium channel blockers
    David Hermann
    Neuroscience Research, GPRD, Abbott GmbH and Co KG, Ludwigshafen, Germany
    Comb Chem High Throughput Screen 16:233-43. 2013
  5. pmc Inhibition of calpain prevents NMDA-induced cell death and beta-amyloid-induced synaptic dysfunction in hippocampal slice cultures
    V Nimmrich
    Neuroscience Research, GPRD, Abbott, Ludwigshafen, Germany
    Br J Pharmacol 159:1523-31. 2010
  6. doi request reprint Inhibition of Calpain Prevents N-Methyl-D-aspartate-Induced Degeneration of the Nucleus Basalis and Associated Behavioral Dysfunction
    Volker Nimmrich
    Neuroscience Research, GPRD, Abbott, Knollstrasse, d 67061 Ludwigshafen, Germany
    J Pharmacol Exp Ther 327:343-52. 2008
  7. doi request reprint Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents
    Volker Nimmrich
    Neuroscience Discovery, Global Pharmaceutical Research and Development, Abbott, d 67061 Ludwigshafen, Germany
    J Neurosci 28:788-97. 2008
  8. ncbi request reprint Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease
    Stefan Barghorn
    Neuroscience Discovery Research, Abbott GmbH and Co KG, Ludwigshafen, Germany
    J Neurochem 95:834-47. 2005
  9. doi request reprint Synaptic transmission is impaired prior to plaque formation in amyloid precursor protein-overexpressing mice without altering behaviorally-correlated sharp wave-ripple complexes
    D Hermann
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott, D 67061, Ludwigshafen, Germany
    Neuroscience 162:1081-90. 2009
  10. doi request reprint Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies
    Heinz Hillen
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott, d 67061 Ludwigshafen, Germany
    J Neurosci 30:10369-79. 2010

Collaborators

Detail Information

Publications14

  1. pmc Cellular and network mechanisms underlying spontaneous sharp wave-ripple complexes in mouse hippocampal slices
    Nikolaus Maier
    Johannes Müller Institut für Physiologie der Charité, Tucholskystrasse 2, 10117 Berlin, Germany
    J Physiol 550:873-87. 2003
    ..This strong separation between members and non-members of the network may serve to ensure a high signal-to-noise ratio in information processing during sharp wave-ripple complexes...
  2. ncbi request reprint Is Alzheimer's disease a result of presynaptic failure? Synaptic dysfunctions induced by oligomeric beta-amyloid
    Volker Nimmrich
    Neuroscience Discovery, GPRD, Abbott, Ludwigshafen, Germany
    Rev Neurosci 20:1-12. 2009
    ..While this hypothesis offers a promising avenue to understand the underlying cause of cognition and memory deficits in the AD brain, it also opens a possibility to address new mechanisms for preventing and ultimately curing AD...
  3. doi request reprint Calcium channel blockers and dementia
    V Nimmrich
    Neuroscience Research, GPRD, AbbVie GmbH, Ludwigshafen, Germany
    Br J Pharmacol 169:1203-10. 2013
    ..Novel low molecular weight compounds suitable for proof-of-concept studies are now available. ..
  4. ncbi request reprint Establishment of a secondary screening assay for P/Q-type calcium channel blockers
    David Hermann
    Neuroscience Research, GPRD, Abbott GmbH and Co KG, Ludwigshafen, Germany
    Comb Chem High Throughput Screen 16:233-43. 2013
    ..The protocol presented here supports hit-to-lead and lead optimization efforts during the development of novel P/Q-type calcium channel blockers, and may be valuable for the generation of assays in other ion channel programs...
  5. pmc Inhibition of calpain prevents NMDA-induced cell death and beta-amyloid-induced synaptic dysfunction in hippocampal slice cultures
    V Nimmrich
    Neuroscience Research, GPRD, Abbott, Ludwigshafen, Germany
    Br J Pharmacol 159:1523-31. 2010
    ..This study was designed to test whether calpain could be involved in both pathological pathways, which would offer a promising avenue for new treatments...
  6. doi request reprint Inhibition of Calpain Prevents N-Methyl-D-aspartate-Induced Degeneration of the Nucleus Basalis and Associated Behavioral Dysfunction
    Volker Nimmrich
    Neuroscience Research, GPRD, Abbott, Knollstrasse, d 67061 Ludwigshafen, Germany
    J Pharmacol Exp Ther 327:343-52. 2008
    ..Thus, calpain inhibition may be a promising and novel approach for the treatment of various neurodegenerative disorders...
  7. doi request reprint Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents
    Volker Nimmrich
    Neuroscience Discovery, Global Pharmaceutical Research and Development, Abbott, d 67061 Ludwigshafen, Germany
    J Neurosci 28:788-97. 2008
    ..Selective enhancement of the P/Q calcium current may provide a promising strategy in the treatment of Alzheimer's disease...
  8. ncbi request reprint Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease
    Stefan Barghorn
    Neuroscience Discovery Research, Abbott GmbH and Co KG, Ludwigshafen, Germany
    J Neurochem 95:834-47. 2005
    ..Selective neutralization of the Abeta globulomer structure epitope is expected to have a high potential for treatment of AD...
  9. doi request reprint Synaptic transmission is impaired prior to plaque formation in amyloid precursor protein-overexpressing mice without altering behaviorally-correlated sharp wave-ripple complexes
    D Hermann
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott, D 67061, Ludwigshafen, Germany
    Neuroscience 162:1081-90. 2009
    ..We propose that mechanisms leading to Abeta-related cognitive decline are different from those related to aging...
  10. doi request reprint Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies
    Heinz Hillen
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott, d 67061 Ludwigshafen, Germany
    J Neurosci 30:10369-79. 2010
    ..Our findings demonstrate that selective reduction of Abeta oligomers by immunotherapy is sufficient to normalize cognitive behavior and synaptic deficits in APP transgenic mice...
  11. pmc A β-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes
    M Mezler
    Neuroscience Research, GPRD, Abbott, Ludwigshafen, Germany
    Br J Pharmacol 165:1572-83. 2012
    ..Using a heterologous expression system, we aimed to prove a direct effect on the membrane channel mediating such current...
  12. pmc P/Q-type calcium channel modulators
    V Nimmrich
    Neuroscience Research, GPRD, Abbott, Ludwigshafen, Germany
    Br J Pharmacol 167:741-59. 2012
    ..Chances and challenges of the development of P/Q channel-selective molecules are discussed...
  13. pmc Induced sharp wave-ripple complexes in the absence of synaptic inhibition in mouse hippocampal slices
    Volker Nimmrich
    Institute of Physiology and Pathophysiology, Heidelberg University, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
    J Physiol 563:663-70. 2005
    ..Gap junctions on the other hand seem to be necessary to orchestrate coordinated activity within the ripple frequency domain...
  14. pmc Dendritic transport and localization of protein kinase Mzeta mRNA: implications for molecular memory consolidation
    Ilham Aliagaevich Muslimov
    Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, Brooklyn, New York 11203, USA
    J Biol Chem 279:52613-22. 2004
    ..Dendritic localization of PKMzeta mRNA provides a molecular basis for the functional integration of synaptic signal transduction and translational control pathways...