Janel M Boyce-Rustay

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. ncbi request reprint Dopamine D3 receptor knockout mice and the motivational effects of ethanol
    Janel M Boyce-Rustay
    Department of Behavioral Neuroscience, L470, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Pharmacol Biochem Behav 75:373-9. 2003
  2. ncbi request reprint Chronic swim stress alters sensitivity to acute behavioral effects of ethanol in mice
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, United States
    Physiol Behav 91:77-86. 2007
  3. pmc Desipramine potentiation of the acute depressant effects of ethanol: modulation by alpha2-adrenoreceptors and stress
    Janel M Boyce-Rustay
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
    Neuropharmacology 55:803-11. 2008
  4. pmc Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
    Behav Brain Res 186:133-7. 2008
  5. doi request reprint Comparison of mechanical allodynia and the affective component of inflammatory pain in rats
    Janel M Boyce-Rustay
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6115, USA
    Neuropharmacology 58:537-43. 2010
  6. ncbi request reprint Ethanol-related behaviors in serotonin transporter knockout mice
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA
    Alcohol Clin Exp Res 30:1957-65. 2006
  7. ncbi request reprint Ethanol-related behaviors in mice lacking the NMDA receptor NR2A subunit
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
    Psychopharmacology (Berl) 187:455-66. 2006
  8. doi request reprint Animal models of acute and chronic inflammatory and nociceptive pain
    Janel M Boyce-Rustay
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA
    Methods Mol Biol 617:41-55. 2010
  9. doi request reprint Characterization of Fasudil in preclinical models of pain
    Janel M Boyce-Rustay
    Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Pain 11:941-9. 2010
  10. ncbi request reprint Neuropathic pain: models and mechanisms
    Michael F Jarvis
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6123, USA
    Curr Pharm Des 15:1711-6. 2009

Detail Information

Publications17

  1. ncbi request reprint Dopamine D3 receptor knockout mice and the motivational effects of ethanol
    Janel M Boyce-Rustay
    Department of Behavioral Neuroscience, L470, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Pharmacol Biochem Behav 75:373-9. 2003
    ..D3 KO and C57 mice had similar response rates of ethanol and food as well as similar water intakes. Overall, these results indicate that elimination of D3 receptor function has little influence on ethanol reward or intake...
  2. ncbi request reprint Chronic swim stress alters sensitivity to acute behavioral effects of ethanol in mice
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, United States
    Physiol Behav 91:77-86. 2007
    ..These data provide further evidence that stress alters the intoxicating effects of high doses of ethanol in a behaviorally selective manner...
  3. pmc Desipramine potentiation of the acute depressant effects of ethanol: modulation by alpha2-adrenoreceptors and stress
    Janel M Boyce-Rustay
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
    Neuropharmacology 55:803-11. 2008
    ....
  4. pmc Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
    Behav Brain Res 186:133-7. 2008
    ..In conclusion, strain differences, that are likely in large part genetic in nature, modify the effects of this stressor on EtOH's effects in a behavior-specific manner...
  5. doi request reprint Comparison of mechanical allodynia and the affective component of inflammatory pain in rats
    Janel M Boyce-Rustay
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6115, USA
    Neuropharmacology 58:537-43. 2010
    ..These studies show that methods other than reflex based measures of pain such as affective pain models could be more predictive of efficacy/potency in the clinic...
  6. ncbi request reprint Ethanol-related behaviors in serotonin transporter knockout mice
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA
    Alcohol Clin Exp Res 30:1957-65. 2006
    ..Increasing evidence supports a role for 5-hydroxytryptamine (5-HT) and the 5-HT transporter (5-HTT) in modulating the neural and behavioral actions of ethanol (EtOH) and other drugs of abuse...
  7. ncbi request reprint Ethanol-related behaviors in mice lacking the NMDA receptor NR2A subunit
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
    Psychopharmacology (Berl) 187:455-66. 2006
    ..While there is compelling evidence that NMDA receptors modulate behavioral effects of ethanol, there is little understanding of how the subunit composition of the NMDA receptor mediates these effects...
  8. doi request reprint Animal models of acute and chronic inflammatory and nociceptive pain
    Janel M Boyce-Rustay
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA
    Methods Mol Biol 617:41-55. 2010
    ..This chapter will focus on rodent models of inflammatory and nociceptive pain that are most used in our laboratory for identification of novel antinociceptive compounds in drug discovery...
  9. doi request reprint Characterization of Fasudil in preclinical models of pain
    Janel M Boyce-Rustay
    Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Pain 11:941-9. 2010
    ..Fasudil was shown to have efficacy in neuropathic and nociceptive pain models. These findings may help identify new therapeutic treatments for pain in the clinic...
  10. ncbi request reprint Neuropathic pain: models and mechanisms
    Michael F Jarvis
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6123, USA
    Curr Pharm Des 15:1711-6. 2009
    ....
  11. ncbi request reprint Genetic inactivation of the NMDA receptor NR2A subunit has anxiolytic- and antidepressant-like effects in mice
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20892, USA
    Neuropsychopharmacology 31:2405-14. 2006
    ..Present results support a role for the NR2A subunit in the modulation of emotional behaviors in rodents and provide insight into the role of glutamate in the pathophysiology and treatment of mood and anxiety disorders...
  12. ncbi request reprint Functional roles of NMDA receptor NR2A and NR2B subunits in the acute intoxicating effects of ethanol in mice
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Synapse 56:222-5. 2005
    ..These findings confirm a major role for NMDA receptors in the acute intoxicating actions of ethanol and provide tentative support for a prepotent role of the NR2B subunit in these effects...
  13. ncbi request reprint Effects of mild early life stress on abnormal emotion-related behaviors in 5-HTT knockout mice
    Jenna C Carroll
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Behav Genet 37:214-22. 2007
    ..Data provide further evidence of emotional abnormalities following genetic disruption of the 5-HTT...
  14. doi request reprint Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²⁺ channel blockers with analgesic activity
    Xenia Beebe
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6100, United States
    Bioorg Med Chem 20:4128-39. 2012
    ..Compound 25 is an N-type Ca(2+) channel blocker that produces antinociception in inflammatory and nociceptive pain models without exhibiting cardiovascular or motor liabilities...
  15. doi request reprint A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats
    Victoria E Scott
    Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Biochem Pharmacol 83:406-18. 2012
    ..L-type Ca²⁺ channels can provide robust antinociception in the absence of deleterious effects on hemodynamic or psychomotor function...
  16. ncbi request reprint Ethanol inhibits clearance of brain serotonin by a serotonin transporter-independent mechanism
    Lynette C Daws
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurosci 26:6431-8. 2006
    ..The present findings provide new insights into the actions of ethanol on brain function and behavior...
  17. ncbi request reprint The role of NMDA receptor binding sites in ethanol place conditioning
    Janel M Boyce-Rustay
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Neurosci 118:822-34. 2004
    ..Moreover, these results suggest CGP-37849 modulates ethanol place conditioning by impairing the ability to learn these tasks...