Affiliation: Abbott Laboratories
- Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndromeBarbara Cool
Department of Metabolic Disease Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA
Cell Metab 3:403-16. 2006..These results demonstrate that small molecule-mediated activation of AMPK in vivo is feasible and represents a promising approach for the treatment of type 2 diabetes and the metabolic syndrome...
- Discovery and SAR development of thienopyridones: a class of small molecule AMPK activatorsGang Zhao
Metabolic Disease Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
Bioorg Med Chem Lett 17:3254-7. 2007..A novel thienopyridone compound (1) was identified and subsequently optimized. The structure-activity relationships that emerged from this effort are described...