Anton Bespalov

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. ncbi request reprint Behavioral analysis of the saccharin deprivation effect in rats
    Olga N Neznanova
    Laboratory of Behavioral Pharmacology, Institute of Pharmacology, Pavlov Medical University, St Petersburg, Russia
    Behav Neurosci 116:747-56. 2002
  2. ncbi request reprint Effects of mGlu1 receptor blockade on working memory, time estimation, and impulsivity in rats
    Irina A Sukhotina
    Laboratory of Behavioral Pharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Leo Tolstoy Str, St Petersburg, 197089, Russia
    Psychopharmacology (Berl) 196:211-20. 2008
  3. ncbi request reprint Drug discrimination analysis of NMDA receptor channel blockers as nicotinic receptor antagonists in rats
    E S Zakharova
    Laboratory of Behavioral Pharmacology, Institute of Pharmacology, Pavlov Medical University, St Petersburg 197089, Russia
    Psychopharmacology (Berl) 179:128-35. 2005
  4. ncbi request reprint The NMDA receptor channel blocker memantine and opioid receptor antagonist naltrexone inhibit the saccharin deprivation effect in rats
    E Zakharova
    Institute of Pharmacology, I P Pavlov Medical University, St Petersburg 197089, Russia
    Behav Pharmacol 15:273-8. 2004
  5. ncbi request reprint Antidepressant treatment in anxiety disorders
    Anton Y Bespalov
    Neuroscience Research, GPRD, Abbott, P O Box 21 08 05, 67008 Ludwigshafen, Germany
    Curr Top Behav Neurosci 2:361-90. 2010
  6. ncbi request reprint Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats
    Anton Y Bespalov
    Institute of Pharmacology, Pavlov Medical University, St Petersburg, Russia
    Neuropharmacology 49:167-78. 2005
  7. ncbi request reprint Behavioral characterization of the mGlu group II/III receptor antagonist, LY-341495, in animal models of anxiety and depression
    Anton Y Bespalov
    Neuroscience Discovery, GPRD, Abbott, P O Box 21 08 05, 67008 Ludwigshafen, Germany
    Eur J Pharmacol 592:96-102. 2008
  8. ncbi request reprint Habituation deficits induced by metabotropic glutamate receptors 2/3 receptor blockade in mice: reversal by antipsychotic drugs
    Anton Bespalov
    Neuroscience Discovery Research, Abbott GmbH and Co KG, D 67008 Ludwigshafen, Germany
    J Pharmacol Exp Ther 320:944-50. 2007
  9. ncbi request reprint AMPA receptor antagonists reverse effects of extended habit training on signaled food approach responding in rats
    A Y Bespalov
    Neuroscience Research, GPRD, Abbott, 67008, Ludwigshafen, Germany
    Psychopharmacology (Berl) 195:11-8. 2007
  10. ncbi request reprint Lowered brain stimulation reward thresholds in rats treated with a combination of caffeine and N-methyl-D-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonists
    Anton Bespalov
    Institute of Pharmacology, IP Pavlov Medical University, St Petersburg, Russia
    Behav Pharmacol 17:295-302. 2006

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Behavioral analysis of the saccharin deprivation effect in rats
    Olga N Neznanova
    Laboratory of Behavioral Pharmacology, Institute of Pharmacology, Pavlov Medical University, St Petersburg, Russia
    Behav Neurosci 116:747-56. 2002
    ..Thus, DE procedures may be useful for studying the effects of continued exposure to stimuli associated with various primary reinforcers such as drugs of abuse...
  2. ncbi request reprint Effects of mGlu1 receptor blockade on working memory, time estimation, and impulsivity in rats
    Irina A Sukhotina
    Laboratory of Behavioral Pharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Leo Tolstoy Str, St Petersburg, 197089, Russia
    Psychopharmacology (Berl) 196:211-20. 2008
    ..Metabotropic glutamate 1 (mGlu1) receptor antagonists were reported to induce cognitive deficits in several animal models using aversive learning procedures...
  3. ncbi request reprint Drug discrimination analysis of NMDA receptor channel blockers as nicotinic receptor antagonists in rats
    E S Zakharova
    Laboratory of Behavioral Pharmacology, Institute of Pharmacology, Pavlov Medical University, St Petersburg 197089, Russia
    Psychopharmacology (Berl) 179:128-35. 2005
    ..However, it is also well established that certain types of NMDA receptor antagonists (channel blockers) potently bind to nicotinic receptors and may act as nicotinic receptor antagonists...
  4. ncbi request reprint The NMDA receptor channel blocker memantine and opioid receptor antagonist naltrexone inhibit the saccharin deprivation effect in rats
    E Zakharova
    Institute of Pharmacology, I P Pavlov Medical University, St Petersburg 197089, Russia
    Behav Pharmacol 15:273-8. 2004
    ..1%, w/v). Taken together with the results of previous studies, these results suggest that naltrexone and memantine attenuate the expression of both the alcohol and saccharin deprivation effects...
