Research Topics
Species | Anton BespalovSummaryAffiliation: Abbott Laboratories Country: USA Publications
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Detail Information
Publications
Behavioral analysis of the saccharin deprivation effect in ratsOlga N Neznanova
Laboratory of Behavioral Pharmacology, Institute of Pharmacology, Pavlov Medical University, St. Petersburg, Russia
Behav Neurosci 116:747-56. 2002..Thus, DE procedures may be useful for studying the effects of continued exposure to stimuli associated with various primary reinforcers such as drugs of abuse...- Effects of mGlu1 receptor blockade on working memory, time estimation, and impulsivity in ratsIrina A Sukhotina
Laboratory of Behavioral Pharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Leo Tolstoy Str, St Petersburg, 197089, Russia
Psychopharmacology (Berl) 196:211-20. 2008..Metabotropic glutamate 1 (mGlu1) receptor antagonists were reported to induce cognitive deficits in several animal models using aversive learning procedures... - Antidepressant treatment in anxiety disordersAnton Y Bespalov
Neuroscience Research, GPRD, Abbott, P O Box 21 08 05, 67008 Ludwigshafen, Germany
Curr Top Behav Neurosci 2:361-90. 2010.... - Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in ratsAnton Y Bespalov
Institute of Pharmacology, Pavlov Medical University, St Petersburg, Russia
Neuropharmacology 49:167-78. 2005.... 
Behavioral characterization of the mGlu group II/III receptor antagonist, LY-341495, in animal models of anxiety and depressionAnton Y Bespalov
Neuroscience Discovery, GPRD, Abbott, P O Box 21 08 05, 67008 Ludwigshafen, Germany
Eur J Pharmacol 592:96-102. 2008..It is concluded that behavioral profile of mGlu2/3 receptor antagonists as represented by LY-341495 is different from that of conventional anxiolytic and antidepressant drugs...- Habituation deficits induced by metabotropic glutamate receptors 2/3 receptor blockade in mice: reversal by antipsychotic drugsAnton Bespalov
Neuroscience Discovery Research, Abbott GmbH and Co KG, D 67008 Ludwigshafen, Germany
J Pharmacol Exp Ther 320:944-50. 2007..Thus, behavioral deficits induced by mGluR2/3 blockade (such as delayed motor hyperactivity) are selectively reversed by clinically used antipsychotic drugs... - AMPA receptor antagonists reverse effects of extended habit training on signaled food approach responding in ratsA Y Bespalov
Neuroscience Research, GPRD, Abbott, 67008, Ludwigshafen, Germany
Psychopharmacology (Berl) 195:11-8. 2007.... - Lowered brain stimulation reward thresholds in rats treated with a combination of caffeine and N-methyl-D-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonistsAnton Bespalov
Institute of Pharmacology, IP Pavlov Medical University, St Petersburg, Russia
Behav Pharmacol 17:295-302. 2006..These results indicate that, within a limited dose range, caffeine in combination with an NMDA receptor channel blocker and a competitive antagonist significantly lowers brain stimulation reward thresholds in rats... - mGlu1 receptor blockade attenuates cue- and nicotine-induced reinstatement of extinguished nicotine self-administration behavior in ratsOlga A Dravolina
Laboratory of Behavioral Pharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Lev Tolstoy Street, St Petersburg 197089, Russia
Neuropharmacology 52:263-9. 2007..Taken together with the previous reports, the present findings further suggest that blockade of mGlu1 receptors may be beneficial for preventing relapse to tobacco smoking in nicotine-dependent individuals... - Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatmentSilke Harich
Neuroscience Discovery Research, Abbott, 67061 Ludwigshafen, Germany
Psychopharmacology (Berl) 192:511-9. 2007.... - Effects of group I metabotropic glutamate receptor antagonists on the behavioral sensitization to motor effects of cocaine in ratsOlga A Dravolina
Laboratory of Behavioral Pharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Lev Tolstoy Street, St Petersburg, Russia
Psychopharmacology (Berl) 187:397-404. 2006..Metabotropic glutamate receptors (mGluRs) were reported to regulate various behavioral effects of addictive drugs... - Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: too little juice or a miswired brain?Gerard J Marek
Neuroscience Development, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois corrected 60064 6075, USA
Mol Pharmacol 77:317-26. 2010..The hope is that by modulating glutamatergic neurotransmission, the dysfunctional circuitry of the schizophrenic brain (both local circuits and long-loop pathways) will be improved... - Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodiesHeinz Hillen
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott, d 67061 Ludwigshafen, Germany
J Neurosci 30:10369-79. 2010..Our findings demonstrate that selective reduction of Abeta oligomers by immunotherapy is sufficient to normalize cognitive behavior and synaptic deficits in APP transgenic mice... - Effect of memantine on cue-induced alcohol craving in recovering alcohol-dependent patientsEvgeny M Krupitsky
Pavlov State Medical University, St Petersburg, Russia
Am J Psychiatry 164:519-23. 2007..The authors assessed whether the NMDA receptor antagonist memantine reduces cue-induced alcohol craving and produces ethanol-like subjective effects... - Facilitation of electrical brain self-stimulation behavior by abused solventsAnton Bespalov
Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Lev Tolstoy Street, St Petersburg 197089, Russia
