Dominique F Bonafoux
Affiliation: Abbott Laboratories
- 2-Aminoimidazoles inhibitors of TGF-beta receptor 1Dominique Bonafoux
Abbot Laboratories, 381 Plantation Street, Worcester, MA 01605 2323, USA
Bioorg Med Chem Lett 19:912-6. 2009..However, 2-acetamidoimidazoles were identified as attractive candidates for further optimization as a result of their significant activity combined to their superior pharmacokinetic profile...
- Aminopyridinecarboxamide-based inhibitors: Structure-activity relationshipDominique F Bonafoux
Department of Medicinal Chemistry, Pfizer Inc, 700 Chesterfield Parkway West, St Louis, MO 63017, United States
Bioorg Med Chem 18:403-14. 2010..The 2-amino-5-chloropyridine-4-carboxamides were identified as the most potent inhibitors with improved cellular activity...
- Strategies for TGF-beta modulation: a review of recent patentsDominique Bonafoux
Abbott Laboratories, Medicinal Chemistry, Worcester, Massachusetts 01605 2323, USA
Expert Opin Ther Pat 19:1759-69. 2009....
- Thienopyrrole acetic acids as antagonists of the CRTH2 receptorDominique Bonafoux
Abbott Laboratories, Worcester, MA 01605, USA
Bioorg Med Chem Lett 21:1861-4. 2011..Early ADME/PK assessment of this chemotype demonstrated bioavailability in mice...