Linqi Zhang

Summary

Affiliation: Aaron Diamond AIDS Research Center
Country: USA

Publications

  1. pmc Host-specific driving force in human immunodeficiency virus type 1 evolution in vivo
    L Zhang
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 71:2555-61. 1997
  2. ncbi request reprint Contribution of human alpha-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor
    Linqi Zhang
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Science 298:995-1000. 2002
  3. pmc Compartmentalization of surface envelope glycoprotein of human immunodeficiency virus type 1 during acute and chronic infection
    Linqi Zhang
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 76:9465-73. 2002
  4. pmc Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in china
    Linqi Zhang
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Floor, New York, NY 10016, USA
    J Virol 78:13591-9. 2004
  5. ncbi request reprint Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals
    Linqi Zhang
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Med Virol 78:1-8. 2006
  6. ncbi request reprint Heterologous MVA-S prime Ad5-S boost regimen induces high and persistent levels of neutralizing antibody response against SARS coronavirus
    Lei Ba
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 1st Avenue, New York, NY 10016, USA
    Appl Microbiol Biotechnol 76:1131-6. 2007
  7. pmc Recombinant modified vaccinia virus Ankara expressing the spike glycoprotein of severe acute respiratory syndrome coronavirus induces protective neutralizing antibodies primarily targeting the receptor binding region
    Zhiwei Chen
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    J Virol 79:2678-88. 2005
  8. ncbi request reprint Intensification of antiretroviral therapy accelerates the decay of the HIV-1 latent reservoir and decreases, but does not eliminate, ongoing virus replication
    Bharat Ramratnam
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY, USA
    J Acquir Immune Defic Syndr 35:33-7. 2004
  9. pmc Single amino acid substitutions in the severe acute respiratory syndrome coronavirus spike glycoprotein determine viral entry and immunogenicity of a major neutralizing domain
    Christopher E Yi
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 1st Avenue, 7th Floor, New York, NY 10016, USA
    J Virol 79:11638-46. 2005
  10. ncbi request reprint Discontinuation of antiretroviral therapy commenced early during the course of human immunodeficiency virus type 1 infection, with or without adjunctive vaccination
    Martin Markowitz
    Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York 10016, USA
    J Infect Dis 186:634-43. 2002

