Research Topics
Species | Janel M Boyce-RustaySummaryAffiliation: Abbott Laboratories Country: USA Publications
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Detail Information
Publications
Dopamine D3 receptor knockout mice and the motivational effects of ethanolJanel M Boyce-Rustay
Department of Behavioral Neuroscience, L470, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
Pharmacol Biochem Behav 75:373-9. 2003..D3 KO and C57 mice had similar response rates of ethanol and food as well as similar water intakes. Overall, these results indicate that elimination of D3 receptor function has little influence on ethanol reward or intake...- Chronic swim stress alters sensitivity to acute behavioral effects of ethanol in miceJanel M Boyce-Rustay
Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, United States
Physiol Behav 91:77-86. 2007..These data provide further evidence that stress alters the intoxicating effects of high doses of ethanol in a behaviorally selective manner... 
Desipramine potentiation of the acute depressant effects of ethanol: modulation by alpha2-adrenoreceptors and stressJanel M Boyce-Rustay
Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
Neuropharmacology 55:803-11. 2008....- Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ miceJanel M Boyce-Rustay
Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
Behav Brain Res 186:133-7. 2008..In conclusion, strain differences, that are likely in large part genetic in nature, modify the effects of this stressor on EtOH's effects in a behavior-specific manner... 
Comparison of mechanical allodynia and the affective component of inflammatory pain in ratsJanel M Boyce-Rustay
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6115, USA
Neuropharmacology 58:537-43. 2010..These studies show that methods other than reflex based measures of pain such as affective pain models could be more predictive of efficacy/potency in the clinic...- Ethanol-related behaviors in serotonin transporter knockout miceJanel M Boyce-Rustay
Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA
Alcohol Clin Exp Res 30:1957-65. 2006..Increasing evidence supports a role for 5-hydroxytryptamine (5-HT) and the 5-HT transporter (5-HTT) in modulating the neural and behavioral actions of ethanol (EtOH) and other drugs of abuse... - Ethanol-related behaviors in mice lacking the NMDA receptor NR2A subunitJanel M Boyce-Rustay
Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
Psychopharmacology (Berl) 187:455-66. 2006..While there is compelling evidence that NMDA receptors modulate behavioral effects of ethanol, there is little understanding of how the subunit composition of the NMDA receptor mediates these effects... - Animal models of acute and chronic inflammatory and nociceptive painJanel M Boyce-Rustay
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA
Methods Mol Biol 617:41-55. 2010..This chapter will focus on rodent models of inflammatory and nociceptive pain that are most used in our laboratory for identification of novel antinociceptive compounds in drug discovery... - Characterization of Fasudil in preclinical models of painJanel M Boyce-Rustay
Abbott Laboratories, Abbott Park, Illinois 60064, USA
J Pain 11:941-9. 2010..Fasudil was shown to have efficacy in neuropathic and nociceptive pain models. These findings may help identify new therapeutic treatments for pain in the clinic... - Neuropathic pain: models and mechanismsMichael F Jarvis
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6123, USA
Curr Pharm Des 15:1711-6. 2009.... - Genetic inactivation of the NMDA receptor NR2A subunit has anxiolytic- and antidepressant-like effects in miceJanel M Boyce-Rustay
Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20892, USA
Neuropsychopharmacology 31:2405-14. 2006..Present results support a role for the NR2A subunit in the modulation of emotional behaviors in rodents and provide insight into the role of glutamate in the pathophysiology and treatment of mood and anxiety disorders... - Functional roles of NMDA receptor NR2A and NR2B subunits in the acute intoxicating effects of ethanol in miceJanel M Boyce-Rustay
Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Synapse 56:222-5. 2005..These findings confirm a major role for NMDA receptors in the acute intoxicating actions of ethanol and provide tentative support for a prepotent role of the NR2B subunit in these effects... - Effects of mild early life stress on abnormal emotion-related behaviors in 5-HTT knockout miceJenna C Carroll
Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Behav Genet 37:214-22. 2007..Data provide further evidence of emotional abnormalities following genetic disruption of the 5-HTT... - Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²⁺ channel blockers with analgesic activityXenia Beebe
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6100, United States
Bioorg Med Chem 20:4128-39. 2012..Compound 25 is an N-type Ca(2+) channel blocker that produces antinociception in inflammatory and nociceptive pain models without exhibiting cardiovascular or motor liabilities... - A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in ratsVictoria E Scott
Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
Biochem Pharmacol 83:406-18. 2012..L-type Ca²⁺ channels can provide robust antinociception in the absence of deleterious effects on hemodynamic or psychomotor function... - Ethanol inhibits clearance of brain serotonin by a serotonin transporter-independent mechanismLynette C Daws
Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
J Neurosci 26:6431-8. 2006..The present findings provide new insights into the actions of ethanol on brain function and behavior... - The role of NMDA receptor binding sites in ethanol place conditioningJanel M Boyce-Rustay
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
Behav Neurosci 118:822-34. 2004..Moreover, these results suggest CGP-37849 modulates ethanol place conditioning by impairing the ability to learn these tasks...