Eric A G Blomme

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. ncbi request reprint Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure
    Wenning Qin
    Department of Genomics Sciences, Pfizer, Inc, St Louis, MO 63167, USA
    Circ Res 93:69-76. 2003
  2. doi request reprint Evaluation of the effects of serial phlebotomy on the transcriptome of major tissues and on the response to toxicants in rats
    Eric A G Blomme
    Department of Cellular, Molecular and Exploratory Toxicology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA
    Toxicol Lett 176:138-48. 2008
  3. doi request reprint Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development
    Eric A G Blomme
    Department of Cellular, Molecular and Exploratory Toxicology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA
    Toxicol Lett 186:22-31. 2009
  4. ncbi request reprint Transcription profiling distinguishes dose-dependent effects in the livers of rats treated with clofibrate
    Jeffrey A Kramer
    Pharmacia Corporation, Global Toxicology, 800 N Lindbergh Blvd, St Louis, Missouri 63167, USA
    Toxicol Pathol 31:417-31. 2003
  5. ncbi request reprint A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor
    Christine Healan-Greenberg
    Abbott Laboratories, Global Pharmaceutical Research and Development, Abbott Park, Illinois 60064 6104, USA
    Drug Metab Dispos 36:500-7. 2008
  6. pmc AhR activation underlies the CYP1A autoinduction by A-998679 in rats
    Michael J Liguori
    Abbott Laboratories, Department of Cellular, Molecular, and Exploratory Toxicology Abbott Park, IL, USA
    Front Genet 3:213. 2012
  7. doi request reprint Liver transcriptomic changes associated with ritonavir-induced hyperlipidemia in sensitive and resistant strains of rats
    Yi Yang
    Abbott Laboratories, Abbott Park, IL, USA
    Vet J 185:75-82. 2010
  8. doi request reprint N-vinylpyrrolidone dimer, a novel formulation excipient, causes hepatic and thyroid hypertrophy through the induction of hepatic microsomal enzymes in rats
    Yi Yang
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA
    Toxicol Lett 208:82-91. 2012
  9. pmc Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example
    Michael J Liguori
    Department of Cellular, Molecular, and Exploratory Toxicology, Abbott Laboratories Abbott Park, IL 60064, USA E Mails A C D J F W E A G B
    Int J Mol Sci 11:4697-714. 2010
  10. ncbi request reprint Trovafloxacin-induced gene expression changes in liver-derived in vitro systems: comparison of primary human hepatocytes to HepG2 cells
    Michael J Liguori
    Department of Cellular, Molecular, and Exploratory Toxicology, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Drug Metab Dispos 36:223-33. 2008

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure
    Wenning Qin
    Department of Genomics Sciences, Pfizer, Inc, St Louis, MO 63167, USA
    Circ Res 93:69-76. 2003
    ..In addition, these data support the hypothesis that aldosterone blockade may provide additional therapeutic benefit in the treatment of heart failure...
  2. doi request reprint Evaluation of the effects of serial phlebotomy on the transcriptome of major tissues and on the response to toxicants in rats
    Eric A G Blomme
    Department of Cellular, Molecular and Exploratory Toxicology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA
    Toxicol Lett 176:138-48. 2008
    ....
  3. doi request reprint Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development
    Eric A G Blomme
    Department of Cellular, Molecular and Exploratory Toxicology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA
    Toxicol Lett 186:22-31. 2009
    ..In general, this technology can not only improve the discipline of toxicology and risk assessment but also represent an extremely effective, hypothesis-generating alternative to rapidly understand mechanisms of hepatotoxicity...
  4. ncbi request reprint Transcription profiling distinguishes dose-dependent effects in the livers of rats treated with clofibrate
    Jeffrey A Kramer
    Pharmacia Corporation, Global Toxicology, 800 N Lindbergh Blvd, St Louis, Missouri 63167, USA
    Toxicol Pathol 31:417-31. 2003
    ....
  5. ncbi request reprint A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor
    Christine Healan-Greenberg
    Abbott Laboratories, Global Pharmaceutical Research and Development, Abbott Park, Illinois 60064 6104, USA
    Drug Metab Dispos 36:500-7. 2008
    ..Among the class of HIV-PIs, which are typically PXR activators, A-792611 seems to have a unique property for PXR antagonism and could be a useful tool for studying nuclear receptor pathway regulation...
  6. pmc AhR activation underlies the CYP1A autoinduction by A-998679 in rats
    Michael J Liguori
    Abbott Laboratories, Department of Cellular, Molecular, and Exploratory Toxicology Abbott Park, IL, USA
    Front Genet 3:213. 2012
    ....
  7. doi request reprint Liver transcriptomic changes associated with ritonavir-induced hyperlipidemia in sensitive and resistant strains of rats
    Yi Yang
    Abbott Laboratories, Abbott Park, IL, USA
    Vet J 185:75-82. 2010
    ..These findings will facilitate the discovery of novel, lipid-neutral HIV PIs and the identification of relevant biomarkers for this adverse event...
  8. doi request reprint N-vinylpyrrolidone dimer, a novel formulation excipient, causes hepatic and thyroid hypertrophy through the induction of hepatic microsomal enzymes in rats
    Yi Yang
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA
    Toxicol Lett 208:82-91. 2012
    ....