Research Grants

Collaborators

Detail Information

Publications50

  1. pmc Host-specific driving force in human immunodeficiency virus type 1 evolution in vivo
    L Zhang
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 71:2555-61. 1997
    ..e., that transmission does not reset the evolutionary clock...
  2. ncbi request reprint Contribution of human alpha-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor
    Linqi Zhang
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Science 298:995-1000. 2002
    ..Taken together, our results indicate that alpha-defensin 1, 2, and 3 collectively account for much of the anti-HIV-1 activity of CAF that is not attributable to beta-chemokines...
  3. pmc Compartmentalization of surface envelope glycoprotein of human immunodeficiency virus type 1 during acute and chronic infection
    Linqi Zhang
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 76:9465-73. 2002
    ....
  4. pmc Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in china
    Linqi Zhang
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Floor, New York, NY 10016, USA
    J Virol 78:13591-9. 2004
    ....
  5. ncbi request reprint Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals
    Linqi Zhang
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Med Virol 78:1-8. 2006
    ....
  6. ncbi request reprint Heterologous MVA-S prime Ad5-S boost regimen induces high and persistent levels of neutralizing antibody response against SARS coronavirus
    Lei Ba
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 1st Avenue, New York, NY 10016, USA
    Appl Microbiol Biotechnol 76:1131-6. 2007
    ..Thus, our data provides a promising optimal regimen for vaccine development in humans against SARS-CoV infection...
  7. pmc Recombinant modified vaccinia virus Ankara expressing the spike glycoprotein of severe acute respiratory syndrome coronavirus induces protective neutralizing antibodies primarily targeting the receptor binding region
    Zhiwei Chen
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    J Virol 79:2678-88. 2005
    ..In addition, ADS-MVA induced potent immune responses which very likely protected Chinese rhesus monkeys from pathogenic SARS-CoV challenge...
  8. ncbi request reprint Intensification of antiretroviral therapy accelerates the decay of the HIV-1 latent reservoir and decreases, but does not eliminate, ongoing virus replication
    Bharat Ramratnam
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY, USA
    J Acquir Immune Defic Syndr 35:33-7. 2004
    ..Additional studies are needed to understand the host- and pathogen-related determinants of incomplete pharmacologic control of HIV-1 replication...
  9. pmc Single amino acid substitutions in the severe acute respiratory syndrome coronavirus spike glycoprotein determine viral entry and immunogenicity of a major neutralizing domain
    Christopher E Yi
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 1st Avenue, 7th Floor, New York, NY 10016, USA
    J Virol 79:11638-46. 2005
    ..Our data have implications for the rational design of vaccine and antiviral agents as well as for understanding viral tropism...
  10. ncbi request reprint Discontinuation of antiretroviral therapy commenced early during the course of human immunodeficiency virus type 1 infection, with or without adjunctive vaccination
    Martin Markowitz
    Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York 10016, USA
    J Infect Dis 186:634-43. 2002
    ....
  11. pmc Natural mutations in the receptor binding domain of spike glycoprotein determine the reactivity of cross-neutralization between palm civet coronavirus and severe acute respiratory syndrome coronavirus
    Li Liu
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    J Virol 81:4694-700. 2007
    ....
  12. ncbi request reprint alpha-defensins released into stimulated CD8+ T-cell supernatants are likely derived from residual granulocytes within the irradiated allogeneic peripheral blood mononuclear cells used as feeders
    Gerasimos J Zaharatos
    Aaron Diamond AIDS Research Center, New York, NY 10016, USA
    J Acquir Immune Defic Syndr 36:993-1005. 2004
    ..Moreover, our data imply that under some experimental conditions, a soluble noncytolytic anti-HIV-1 factor other than beta-chemokines is either not produced by CD8+ T-cells or is present in too small quantity to be effective...
  13. ncbi request reprint Genetic characterization of diverse HIV-1 strains in an immigrant population living in New York City
    Hsi Hsun Lin
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    J Acquir Immune Defic Syndr 41:399-404. 2006
    ..Public health officials and physicians should be aware of the growing genetic diversity of HIV-1 in this country, particularly in areas with sizable immigrant populations...
