Torben R Neelands

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. doi request reprint Elevated temperatures alter TRPV1 agonist-evoked excitability of dorsal root ganglion neurons
    T R Neelands
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R04PM, AP9A, 100 Abbott Park Road, Abbott Park, IL 60064 6123, USA
    Inflamm Res 57:404-9. 2008
  2. doi request reprint Differential effects of temperature on acid-activated currents mediated by TRPV1 and ASIC channels in rat dorsal root ganglion neurons
    Torben R Neelands
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R4PM, AP9A, Abbott Park, IL 60064 6123, USA
    Brain Res 1329:55-66. 2010
  3. pmc Acidification of rat TRPV1 alters the kinetics of capsaicin responses
    Torben R Neelands
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R04PM, AP9A, Abbott Park, IL 60064 6123, USA
    Mol Pain 1:28. 2005
  4. doi request reprint Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia
    Heath A McDonald
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Eur J Pharmacol 596:62-9. 2008
  5. ncbi request reprint [3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor
    Bruce R Bianchi
    Department of Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R4PM, AP9A 2, 100 Abbott Park Rd, Abbott Park, IL 60064 6123, USA
    J Pharmacol Exp Ther 323:285-93. 2007
  6. doi request reprint Transient receptor potential A1 mediates an osmotically activated ion channel
    Xu Feng Zhang
    Neuroscience Research, R4PM, AP9A, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6125, USA
    Eur J Neurosci 27:605-11. 2008
  7. doi request reprint Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature
    Regina M Reilly
    Departments of Neuroscience Research and Integrative Pharmacology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Pharmacol Exp Ther 342:416-28. 2012
  8. pmc Coexpression and activation of TRPV1 suppress the activity of the KCNQ2/3 channel
    Xu Feng Zhang
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    J Gen Physiol 138:341-52. 2011
  9. ncbi request reprint TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells
    Melissa H Vos
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Neurochem 99:1088-102. 2006
  10. ncbi request reprint A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid
    Rachid El Kouhen
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6123, USA
    J Pharmacol Exp Ther 314:400-9. 2005

