Heinz Hillen

Summary

Affiliation: Abbott Laboratories

Country: USA

Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies
Heinz Hillen
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott, d 67061 Ludwigshafen, Germany
J Neurosci 30:10369-79. 2010
Abeta-globulomers are formed independently of the fibril pathway
Gerald P Gellermann
Neuroscience Discovery Research, Abbott GmbH and Co KG, Knollstrasse, d 67061 Ludwigshafen, Germany
Neurobiol Dis 30:212-20. 2008
Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents
Volker Nimmrich
Neuroscience Discovery, Global Pharmaceutical Research and Development, Abbott, d 67061 Ludwigshafen, Germany
J Neurosci 28:788-97. 2008

Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies
Heinz Hillen
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott, d 67061 Ludwigshafen, Germany
J Neurosci 30:10369-79. 2010
..Our findings demonstrate that selective reduction of Abeta oligomers by immunotherapy is sufficient to normalize cognitive behavior and synaptic deficits in APP transgenic mice...
Abeta-globulomers are formed independently of the fibril pathway
Gerald P Gellermann
Neuroscience Discovery Research, Abbott GmbH and Co KG, Knollstrasse, d 67061 Ludwigshafen, Germany
Neurobiol Dis 30:212-20. 2008
..We hypothesize that a conformational switch of A beta is decisive for either fibril formation or alternatively and independently A beta-globulomer formation...
Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents
Volker Nimmrich
Neuroscience Discovery, Global Pharmaceutical Research and Development, Abbott, d 67061 Ludwigshafen, Germany
J Neurosci 28:788-97. 2008
..Selective enhancement of the P/Q calcium current may provide a promising strategy in the treatment of Alzheimer's disease...