  9. pmc Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example
    Michael J Liguori
    Department of Cellular, Molecular, and Exploratory Toxicology, Abbott Laboratories Abbott Park, IL 60064, USA E Mails A C D J F W E A G B
    Int J Mol Sci 11:4697-714. 2010
    ..Comparison of TNFα/TVX and LPS/TVX gene expression profiles revealed similarities in the regulation of biochemical pathways. In conclusion, TNFα could be used in lieu of LPS as an inflammatory stimulus in this model of IDRs...
  10. ncbi request reprint Trovafloxacin-induced gene expression changes in liver-derived in vitro systems: comparison of primary human hepatocytes to HepG2 cells
    Michael J Liguori
    Department of Cellular, Molecular, and Exploratory Toxicology, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Drug Metab Dispos 36:223-33. 2008
    ....
  11. doi request reprint Role of cytochrome P450c17α in dibromoacetic acid-induced testicular toxicity in rats
    Tracy L Carr
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Arch Toxicol 85:513-23. 2011
    ..This disruption of testicular steroidogenesis is likely to contribute to the mechanism of failed spermiation observed in rats following exposure to DBAA...
  12. pmc Global transcriptomic profiling using small volumes of whole blood: a cost-effective method for translational genomic biomarker identification in small animals
    Meagan M Fricano
    Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA E Mails M M F A C D P M J M J L E A G B
    Int J Mol Sci 12:2502-17. 2011
    ....
  13. ncbi request reprint Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils
    Jeffrey F Waring
    Department of Cellular and Molecular Toxicology, Abbott Laboratories, Bldg AP9A R463, 100 Abbott Park Road, Abbott Park, IL 60064 6104, USA
    J Pharmacol Exp Ther 316:1080-7. 2006
    ..Furthermore, they identify gene expression changes that could be explored as biomarkers for idiosyncratic toxicity and lead to enhanced understanding of the mechanism(s) underlying hepatotoxicity induced by TVX...
  14. doi request reprint Transcriptomic evaluation of canine suspension-shipped and pre-plated hepatocytes: comparison to liver
    Amy C Ditewig
    AbbVie Inc, 1 North Waukegan Road, North Chicago, IL 60064, USA
    Toxicol Mech Methods 23:479-90. 2013
    ..The study objectives were to determine if canine hepatocytes shipped in suspension or pre-plated were transcriptomically different from one another and their liver of origin, and to understand temporal transcriptomic changes...
  15. ncbi request reprint Toxicogenomics in drug discovery: from preclinical studies to clinical trials
    Yi Yang
    Department of Cellular and Molecular Toxicology, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6123, USA
    Chem Biol Interact 150:71-85. 2004
    ..This review will focus on how toxicogenomics can or has been applied in drug discovery and development, and will discuss some of the challenges that still remain...
  16. ncbi request reprint Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation
    Xiaomin Deng
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Pharmacol Exp Ther 319:1191-9. 2006
    ..These results demonstrate that inflammation-DCLF interaction precipitates hepatotoxicity in rats and raise the possibility of creating animal models that predict human IADRs...
  17. ncbi request reprint Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats
    Eileen R Blasi
    Pharmacia Corporation, Cardiovascular and Metabolic Diseases, Global Medical Affairs, and Global Toxicology, St Louis, Missouri 63167, USA
    Kidney Int 63:1791-800. 2003
    ..We evaluated the role of aldosterone as a mediator of renal inflammation and fibrosis in a rat model of aldosterone/salt hypertension using the selective aldosterone blocker, eplerenone...
  18. ncbi request reprint Effects of transforming growth factor-beta1 on parathyroid hormone-related protein mRNA expression and protein secretion in canine prostate epithelial, stromal, and carcinoma cells
    Rani S Sellers
    The Department of Veterinary Biosciences, The Ohio State University, Columbus, 43210, USA
    Prostate 58:366-73. 2004
    ..We examined the effect of transforming growth factor-beta1 (TGF beta 1) on PTHrP mRNA expression and PTHrP secretion in normal canine prostate epithelial cells (PEC) and stromal cells (PSC), and in canine prostate carcinoma cells (PCC)...
  19. ncbi request reprint Acute molecular markers of rodent hepatic carcinogenesis identified by transcription profiling
    Jeffrey A Kramer
    Pfizer Corporation, World Wide Safety Science, 800 North Lindbergh Boulevard, St Louis, Missouri 63167, USA a
    Chem Res Toxicol 17:463-70. 2004
    ....
  20. ncbi request reprint Differential display in rat livers treated for 13 weeks with phenobarbital implicates a role for metabolic and oxidative stress in nongenotoxic carcinogenicity
    Mollisa M Elrick
    Pfizer Corporation, Worldwide Safety Sciences, St Louis, Missouri 63167, USA
    Toxicol Pathol 33:118-26. 2005
    ..In order to access the full article online, you must either have an individual subscription or a member subscription accessed through www.toxpath.org...
  21. ncbi request reprint Aldosterone induces a vascular inflammatory phenotype in the rat heart
    Ricardo Rocha
    Division of Cardiovascular and Metabolic Diseases, Pharmacia Corporation, Skokie, IL 60077, USA
    Am J Physiol Heart Circ Physiol 283:H1802-10. 2002
    ....