Y C Martin

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. ncbi request reprint Molecular diversity: how we measure it? Has it lived up to its promise?
    Y C Martin
    Abbott Laboratories, Abbott Park, IL 60064, USA
    Farmaco 56:137-9. 2001
  2. ncbi request reprint Do structurally similar molecules have similar biological activity?
    Yvonne C Martin
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6100, USA
    J Med Chem 45:4350-8. 2002
  3. ncbi request reprint A general and fast scoring function for protein-ligand interactions: a simplified potential approach
    I Muegge
    Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064 6100, USA
    J Med Chem 42:791-804. 1999
  4. ncbi request reprint Computational methods in molecular diversity and combinatorial chemistry
    M G Bures
    Abbott Laboratories, Abbott Park, IL 60064 3500, USA
    Curr Opin Chem Biol 2:376-80. 1998
  5. ncbi request reprint Ligand binding to domain-3 of human serum albumin: a chemometric analysis
    Philip J Hajduk
    Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, IL 60044, USA
    J Comput Aided Mol Des 17:93-102. 2003
  6. ncbi request reprint A bioavailability score
    Yvonne C Martin
    Advanced Technology Division, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6100, USA yvonne c martin abbott com
    J Med Chem 48:3164-70. 2005

Detail Information

Publications6

  1. ncbi request reprint Molecular diversity: how we measure it? Has it lived up to its promise?
    Y C Martin
    Abbott Laboratories, Abbott Park, IL 60064, USA
    Farmaco 56:137-9. 2001
    ..There continues to be an opportunity for innovative computational approaches to solving problems in medicinal chemistry...
  2. ncbi request reprint Do structurally similar molecules have similar biological activity?
    Yvonne C Martin
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6100, USA
    J Med Chem 45:4350-8. 2002
    ..The current study emphasizes the statistical or probabilistic nature of library design and that perfect results cannot be expected...
  3. ncbi request reprint A general and fast scoring function for protein-ligand interactions: a simplified potential approach
    I Muegge
    Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064 6100, USA
    J Med Chem 42:791-804. 1999
    ..The use of the new scoring function in docking studies is outlined...
  4. ncbi request reprint Computational methods in molecular diversity and combinatorial chemistry
    M G Bures
    Abbott Laboratories, Abbott Park, IL 60064 3500, USA
    Curr Opin Chem Biol 2:376-80. 1998
    ..Recent advances include a number of new and meaningful measures of molecular diversity and the use of genetic algorithms to help design diverse libraries...
  5. ncbi request reprint Ligand binding to domain-3 of human serum albumin: a chemometric analysis
    Philip J Hajduk
    Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, IL 60044, USA
    J Comput Aided Mol Des 17:93-102. 2003
    ..This information can be valuable for optimizing a particular series of compounds for drug development...
  6. ncbi request reprint A bioavailability score
    Yvonne C Martin
    Advanced Technology Division, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6100, USA yvonne c martin abbott com
    J Med Chem 48:3164-70. 2005
    ..This same categorization distinguishes compounds that are poorly permeable from those that are permeable in Caco-2 cells. Further validation is provided with human bioavailability values from the literature...