  14. pmc Human immunodeficiency virus type 1 induces persistent changes in mucosal and blood gammadelta T cells despite suppressive therapy
    Michael A Poles
    New York University School of Medicine Department of Medicine, New York, New York, USA
    J Virol 77:10456-67. 2003
    ....
  15. pmc Determination of virus burst size in vivo using a single-cycle SIV in rhesus macaques
    Hannah Yuan Chen
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 104:19079-84. 2007
    ....
  16. ncbi request reprint Impact of thymectomy on the peripheral T cell pool in rhesus macaques before and after infection with simian immunodeficiency virus
    Sarah Tuttleton Arron
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    Eur J Immunol 35:46-55. 2005
    ..We therefore conclude that peripheral destructive processes, rather than a loss of thymic output, appear to be the main causes of T cell depletion in SIV infection...
  17. pmc In vivo distribution of the human immunodeficiency virus/simian immunodeficiency virus coreceptors: CXCR4, CCR3, and CCR5
    L Zhang
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 72:5035-45. 1998
    ..These findings may be helpful in understanding certain aspects of HIV and SIV pathogenesis and transmission...
  18. ncbi request reprint Effect of HIV-1 infection on lymphocyte proliferation in gut-associated lymphoid tissue
    A H Talal
    Aaron Diamond AIDS Research Center, New York City, New York, USA
    J Acquir Immune Defic Syndr 26:208-17. 2001
    ..To determine the change in the percentage of proliferative and activated lymphocytes in gut-associated lymphoid tissue (GALT) in HIV-1-infected subjects compared with that in uninfected controls...
  19. pmc Chemokine coreceptor usage by diverse primary isolates of human immunodeficiency virus type 1
    L Zhang
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 72:9307-12. 1998
    ....
  20. ncbi request reprint HIV type 1 subtypes, coreceptor usage, and CCR5 polymorphism
    L Zhang
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    AIDS Res Hum Retroviruses 13:1357-66. 1997
    ..Therefore, the uneven worldwide distribution of HIV-1 subtypes is more likely the result of stochastic dissemination...
  21. pmc Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection
    L A Chakrabarti
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 74:1209-23. 2000
    ..Normal T-cell turnover in SIV-infected mangabeys provides an explanation for the long-term maintenance of a functional immune system in these hosts...
  22. ncbi request reprint Open-label phase II trial of amprenavir, abacavir, and fixed-dose zidovudine/lamivudine in newly and chronically HIV-1--infected patients
    R G Kost
    The Aaron Diamond AIDS Research Center, New York, New York 10016, USA
    J Acquir Immune Defic Syndr 26:332-9. 2001
    ..Patient intolerance may limit the efficacy of this combination...
  23. ncbi request reprint Age-dependent changes in T cell homeostasis and SIV load in sooty mangabeys
    L A Chakrabarti
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    J Med Primatol 29:158-65. 2000
    ..Thus, the number of susceptible target cells may be a limiting factor in natural SIV infection...
  24. pmc Safety and immunogenicity of ALVAC vCP1452 and recombinant gp160 in newly human immunodeficiency virus type 1-infected patients treated with prolonged highly active antiretroviral therapy
    Xia Jin
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 1st Avenue, 7th Floor, New York, NY 10016, USA
    J Virol 76:2206-16. 2002
    ..In summary, vaccination with vCP1452 and recombinant gp160 appears safe and immunogenic in newly HIV-1-infected patients on HAART...
  25. pmc Residual viral replication during antiretroviral therapy boosts human immunodeficiency virus type 1-specific CD8+ T-cell responses in subjects treated early after infection
    Gabriel M Ortiz
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
    J Virol 76:411-5. 2002
    ..HIV-1-specific CD8+ T cells can increase in number after HAART in subjects treated early after infection who have episodes of transient viremia...
  26. pmc Markers for hepatitis A, B and C in methadone maintained patients: an unexpectedly high co-infection with silent hepatitis B
    Gavin Bart
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, NY, NY 10021, USA
    Addiction 103:681-6. 2008
    ..To determine the prevalence of hepatitis A, B and C viruses in patients attending a methadone maintenance clinic in New York City...
  27. ncbi request reprint Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations
    Sharon R Lewin
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY
    Blood 100:2235-42. 2002
    ..T-cell neogenesis, appropriate to age but delayed in adult recipients of T-cell-depleted allografts, justifies interventions to hasten this process and to stimulate desirable cellular immune responses...