  5. ncbi request reprint Antidepressant treatment in anxiety disorders
    Anton Y Bespalov
    Neuroscience Research, GPRD, Abbott, P O Box 21 08 05, 67008 Ludwigshafen, Germany
    Curr Top Behav Neurosci 2:361-90. 2010
    ....
  6. ncbi request reprint Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats
    Anton Y Bespalov
    Institute of Pharmacology, Pavlov Medical University, St Petersburg, Russia
    Neuropharmacology 49:167-78. 2005
    ....
  7. ncbi request reprint Behavioral characterization of the mGlu group II/III receptor antagonist, LY-341495, in animal models of anxiety and depression
    Anton Y Bespalov
    Neuroscience Discovery, GPRD, Abbott, P O Box 21 08 05, 67008 Ludwigshafen, Germany
    Eur J Pharmacol 592:96-102. 2008
    ..It is concluded that behavioral profile of mGlu2/3 receptor antagonists as represented by LY-341495 is different from that of conventional anxiolytic and antidepressant drugs...
  8. ncbi request reprint Habituation deficits induced by metabotropic glutamate receptors 2/3 receptor blockade in mice: reversal by antipsychotic drugs
    Anton Bespalov
    Neuroscience Discovery Research, Abbott GmbH and Co KG, D 67008 Ludwigshafen, Germany
    J Pharmacol Exp Ther 320:944-50. 2007
    ..Thus, behavioral deficits induced by mGluR2/3 blockade (such as delayed motor hyperactivity) are selectively reversed by clinically used antipsychotic drugs...
  9. ncbi request reprint AMPA receptor antagonists reverse effects of extended habit training on signaled food approach responding in rats
    A Y Bespalov
    Neuroscience Research, GPRD, Abbott, 67008, Ludwigshafen, Germany
    Psychopharmacology (Berl) 195:11-8. 2007
    ....
  10. ncbi request reprint Lowered brain stimulation reward thresholds in rats treated with a combination of caffeine and N-methyl-D-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonists
    Anton Bespalov
    Institute of Pharmacology, IP Pavlov Medical University, St Petersburg, Russia
    Behav Pharmacol 17:295-302. 2006
    ..These results indicate that, within a limited dose range, caffeine in combination with an NMDA receptor channel blocker and a competitive antagonist significantly lowers brain stimulation reward thresholds in rats...
  11. ncbi request reprint mGlu1 receptor blockade attenuates cue- and nicotine-induced reinstatement of extinguished nicotine self-administration behavior in rats
    Olga A Dravolina
    Laboratory of Behavioral Pharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Lev Tolstoy Street, St Petersburg 197089, Russia
    Neuropharmacology 52:263-9. 2007
    ..Taken together with the previous reports, the present findings further suggest that blockade of mGlu1 receptors may be beneficial for preventing relapse to tobacco smoking in nicotine-dependent individuals...
  12. ncbi request reprint Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment
    Silke Harich
    Neuroscience Discovery Research, Abbott, 67061 Ludwigshafen, Germany
    Psychopharmacology (Berl) 192:511-9. 2007
    ....
  13. ncbi request reprint Effects of group I metabotropic glutamate receptor antagonists on the behavioral sensitization to motor effects of cocaine in rats
    Olga A Dravolina
    Laboratory of Behavioral Pharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Lev Tolstoy Street, St Petersburg, Russia
    Psychopharmacology (Berl) 187:397-404. 2006
    ..Metabotropic glutamate receptors (mGluRs) were reported to regulate various behavioral effects of addictive drugs...
  14. doi request reprint Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: too little juice or a miswired brain?
    Gerard J Marek
    Neuroscience Development, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois corrected 60064 6075, USA
    Mol Pharmacol 77:317-26. 2010
    ..The hope is that by modulating glutamatergic neurotransmission, the dysfunctional circuitry of the schizophrenic brain (both local circuits and long-loop pathways) will be improved...
  15. ncbi request reprint Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies
    Heinz Hillen
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott, d 67061 Ludwigshafen, Germany
    J Neurosci 30:10369-79. 2010
    ..Our findings demonstrate that selective reduction of Abeta oligomers by immunotherapy is sufficient to normalize cognitive behavior and synaptic deficits in APP transgenic mice...
  16. ncbi request reprint Effect of memantine on cue-induced alcohol craving in recovering alcohol-dependent patients
    Evgeny M Krupitsky
    Pavlov State Medical University, St Petersburg, Russia
    Am J Psychiatry 164:519-23. 2007
    ..The authors assessed whether the NMDA receptor antagonist memantine reduces cue-induced alcohol craving and produces ethanol-like subjective effects...
  17. ncbi request reprint Facilitation of electrical brain self-stimulation behavior by abused solvents
    Anton Bespalov
    Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Lev Tolstoy Street, St Petersburg 197089, Russia
    Pharmacol Biochem Behav 75:199-208. 2003
    ..Data from intracranial self-stimulation studies of solvents may be useful in abuse potential assessment of individual compounds and for examining neural and behavioral processes involved in inhalant abuse...
