Research Topics
| Jennifer M FrostSummaryAffiliation: Abbott Laboratories Country: USA Publications
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Detail Information
Publications
Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonistsJennifer M Frost
Neuroscience Research, Abbott Laboratories, Abbott Park, IL 60064, USA
J Med Chem 49:7843-53. 2006..e., 24, 25, 28, 30, 32, and 47) exhibit equivalent or greater affinity for the halpha4beta2 receptor relative to epibatidine, and like epibatidine, many exhibit robust analgesic efficacy in the rat formalin model of persistent pain...
Indol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor activityJennifer M Frost
Neurological Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
J Med Chem 51:1904-12. 2008..Several agonists were active in the complete Freund's adjuvant model of chronic inflammatory thermal hyperalgesia ( 32, 15)...- Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activityJennifer M Frost
Neurological Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R47W, AP9A, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA
J Med Chem 53:295-315. 2010..N1 aromatic side chains also afforded several high affinity CB(2) receptor agonists (61, 63, 65, and 69) but were generally less potent in an in vitro CB(2) functional assay than were nonaromatic side chain analogues... - Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptorsWilliam H Bunnelle
Neuroscience Research, Abbott Laboratories, Department R47W, Building AP9A, Abbott Park, Illinois 60064 6117, USA
J Med Chem 50:3627-44. 2007.... - SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophoreMichael R Schrimpf
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6117, USA
Bioorg Med Chem Lett 22:1633-8. 2012..Analogs in which the fluorenone core is replaced with either dibenzothiophene-5,5-dioxide or xanthenone also retain potent activity... - Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivityWilliam H Bunnelle
Department R47W, Neuroscience Research, Abbott Laboratories, Abbott Park, Illinois 60064 6117, USA
J Med Chem 52:4126-41. 2009..The effects of substitution on subtype selectivity provide some insight into the differences in the ligand binding domains of the alpha4beta2 and alpha7 receptors, especially in regions removed from the cation binding pocket... - Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing propertiesKarin R Tietje
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
CNS Neurosci Ther 14:65-82. 2008.... - Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB₂ receptor agonists for pain managementDerek W Nelson
Neurological Diseases Research, Global Pharmaceutical R and D, Abbott, 100 Abbott Park Road, Abbott Park, IL 60064, USA
Bioorg Med Chem Lett 22:2604-8. 2012..Control experiments using a CB(2) antagonist demonstrated the efficacy in the pain models resulted from CB(2) agonism... - Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathwaysRobert S Bitner
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
J Neurosci 27:10578-87. 2007....