  28. pmc The liver is a major organ for clearing simian immunodeficiency virus in rhesus monkeys
    Linqi Zhang
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York 10016, USA
    J Virol 76:5271-3. 2002
    ..The rapid clearance and degradation of exogenously infused virions may pose a major obstacle for gene therapy with viral vectors, unless strategies to overcome the rapid in vivo elimination of these particles are developed...
  29. doi request reprint Hepatic inflammatory cytokine mRNA expression in hepatitis C virus-human immunodeficiency virus co-infection
    S A Gonzalez
    Center for the Study of Hepatitis C and Division of Gastroenterology and Hepatology, Weill Medical College of Cornell University, New York, NY 10065 4896, USA
    J Viral Hepat 15:331-8. 2008
    ..Further studies are needed to assess whether decreased IFN-gamma secretion by HCV-specific CD4+ cells may account for accelerated fibrogenesis in these patients...
  30. ncbi request reprint An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen
    A S Doane
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Oncogene 25:3994-4008. 2006
    ..This subset of BCs, characterized by a hormonally regulated transcriptional program and response to androgen, suggests the potential for therapeutic strategies targeting the androgen signaling pathway...
  31. ncbi request reprint Anti-HIV agent MAP30 modulates the expression profile of viral and cellular genes for proliferation and apoptosis in AIDS-related lymphoma cells infected with Kaposi's sarcoma-associated virus
    Y Sun
    Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
    Biochem Biophys Res Commun 287:983-94. 2001
    ..These results provide valuable insight into the molecular mechanisms of MAP30 anti-KS action and suggest its utility as a therapeutic agent against AIDS-related tumors...
  32. ncbi request reprint Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model
    X M Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029-6574, USA
    J Allergy Clin Immunol 108:639-46. 2001
    ..CONCLUSION: FAHF-1 protected peanut-sensitized mice from anaphylactic reactions and significantly reversed established IgE-mediated peanut allergy. This suggests that FAHF-1 might prove valuable for the treatment of peanut allergy...
  33. ncbi request reprint Phosphorylase phosphatase: new horizons for an old enzyme
    E Y Lee
    Department Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York, USA
    Front Biosci 4:D270-85. 1999
    ....
  34. doi request reprint Design and evaluation of sifuvirtide, a novel HIV-1 fusion inhibitor
    Yuxian He
    AIDS Research Center, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    J Biol Chem 283:11126-34. 2008
    ..0 +/- 8.6 h and 26.0 +/- 7.9 h, respectively. In summary, sifuvirtide has potential to become an ideal fusion inhibitor for treatment of HIV/AIDS patients, including those with HIV-1 strains resistant to T20...
  35. ncbi request reprint The attenuation of vaccinia Tian Tan strain by the removal of the viral M1L-K2L genes
    Weijun Zhu
    Modern Virology Research Center and AIDS Center, State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Hubei 430072, PR China
    J Virol Methods 144:17-26. 2007
    ..Collectively, the removal of the M1L-K2L genes is a useful method to generate an attenuated vaccinia Tian Tan vaccine vector...
  36. doi request reprint The changing face of HIV in China
    Lin Lu
    Yunnan Center for Disease Control and Prevention, Yunnan, People s Republic of China
    Nature 455:609-11. 2008
    ..HIV has advanced from high-risk groups such as intravenous drug users to some in the general population, according to comprehensive new data from the south of China. What needs to be done to halt its spread?..
  37. ncbi request reprint Complete genomic sequences for hepatitis C virus subtypes 6e and 6g isolated from Chinese patients with injection drug use and HIV-1 co-infection
    Chunhua Li
    Division of Gastroenterology Hepatology, Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Med Virol 78:1061-9. 2006
    ..This suggests that subtype 6e could become epidemic in southern China by network transmission among injection drug users...
  38. pmc Dominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan province of China
    Yong Zhang
    Yunnan Center for Disease Control and Prevention, Kunming, Yunnan, People s Republic of China
    PLoS Med 3:e443. 2006
    ..However, the molecular epidemiology of HIV-1 in Yunnan has not been fully characterized...
  39. ncbi request reprint An epidemic of HIV type I CRF07_BC infection among injection drug users in Taiwan
    Hsi Hsun Lin
    Section of Infectious Diseases, Department of Medicine, E Da Hospital I Shou University, Kaohsiung County 824, Taiwan, Republic of China
    J Acquir Immune Defic Syndr 42:248-55. 2006