  18. ncbi request reprint Effects of nicotinic and NMDA receptor channel blockers on intravenous cocaine and nicotine self-administration in mice
    Elena A Blokhina
    Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Lev Tolstoy Street, St Petersburg 197089, Russia
    Eur Neuropsychopharmacol 15:219-25. 2005
    ..Taken together with the previous reports, these results indicate that nicotinic receptor blockers antagonize acute reinforcing effects of cocaine while NMDA receptor blockade may have limited effectiveness...
  19. ncbi request reprint Anti-allodynic interactions between NMDA receptor channel blockers and morphine or clonidine in neuropathic rats
    Andrey A Malyshkin
    Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Lev Tolstoy Street, St Petersburg 197089, Russia
    Eur J Pharmacol 519:80-5. 2005
    ....
  20. ncbi request reprint Lack of depression-like effects of saccharin deprivation in rats: forced swim test, differential reinforcement of low rates and intracranial self-stimulation procedures
    Irina A Sukhotina
    Institute of Pharmacology, Lab of Behavioral Pharmacology, Pavlov Medical University, 6 8 Lev Tolstoy Street, St Petersburg 197089, Russia
    Behav Neurosci 117:970-7. 2003
    ..In contrast, saccharin-deprived rats demonstrated improved performance in the behavioral paradigms used here...
  21. ncbi request reprint Intravenous self-administration of abused solvents and anesthetics in mice
    Elena A Blokhina
    Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Leo Tolstoy Street, St Petersburg 197089, Russia
    Eur J Pharmacol 485:211-8. 2004
    ..These data suggest that the reinforcing effects of abused inhalants can be studied using i.v. self-administration procedures...
  22. ncbi request reprint Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain
    Ivan O Medvedev
    Institute of Pharmacology, Pavlov Medical University, 6 8 Lev Tolstoy Street, 197089 St Petersburg, Russia
    Neuropharmacology 47:175-83. 2004
    ..Thus, studies on the prevention and management of chronic pain should focus on preemptive or long-term administration of NMDA receptor antagonists...
  23. ncbi request reprint Effects of memantine on estrogen-dependent acute tolerance to the morphine analgesia in female rats
    Elena V Shekunova
    Laboratory of Behavioural Pharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Lev Tolstoy St, St Petersburg 197089, Russia
    Eur J Pharmacol 535:78-85. 2006
    ..Thus, estrogens were found to play a key role in induction of acute tolerance to morphine antinociception. Estradiol-induced acute morphine tolerance may have NMDA receptor-dependent mechanisms...
  24. ncbi request reprint Estrous cycle stage-dependent expression of acute tolerance to morphine analgesia in rats
    Elena V Shekunova
    Laboratory of Behavioural Pharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Leo Tolstoy St, 197089 St Petersburg, Russia
    Eur J Pharmacol 486:259-64. 2004
    ..These results suggest that pain management strategies can be optimized through the use of sex- and estrous cycle-specific techniques...
  25. ncbi request reprint Facilitation of aggressive and sexual behaviors by saccharin deprivation in rats
    Irina V Belozertseva
    Laboratory of Behavioral Pharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Lev Tolstoy Street, St Petersburg 197089, Russia
    Physiol Behav 80:531-9. 2004
    ..These results suggest that the saccharin deprivation exposures may facilitate aggressive and sexual behaviors. Alternative behavioral strategy may serve as a mechanism of coping with the deprivation state...
  26. ncbi request reprint Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats
    Małgorzata Pietraszek
    Preclinical R and D, Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, 60318 Frankfurt am Main, Germany
    Eur J Pharmacol 514:25-34. 2005
    ....
  27. ncbi request reprint Site-selective N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate antagonists produce distinct effects in rats performing complex discriminations
    Catherine B Willmore
    Department of Pharmaceutical Sciences, University of Maryland, Baltimore, 21201, USA
    Neurobiol Learn Mem 78:347-64. 2002
    ....
  28. ncbi request reprint Naltrexone for heroin dependence treatment in St. Petersburg, Russia
    Evgeny M Krupitsky
    St Petersburg Scientific Research Center of Addictions and Psychopharmacology, affiliated with St Petersburg State Pavlov Medical University, Russia
    J Subst Abuse Treat 26:285-94. 2004
    ..05). Since heroin dependence is the main way HIV is being spread in Russia, naltrexone is likely to improve treatment outcome and help reduce the spread of HIV if it can be made more widely available...
  29. ncbi request reprint Naltrexone with or without fluoxetine for preventing relapse to heroin addiction in St. Petersburg, Russia
    Evgeny M Krupitsky
    St Petersburg Scientific Research Center of Addictions and Psychopharmacology, St Petersburg, Russia
    J Subst Abuse Treat 31:319-28. 2006
    ..More widespread use of naltrexone could be an important addition to addiction treatment and HIV prevention in Russia...
  30. ncbi request reprint Analgesic effects of morphine and loperamide in the rat formalin test: interactions with NMDA receptor antagonists
    Natalja Sevostianova
    Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, 60318 Frankfurt am Main, Germany
    Eur J Pharmacol 525:83-90. 2005
    ..Present results suggest that central NMDA receptor blockade may be necessary to enhance analgesia induced through peripheral opioid mechanisms in formalin-evoked nociception...