Dominique F Bonafoux

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. ncbi 2-Aminoimidazoles inhibitors of TGF-beta receptor 1
    Dominique Bonafoux
    Abbot Laboratories, 381 Plantation Street, Worcester, MA 01605 2323, USA
    Bioorg Med Chem Lett 19:912-6. 2009
  2. ncbi Aminopyridinecarboxamide-based inhibitors: Structure-activity relationship
    Dominique F Bonafoux
    Department of Medicinal Chemistry, Pfizer Inc, 700 Chesterfield Parkway West, St Louis, MO 63017, United States
    Bioorg Med Chem 18:403-14. 2010
  3. ncbi Strategies for TGF-beta modulation: a review of recent patents
    Dominique Bonafoux
    Abbott Laboratories, Medicinal Chemistry, Worcester, Massachusetts 01605 2323, USA
    Expert Opin Ther Pat 19:1759-69. 2009
  4. ncbi Thienopyrrole acetic acids as antagonists of the CRTH2 receptor
    Dominique Bonafoux
    Abbott Laboratories, Worcester, MA 01605, USA
    Bioorg Med Chem Lett 21:1861-4. 2011

Detail Information

Publications4

  1. ncbi 2-Aminoimidazoles inhibitors of TGF-beta receptor 1
    Dominique Bonafoux
    Abbot Laboratories, 381 Plantation Street, Worcester, MA 01605 2323, USA
    Bioorg Med Chem Lett 19:912-6. 2009
    ..However, 2-acetamidoimidazoles were identified as attractive candidates for further optimization as a result of their significant activity combined to their superior pharmacokinetic profile...
  2. ncbi Aminopyridinecarboxamide-based inhibitors: Structure-activity relationship
    Dominique F Bonafoux
    Department of Medicinal Chemistry, Pfizer Inc, 700 Chesterfield Parkway West, St Louis, MO 63017, United States
    Bioorg Med Chem 18:403-14. 2010
    ..The 2-amino-5-chloropyridine-4-carboxamides were identified as the most potent inhibitors with improved cellular activity...
  3. ncbi Strategies for TGF-beta modulation: a review of recent patents
    Dominique Bonafoux
    Abbott Laboratories, Medicinal Chemistry, Worcester, Massachusetts 01605 2323, USA
    Expert Opin Ther Pat 19:1759-69. 2009
    ....
  4. ncbi Thienopyrrole acetic acids as antagonists of the CRTH2 receptor
    Dominique Bonafoux
    Abbott Laboratories, Worcester, MA 01605, USA
    Bioorg Med Chem Lett 21:1861-4. 2011
    ..Early ADME/PK assessment of this chemotype demonstrated bioavailability in mice...