E K H Han

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. ncbi Functional analysis of focal adhesion kinase (FAK) reduction by small inhibitory RNAs
    Edward Kyu Ho Han
    Abbott Laboratories, Global Pharmaceutical Research Division, Cancer Division, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    Anticancer Res 24:3899-905. 2004
  2. ncbi Chkl binds and phosphorylates BAD protein
    Edward Kyu Ho Han
    Department R47S, AP9A, Cancer Research, Global Pharmaceutical Research Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Anticancer Res 24:3907-10. 2004
  3. ncbi Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition
    E K H Han
    Abbott Laboratories, Global Pharmaceutical Research Division, Cancer Research, IL 60064, USA
    Oncogene 26:5655-61. 2007
  4. ncbi Role of focal adhesion kinase in human cancer: a potential target for drug discovery
    Edward Kyu Ho Han
    Abbott Laboratories, Global Pharmaceutical Research Division, Cancer Research, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    Anticancer Agents Med Chem 7:681-4. 2007
  5. ncbi Characterization of Akt overexpression in MiaPaCa-2 cells: prohibitin is an Akt substrate both in vitro and in cells
    Edward Kyu Ho Han
    Abbott Laboratories, Department of R47S, Cancer Research, Global Pharmaceutical Research Division, Abbott Park, IL 60064, USA
    Anticancer Res 28:957-63. 2008

Detail Information

Publications5

  1. ncbi Functional analysis of focal adhesion kinase (FAK) reduction by small inhibitory RNAs
    Edward Kyu Ho Han
    Abbott Laboratories, Global Pharmaceutical Research Division, Cancer Division, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    Anticancer Res 24:3899-905. 2004
    ..Our results demonstrated that inhibition of FAK protein leads to alterations in cell growth and migration...
  2. ncbi Chkl binds and phosphorylates BAD protein
    Edward Kyu Ho Han
    Department R47S, AP9A, Cancer Research, Global Pharmaceutical Research Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Anticancer Res 24:3907-10. 2004
    ..Taken together, our results suggest that Chk1 may inactivate BAD by associating with and phosphorylating residues critical for BAD function in response to DNA damage...
  3. ncbi Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition
    E K H Han
    Abbott Laboratories, Global Pharmaceutical Research Division, Cancer Research, IL 60064, USA
    Oncogene 26:5655-61. 2007
    ....
  4. ncbi Role of focal adhesion kinase in human cancer: a potential target for drug discovery
    Edward Kyu Ho Han
    Abbott Laboratories, Global Pharmaceutical Research Division, Cancer Research, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    Anticancer Agents Med Chem 7:681-4. 2007
    ..Taken together, these studies suggest that FAK is a potentially good target for drug discovery. In this review, FAK and its relationship to cancer, as well as approaches to therapeutic intervention of FAK will be discussed...
  5. ncbi Characterization of Akt overexpression in MiaPaCa-2 cells: prohibitin is an Akt substrate both in vitro and in cells
    Edward Kyu Ho Han
    Abbott Laboratories, Department of R47S, Cancer Research, Global Pharmaceutical Research Division, Abbott Park, IL 60064, USA
    Anticancer Res 28:957-63. 2008
    ..In this study, we identified prohibitin as a substrate for Akt both in vitro and in vivo. These studies suggest that Akt may regulate the cellular function of prohibitin via its phosphorylation...