Collaborators

Detail Information

Publications16

  1. doi request reprint Elevated temperatures alter TRPV1 agonist-evoked excitability of dorsal root ganglion neurons
    T R Neelands
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R04PM, AP9A, 100 Abbott Park Road, Abbott Park, IL 60064 6123, USA
    Inflamm Res 57:404-9. 2008
    ..Together these results provide evidence that a synergistic interaction of TRPV1 ligands and elevated temperature activates TRPV1 receptors and results in profound effects on membrane excitability...
  2. doi request reprint Differential effects of temperature on acid-activated currents mediated by TRPV1 and ASIC channels in rat dorsal root ganglion neurons
    Torben R Neelands
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R4PM, AP9A, Abbott Park, IL 60064 6123, USA
    Brain Res 1329:55-66. 2010
    ..These results indicate that the ambient temperature at which acidosis occurs has a profound effect on the contribution of ASIC and TRPV1 channels, therefore, altering the neuronal excitability...
  3. pmc Acidification of rat TRPV1 alters the kinetics of capsaicin responses
    Torben R Neelands
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R04PM, AP9A, Abbott Park, IL 60064 6123, USA
    Mol Pain 1:28. 2005
    ..Since inflammation is associated with tissue acidosis, these findings enhance understanding of TRPV1 receptor responses in inflammatory pain where tissue acidosis is prevalent...
  4. doi request reprint Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia
    Heath A McDonald
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Eur J Pharmacol 596:62-9. 2008
    ..These data show that A-425619 is a potent TRPV1 antagonist at the native TRPV1 receptors, and suggest that the pharmacological profile for TRPV1 receptors on dorsal root ganglia and trigeminal ganglia is very similar...
  5. ncbi request reprint [3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor
    Bruce R Bianchi
    Department of Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R4PM, AP9A 2, 100 Abbott Park Rd, Abbott Park, IL 60064 6123, USA
    J Pharmacol Exp Ther 323:285-93. 2007
    ....
  6. doi request reprint Transient receptor potential A1 mediates an osmotically activated ion channel
    Xu Feng Zhang
    Neuroscience Research, R4PM, AP9A, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6125, USA
    Eur J Neurosci 27:605-11. 2008
    ..Taken together, these findings indicate that TRPA1 mediates an osmotically-activated ion channel and support a role for TRPA1 in mechanosensation...
  7. doi request reprint Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature
    Regina M Reilly
    Departments of Neuroscience Research and Integrative Pharmacology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Pharmacol Exp Ther 342:416-28. 2012
    ..Although both classes of compounds elicit equivalent analgesia in a rat model of knee joint pain, the acid-sparing antagonist tested is not effective in a mouse model of bone cancer pain...
  8. pmc Coexpression and activation of TRPV1 suppress the activity of the KCNQ2/3 channel
    Xu Feng Zhang
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    J Gen Physiol 138:341-52. 2011
    ..Such neurons may thus have a lower threshold for activation, which may indirectly facilitate TRPV1 in integrating multiple noxious signals and/or in the establishment or maintenance of chronic pain...
  9. ncbi request reprint TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells
    Melissa H Vos
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Neurochem 99:1088-102. 2006
    ..Taken together, these data support the hypothesis that TRPV1b is a naturally existing inhibitory modulator of TRPV1...
  10. ncbi request reprint A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid
    Rachid El Kouhen
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6123, USA
    J Pharmacol Exp Ther 314:400-9. 2005
    ..These data show that A-425619 is a structurally novel, potent, and selective TRPV1 antagonist...
  11. doi request reprint (R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo
    Carol S Surowy
    Abbott Laboratories, R4PM, AP9 1, 100 Abbott Park Road, Abbott Park, IL 60064 6118, USA
    J Pharmacol Exp Ther 326:879-88. 2008
    ..ABT-102 is a novel and selective TRPV1 antagonist with pharmacological and functional properties that support its advancement into clinical studies...
  12. doi request reprint Development and validation of a medium-throughput electrophysiological assay for KCNQ2/3 channel openers using QPatch HT
    Xu Feng Zhang
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064 6125, USA
    Assay Drug Dev Technol 11:17-24. 2013
    ....
  13. doi request reprint A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model
    Pamela S Puttfarcken
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Pain 150:319-26. 2010
    ..These findings suggest that repeated dosing of TRPV1 antagonists enhances therapeutic potency and duration of action against OA pain, at least in part, by the sustained reduction in release of glutamate and CGRP from the spinal cord...
  14. doi request reprint Comparative analysis of inactivated-state block of N-type (Ca(v)2.2) calcium channels
    Timothy A Vortherms
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Dept R4PM, Bldg AP9A, 100 Abbott Park Road, Abbott Park, IL 60064 6125, USA
    Inflamm Res 60:683-93. 2011
    ....
  15. doi request reprint Expression and purification of human TRPV1 in baculovirus-infected insect cells for structural studies
    Alla Korepanova
    Department of Structural Biology, R46Y, Abbott Laboratories, Bldg AP10 LL8, 100 Abbott Park Rd, Abbott Park, IL 60064 6098, USA
    Protein Expr Purif 65:38-50. 2009
    ..Specific ligand binding experiments confirmed the protein integrity of the purified human TRPV1...
  16. pmc 2', 3'-O-(2,4,6,trinitrophenyl)-ATP and A-317491 are competitive antagonists at a slowly desensitizing chimeric human P2X3 receptor
    Torben R Neelands
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R04PM, AP9A, Abbott Park, IL 60064 6123, USA
    Br J Pharmacol 140:202-10. 2003
    ..2 and 52.1 nm, respectively), supporting the hypothesis that rapid receptor desensitization can mask the competitive antagonism of wild-type homomeric P2X3 receptors...