    ..These provide information relevant to the development of antiviral therapy and vaccine in Taiwan and may assist public health workers in the prevention of HIV-1 spread...
  40. ncbi request reprint Differential restoration of myeloid and plasmacytoid dendritic cells in HIV-1-infected children after treatment with highly active antiretroviral therapy
    Zheng Zhang
    Research Center of Biological Therapy, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China
    J Immunol 176:5644-51. 2006
    ..These findings may help guide the development of HIV-1-specific immune therapy aimed at fully restoring host immune function in chronically HIV-1-infected children...
  41. ncbi request reprint High prevalence of HIV infection among women and their children in Henan Province, China
    Ke Zhuang
    J Acquir Immune Defic Syndr 33:649-50. 2003
  42. ncbi request reprint HIV-1 subtype B' dictates the AIDS epidemic among paid blood donors in the Henan and Hubei provinces of China
    Bo Su
    Modern Virology Research Center, College of Life Sciences, Wuhan University, Hubei 430072, PR China
    AIDS 17:2515-20. 2003
    ..To investigate the genetic background of HIV-1 strains among infected paid blood donors (PBD) in the Henan and Hubei provinces of China...
  43. ncbi request reprint SARS coronavirus spike polypeptide DNA vaccine priming with recombinant spike polypeptide from Escherichia coli as booster induces high titer of neutralizing antibody against SARS coronavirus
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, Room 423, University Pathology Building, Queen Mary Hospital, Hong Kong
    Vaccine 23:4959-68. 2005
    ..The present observation may have major practical value, such as immunization of civet cats, since production of recombinant proteins from E. coli is far less expensive than production of recombinant proteins using eukaryotic systems...
  44. ncbi request reprint Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics
    Richard Y Kao
    Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Chem Biol 11:1293-9. 2004
    ....
  45. ncbi request reprint Genetic characterization of full-length HIV type 1 genomes from 3 infected paid blood donors in Henan, China
    Li Liu
    J Acquir Immune Defic Syndr 40:501-3. 2005
  46. ncbi request reprint Host range, growth property, and virulence of the smallpox vaccine: vaccinia virus Tian Tan strain
    Qing Fang
    Modern Virology Research Center and AIDS Center, National Key Laboratory of Virology, College of Life Sciences, Wuhan University, Hubei 430072, PR China
    Virology 335:242-51. 2005
    ..Our data demonstrate the need for further attenuation of VTT to serve either as a safer smallpox vaccine or as a live vaccine vector for other pathogens...
  47. pmc Real-time PCR assay using molecular beacon for quantitation of hepatitis B virus DNA
    Simon Siu Man Sum
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong
    J Clin Microbiol 42:3438-40. 2004
    ....
  48. ncbi request reprint Significant changes of peripheral T lymphocyte subsets in patients with severe acute respiratory syndrome
    Taisheng Li
    Department of Infectious Diseases, Peking Union Medical College Hospital, No 1 Shuaifuyuan, Wangfujing, Beijing, China 100730
    J Infect Dis 189:648-51. 2004
    ....
  49. ncbi request reprint Synthesis and biological evaluation of 1,3,3,4-tetrasubstituted pyrrolidine CCR5 receptor antagonists. Discovery of a potent and orally bioavailable anti-HIV agent
    Dawei Ma
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
    ChemMedChem 2:187-93. 2007
    ..3 nM to 30 nM. This molecule showed oral bioavailabilities of 41.2 % and 21.6 % in rats and dogs, respectively. Thus, compound 30 is a promising candidate for the treatment of HIV-1 infection...
  50. ncbi request reprint Analysis of length variation in the V1-V2 region of env in nonsubtype B HIV type 1 from Uganda
    Alexandra M Klevytska
    Department of Pathology, Johns Hopkins Medical Institutions, Ross Building 646, 720 Rutland Avenue, Baltimore, MD 21205, USA
    AIDS Res Hum Retroviruses 18:791-6. 2002
    ..This assay may be helpful for studies examining the impact of env length diversity on HIV-1 transmission and pathogenesis in regions where these subtypes are prevalent...

Research Grants7

  1. CONTRIBUTION OF THE THYMUS TO SIV PATHOGENESIS
    Linqi Zhang; Fiscal Year: 2000
    ....
  2. CONTRIBUTION OF THE THYMUS TO SIV PATHOGENESIS
    Linqi Zhang; Fiscal Year: 2001
    ....
  3. CONTRIBUTION OF THE THYMUS TO SIV PATHOGENESIS
    Linqi Zhang; Fiscal Year: 2002
    ....
  4. CONTRIBUTION OF THE THYMUS TO SIV PATHOGENESIS
    Linqi Zhang; Fiscal Year: 2003
    ....
  5. A Novel Model for the Study of Lung Pathogenesis of SARS
    Linqi Zhang; Fiscal Year: 2007
    ..These methods are repeatedly used to support each of the aims. ..