Sandhya Vasan

Summary

Affiliation: Aaron Diamond AIDS Research Center
Country: USA

Publications

  1. doi request reprint Clinical development of a novel CD1d-binding NKT cell ligand as a vaccine adjuvant
    Neal N Padte
    Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY 10016, USA
    Clin Immunol 140:142-51. 2011
  2. pmc In vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers
    Sandhya Vasan
    Aaron Diamond AIDS Research Center, New York, New York, United States of America
    PLoS ONE 6:e19252. 2011
  3. pmc A double-edged sword: the role of NKT cells in malaria and HIV infection and immunity
    Sandhya Vasan
    Aaron Diamond AIDS Research Center, New York, NY 10016, United States
    Semin Immunol 22:87-96. 2010
  4. pmc Phase 1 safety and immunogenicity evaluation of ADVAX, a multigenic, DNA-based clade C/B' HIV-1 candidate vaccine
    Sandhya Vasan
    Aaron Diamond AIDS Research Center, New York, New York, United States of America
    PLoS ONE 5:e8617. 2010
  5. pmc Phase 1 safety and immunogenicity evaluation of ADMVA, a multigenic, modified vaccinia Ankara-HIV-1 B'/C candidate vaccine
    Sandhya Vasan
    Aaron Diamond AIDS Research Center, New York, New York, United States of America
    PLoS ONE 5:e8816. 2010
  6. pmc Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant
    Xiangming Li
    Aaron Diamond AIDS Research Center, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 107:13010-5. 2010
  7. pmc Neutralization profiles of newly transmitted human immunodeficiency virus type 1 by monoclonal antibodies 2G12, 2F5, and 4E10
    Saurabh Mehandru
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Floor, New York, NY 10016, USA
    J Virol 78:14039-42. 2004
  8. ncbi request reprint Function of NKT cells, potential anti-HIV effector cells, are improved by beginning HAART during acute HIV-1 infection
    Sandhya Vasan
    Aaron Diamond AIDS Research Center, Rockefeller University, 455 First Avenue, 7th Floor, New York, NY 10016, USA
    Int Immunol 19:943-51. 2007
  9. pmc A Glycolipid Adjuvant, 7DW8-5, Enhances CD8+ T Cell Responses Induced by an Adenovirus-Vectored Malaria Vaccine in Non-Human Primates
    Neal N Padte
    Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, New York, United States of America
    PLoS ONE 8:e78407. 2013
  10. doi request reprint HIV-1 and influenza antigens synthetically linked to IgG2a Fc elicit superior humoral responses compared to unmodified antigens in mice
    Gerasimos J Zaharatos
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, 7th Floor, New York, NY 10016, USA
    Vaccine 30:42-50. 2011

Collaborators

Detail Information

Publications10

  1. doi request reprint Clinical development of a novel CD1d-binding NKT cell ligand as a vaccine adjuvant
    Neal N Padte
    Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY 10016, USA
    Clin Immunol 140:142-51. 2011
    ..This review discusses the discovery and characterization of 7DW8-5 and the practical considerations of its preclinical and clinical development as a potential glycolipid adjuvant for candidate malaria and HIV vaccines...
  2. pmc In vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers
    Sandhya Vasan
    Aaron Diamond AIDS Research Center, New York, New York, United States of America
    PLoS ONE 6:e19252. 2011
    ..DNA-based vaccines have been safe but weakly immunogenic in humans to date...
  3. pmc A double-edged sword: the role of NKT cells in malaria and HIV infection and immunity
    Sandhya Vasan
    Aaron Diamond AIDS Research Center, New York, NY 10016, United States
    Semin Immunol 22:87-96. 2010
    ..This review discusses the various features of the interaction between NKT cells and malaria parasites and HIV, and the potential to harness this interaction for therapeutic and vaccine strategies...
  4. pmc Phase 1 safety and immunogenicity evaluation of ADVAX, a multigenic, DNA-based clade C/B' HIV-1 candidate vaccine
    Sandhya Vasan
    Aaron Diamond AIDS Research Center, New York, New York, United States of America
    PLoS ONE 5:e8617. 2010
    ..Sequences were derived from a prevalent circulating recombinant form in Yunnan, China, an area of high HIV-1 incidence. The objective was to evaluate the safety and immunogenicity of ADVAX in human volunteers...
  5. pmc Phase 1 safety and immunogenicity evaluation of ADMVA, a multigenic, modified vaccinia Ankara-HIV-1 B'/C candidate vaccine
    Sandhya Vasan
    Aaron Diamond AIDS Research Center, New York, New York, United States of America
    PLoS ONE 5:e8816. 2010
    ..Sequences were derived from a prevalent circulating HIV-1 recombinant form in Yunnan, China, an area of high HIV incidence. The objective was to evaluate the safety and immunogenicity of ADMVA in human volunteers...
  6. pmc Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant
    Xiangming Li
    Aaron Diamond AIDS Research Center, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 107:13010-5. 2010
    ..Through this rigorous and iterative screening process, we have identified a lead candidate glycolipid, 7DW8-5, that exhibits a superior adjuvant effect than alpha-GalCer on HIV and malaria vaccines in mice...
  7. pmc Neutralization profiles of newly transmitted human immunodeficiency virus type 1 by monoclonal antibodies 2G12, 2F5, and 4E10
    Saurabh Mehandru
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Floor, New York, NY 10016, USA
    J Virol 78:14039-42. 2004
    ..We propose that the induction of 4E10-like antibodies should be a priority in designing immunogens to prevent HIV-1 infection...
  8. ncbi request reprint Function of NKT cells, potential anti-HIV effector cells, are improved by beginning HAART during acute HIV-1 infection
    Sandhya Vasan
    Aaron Diamond AIDS Research Center, Rockefeller University, 455 First Avenue, 7th Floor, New York, NY 10016, USA
    Int Immunol 19:943-51. 2007
    ..Finally, preservation of NKT cell function may be important in HIV-infected individuals, as NKT cells display an anti-HIV-1 activity in vitro, mediated by IFN-gamma secretion...
  9. pmc A Glycolipid Adjuvant, 7DW8-5, Enhances CD8+ T Cell Responses Induced by an Adenovirus-Vectored Malaria Vaccine in Non-Human Primates
    Neal N Padte
    Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, New York, United States of America
    PLoS ONE 8:e78407. 2013
    ..Our results indicate that 7DW8-5 is safe and well-tolerated and provides a significant enhancement (up to 9-fold) in malaria-specific CD8+ T-cell responses after both priming and boosting phases, supporting further clinical development. ..
  10. doi request reprint HIV-1 and influenza antigens synthetically linked to IgG2a Fc elicit superior humoral responses compared to unmodified antigens in mice
    Gerasimos J Zaharatos
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, 7th Floor, New York, NY 10016, USA
    Vaccine 30:42-50. 2011
    ....