Pharmacol Biochem Behav 75:199-208. 2003..Data from intracranial self-stimulation studies of solvents may be useful in abuse potential assessment of individual compounds and for examining neural and behavioral processes involved in inhalant abuse... - Anti-allodynic interactions between NMDA receptor channel blockers and morphine or clonidine in neuropathic ratsAndrey A Malyshkin
Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, 6/8 Lev Tolstoy Street, St. Petersburg 197089, Russia
Eur J Pharmacol 519:80-5. 2005.... - Lack of depression-like effects of saccharin deprivation in rats: forced swim test, differential reinforcement of low rates and intracranial self-stimulation proceduresIrina A Sukhotina
Institute of Pharmacology, Lab of Behavioral Pharmacology, Pavlov Medical University, 6/8 Lev Tolstoy Street, St Petersburg 197089, Russia
Behav Neurosci 117:970-7. 2003..In contrast, saccharin-deprived rats demonstrated improved performance in the behavioral paradigms used here... - Effects of nicotinic and NMDA receptor channel blockers on intravenous cocaine and nicotine self-administration in miceElena A Blokhina
Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, 6/8 Lev Tolstoy Street, St. Petersburg 197089, Russia
Eur Neuropsychopharmacol 15:219-25. 2005..Taken together with the previous reports, these results indicate that nicotinic receptor blockers antagonize acute reinforcing effects of cocaine while NMDA receptor blockade may have limited effectiveness... - Effects of memantine on estrogen-dependent acute tolerance to the morphine analgesia in female ratsElena V Shekunova
Laboratory of Behavioural Pharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Lev Tolstoy St, St Petersburg 197089, Russia
Eur J Pharmacol 535:78-85. 2006..Thus, estrogens were found to play a key role in induction of acute tolerance to morphine antinociception. Estradiol-induced acute morphine tolerance may have NMDA receptor-dependent mechanisms... - Intravenous self-administration of abused solvents and anesthetics in miceElena A Blokhina
Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, 6/8 Leo Tolstoy Street, St. Petersburg 197089, Russia
Eur J Pharmacol 485:211-8. 2004..These data suggest that the reinforcing effects of abused inhalants can be studied using i.v. self-administration procedures... - Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic painIvan O Medvedev
Institute of Pharmacology, Pavlov Medical University, 6/8 Lev Tolstoy Street, 197089 St. Petersburg, Russia
Neuropharmacology 47:175-83. 2004..Thus, studies on the prevention and management of chronic pain should focus on preemptive or long-term administration of NMDA receptor antagonists... - Estrous cycle stage-dependent expression of acute tolerance to morphine analgesia in ratsElena V Shekunova
Laboratory of Behavioural Pharmacology, Institute of Pharmacology, Pavlov Medical University, 6/8 Leo Tolstoy St, 197089 St. Petersburg, Russia
Eur J Pharmacol 486:259-64. 2004..These results suggest that pain management strategies can be optimized through the use of sex- and estrous cycle-specific techniques... - Facilitation of aggressive and sexual behaviors by saccharin deprivation in ratsIrina V Belozertseva
Laboratory of Behavioral Pharmacology, Institute of Pharmacology, Pavlov Medical University, 6/8 Lev Tolstoy Street, St. Petersburg 197089, Russia
Physiol Behav 80:531-9. 2004..These results suggest that the saccharin deprivation exposures may facilitate aggressive and sexual behaviors. Alternative behavioral strategy may serve as a mechanism of coping with the deprivation state... - Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in ratsMałgorzata Pietraszek
Preclinical R and D, Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, 60318 Frankfurt am Main, Germany
Eur J Pharmacol 514:25-34. 2005.... - Site-selective N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate antagonists produce distinct effects in rats performing complex discriminationsCatherine B Willmore
Department of Pharmaceutical Sciences, University of Maryland, Baltimore, 21201, USA
Neurobiol Learn Mem 78:347-64. 2002.... - Naltrexone for heroin dependence treatment in St. Petersburg, RussiaEvgeny M Krupitsky
St. Petersburg Scientific Research Center of Addictions and Psychopharmacology, affiliated with St. Petersburg State Pavlov Medical University, Russia
J Subst Abuse Treat 26:285-94. 2004..05). Since heroin dependence is the main way HIV is being spread in Russia, naltrexone is likely to improve treatment outcome and help reduce the spread of HIV if it can be made more widely available... - Naltrexone with or without fluoxetine for preventing relapse to heroin addiction in St. Petersburg, RussiaEvgeny M Krupitsky
St. Petersburg Scientific-Research Center of Addictions and Psychopharmacology, St. Petersburg, Russia
J Subst Abuse Treat 31:319-28. 2006..More widespread use of naltrexone could be an important addition to addiction treatment and HIV prevention in Russia... - Analgesic effects of morphine and loperamide in the rat formalin test: interactions with NMDA receptor antagonistsNatalja Sevostianova
Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, 60318 Frankfurt am Main, Germany
Eur J Pharmacol 525:83-90. 2005..Present results suggest that central NMDA receptor blockade may be necessary to enhance analgesia induced through peripheral opioid mechanisms in formalin-evoked nociception...